Impedance Imaging for Breast Cancer DiagnosisTzu-Jen Kao1, Ning Liu3, Hongjun Xia1, Bong Seok Kim1, David Isaacson2, Gary J. Saulnier3, Jonathan C. Newell1 1Departments of Biomedical Engineering, 2Mathematical Sciences3Department of Electrical, Computer and Systems Engineering Rensselaer Polytechnic Institute Introduction:The long-term goal of this project is to develop Electrical Impedance Tomography (EIT) technology to improve the diagnosis of breast cancer.Breast Cancer is responsible for over 40,000 deaths annually among women in the United Stated. Early detection of breast cancer improves the chances that it can be treated successfully. Also, improved detection techniques may be able to reduce the number of biopsies that are performed. Even using combined diagnostic techniques, such as mammography, MRI, clinical breast examination, only 20-40 % of the biopsies that are performed actually reveal cancer . Electrical Impedance Tomography, also called Electrical Impedance Imaging, is a non-invasive technique used to image the electrical conductivity and permittivity within a body from measurements taken on the body surface . Small electric currents are passed through the body using electrodes attached to the skin; the resulting voltages are then measured and used by mathematical algorithms to reconstruct the values of the electrical conductivity and permittivity within the body.It has been known for some time that breast tumors have a significantly higher conductivity and permittivity than surrounding normal tissue. Hence, by forming images of the electrical conductivity of the breast, tumors may be detected and differentiated from normal tissue. EIT does not use ionizing radiation and employs relatively low-cost instrumentation, making it less expensive and/or safer than x-ray mammography, MRI and CT. Future Plans: We are presently testing the ACT 4 hardware and implementing the initial version of the system software and firmware. Over the next few weeks we expect to begin collecting complete data sets and testing the instrument performance. Initial testing will use laboratory test phantoms with conductivity similar to that of the human body. Once the instrument is fully tested and its performance characterized, it will be used to study breast cancer patients at Massachusetts General Hospital. The study, involving a small number of patients who will be undergoing biopsies, will establish the ability of EIT to detect cancer by directly comparing EIT results with biopsy results. ReferencesPublications Acknowledging NSF Support: Ning Liu, Gary J. Saulnier, J.C. Newell, D. Isaacson and T-J Kao. ACT4: A High-Precision, Multi-frequency Electrical Impedance Tomography Conference on Biomedical Applications of Electrical Impedance Tomography, University College London, June 22-24th, 2005.2. Hongjun Xia, A. S. Ross E. Brevdo, T-J Kao, Ning Liu, B. S. Kim, J.C. Newell, G. J. Saulnier and D. Isaacson. The Application software of ACT4. Conference on Biomedical Applications of Electrical Impedance Tomography, University College London, June 22-24th, 2005. 3. Choi, M.H., T-J Kao, D. Isaacson, G.J. Saulnier and J.C. Newell. A Simplified Model of a Mammography Geometry for Breast Cancer Imaging with Electrical Impedance Tomography Proc. IEEE-EMBS Conf. 26, In Press 2005.
Others:4. American Cancer Society, http://www.cancer.org/docroot/home5. M. Cheney, D. Isaacson, Newell, S. Simske, and J. Goble, NOSER: An Algorithm for Solving the Inverse Conductivity Problem Int.. J. Imag. Syst. Tech., vol. 2, pp. 66-75,1990. 6. Jossinet, J. and M. Schmitt. A review of Parameters for Bioelectrical characterization of Breast Tissue Ann. NY Acad. Sci. Vol. 873:30-41, 1999 7. Cheng, K-S., D. Isaacson, J.C. Newell and D.G. Gisser. Electrode Models for Electric Current Computed Tomography IEEE Trans. Biomed. Eng. 36:918-924, 1989.The ACT 4 system is hosted by a Pentium-based personal computer. Through the computer, the operator is able to control the hardware, display and manipulate images and manage the information database. The user interface software is designed to be used in both clinical and laboratory environments and is implemented as a window-style program coded in Visual C++. The interface to allow access to low-level hardware functions will be available for laboratory/experimental use. A simplified interface offering only the functions needed for collecting patient data will be available for clinical use.
Contact Info:Jonathan Newell, Ph. D. Professor of Biomedical Engineering E-mail: email@example.com Rensselaer Polytechnic Institute Web site: http://www.rpi.edu/~newelj/eit.html
110 Eighth St. Troy, NY 12180-3590Phone : 518-276-6433 FAX : 518-276-3035Hardware and Software: [1, 2]The ACT 4 hardware and software supports 64 electrodes that will produce 3-D images of conductivity and permittivity in real time using applied excitations with frequencies between 1 KHz and 1 MHz. It will be able to apply arbitrary patterns of voltage or currents while measuring the resulting currents and voltages, respectively. The operator will be able to select various combinations of image rate and measurement precision, including real-time operation to visualization cardiac-frequency events.To support a high-speed, high-precision, multi-channel instrument, we designed a distributed digital system, including a computer, digital signal processors (DSPs) and field-programmable gate arrays (FPGAs). The computer provides a user interface to control the instrument and to display the results for analysis. Four DSPs are working in parallel to implement the real-time reconstruction algorithm. We use FPGAs mainly to implement the signal generation, voltmeter and control for the ACT 4 analog circuits. FPGAs are also used to implement the interface between multiple channels through a VME-64x backplane, and between the computer and the instrument. Reconstructed Images:Model of the mammogram geometry:Experimental Design: Size of Electrode Array: 5 x 5 cmDim. of the box : 5 cm x 5 cm x 5 cmSize of Electrode: 1.0 x 1.0 cmGap between Electrodes: 2 mm
Conductivity 0 = 0.364 S/mAgar Target size: 5 mm cubeConductivity = 0.901 S/mSolid line: reconstructed voxel conductivity Dotted line: ideal computed conductivity of voxelImportance of this work:The reconstruction of conductivity images in a mammogram geometry will provide a foundation for the comparison of EIT as a breast cancer detection tool with the X-ray mammography.This work is supported in part by CenSSIS, the Center for Subsurface Sensing and Imaging Systems, under the Engineering Research Centers Program of the National Science Foundation (Award Number EEC-9986821).
This work is supported in part by NIBIB, the National Institute of Biomedical Imaging and Bioengineering under Grant Number R01-EB000456-01.