Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrab© de Angelis Project Office:

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Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrab de Angelis Project Office: Dr. Michael Raess, Dr. Ana de Castro Helmholtz Zentrum Mnchen Slide 2 www.infrafrontier.eu European Strategy Forum on Research Infrastructures Slide 3 www.infrafrontier.eu ESFRI roadmap BBMRI biobanking EATRIS translational research ECRIN clinical trials ELIXIR bioinformatics Infrafrontier animal disease models INSTRUCT structural biology EU-OPENSCREEN chemical biology BLS4 high security labs Euro-BioImaging - bioimaging EMBRC marine biology Firstroadmap in 2006 Firstroadmap in 2006 Firstroadmap in 2006 35 projects Update in Dec2008 Update in Dec2008 Update in Dec2008 + 10 projects Slide 4 www.infrafrontier.eu Grand Challenges - Understand genetic and environmental impact on human health - Develop novel strategies for diagnosis, prevention and therapies Slide 5 www.infrafrontier.eu Current Biology Why mouse? Mouse genome fully sequenced 95% similarity of the genes of mice and men Easy to breed and handle in captivity Extensive toolbox for manipulating the mouse genome Slide 6 www.infrafrontier.eu Why mouse? Mouse models achieve high impact Publications on Mouse Models Slide 7 www.infrafrontier.eu Shortage on capacities and access: Phenotyping (characterising mouse models) Mouse Clinics EUMODIC, Infrafrontier Archiving and Dissemination of mice and data Repositories EMMA, Infrafrontier The challenge Slide 8 www.infrafrontier.eu Required capacities Archiving and distribution Phenotyping 1500 p.a. 420 p.a. 1500 p.a. 350 p.a. Slide 9 www.infrafrontier.eu Access to phenotyping data and mouse models Infrafrontier Phenomefrontier Archivefrontier + emerging centres Infrafrontier: two main parts Systemic Phenotyping Archivefrontier/EMMA Archiving / Distribution Access to phenotyping services, data and mouse models Slide 10 www.infrafrontier.eu Capacity building required! Slide 11 www.infrafrontier.eu Osteogenesis imperfecta A group of genetic bone disorders... Noted People with OI Jazz pianist Michel Petrucciani Actor writer and ethicist Peter Radke... In the mouse model: Bisphosphonate treatment reverses bone phenotype but does not lower mortality Slide 12 www.infrafrontier.eu The German Mouse Clinic www.mouseclinic.de Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009 Slide 13 www.infrafrontier.eu - Mutation in collagen I Bone phenotype Mineralisation defect Bone deformity fractures Beaded ribs Reduced Bone mineral content & decreased bone mineral density Systemic Lung phenotype Heart phenotype Reduced fat mass & increased lean mass Metabolic alterations Mouse model for Osteogenesis imperfecta Slide 14 www.infrafrontier.eu 12 European Countries + Canada Research Institutions + Funding Agencies Infrafrontier partners Slide 15 www.infrafrontier.eu Infrafrontier partners Slide 16 www.infrafrontier.eu Infrastructure Large Project Smaller Project Slide 17 www.infrafrontier.eu Very large Project: International Mouse Phenotyping Consortium (IMPC) Slide 18 www.infrafrontier.eu Infrafrontier and IMPC Keep in mind: Infrafrontier is a BMS research infrastructure, NOT a single project Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects) State of the art research infrastructures are highly dynamic entities Slide 19 www.infrafrontier.eu Official start:01 March 2008 36 months until: 28 February 2011 4.5 Mio funding by the European Commission Infrafrontier preparatory phase www.infrafrontier.eu Slide 20 Infrafrontier implementation Slide 21 www.infrafrontier.eu Infrafrontier implementation Slide 22 www.infrafrontier.eu Access to mouse resources and data Slide 23 www.infrafrontier.eu Operation Costs Cohort Breeding 23,000 30,000 per line Cohort Breeding 23,000 30,000 per line Phenotyping 15,000 20,000 per line Phenotyping 15,000 20,000 per line Mouse Archiving 3,500 4,400 per line Mouse Archiving 3,500 4,400 per line Mouse Distribution 1,100 2,100 per line Mouse Distribution 1,100 2,100 per line ES Cell Distribution ? per line ES Cell Distribution ? per line User Fees 1,100 1,700 User Fees 1,100 1,700 User Fees 500 700 User Fees 500 700 User Fees to be developed User Fees to be developed Slide 24 www.infrafrontier.eu New mouse clinics and EMMA nodes Established facilities New facilities Slide 25 www.infrafrontier.eu Physical Infrastructure Personnel Operation Technology Development Integration of national & European funds National infrastructure funds National and European Projects Funding Strategy Slide 26 www.infrafrontier.eu MS European Commission Central Coordination MS MS = Member State Decentralised funding model Slide 27 www.infrafrontier.eu Governance Infrafrontier ERIC (Boards) Slide 28 www.infrafrontier.eu Governance Infrafrontier ERIC (Tasks) Slide 29 www.infrafrontier.eu More Information . www.infrafrontier.eu Slide 30 Resource Sharing Policy The Rome Agenda: Funding organizations should cover the costs of deposition of materials arising from projects as part of the project budget. Funding agencies should ensure appropriate data- sharing plans at the outset of projects Slide 31 www.infrafrontier.eu More Information . Coordinator: Prof. Dr. Martin Hrab de Angelis hrabe@helmholtz-muenchen.de Project Office: Dr. Michael Raess Dr. Ana de Castro infrafrontier@helmholtz-muenchen.de Helmholtz Zentrum Mnchen Institute of Experimental Genetics Ingolstdter Landstrasse 1 85764 Neuherberg Slide 32 Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes Coordinator: Prof. Martin Hrab de Angelis Project Office: Dr. Michael Raess, Dr. Ana de Castro Helmholtz Zentrum Mnchen Slide 33 www.infrafrontier.eu Scope of Activities Slide 34 www.infrafrontier.eu Constructing Required Capacities Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 for Construction ~ 5,000,000 for Equipment Adding capacities for 100 lines ~ 6,500,000 Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 for Construction ~ 5,000,000 for Equipment Adding capacities for 100 lines ~ 6,500,000 EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 for Construction ~ 2,000,000 for Equipment Adding capacities for 100 lines ~ 1,300,000 EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 for Construction ~ 2,000,000 for Equipment Adding capacities for 100 lines ~ 1,300,000 Slide 35 www.infrafrontier.eu Maintaining Capacities Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year Slide 36 www.infrafrontier.eu Infrafrontier project key objectives Preparation to meet increasing demands for phenotyping and archiving capacity building Developing a business plan based on a sustainable funding concept Identification of the most suitable legal form Providing a strategic plan for the construction phase Reaching a legal agreement between all partners Slide 37 www.infrafrontier.eu Implementation Preparatory Phase Key deliverables WP2 Strategy and Governance WP3 Legal Work WP4 Financial Work & Funding 2008 2009 2010 2011 WP2 WP3 Legal Work MoU Strategic Plan Draft Strategic Plan WP4 Finance Business Plan Legal status Update