HEMATOLOGI BTM

8/16/2019 HEMATOLOGI BTM

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OBAT YANG BEKERJAOBAT YANG BEKERJA

PADA SISTEMPADA SISTEMHEMATOLOGIK HEMATOLOGIK Dr.RAHMATINI, M KesDr.RAHMATINI, M Kes

Bagian Farmak!gi " Tera#iBagian Farmak!gi " Tera#iFak$!%as Ke&k%eran 'nan&Fak$!%as Ke&k%eran 'nan&


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HEMOSTASISHEMOSTASIS

Prses #eng(en%ian #er&ara(an se)araPrses #eng(en%ian #er&ara(an se)ara

s#n%an #a&a #em*$!$( &ara( +angs#n%an #a&a #em*$!$( &ara( +ang

)e&era.)e&era.

Fak%r +ang *er#eran Fak%r +ang *er#eran

-.Pem*$!$( &ara(-.Pem*$!$( &ara(

.Trm*si%.Trm*si% /.Fak%r #em*ek$an/.Fak%r #em*ek$an


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DEFINISIDEFINISI

An%i kag$!an An%i kag$!an

O*a% +ang meng(am*a% #em*en%$kanO*a% +ang meng(am*a% #em*en%$kan

*ek$an &ara( &gn men)ega(*ek$an &ara( &gn men)ega(

#em*en%$kan 0*rin +ang mer$#akan#em*en%$kan 0*rin +ang mer$#akan

*a(an esensia! $n%$k #em*en%$kan*a(an esensia! $n%$k #em*en%$kan

%rm*$s.%rm*$s.


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DEFINISIDEFINISI

Trm*!i%ik Trm*!i%ik

O*a% +ang meng(an)$rkan *ek$anO*a% +ang meng(an)$rkan *ek$an

&ara( 2 mem#er)e#a% &egra&asi&ara( 2 mem#er)e#a% &egra&asi0*rin0*rin

&an 0*ringen !e( #!asmin&an 0*ringen !e( #!asmin

se(inggase(inggamem*an%$ !ar$%n+a *ek$an &ara(3mem*an%$ !ar$%n+a *ek$an &ara(3


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ANTI TROMBOTIK ANTI TROMBOTIK

4 O*a% an%i #!a%e!e%4 O*a% an%i #!a%e!e%

4 an%i agregasi %rm*si%,4 an%i agregasi %rm*si%,

men)ega( #er!eka%an 2a&(esi3men)ega( #er!eka%an 2a&(esi3#!a%e!e% &engan &in&ing#!a%e!e% &engan &in&ing

#em*$!$( &ara( +ang )e&era#em*$!$( &ara( +ang )e&era

a%a$ &engan #!a%e!e% !ainn+a.a%a$ &engan #!a%e!e% !ainn+a.


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DEFINISIDEFINISI

Hems%a%ik Hems%a%ik

O*a% +ang &a#a%O*a% +ang &a#a%

meng(en%ikanmeng(en%ikan#er&ara(an#er&ara(an


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An%i kag$!anAn%i kag$!an

In&ikasi In&ikasi

men)ega( %er*en%$k " me!$asmen)ega( %er*en%$k " me!$as

n+a %rm*$s5 em*!$sn+a %rm*$s5 em*!$s in 6i6 "in 6i6 "

in 6i%rin 6i%r

K!asi0kasi -.He#arinK!asi0kasi -.He#arin

.An%i kag$!an ra!.An%i kag$!an ra!

/.An%i kag$!an #engika% in/.An%i kag$!an #engika% in

ka!si$mka!si$m


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He#arinHe#arin

Ter&iri &ari En&gen " eksgen Ter&iri &ari En&gen " eksgen

Mekanisme ker7a Mem#er)e#a%Mekanisme ker7a Mem#er)e#a%

inak%i6asiinak%i6asi

8ak%r #em*ek$ &ara(8ak%r #em*ek$ &ara(

in 6i%r 9 %i&ak mer$*a( (asi! #emin 6i%r 9 %i&ak mer$*a( (asi! #em

&ara(&ara(

9 Mer$*a( *en%$k eri%rsi% " !e$9 Mer$*a( *en%$k eri%rsi% " !e$

ksi%ksi%


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He#arinHe#arin

Mni%r #eng*a%an Mni%r #eng*a%an

-.Ke%e#a%an &sis-.Ke%e#a%an &sis

.Pem &ara( *erka!a se!ama.Pem &ara( *erka!a se!ama

#eng*a%an#eng*a%an

Parame%er )!%%ing %ime5 :ak%$ #emParame%er )!%%ing %ime5 :ak%$ #em

*ek$an, PTT, APTT*ek$an, PTT, APTT

Farmakkine%ika Farmakkine%ika

Ora!Ora! a*sr*si 9 ,a*sr*si 9 , SK,I 6ena, imSK,I 6ena, im


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He#arinHe#arin

E8ek sam#ing E8ek sam#ing

Per&ara(an sa!$ran )erna "Per&ara(an sa!$ran )erna "

(ema%$ria(ema%$ria Reaksi (i#ersensi%i8 2&emam,Reaksi (i#ersensi%i8 2&emam,

menggigi!, $r%ikaria, s+k ana0!ak%ik3menggigi!, $r%ikaria, s+k ana0!ak%ik3

Mia!gia, s%e#rsisMia!gia, s%e#rsis #em* 7k#em* 7k#an7ang, %rm*si%#enia#an7ang, %rm*si%#enia


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He#arinHe#arin

Kn%ra in&ikasi ;Kn%ra in&ikasi ;

-.Per&ara(an5 ke)en&r$ngan-.Per&ara(an5 ke)en&r$ngan

#er&ara(an#er&ara(an

.Ps% #erasi 2ma%a, %ak " M.Ps% #erasi 2ma%a, %ak " M

s#ina!iss#ina!is

/.Ps% !$m*a! #$ngsi, anes%esi/.Ps% !$m*a! #$ngsi, anes%esi


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He#arinHe#arin

In%ksikasi In%ksikasi

Per&ara(an ringan s%# (e#arinPer&ara(an ringan s%# (e#arin

Per&ara(an *era% an%agnisPer&ara(an *era% an%agnis(e#arin(e#arin

e? #r%amin s$!8a%e? #r%amin s$!8a% mengika%5mengika%5

mengmeng inak%i6asi (e#arininak%i6asi (e#arin


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An%i kag$!an ra!An%i kag$!an ra!

Ter&iri &ari Ter&iri &ari

< (i&rksi k$marin,:ar8arin< (i&rksi k$marin,:ar8arin

Mekanisme ker7a an%agnis @i% K Mekanisme ker7a an%agnis @i% K 6i% K mer$#akan k8ak%r &a!am6i% K mer$#akan k8ak%r &a!am

ak%i6asiak%i6asi

8ak%r #em*ek$ &ara( II, @II, I,8ak%r #em*ek$ &ara( II, @II, I,


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Farmakkine%ikaFarmakkine%ika

E8ek n+a%a se%e!a( -9< 7amE8ek n+a%a se%e!a( -9< 7am

Res#n &i#engar$(i !e( Res#n &i#engar$(i !e( 9 as$#an 6i%amin K 9 as$#an 6i%amin K

9 7$m!a( !emak &a!am makanan9 7$m!a( !emak &a!am makanan

9 in%eraksi *a%9 in%eraksi *a% 9 gene%ik9 gene%ik


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Se&iaan Se&iaan

&ik$mar!, :ar8arin&ik$mar!, :ar8arin ra!, I , Ira!, I , I

6ena6ena

e8ek sam#ing e8ek sam#ing

-.Per&ara(an-.Per&ara(an !en&ir, k$!i%, sa!!en&ir, k$!i%, sa!

)erna,)erna, sa! kemi(sa! kemi(

Le$k#enia, &emam, $rin 7inggaLe$k#enia, &emam, $rin 7ingga


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Kn%ra in&ikasi Kn%ra in&ikasi

-. Pen+aki% #er&ara(an-. Pen+aki% #er&ara(an

. ani%a (ami!. ani%a (ami! /. Pa+a( 7an%$ng/. Pa+a( 7an%$ng &sis&sis

&i%$r$nkan&i%$r$nkan


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An%i kag$!an #engika% inAn%i kag$!an #engika% in

ka!si$mka!si$m

-.Na%ri$m si%ra%-.Na%ri$m si%ra%

.Asam ksa!a%.Asam ksa!a%

/.Na%ri$m e&e%a%/.Na%ri$m e&e%a%


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TROMBOLITIK TROMBOLITIK

Me!ar$%kan %rm*$s +ang s$&a(Me!ar$%kan %rm*$s +ang s$&a(

%er*en%$k%er*en%$k

Pem*erian se&ini m$ngkinPem*erian se&ini m$ngkin

E? S%re#%kinase,$rkinase &!!E? S%re#%kinase,$rkinase &!!

In&ikasiIn&ikasi

In8ark mikar&In8ark mikar& Trm*sis 6ena Trm*sis 6ena

Em*!i #ar$Em*!i #ar$


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An%i Trm*%ikAn%i Trm*%ik

E? As#irin, k!#i&gre!,E? As#irin, k!#i&gre!,

Di#iri&am!, &eks%ran,Di#iri&am!, &eks%ran,

Tik!#i&in, #rs%asik!in 2PGI93. Tik!#i&in, #rs%asik!in 2PGI93.As#irin 2ase%sa!3As#irin 2ase%sa!3

Meng(am*a% sin%esis %rm*ksan A Meng(am*a% sin%esis %rm*ksan A

Meng(am*a% enCim sik!ksigenaseMeng(am*a% enCim sik!ksigenase Se&iaan - mgSe&iaan - mg


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ANTI TROMBOTIK ANTI TROMBOTIK

K!#i&gre!K!#i&gre!

Dsis +ang &ig$nakan = mg5(ari,Dsis +ang &ig$nakan = mg5(ari,

ka&ang &ikm*inasi &engan as#irinka&ang &ikm*inasi &engan as#irin

In&ikasi men)ega( *er$!angn+aIn&ikasi men)ega( *er$!angn+a

s%rkes%rke


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HEMOSTATIK HEMOSTATIK

O*a% $n%$k meng(en%ikan #er&ara(anO*a% $n%$k meng(en%ikan #er&ara(an

Per&ara(an ke)i! Per&ara(an ke)i!

9Penekanan, #en&inginan,9Penekanan, #en&inginan,ka$%erisasika$%erisasi

Per&ara(an !$as Per&ara(an !$as

9Hems%a%ik Lka!9Hems%a%ik Lka! Sis%emikSis%emik


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Hems%a%ik sis%emikHems%a%ik sis%emik

Trans8$si &ara( Trans8$si &ara( #er&ara(an s%##er&ara(an s%#

karenakarena

2Fak%r #em*ek$ !engka#32Fak%r #em*ek$ !engka#3

Fak%r an%i (em0!ik 2Fak%r @III3Fak%r an%i (em0!ik 2Fak%r @III3

Km#!ek 8ak%r I,@i%amin K Km#!ek 8ak%r I,@i%amin K

Asam aminka#ra%Asam aminka#ra%Asam %raneksama%Asam %raneksama%


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REFERENSIREFERENSI

Farmak!gi " Tera#i FK'IFarmak!gi " Tera#i FK'I

H$man P(arma)!g+,Br&+H$man P(arma)!g+,Br&+ et alet al

E%)E%)

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HEMATOLOGI BTM