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IPTR /UNOS
International Pancreas Transplant Registry
IPTR /UNOS
Pancreas Transplants
pre 7819781979198019811982198319841985198619871988198919901991199219931994199519961997199819992000200120022003200420052006200720082009
0
200
400
600
800
1000
1200
1400
1600
Pancreas Transplants 12/16/1966 – 12/31/2009
USA: n = 23,850
Non US n = 11,365
1/10
IPTR /UNOS
US Pancreas Transplants
pre 78
1979
1981
1983
1985
1987
1989
1991
1993
1995
1997
1999
2001
2003
2005
2007
2009
0
200
400
600
800
1000
1200
1400
1600
USA Pancreas Transplants 12/16/1966 – 12/31/2010
USA: n = 25,031
1/11
IPTR /UNOS
19881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010
020406080
100120140160
0
200
400
600
800
1000
1200
1400
1600# Cen-ters
# of Txs
Centers
Number of Tx Centers and Number of Txs
01/11
Transplants
USA Pancreas Transplants 1/1/1988 – 12/31/2010
IPTR /UNOS
Pancreas Transplant CategoriesUSA SPK, PAK and PTA Transplants 1/1/1988 – 12/31/2010
01/11
1988
1990
1992
1994
1996
1998
2000
2002
2004
2006
2008
2010
0
200
400
600
800
1000
1200
PTAPAKSPK
Nu
mb
er o
f T
ran
spla
nts
IPTR /UNOS
Pancreas RetransplantsUSA Pancreas Transplants 1/1/1988 – 12/31/2010
1/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
0
20
40
60
80
100
120
140
160
180
PAK
PTA
SPK
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
5
10
15
20
25
30
35
40%#
IPTR /UNOS
PAK PTA SPK0
100
200
300
400
500
600
700
800
900
SPKPTAPAK
Primary Transplant Type
# o
f re
tra
ns
pla
nts
USA Primary Pancreas Transplants 1/1/1988 – 12/31/2010
Type of Primary and Retransplant
IPTR /UNOS
Recipient AgeUSA Primary Pancreas Transplants 1/1/1988 – 12/31/2010
PAKPTASPK
IPTR /UNOS
Duration of DiabetesUSA Primary DD Pancreas Transplants 1/1/1996 –12/31/2010
PAKPTASPK
IPTR /UNOS
Age at Tx by Diabetes TypeUSA Primary DD Pancreas Transplants 1/1/2006 –12/31/2010
Type 1Type 2
PAK PTA SPK
20
30
40
50
60
70
Re
cip
ien
t A
ge
[Y
rs]
IPTR /UNOS
Diabetes Type and DurationUSA Primary DD Pancreas Transplants 1/1/2000 –12/31/2008
Type 1Type 2
PAK PTA SPK0
10
20
30
40
50
60
Du
rati
on
of
Dia
be
tes
[Y
rs]
IPTR /UNOS
Recipient GenderUSA Primary DD Pancreas Transplants 1/1/1988 – 12/31/2010
1/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/0
10
20
30
40
50
60
70
PAK
PTA
SPK
% Male
IPTR /UNOS
Patients with Type 2 Diabetes USA Primary DD Pancreas Transplants 1/1/1994 – 12/31/2010
2/11
1994/95
1996/97
1998/99
2000/01
2002/03
2004/05
2006/07
2008/09
2010/
0123456789
10PAK
PTA
SPK
%
IPTR /UNOS
AfricanAmerican RecipientsUSA Primary DD Pancreas Transplants 1/1/1994 – 12/31/2010
2/11
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/02468
101214161820
PAK
PTA
SPK
%
IPTR /UNOS
Duct Management TechniqueUSA DD Primary Pancreas Transplants 1/1/1988 –12/31/2010
2/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/0
20
40
60
80
100PAK
PTA
SPK
% ED drained
IPTR /UNOS
Portal Drainage in ED TxsUSA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010
2/11
1996/97
1998/99
2000/01
2002/03
2004/05
2006/07
2008/09
2010/
0
10
20
30
40
50
60PAK
PTA
SPK
%
IPTR /UNOS
Use of a Roux-Loop in ED TxsUSA Primary DD Pancreas Transplants, 1/1/1996 – 12/31/2010
2/11
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/0
10
20
30
40
50
60 PAK
PTA
SPK
%
IPTR /UNOS
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/0
10
20
30
40
50
60
70
PAKPTASPK
HLA A,B,DR MismatchingUSA Primary DD Pancreas Transplants 1/1/1988 – 12/31/2010
3/11
% of 5 or 6 HLA Mismatch
IPTR /UNOS
Anti-T-Cell InductionUSA DD Primary Pancreas Transplants 1/1/1988 – 12/31/2010
2/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/09
2010
/0
20
40
60
80
100
PAK
PTA
SPK
%
IPTR /UNOS
Class I PRA levels > 20%USA DD Primary Pancreas Transplants 7/1/2004 – 12/31/2010
2/11
2004
/05
2006
/07
2008
/09
2010
/0
4
8
12
16
PAK
PTA
SPK
%
IPTR /UNOS
Class II PRA levels > 20%USA DD Primary Pancreas Transplants 7/1/2004 – 12/31/2010
2/11
2004
/05
2006
/07
2008
/09
2010
/0
4
8
12
PAK
PTA
SPK
%
IPTR /UNOS
SPK Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
90
No Abs
Depl Abs
NonDepl Abs
Both
Transplant Year
%
3/11
IPTR /UNOS
PAK Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
No Abs
Depl Abs
NonDepl Abs
Both
Transplant Year
%
3/11
IPTR /UNOS
PTA Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
90
100
No Abs
Depl Abs
NonDepl Abs
Both
Transplant Year
%
3/11
IPTR /UNOS
PAK PTA SPK0
10
20
30
40
50
60
70
80
90%
Antibody TherapyUSA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010
No ABs
Depl. AB
NonDepl. AB
Both ABs
3/11
IPTR /UNOS
Overall Initial Steroid AvoidanceUSA Primary DD Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
10
20
30
40
50
60
70
80
SPK
PAK
PTA
Transplant Year
%
3/11
IPTR /UNOS
PAK PTA SPK0
20
40
60
80
MMF
CsA/MMF
TAC/MMF
TAC
SRL based
%
Major Immunosuppressive ProtocolsUSA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010
3/11