Information About Acetylation Modification for StudentsSummaryRegulating certain metabolic enzymes in the human body and controling diabetes are the main function of protein acetylation. So it is very important for scientists to do experiment in this field. Here I will introduce something about the Acetylation Modification for you. BodyWhat is the protein acetylation? It is the process that Acetyl is added to protein lysine residues and then it can be used by cells to control gene expression, protein activity or physiological processes. Histone acetylation occurs in specific lysine residues in the N-terminal basic amino acid concentration area. And then acetyl coenzyme A will be transferred to the lysine sNH3 + and a positive charge will be neutralized. Now I will mainly introduce the acetylation modification, including its function and meaning to you. The function of acetylation modification As we mentioned above, the main function of acetylation modification is to regulate certain metabolic enzymes in the human body and control diabetes. That means that it is a great achievement for diabetes treatment by regulating a metabolic enzymes--PEPCK1 to control glucose concentration effictively. This achievement has been published on the international cell magazine--Molecular Cell. It is reported that there is a process called as “Gluconeogenesis”, which means that amino acid and some other non-glucose nutrients in human body are transferred into glucose. Generally speaking, our body will transfer glucose automatically. And the PEPCK1 is the key enzyme for controling the process of “Gluconeogenesis”. The function of PEPCK1 is to change the other energy into glucose through the gluconeogenesis. If the activity of PEPCK1 is nuch higher than normal level, the content of glucose in blood will be increased and then the diabbetes is coming. So ir is a very important method to control diabetes by regulating PEPCK1 seriously. The meaning of researching acetylation modificationThe main function of acetylation modification is mainly focusing on affecting the structure of chromosome and activatiing the nuclear transcription factor. What’s more, researchers from FuDan University had found out other meaning of the acetylation modification: 1. Protein acetylation modification is not minority, it is most likely to affect a wide modification of every aspects under the physiological state of cells. It can be regarded as a mile stone in this field. 2. It is the first time to find that the acetylation modification exsits in the metabolic enzymes and it also regulate the metabolomic system and the activity of metabolic enzyme. This can be an important basis for the use of all kinds of medicine and vitamins. 3. The protein acetylation has high specificity features. 4. As we all know that 80% diseases of human have connection with metabolism, so this research offer the new idea for prepare medicine for regulating metabolism.

There are other information about the protein acetylation. It will become the main field for scientists to do experiment on diabetes.