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CHEMICAL ENGINEERING SCIENCE EDITOR-IN-CHIEF PROF. A. P. J. MIDDELBERG BIOMOLECULAR AND BIOLOGICAL ENGINEERING, BIOCHEMICAL AND BIOPROCESS ENGINEERING Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia. E-mail: [email protected] EXECUTIVE EDITORS PROF. M. MAZZOTTI SEPARATIONS SCIENCE AND TECHNOLOGY ETH-Zentrum, Institut f. Verfahrenstechnik, ML G 27, Sonneggstrasse 3, 8092 Zürich, Switzerland. E-mail: [email protected] PROF. S. NAIR CHEMICAL AND BIOMOLECULAR ENGINEERING Georgia Institute of Technology, School of Chemical and Biomolecular Engineering, 311 Ferst Dr NW Atlanta, Georgia 30332-0100 USA E-mail: [email protected] PROF. K. SUNDMACHER PARTICLE TECHNOLOGY, PROCESS SYSTEMS ENGINEERING Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D-39106 Magdeburg, Germany & Otto-von- Guericke-University, Process Systems Engineering, Universitätsplatz 2, D-39106 Magdeburg, Germany Phone +49 (0) 391 6110-350 Fax +49 (0) 391 6110-353 E-mail: [email protected] PROF. D. G. VLACHOS MATERIALS ENGINEERING, REACTION ENGINEERING AND CATALYSIS Department of Chemical Engineering, University of Delaware, 325 CLB, 150 Academy Street, Newark, DE, 19716 USA. PROF. C. H. WANG CHEMICAL AND BIOMOLECULAR ENGINEERING Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, E-mail: [email protected] C. ADJIMAN (London, UK) H. BRIESEN (Freising, Germany) P. DAUENHAUER (St. Amherst, USA) W. GE (Beijing, China) K. HAPGOOD (Clayton, Australia) V. KALRA (Philadelphia, USA) S. LEONG (Singapore, Singapore) A. PARK (New York, USA) F. ARNOLD (Pasadena, CA, USA) A.T. BELL (BERKELEY CA, USA) B. BISCANS (Toulouse, France) A. BOMMARIUS (Atlanta, GA, USA) K. CARPENTER (Singapore) M.O. COPPENS (London, UK) L. F. GLADDEN (Cambridge, UK) R. GORTE (Philadelphia, PA, USA) Y. KEVREKIDIS (Princeton, NJ, USA) D. J. LEE (Taipei, Taiwan) S. Y. LEE (Daejeon, Korea) J. LI (Beijing, People’s Republic of China) M. LU (Brisbane, Australia) W. MARQUARDT (Aachen, Germany) I. METCALFE (Newcastle upon Tyne, UK) F. MUZZIO (Piscataway, NJ, USA) K. NIGAM (Kanpur, India) R. ROUSSEAU (Atlanta, GA, USA) A. SHARMA (Kanpur, India) S. SKOGESTAD (Trondheim, Norway) D. N. THEODOROU (Athens, Greece) M. TIRRELL (Chicago, IL, USA) L. A. M. VAN DER WIELEN (Delft, Netherlands) R. YANG (Ann Arbor, MI, USA) W. ZIMMERMAN (Sheffield, UK) INTERNATIONAL ADVISORY PANEL ASSOCIATE EDITORIAL BOARD continued on inside back cover AIMS AND SCOPE Chemical Engineering Science publishes papers on the fundamentals of chemical engineering, including the development of chemical engineering knowledge and process into and from other disciplines including biology, chemistry, physics, and applied mathematics. We welcome manuscripts describing original research, with significant results based on experiments and/or developments in theory. Such results may be the outcome of studies that range from the molecular level to the plant level. Increasingly, published research addresses and impacts global issues. We also will consider critical reviews of cutting-edge developments, and prospective authors are encouraged to contact an Executive Editor prior to submission. Industrial areas covered by the journal include biotechnology, chemicals, energy, food, materials, microelectronics, nanotechnology, specialty chemicals and pharmaceuticals. The journal classifies research into the following main fields within chemical engineering: biomolecular and biological engineering – the chemical engineering of molecular and cellular products or systems, including through the use of modern tools such as protein and enzyme engineering and directed evolution; all fields at the intersection of chemical engineering and biology, including systems biotechnology, tissue engineering, drug and therapeutic delivery and bioassay development;

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CHEMICAL ENGINEERING SCIENCE

EDITOR-IN-CHIEFPROF. A. P. J. MIDDELBERG BIOMOLECULAR AND BIOLOGICAL ENGINEERING, BIOCHEMICAL AND BIOPROCESS ENGINEERING

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Australia. E-mail: [email protected]

EXECUTIVE EDITORSPROF. M. MAZZOTTI SEPARATIONS SCIENCE AND TECHNOLOGY

ETH-Zentrum, Institut f. Verfahrenstechnik, ML G 27, Sonneggstrasse 3, 8092 Zürich, Switzerland. E-mail: [email protected]. S. NAIR CHEMICAL AND BIOMOLECULAR ENGINEERING

Georgia Institute of Technology, School of Chemical and Biomolecular Engineering, 311 Ferst Dr NW Atlanta, Georgia 30332-0100 USA E-mail: [email protected]. K. SUNDMACHER PARTICLE TECHNOLOGY, PROCESS SYSTEMS ENGINEERING

Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D-39106 Magdeburg, Germany & Otto-von- Guericke-University, Process Systems Engineering, Universitätsplatz 2, D-39106 Magdeburg, Germany Phone +49 (0) 391 6110-350

Fax +49 (0) 391 6110-353 E-mail: [email protected] PROF. D. G. VLACHOS MATERIALS ENGINEERING, REACTION ENGINEERING AND CATALYSIS

Department of Chemical Engineering, University of Delaware, 325 CLB, 150 Academy Street, Newark, DE, 19716 USA.PROF. C. H. WANG CHEMICAL AND BIOMOLECULAR ENGINEERING Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, E-mail: [email protected]

C. ADJIMAN (London, UK)H. BRIESEN (Freising, Germany)P. DAUENHAUER (St. Amherst, USA)W. GE (Beijing, China)

K. HAPGOOD (Clayton, Australia)V. KALRA (Philadelphia, USA)S. LEONG (Singapore, Singapore)A. PARK (New York, USA)

F. ARNOLD (Pasadena, CA, USA)A.T. BELL (BERKELEY CA, USA)B. BISCANS (Toulouse, France)A. BOMMARIUS (Atlanta, GA, USA)K. CARPENTER (Singapore)M.O. COPPENS (London, UK) L. F. GLADDEN (Cambridge, UK) R. GORTE (Philadelphia, PA, USA)Y. KEVREKIDIS (Princeton, NJ, USA) D. J. LEE (Taipei, Taiwan) S. Y. LEE (Daejeon, Korea)J. LI (Beijing, People’s Republic of China)M. LU (Brisbane, Australia)

W. MARQUARDT (Aachen, Germany) I. METCALFE (Newcastle upon Tyne, UK)F. MUZZIO (Piscataway, NJ, USA)K. NIGAM (Kanpur, India) R. ROUSSEAU (Atlanta, GA, USA) A. SHARMA (Kanpur, India)S. SKOGESTAD (Trondheim, Norway) D. N. THEODOROU (Athens, Greece) M. TIRRELL (Chicago, IL, USA)L. A. M. VAN DER WIELEN (Delft, Netherlands)R. YANG (Ann Arbor, MI, USA)W. ZIMMERMAN (Sheffield, UK)

INTERNATIONAL ADVISORY PANEL

ASSOCIATE EDITORIAL BOARD

continued on inside back cover

AIMS AND SCOPEChemical Engineering Science publishes papers on the fundamentals of chemical engineering,

including the development of chemical engineering knowledge and process into and from other disciplines including biology, chemistry, physics, and applied mathematics. We welcome manuscripts describing original research, with significant results based on experiments and/or developments in theory. Such results may be the outcome of studies that range from the molecular level to the plant level. Increasingly, published research addresses and impacts global issues. We also will consider critical reviews of cutting-edge developments, and prospective authors are encouraged to contact an Executive Editor prior to submission.

Industrial areas covered by the journal include biotechnology, chemicals, energy, food, materials, microelectronics, nanotechnology, specialty chemicals and pharmaceuticals.

The journal classifies research into the following main fields within chemical engineering:

biomolecular and biological engineering – the chemical engineering of molecular and cellular products or systems, including through the use of modern tools such as protein and enzyme engineering and directed evolution; all fields at the intersection of chemical engineering and biology, including systems biotechnology, tissue engineering, drug and therapeutic delivery and bioassay development;