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Choosing the path of least resistanceHot Melt Extrusion vs. Spray Drying
© 2014 Hovione
Hot Melt Extrusion Spray Drying
Solubilization and Stability
Challenges
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300
No dependence on
organic solubility
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
Commercial Feasibility
Decreases
Max
imum
Org
anic
So
lub
ility
(%
)
Drug Melting Point (ºC)
100
0
5
10
15
20
150 200 250 300
No drug loading or melting
point limitations related to process
Dru
g L
oad
ing
(%
)
Drug Melting Point (ºC)
100
0
25
50
75
100
150 200 250 300
![Preparation and Evaluation of Ibuprofen Solid Dispersion ......Solid dispersion is achieved by spray-drying [22,23], hot-melt extrusion [24,25], supercritical fluid [26], and cryogenic](https://img.dokumen.tips/doc/110x75/5fab747a16b83b5155485ea6/preparation-and-evaluation-of-ibuprofen-solid-dispersion-solid-dispersion.jpg)
