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JULY 2015 Edition 7 University Hospitals Case Medical Center delivers stroke clot-buster better than national average in new benchmark report Ohio Department of Health Coverdell Stroke Program presents data on UH performance CLEVELAND -- A new benchmark report from the Ohio Department of Health Coverdell Stroke Program shows that University Hospitals Case Medical Center is 12.4 percent better than the national average in administering the clot-busting drug t- PA within 60 minutes or less of the patient’s arrival at the emergency department (“door-to-needle time”) and 15.5 percent ahead of Ohio hospitals participating in the report. The clot-buster t-PA is intravenous tissue-type plasminogen activator, which is the only FDA approved drug for dissolving the blockage at the root of ischemic strokes. The benefits of t-PA in acute ischemic stroke are time dependent, and guidelines call for it to be administered within 60 minutes of a patient arriving at the emergency department. Other highlights of the report include that the medical center is 16.5 percent ahead of the Ohio average in scheduling primary care provider follow-up appointments and nearly 35 percent ahead of the Ohio average in scheduling follow-up appointments with neurologists both prior to being discharged home. According to the report, follow-up care with a primary care provider can facilitate recovery from stroke. (Continued on page 2) Terry Adelman, Volunteer Co-chair Claire Morgan, Volunteer Co-chair Helen Braun Anthony J. Caruso, PhD Diane Collier David E Cook David & Karen Crane Jeffrey Cristal Michael Cristal Anthony Furlan, MD Kimberly Ganley Judy Goodman Sally Gries Cynthia Halle Jennie Hwang, PhD Robert Jackson, Esq. Wendy Adelman Kampinski Ruth H. Kanner Cynthia Lammert Russ & Connie Lincoln Richard & Marilyn Miller Katherine O'Neill Lee Powar Howard Rabb Stanley & Sue Rubin Gordon & Evelyn Safran Thomas Scherr Gail Schlang Mark & Christina Schumann Warren Selman, MD Margaret Singerman Virginia Spitz Rick Stege, Esq. Lester Stoller Robert & Shelly Wallens Steven & Joni Wasserman Stephen & Penni Weinberg Sheila Wyse Daniel & Ellen Zelman Mary Jo Zingale Warren Selman, MD Department Chairman, Neurological Surgery UHCMC Neurosurgeon-in-Chief, UH Neurosurgery Director, Neurological Institute, UHCMC Anthony Furlan, MD Department Chairman, Neurology UHCMC Co-Director, Neurological Institute, UHCMC Rebecca Kahl, MBA Interim Director of Operations Tracy Gruschow Interim NI Practice Manager MESSAGE FROM THE DIRECTORS Neurological Institute Leadership Council Members Neurological Institute Leadership

July NI Newsletter 2015

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Page 1: July NI Newsletter 2015

J U L Y 2 0 1 5 E d i t i o n 7

University Hospitals Case Medical Center delivers

stroke clot-buster better than national average in new

benchmark report Ohio Department of Health Coverdell Stroke Program presents

data on UH performance

CLEVELAND -- A new benchmark report from the Ohio

Department of Health Coverdell Stroke Program shows that

University Hospitals Case Medical Center is 12.4 percent better

than the national average in administering the clot-busting drug t-

PA within 60 minutes or less of the patient’s arrival at the

emergency department (“door-to-needle time”) and 15.5 percent

ahead of Ohio hospitals participating in the report.

The clot-buster t-PA is intravenous tissue-type plasminogen

activator, which is the only FDA approved drug for dissolving the

blockage at the root of ischemic strokes. The benefits of t-PA in

acute ischemic stroke are time dependent, and guidelines call for it

to be administered within 60 minutes of a patient arriving at the

emergency department.

Other highlights of the report include that the medical center is 16.5

percent ahead of the Ohio average in scheduling primary care

provider follow-up appointments and nearly 35 percent ahead of the

Ohio average in scheduling follow-up appointments with

neurologists – both prior to being discharged home. According to

the report, follow-up care with a primary care provider can facilitate

recovery from stroke.

(Continued on page 2)

Terry Adelman, Volunteer Co-chair Claire Morgan, Volunteer Co-chair

Helen Braun Anthony J. Caruso, PhD Diane Collier David E Cook David & Karen Crane Jeffrey Cristal Michael Cristal Anthony Furlan, MD Kimberly Ganley Judy Goodman Sally Gries Cynthia Halle Jennie Hwang, PhD Robert Jackson, Esq. Wendy Adelman Kampinski Ruth H. Kanner Cynthia Lammert Russ & Connie Lincoln Richard & Marilyn Miller Katherine O'Neill Lee Powar Howard Rabb Stanley & Sue Rubin Gordon & Evelyn Safran Thomas Scherr Gail Schlang Mark & Christina Schumann Warren Selman, MD Margaret Singerman Virginia Spitz Rick Stege, Esq. Lester Stoller Robert & Shelly Wallens Steven & Joni Wasserman Stephen & Penni Weinberg Sheila Wyse Daniel & Ellen Zelman Mary Jo Zingale

Warren Selman, MD Department Chairman, Neurological Surgery UHCMC Neurosurgeon-in-Chief, UH Neurosurgery Director,

Neurological Institute, UHCMC

Anthony Furlan, MD Department Chairman, Neurology UHCMC Co-Director,

Neurological Institute, UHCMC

Rebecca Kahl, MBA Interim Director of Operations

Tracy Gruschow

Interim NI Practice Manager

MESSAGE FROM THE DIRECTORS

Neurological Institute Leadership

Council Members

Neurological Institute Leadership

Page 2: July NI Newsletter 2015

JUNE, 2015 2

STAFF CHANGES AND

SPECIAL ANNOUNCEMENTS

WELCOME Fernandez Baca Vaca, MD will join the

Department of Neurology Epilepsy Center

in July, 2015.

Yin Hu, MD will join the Department of

Neurological Surgery in July, 2015.

Stacy Loejos, RN, will join the

Department of Neurological Surgery as

RN to Dr. Jonathan Miller.

FAREWELL Doris Evans, Academic Education

Coordinator is retiring effective July 17,

2015. You are invited to a reception in

honor of Doris on July 17th in the 5th Floor

Bolwell Conference Rooms 5198/5199

beginning at 2 pm – 5 pm. Kindly RSVP

by July 15th to

[email protected] or call

(216) 983-5741.

Kim Pierce, Secretary, resigned and

transitioned to UH Pain Management on

June 26, 2015.

John Turnbull, Neurological Image &

System Engineer, resigned and

transitioned to CWRU on May 25, 2015.

ROBERT DAROFF, MD

INTERVIEWED BY AAN Dr. Robert Daroff gave an oral history

interview with Dr. Douglas Lanska, a

former UH Neurology resident on behalf

of The American Academy of Neurology.

The entire interview consisting of 5

Appendices are available for access

through the link listed below. Oral

History Interview Transcripts:

www.AAN.com/membership/history

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

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(Continued from page 1)

In addition UH Case Medical Center exceeded the national

average in eight of ten quality measures. “One American dies

from stroke every four minutes and it is a leading cause of

serious long-term disability,” said Dr. Sila. “We continually

strive to make improvements in our rapid response to strokes

at UH Case Medical Center and through our regional stroke

network at our community hospitals.”

“The Coverdell program is a data-driven quality

improvement program demonstrating that we are delivering

the right care at the right time for our patients and it gives us

a roadmap for future developments,” said Dr. Sila. “Research

shows that getting treated at a primary stroke center staffed

by medical experts using the latest technologies gives a

patient the best chance for a favorable outcome and fuller

recovery,” she said.

Warren Selman, MD Anthony Furlan, MD Chairman, Neurological Surgery Chairman, Department of Neurology

Director, Neurological Institute Co-Director, Neurological Institute

DR. MAUREEN MCENERY ELECTED

FACULTY COUNCIL CHAIR Case Western Reserve University’s School of Medicine

recently held Faculty Council Elections and our own, Dr.

Maureen W. McEnery, Associate Professor in the

Department of Neurology with a secondary appointment in

the Department of Neuroscience was elected as the next

Faculty Council chair-elect. The Steering Committee for the

2015-2016 academic year is: Bill Schilling (Chair), Mark

Aulisio (past-Chair), Maureen McEnery (Chair-elect), Mark

Aeder, Devra Becker, Colleen Croniger, William Merrick,

and Nicole Ward. Dr. Jo Ann Wise will serve on the

Nominating Committee. Please congratulate Dr. McEnery in

accepting this role of service.

NEW PROGRAMS AND SERVICES UH Systems Stroke Program Initiative focuses on admitting

low-risk ICH patients to UH Ahuja, based on data collected

at UHCMC and presented at the American Stroke

Association International Stroke Conference in February by

Dr. Oladi Bentho, UH Department of Neurology and Dr. Wei

Xiong, UH Department of Neurology.

Page 3: July NI Newsletter 2015

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

JUNE 2015 3

PROFESSIONAL PRESENTATIONS

AND CONFERENCES

Brian S. Appleby, MD, UH Department of Neurology Psychiatry, was an invited presenter at the CJD Support Group Network Annual Meeting, Melbourne, Australia, October 19, 2014. Topic: "Why do prion diseases look so different?"

PUBLICATIONS Brei TJ, Woodrome SE, Fastenau PS, Buran CF, Sawin KJ. Depressive Symptoms in Parents of Adolescents with Myelomeningocele: The Association of Clinical, Adolescent Neuropsychological Functioning, and Family Protective Factors. Journal of Pediatric Rehabilitation Medicine. In press, 2014.

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

CENTERS OF EXCELLENCE

University Hospitals Offers Leading

Neurological Expertise

Across 15 Centers of Excellence

At University Hospitals Neurological Institute, a

team of nationally recognized experts deliver

comprehensive, coordinated care for disorders of

the brain and nervous system.

Recognized by U.S. News and World Report as

one of the finest neurology and neurosurgery

programs in the country, UH Neurological

Institute delivers innovative, integrated and

individualized care to patients with diseases

affecting the nervous system at convenient

locations throughout northern Ohio.

With 15 centers of excellence, UH Neurological

Institute delivers individualized treatment,

innovative techniques and access to some of the

most innovative research designed to advance

the science of neurological medicine.

For example, we are the only U.S. hospital

offering multiple hippocampus transections as a

surgical solution to eliminate seizures and

effectively cure epilepsy. Also, we were the first

in the world to test diaphragm pacing

stimulation.

This technique can slow the rate of breathing

failure in patients with amyotrophic lateral

sclerosis (ALS) or Lou Gehrig's disease.

Innovative, Integrated and

Individualized Care for Patients

with Neurological Disorders

University Hospitals Neurological Institute

in Cleveland – the leading institute in

Northeast Ohio – offers the full range of

neurological and neurosurgical services at

our primary location, UH Case Medical

Center.

In addition, patients can be seen close to

home at one of our many community

medical and health centers.

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

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INAUGURAL ROBERT J. MACIUNAS

LECTURE The Inaugural Robert J. Maciunas Lecture was held on

Wednesday, May 13th to honor the life and career of Dr.

Maciunas who was the Director of the Gamma Knife Center, the

Center for Image-Guided Neurosurgery and served as Vice

Chairman of the Department of Neurological Surgery at

University Hospitals Case Medical Center.

He was well known for his many advances in the field of

stereotactic and functional neurosurgery, pioneering several

techniques for brain surgery, particularly for helping patients

with Tourette syndrome.

Douglas Kondziolka, M.D., MSc, Professor and Director of the

Center for Advanced Radiosurgery at NYU Langone Medical

Center and Vice Chair of Clinical Research at New York

University School of Medicine, was the invited speaker and

gave a presentation entitled, “If not us, then who.” Dr.

Maciunas’ wife, Ann Failinger, and his two sons Joseph and

Nicholas were in attendance.

(L to R) Dr. Warren Selman, Nicholas Maciunas, Dr. Ann

Failinger, Joseph Maciunas, and Dr. Douglas Kondziolka

Page 4: July NI Newsletter 2015

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JUNE 2015 4

DEGREES AND PROFESSIONAL

CERTIFICATIONS EARNED Cathy Sila, MD, UH Department of Neurology received

an Advancing Manager Certificate, from the

Weatherhead School of Management

Cathy Sila, MD, UH Department of Neurology, -

Vascular Neurology Board Recertification

RESEARCH TRIALS AND STUDIES Protocol Synopsis DAWN™ Trial - DWI or CTP Assessment

with Clinical Mismatch in the Triage of Wake Up and Late

Presenting Strokes Undergoing Neurointervention

Primary Objective: To evaluate the hypothesis that Trevo

thrombectomy plus medical management leads to superior

clinical outcomes at 90 days as compared to medical

management alone in appropriately selected subjects

experiencing an acute ischemic stroke when treatment is

initiated within 6-24 hours after last seen well.

Study Design: Prospective, randomized, multi-center, Phase

II/III (feasibility/pivotal), adaptive, population enrichment,

blinded endpoint, controlled trial. Subjects will be randomized

1:1 to Trevo thrombectomy plus medical management or

medical management alone. Stratification will occur by:

Clinical Imaging Mismatch (CIM) subgroup (see Imaging

Inclusion Criteria), Time Last Seen Well (TLSW) ≥ 6 to < 12

hours vs. >12 to ≤ 24 hours, and Baseline Occlusion Location

(ICA vs. M1).

Planned Number of Subjects: A maximum of 500 subjects is

planned to be enrolled; 250 in the Treatment arm and 250 in the

Control arm. The minimum sample size is 150 subjects. We

expect to enroll 10 patients at UHCMC

Primary Endpoint: Difference between the average weighted

modified Rankin Scale score at 90 days between the active and

control groups.

Study Duration: Enrollment: approximately 36 months;

Subject participation: 90 days (± 14)

For General inclusion criteria information, please contact

the Coordinator Val Cwiklinski RN (pager 35588) or the

Principal Investigator Dr. Cathy Sila for more information.

Or go to ClinicalTrials.gov and search Trevo and Medical

Management.

RESEARCH TRIALS AND STUDIES

contd. Study of Deferoxamine Mesylate in Intracerebral

Hemorrhage (iDEF). This is a prospective, multi-

center, double-blind, randomized, placebo-

controlled, phase-II clinical trial. Subjects will be

randomized to either deferoxamine mesylate (DFO)

at 32 mg/kg/day (up to a maximum daily dose of

6000 mg/day), or saline placebo, given by IV

infusion for 3 consecutive days. Treatment will be

initiated within 24 hours after ICH symptom onset.

Randomization will control baseline imbalances

associated with baseline ICH score, ICH onset-to-

treatment time (OTT), ICH volume, baseline

NIHSS score, and warfarin use. All subjects will be

followed for 6 months and will receive standard of

care therapy while participating in the study.

Throughout the study, we will continue to assess the

safety of DFO. At the conclusion of the study, the

proportion of DFO-treated subjects with a good

clinical outcome at 3 months (defined as modified

Rankin Scale (mRS) score of 0-2) will be compared

to the placebo proportion in a futility analysis to

determine if it is futile to move DFO forward to

Phase III efficacy evaluation.

Michael DeGeorgia is the PI of the

study. Research nurses are Dave Korosec, RN, (cell

phone 440-477-4971) and Valerie Cwiklinski, RN,

(cell phone 440-220-0168 or pager #35588).

CLINICAL TRIALS

NRG BN002: Phase I Study of Ipilimumab,

Nivolumab, and the Combination in Patients with

Newly Diagnosed Glioblastoma, an NCI-funded

multicenter trial co-Chaired by Dr. Andrew Sloan,

was approved by CTEP, the FDA and the NIH

Central IRB and will open at 10 sites in July-

August, 2015.

Page 5: July NI Newsletter 2015

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

JUNE 2015 5

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UH GEAUGA MEDICAL CENTER

RECOGNIZED AS ONE OF THE 2015

AMERICA’S BEST STROKE CENTERS UH Geauga Medical Center earned the Women’s

Choice Award for American’s Best Stroke Centers.

This distinction is the first of its kind in the nation and

is awarded to hospitals that carry the certification of

an Advanced Primary Stroke Center or Advanced

Comprehensive Stroke Center by the Joint

Commission combined with achieving above average

patient recommendation scores.

PROFESSIONAL PRESENTATIONS Shivam Om Mittal, MD participated in presenting

two poster presentations at the 19th Movement

Disorder Society International Congress on June

17th-June 18th.

Shivam Om Mittal, Duarte G Machado.

Wide spectrum of clinical presentation of

ataxia with occulomotor apraxia type II.

Shivam Om Mittal, Ashish Ranpura, Arash

Salarhdini, Bahman Jabbari. Hand

stereotypies in Wilson's disease

Jun Park, MD, Asim Shahid, MD, UH Department

of Pediatric Epilepsy, Jonathan Miller, MD, UH

Department of Neurosurgery and Han Lüders, MD,

UH Department of Neurology presented at the 8th

International Epilepsy Colloquium in Grenoble,

France on June 17, 2015. Topic: "Infant with TSC 1

Mutation and focal status epileptics treated with

Leukotomy at 3 months of age."

.

Andrew Sloan, MD, UH Department of

Neurological Surgery, lectured on "Cancer Related

Cord Compression” to UHMG and Seidman

Cancer Center Clinicians on May 13, 2015.

Andrew Sloan, MD, UH Department of

Neurological Surgery, was the invited Oral

Platform presenter on Brain Tumors: What the

Neurosurgeon Wants at the International Society

for MRI in Medicine, in Toronto, CA, May 31,

2015.

Andrew Sloan, MD, UH Department of

Neurological Surgery was the invited Oral

Platform presenter on Laser Interstitial

Thermotherapy (LITT) vs. Stereotactic

Radiosurgery (SRS). Complementary rather than

Competing Technologies at the International

Gamma Knife Meeting.

Andrew Sloan, MD, UH Department of

Neurological Surgery presented on Laser

Interstitial Thermotherapy for the treatment of

newly diagnosed GBM at the AANS Tumor

Satellite Symposium, in Washington, DC, May

2015.

Andrew Sloan, MD, presented on MRI

Fingerprinting for Diagnosis of Malignant Glioma

and Assessment of Treatment Response at the

AANS Tumor Satellite Symposium, in

Washington, DC, May 2015.

Andrew Sloan, MD, D. Bondy, P. Harris and A.

Kerstetter-Fogle presented on The Role of the

Robo-Slit family of Genes in GBM Invasion at the

AANS Annual Meeting, in Washington, DC, May

2015 (Oral)

Andrew Sloan, MD, UH Department of

Neurological Surgery presented on The Role of the

Neurosurgeon in Brain Tumor Clinical Trials at the

AANS Annual Meeting, in Washington, DC, May

2015.

Page 6: July NI Newsletter 2015

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

JUNE 2015 6

SAVE THE DATE - Mark your calendars!

2015 CLEVELAND HYDROCEPHALUS ASSOCIATION WALK The UH Neurological Institute and Rainbow Babies and Children’s Hospital are proud to be a Gold sponsor

of the 2015 Cleveland Hydrocephalus Association WALK on Sunday, August 30. We will be creating a

team for the walk and would be thrilled if you could join us to show support for our patients with

hydrocephalus. If you are interested in walking with us, please e-mail Bri Martinez at

[email protected] to let her know of your interest and for details on registering for the

walk. We will be ordering team t-shirts, price TBD, so please also include your t-shirt size in the email.

7th ANNUAL PARKINSON DISEASE BOOT CAMP Saturday, September 19, 2015

John S. Knight Center

77 East Mill Street, Akron, OH

For more information contact Barbara Bryson at [email protected]

WALK TO END ALZHEIMER'S CLEVELAND AREA CHAPTER September 13, 2015 at the Lake Farm Park, Kirtland, OH http://act.alz.org/site/TR/Walk2015/OH-

ClevelandArea?fr_id=7708&pg=entry

September 19, 2015 at the All Pro Freight Stadium, Avon, OH http://act.alz.org/site/TR/Walk2015/OH-

ClevelandArea?fr_id=7706&pg=entry

September 27, 2015 at the Cleveland Metroparks Zoo, Cleveland,

OH http://act.alz.org/site/TR/Walk2015/OH-ClevelandArea?fr_id=7707&pg=entry

For more information contact Katie Mang at [email protected].

2015 CLEVELAND HEART AND STROKE WALK Saturday, September 26, 2015 – The NI is looking for someone to volunteer to serve as the team captain to

organize a NI group to participate in this year’s walk. If you are interested, please contact Julie Fussner or

Barbara Bryson as soon as possible. [email protected] or [email protected]

4TH ANNUAL DAN AND LINDA ROCKER SILVERBERG HEAL THE HEALER

SYMPOSIUM Friday, October 16, 2015 7:30 am – 4:30 pm

700 Beta Banquet & Conference Center

700 Beta Drive, Mayfield Village, OH 44143

To register for the symposium, call 216 983-1239 – More information to come!

Page 7: July NI Newsletter 2015

U H h o s p i t a l s . o r g / n e u r o 2 1 6 - 8 4 4 - 2 7 2 4

JUNE 2015 7

EDUCATION OPPORTUNITIES GRAND ROUNDS SCHEDULE

Epilepsy Grand Rounds – Frohring Auditorium – CANCELLED FOR THE SUMMER

Neurology Grand Rounds Kulas Auditorium 8 am – CANCELLED FOR THE SUMMER

Neuromuscular Grand Rounds – Lerner Tower 2nd Fl., Room 2060 9:30 am - CANCELLED FOR

THE SUMMER

Pediatric Epilepsy Grand Rounds – RBC 8th Floor Conference Room 11:00 am

Every 4th Monday of the month

Topic: Case Management

Neurosurgical Clinical Conference – Hanna House 5th Floor, Room 537 7:15 am

TBA

If you have any questions regarding department Grand Rounds schedule, please contact:

Lois Hengenius, Neurosurgery Clinical Conference, 216 844-3472

Angela Javorsky, Epilepsy Grand Rounds, 216 844-1764

Roberta Phelps, Neuromuscular Grand Rounds, 216 844-4854

Kim Puskus, Neurology Grand Rounds, 844-3194

Angel Warner, Pediatric Epilepsy Course 216-286-6562

Carlee Seelbach, Connor Integrative Medicine Network 216-593-5533

DAISY AWARD – JOE FAULKNER, RN, NSU

Joe Faulkner RN, NSU received the Daisy Award. DAISY is an acronym for Diseases Attacking the Immune

System. In 1999 the Foundation was formed by the family of J. Patrick Barnes, who at age 33 died of complications

of Idiopathic Thrombocytopenic Purpura (ITP). In Patrick's memory his family started The DAISY Program to

recognize the skillful and amazingly compassionate care he received from his nurses. Congratulations Joe!

Page 8: July NI Newsletter 2015

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JUNE 2015 8

PUBLICATIONS Awan M, Liu S, Sahgal A, Das S, Chao ST, Chang EL, Knisely JP, Redmond K, Sohn JW, Machtay M, Sloan

AE, Mansur DB, Rogers LR, Lo SS. Extra-CNS metastasis from glioblastoma: a rare clinical entity. Expert

Rev Anticancer Ther. 2015 May;15(5):545-52. doi: 10.1586/14737140.2015.1028374. PubMed PMID:

25907706.

Blixen C, Perzynski A, Cage J, Smyth K, Moore S, Sila C, Pundik S, Sajatovic M. Using focus groups to

inform the development of stroke recovery and prevention programs for younger African-American

men. Topics in Stroke Rehabilitation 2015.

Blixen C, Perzynski A, Cage J, Smyth K, Moore S, Sila C, Pundik S, Sajatovic M. Stroke recovery and

prevention barriers among young african-american men: potential avenues to reduce health disparities. Topics

in Stroke Rehabilitation 21(5):432-42, 2014.

Brandt WD, Schreck KC, Bar EE, Taylor I, Marchionni L, Raabe E, Eberhart CG, Rodriguez FJ. Notch

signaling activation in pediatric low-grade astrocytoma. JNeuropathol Exp Neurol. 2015 Feb;74(2):121-31. doi:

10.1097/NEN.0000000000000155. PubMed PMID: 25575134; PubMed Central PMCID: PMC4357229.

Brat DJ et al …Sloan,AE, Barnholtz-Sloan J, Cohen ML, Ostrom Q and others. Cancer Genome Atlas

Research Network, Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N

Engl J Med. 2015 Jun 25;372(26):2481-98. doi: 10.1056/NEJMoa1402121. Epub 2015 Jun 10. PubMed PMID:

26061751.

Brett-Morris A, Wright BM, Seo Y, Pasupuleti V, Zhang J, Lu J, Spina R, Bar EE, Gujrati M, Schur R, Lu

ZR, Welford SM. The polyamine catabolic enzyme SAT1modulates tumorigenesis and radiation response in

GBM. Cancer Res. 2014 Dec1;74(23):6925-34. doi: 10.1158/0008-5472.CAN-14-1249. Epub 2014 Oct 2.

PubMed PMID: 25277523; PubMed Central PMCID: PMC4423404.

Chien LN, Ostrom QT, Gittleman H, Lin JW, Sloan AE, Barnett GH, Elder JB, McPherson C, Warnick R,

Chiang YH, Lin CM, Rogers LR, Chiou HY, Barnholtz-Sloan JS. International Differences in Treatment and

Clinical Outcomes for High Grade Glioma. PLoS One. 2015 Jun 10;10(6):e0129602. doi:

0.1371/journal.pone.0129602. eCollection 2015. PubMed PMID: 26061037; PubMed Central PMCID:

PMC4465035.

Kahlert UD, Suwala AK, Raabe EH, Siebzehnrubl FA, Suarez MJ, Orr BA, Bar EE, Maciaczyk J, Eberhart

CG. ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres. Brain

Pathol. 2014 Dec 17. doi: 10.1111/bpa.12240. [Epub ahead of print] PubMed PMID: 25521330; PubMed

Central PMCID: PMC4470885.

Kim B, Sila C. Seizures in Cerebrovascular Disorders, in MZ Koubeissi, A Alshekhle and P Mehndiratta (ed):

Seizures, 2015.

Kshettry VR, Hsieh JK, Ostrom QT, Kruchko C, Benzel EC, Barnholtz-Sloan JS. Descriptive Epidemiology

of Spinal Meningiomas in the United States. Spine (Phila Pa 1976). 2015 May 20. [Epub ahead of print]

PubMed PMID: 25996535.

Page 9: July NI Newsletter 2015

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JUNE 2015 9

PUBLICATIONS (continued from page 8)

Kshettry VR, Hsieh JK, Ostrom QT, Kruchko C, Barnholtz-Sloan JS. Incidence of vestibular schwannomas

in the United States. J Neurooncol. 2015 May 30. [Epub ahead of print] PubMed PMID: 26024654.

Kulhari A, Kalra N, Sila C. Noncompaction Cardiomyopathy and Stroke: Case Report and Literature

Review. J Stroke Cerebrovasc Dis 2015.

Lim KJ, Brandt WD, Heth JA, Muraszko KM, Fan X, Bar EE, Eberhart CG. Lateral inhibition of Notch

signaling in neoplastic cells. Oncotarget. 2015 Jan30;6(3):1666-77. PubMed PMID: 25557173; PubMed

Central PMCID: PMC4359323.

Lym RL, Ostrom QT, Kruchko C, Couce M, Brat DJ, Louis DN, Barnholtz-Sloan JS. Completeness and

concordancy of WHO grade assignment for brain and central nervous system tumors in the United States,

2004-2011. J Neurooncol. 2015 May;123(1):43-51. doi: 10.1007/s11060-015-1775-4. Epub 2015 Apr 12.

PubMed PMID: 25864099; PubMed Central PMCID: PMC4441798.

Nakibuuka J, Sajatovic M, Nankabirwa J, Furlan AJ, Kayima J, Ddumba E, Katabira E, Byakika-Tusiime J.

Stroke risk factors differ between rural and urban communities: population survey in central

Uganda. Neuroepidemiology 44(3):156-165, 2015.

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner

MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. Response to "the epidemiology of glioma in adults: a

'state of the science' review". Neuro Oncol. 2015 Apr;17(4):624-6. doi: 10.1093/neuonc/nov022. PubMed

PMID: 25762697.

Rabin M, Om Mittal S, Jabbari B. Tremor and Klinefelter’s syndrome. Tremor Other Hyperkinet Mov 2015;

5. doi: 10.7916/D84M93KR.

Ridgel A, Walter BL, Tatsuoka C, Walter E, Colón-Zimmermann K, Welter E, Sajatovic M. Enhanced

Exercise Therapy in Parkinson's disease: A comparative effectiveness trial. Journal of Science and Medicine

in Sport, 2015 [Epub ahead of print].

Shams T, Grossman J, Sila C. Neurologic Complications of Infectious Endocarditis, in K Roos (ed):

Neurobiology of Disease Second Edition, 2015.

Shan L, Diaz O, Zhang Y, Ladenheim B, Cadet J, Chiang Y, Olson L, Hoffer BJ, Bäckman C. L-Dopa

induced dyskinesias in Parkinsonian mice: Disease severity or L-Dopa history. Brain Research 1618:261–

269, 2015.

Virk SM, Gibson RM, Quinones-Mateu ME, Barnholtz-Sloan JS. Identification of variants in primary and

recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing. PLoS One. 2015

May 7;10(5):e0124178. doi: 10.1371/journal.pone.0124178. eCollection 2015. PubMed PMID: 25950952;

PubMed Central PMCID: PMC4423782.

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JUNE 2015 10

NEUROLOGY & NEUROSURGERY RESIDENT & FELLOWS GRADUATIONS

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JUNE 2015 11

NEUROLOGY & NEUROSURGERY RESIDENT & FELLOWS GRADUATIONS

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JUNE 2015 12

NEUROLOGY & NEUROSURGERY RESIDENT & FELLOWS GRADUATIONS

Neurology PGY3 Residents presented The Dennis M. Landis

Teaching Excellence Award to Dr. Alan Lerner

Neurology PGY4 Residents presented The

Robert B. Daroff Teaching Excellence

Award to Dr. Cathy Sila

2015 Department of Neurology Residents Graduation

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JUNE 2015 13

NEUROLOGY & NEUROSURGERY RESIDENT & FELLOWS GRADUATIONS

Saba Saeed, MD;

Guadalupe Fernandez‐ Baca Vaca, MD and

Kunal Kumar, MD Kunal Kumar, MD; Barbara Shapiro, MD and

Oladi Bentho, MD

Oladi Bentho, MD; Guadalupe Fernandez-Baca Vaca, MD;

Manaf Zawahreh, MD and

Sikawat Thanaviratananich, MD

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JUNE 2015 14

May is stroke awareness month. This issue is so important especially when you

consider it is the third leading cause of death in the United States. Members of

the Neurological Institute administered 325 screenings at CMC and 715

throughout the whole system.

STROKE AWARENESS SCREENINGS

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JUNE 2015 15

NI NEWSLETTER SUBMISSION INFORMATION

Next Print Date: August 4, 2015; Submission deadline: July 24th

Email: [email protected] (216) 983-5741

In an effort to keep the newsletter 10 pages or less, we are requesting that you only submit four of

your top publications per month beginning the month of July, 2015.

DR. EDWARD WESTBROOK’S RETIREMENT CELEBRATION – JUNE 22, 2015

Edward Westbrook, MD and Nancy

Tinsley

Edward Westbrook, MD; Anthony

Furlan, MD; Lisa Rogers, MD and

Patrick Sweeney, MD, CCF

Edward Westbrook, MD and

Michael Devereaux, MD

Michael DeGeorgia, MD; Richard Lederman, MD, CCF; Nancy

Bass, MD; Edward Westbrook, MD, Anthony Furlan, MD and

Patrick Sweeney, MD, CCF

Edward Westbrook, MD; Anita Cooper (Dr.

Westbrook’s secretary) and Lisa Rogers, MD