GOBIND GILL

Vasopressin

Structure

http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Arginine_vasopressin3d.png/778px-Arginine_vasopressin3d.png

Structure

http://www.cancer-therapy.org/CT/v2/B/HTML/32.%20Gomez%20et%20al,%20279-290%20copy.html

Background

HypothalamusPituitary GlandStimuliiFunctions

Water retention in kidney Blood vessel constriction

Regulation in Kidney

http://vasopressin.files.wordpress.com/2011/09/neg-feedback2.jpg

Regulation in Kidney

http://vasopressin.files.wordpress.com/2011/09/neg-feedback3.jpg

Site of Action in Kidney

http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image007.jpg

Mechanism of Action

http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image008.jpg

Mechanism of Action

http://www.samsca.com/role-vasopressin.aspx

Mechanism of action

http://vasopressin.files.wordpress.com/2011/09/vasopressin-receptor.jpg

Other Influencers

Vasopressin-Related Disorders

Central diabetes insipidus Thirst Dehydration Large volume of dilute urine Treatment: desmopressin

Hyponatremia Low blood osmolarity Increased water retention Side effects: headache, nausea vomiting, fatigue, loss

of apetite Treatment: VR2 agonist

Questions