Inflammation. Inflammation definition Inflammation – what for?

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  • Inflammation

  • Inflammationdefinition

  • Inflammation what for?

  • Regeneration, scarring

  • The inflammatory response consists of two main components:

    - vascular reaction

    - cellular reaction

  • Cells included in inflammatory reaction

  • Neutrophils

  • Macrophages

  • Lymphocytes

  • Plasma cells

  • Eosinophils

  • Inflammation nomenclature

  • Inflammation is divided into:

    -acute inflammation

    -chronic inflammation

  • Acute inflammation

  • Acute inflammationMajor components:

  • Acute inflammationCauses

  • Acute inflammation-vascular changes

  • Acute inflammation

    A hallmark of acute inflammation is increased vascular permeability leading to the escape of protein-rich fluid (exudate) into the extravascular tissue. A marked outflow of fluid and its accumulation in the interstitial tissue results in edema (inflammatory edema).

  • Acute inflammation cellular reaction

  • Acute inflammation

  • Acute inflammation phagocytosis

  • Acute inflammationRemember!During phagocytosis leukocytes release microbicidal and other products (lysosomal enzymes,prostaglandins and others) into the extracelular space. These products are capable of causing endothelial injury and tissue damage and may thus amplify the effects of the initial injurious agent. Thus, if persistent and unchecked, the leukocyte infiltrate itself becomes the offender. Leukocyte-dependent tissue injury underlies many acute and chronic human diseases.

  • Acute inflammation outcomes


  • Acute inflammation outcomes


  • Acute inflammation outcomes


  • Acute inflammation outcomes


  • Morphologic patterns of inflammation.

  • Morphologic patterns of inflammation.

    1. Exudative inflammation2. Destructive inflammation3. Proliferative inflammation

  • Exudative inflammation

  • Exudative inflammationsubtypes

  • Serous inflammation

  • Serous inflammation

    When serous inflammation affects mucinous membrane, the exudate is a mixture of fluid and mucus. It is sometimes called catharrh (from Latin word catarrhus).Example: rhinitis (running nose).

  • Fibrinous inflammation

  • Ulcer

  • Purulent inflammation

  • Purulent inflammation circumscribed.

  • Purulent inflammation diffused

    Pyorrhea purulent superficial inflammation of mucous or serous membrane.

    Phlegmon deep inflammation of soft tissue (eg. subcutaneous tissue).

  • Purulent inflammation gangrene.

  • Hemorhagic inflammation

  • Destructive inflammation

  • Proliferative inflammation

  • Chronic inflammation

  • Chronic inflammation causes

  • Chronic inflammation characteristic features

  • Acute versus chronic inflammation

  • Acute versus chronic inflammation

  • Granulomatous inflammation 1

  • Granulomatous inflammation 2

  • Granulomatous inflammation 3

  • Granulomatous inflammation 4

  • Granulomatous inflammation 5

  • Granulomatous inflammationEpithelioid cell

  • Granulomatous inflammationLanghans-type giant cell

  • Granulomatous inflammationGranulomas


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