GNIPST Bulletin 37.2

8/11/2019 GNIPST Bulletin 37.2

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05th

September, 2014 Volume No.: 37 Issue No.: 02

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BAS

LEARNING AND PRACTICE

ontentsMessage from PRINCIPAL

Editorial board

Historical article

News Update

Knowledge based Article

Disease Related Breaking

News

Upcoming Events

Drugs Update

Campus NewsStudents Section

Editors Note

Archive

GNIPST Photo Gallery

or your comments/contribution

For ack-Issues,

ailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL

SCIENCE AND TECHNOLOGY

Website:http://gnipst.ac.in
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7


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MESSAGE FROM PRINCIPAL

"It can happen. It does happen.But it can't happen if you quit." Lauren Dane.

We are what we repeatedly do.

Excellence then is not an act, but a habit. Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank tlast years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academexcellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners a

supported in maximizing their potential and talents. Education needs to focus on personalized learni

and instruction, while promoting an education system that is impartial, universally accessible, and meetithe needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order achieve their aims. We are all very proud of you, our students, and your accomplishments and loo

forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looki

forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken

this direction and fruits of these efforts will be received by our students in the near future. Our Teacheare committed and dedicated for the development of the institution by imparting their knowledge and pl

the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positi

challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holist

needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of t

opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us this path.

My best wishes to all.

Dr. A. Sengupta

Click here to go at the top

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTAEDITOR MS. JEENATARA BEGUM

ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

History of Teachers Day in India:While the world celebrates international Teachers Day on the 15th

of October, India celebrates it on the 5th of September, which is

also the birthday of the famous teacher, academic philosopher and

the second President of India, Mr. Sarvepalli Radhakrishan.Dr. Sarvepalli Radhakrishnan was born in the year 1888 in a well-known religious state in Chennai, then called Madras. He was thesecond son of Veera Samayya, a tehsildar in a zamindari. It was amiddle-class, respectable Hindu Brahmin family.He graduated with a Masters Degree in Arts from MadrasUniversity. In partial fulfillment for his M.A. degree,Radhakrishnan wrote a thesis on the ethics of the Vedanta titled

The Ethics of the Vedanta and Its Metaphysical Presuppositions,which was a reply to the charge that the Vedanta system had noroom for ethics.The Origin of Teachers Day: Since 1962, 5th of September has been

celebrated as Teachers Day in India. Dr. Sarvepalli

Radhakhrishnan was a philosopher and a teacher par excellence.

Some of his students and friends approached him and requested

him to allow them to celebrate his birthday. In reply, Dr,

Radhakrishnan said, Instead of celebrating my birthdayseparately, it would be my proud privilege if September 5th is

observed as Teachers day. The request showed

Dr.Radhakrishnans love for the teaching profession. From then

onwards, his birthday is observed as Teachers Day in India.


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He showed how western philosophers, despite all claims to

objectivity, were biased by theological influences from their wider

culture. In one of his major works he also showed that Indian

philosophy, once translated into standard academic jargon, is

worthy of being called philosophy by western standards. His main

contribution to Indian thought, therefore, is that he placed it on

the map, thereby earning Indian philosophy a respect that it had

not had before.

Dr. Radhakrishnan was of the opinion that only the right kind ofeducation could solve many ills of the society and the country. Hewanted to bring in a change in the educational system by

improving the quality of education and building up a strongrelationship between the teacher and the taught. In his opinion,teachers should be the best minds of the country; they should notmerely instruct but should gain the true affection of pupils, and therespect for teachers cannot be ordered but it should be earned.After 1946, his philosophical career was cut short when hiscountry needed him as ambassador to UNESCO and later toMoscow. He was later to become the first Vice-President andfinally the President (1962-1967) of India. He was awarded theBharat Ratna in 1954. The University of Oxford instituted theRadhakrishnan Chevening Scholarships and the RadhakrishnanMemorial Award in his memory. He also received the Peace Prizeof the German Book Trade in 1961.Even as the president Sarvepalli remained a humble man. It was anopen house at the Rashtrapati Bhavan and people from all sectionsof society were welcome to meet him. In addition he accepted onlyRs. 2,500 out of his salary of Rs. 10,000 and donated the remaining

amount to the Prime Ministers National Relief Fund every month.He remained a teacher in many ways and even adopted theauthoritative tone of a headmaster in many of his letters to hisministers. Sarvepalli Radhakrishnan passed away on April 17, 1975.


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NEWS UPDATE

Use of dengue vaccine may cause short-term

spikes in its prevalence: (5thSeptember, 2014)As researchers continue to work toward vaccines for serioustropical diseases such as dengue fever, experts caution in a newreport that such vaccines will probably cause temporary butsignificant spikes in the disease in the years after they are firstused.

First international standards for growth of

developing babies, size of newborns: (5

th

September, 2014)The first international standards for fetal growth and newborn sizehave been developed by a global team led by scientists. Now, forthe first time, all 120 million babies born each year across theworld can be assessed using a common set of standards, reflectinghow babies should grow when mothers have adequate health,nutrition, medical care and socioeconomic status.

One in five child deaths in England preventable,as are many other types, study shows: (5th

September, 2014)A new series of articles highlights the substantial number ofpreventable deaths in England. For example, 20% of child deathsreviewed between 2010 and 2011 (800 of 4601) were frompreventable causes including accidents, suicide, abuse, and neglect.Moreover, the series reveals that death rates vary widely between

and within high income countries and between different agegroups. At an international level, a higher proportion of deaths inolder children in the USA, Australia, and New Zealand are due toexternal causes.


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New blood test could offer more tailored

treatment of ovarian cancer: (5th September,

2014)A new blood test allowing doctors to predict which ovarian cancerpatients will respond to particular types of treatment is a stepcloser following a new study. Researchers say the test could bedeveloped and used in hospitals within the next few years.

Caffeine therapy for apnea of prematurity does

not have long-term harmful effects on sleep:

(5thSeptember, 2014)

Caffeine therapy for apnea of prematurity has no long-termharmful effects on sleep or control of breathing, according to a newstudy of 201 preterm children assessed at ages 5-12, the first studyin humans to examine the long-term effects of neonatal caffeinetreatment on sleep regulation and ventilatory control.

Novel microneedle patch for faster, effective

delivery of painkiller, collagen: (5th September,

2014)A simple technique has been developed to encapsulate lidocaine, acommon painkiller, or collagen in the tiny needles attached to anadhesive patch. When applied to the skin, the microneedles deliverthe drug or collagen rapidly into the skin without any discomfortto the user.

Potassium-rich foods cut stroke, death risks

among older women: (4thSeptember, 2014)

Older women who eat foods with higher amounts of potassiummay be at lower risk of stroke and death than women whoconsume less potassium-rich foods. The health benefits frompotassium-rich foods are greater among older women who do nothave high blood pressure. Most older American women do not eatthe recommended amounts of potassium from foods.


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Rare stem cells hold potential for infertility

treatments: (4thSeptember, 2014)Rare stem cells in testis that produce a biomarker protein called

PAX7 help give rise to new sperm cells -- and may hold a key torestoring fertility, research suggests. Infertility, which the Centersfor Disease Control estimates affects as many as 4.7 million men inthe United States, is a key complication of cancer treatments, suchas chemotherapy and radiation therapy.

Knowing how bacteria take out trash could lead

to new antibiotics: (4thSeptember, 2014)A team of scientists has reconstructed how bacteria tightly control

their growth and division, the cell cycle, by destroying specificproteins through regulated protein degradation. All organisms usecontrolled protein degradation to alter cell behavior in response tochanging environment. A process as reliable and stable as celldivision also has to be flexible, to allow the organism to grow andrespond. But little has been known about the molecular mechanicsof how this works.

Minimally invasive, high-performance intervention

for staging lung cancer: (4thSeptember, 2014)Endoscopic biopsy of lymph nodes between the two lungs(mediastinum) is a sensitive and accurate technique that canreplace mediastinal surgery for staging lung cancer in patientswith potentially resectable tumors. The new study shows that it isnot necessary to perform surgery to confirm negative resultsobtained through the endoscopic approach during the pre-operative evaluation of patients with this type of cancer. This

discovery has many advantages for both the patients and thehealth-care system.


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Important regulators of immune cell response

identified: (4thSeptember, 2014)A more effective method to determine how T cells differentiate

into specialized cell types has been identified by researchers. Thenew approach could help accelerate laboratory research and thedevelopment of potential therapeutics, including vaccines. Themethod may also be used to identify the genes that underlie tumorcell development.

Avian influenza virus isolated in harbor seals

poses a threat to humans: (4th September,

2014)The avian influenza A H3N8 virus that killed harbor seals alongthe New England coast can spread through respiratory dropletsand poses a threat to humans, scientists have found. The findingsreinforce the need for continued surveillance of flu virusescirculating in wild and domestic animals to understand the riskthe viruses pose to humans, said the study's first author.

For detail mail toeditor

KNOWLEDGE BASED ARTICLE

Edible vaccines

Plants offer enormous potential as production platform for

vaccines. Stable integration of a gene into the plant nuclear or

chloroplast genome can transform higher plants (tobacco, potato,

tomato, and banana) into bioreactors for the production of subunit

vaccines. From here, the existence of edible vaccines comes into

being. This plant derived vaccines present an alternative to

conventional vaccines by facilitating safe and effective oral delivery

through the consumption of edible plant tissue.


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Owing to its low cost, it would suitable for developing countries

like India. Edible vaccines are mucosal targeted vaccines which

causes stimulation of both systemic and mucosal immune

response. Todays development of novel vaccines stresses the need

for edible vaccines that are inexpensive and easily administered.

The production of recombinant vaccines in plants may overcome

some of the major difficulties encountered while using traditional

or sub-unit vaccines. In developing countries, difficulties include

vaccine affordability, the need for cold chain from producer to

the site of use of the vaccine and also on dependence on injections

whereas plant derived vaccines do not face these issues. The offer

increased safety, envisaged low cost of programme for massvaccination and wider use of vaccination for veterinary use. Thus,

the use of plant vaccine may overcome some of the major diseases

like measles, cholera, hepatitis B, hey may also help to suppress

auto immune disorders like type I diabetes, diarrhoea, multiple

sclerosis and rheumatoid arthritis. They also offer a unique

opportunity and a convenient tool against the threat against

bioterrorism.

Advantages-

Potential advantages of plant based vaccines are-

Edible means of administration

Reduced need for medical personnel and sterile injection

conditions

Economical in mass production and transportation

Therapeutic proteins are free from pathogens and toxins

Storage near the site of use

Heat stable, eliminating the need for refrigeration.

Subunit vaccine(not attenuated pathogens) means improved safety


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This pocket is filled with a cluster of B-cells, T-cells andmacrophages.

M-cells express class II MHC molecules and antigenstransported across the mucous membrane by M-cells can activate

B-cells within these lymphoid follicles. The activated B-cells leave the lymphoid follicles and migrate to

diffuse mucosal associated lymphoid tissue(MALT) where theydifferentiate into plasma cells that secrete the IgA calss ofantibodies.

These IgA antibodies are transported across the epithelial cellsinto secretions of the lumen where they can interact with theantigens present in the lumen.


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Oral delivery, mucosal and systemic antibody responses:

Plant-derived vaccines have demonstrated the ability to induce

both systemic and mucosal immune responses. The major obstacle to oral vaccination is the digestion of the

antigenic protein in the stomach.

Vaccines derived and delivered by plant cells have been shown toovercome this problem through the protective effect of the plantcell wall.

Like liposome and microcapsules, the plant cell wall allowsgradual release of the antigen onto the vast surface area of the

lower digestive tract. Further problems may be associated with poor immunogenicity or

the induction of tolerance.

Binding to a targeting molecule or carrier peptide, such as HbsAg,has been shown to overcome poor immunogenicity of orallydelivered subunit vaccines.

A unique opportunity against the threat of bio-weapons:

A number of infectious diseases, including smallpox, anthrax andplague have recently raised concern for their possible use inactions of bio-terrorism.

Nations at risk are now faced with the need to be ready tovaccinate part or all of their population within limited periods oftime.

This means that millions of vaccine doses have to be prepared,

stored and renewed at intervals of time. The economic and technical benefits offered by plant-derived

vaccines propose these vaccines as ideal substitutes fortraditional vaccines.

Research on plants that produce antigens against major pathogensfeared in case of bio-terrorism is already under way.


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Dosage:To explain the concept of oral therauptic protein delivery,

hepatitis B surface antigen(HBsAg) was used for oralimmunisation. No primary immune response was detected aftertwo 300microgram doses of yeast derived HBsAg. However aprimary response began after two servings of transgenic potatoescontaining, 85-300microgram of HBsAg.

Side effects:

A research by National Institute Of Allergy & Infectious Diseases(NIAID), National Institutes of Health (NIH) and University of

Maryland School Of Medicine showed no significant side effects.

Limitations:

Development of immune tolerance to vaccine peptide or protein

Consistency of dosage form fruit to fruit, plant to plant , and from

generation to generation is not similar Stability of vaccine in fruit is not known

Selection of best plant is difficult

Certain foods like potato are not eaten raw, and cooking the food

might weaken the medicine present in it.

Anurag Chanda

Student, GNIPST

B.Pharm, 4thYear


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DISEASE RELATED BREAKING NEWS

Human infection with avian influenza A (H7N9)

virus: (4thSeptember, 2014)On 2 September 2014, the National Health and Family Planning

Commission of China notified WHO of 2 additional laboratory-

confirmed cases of human infection with avian influenza A(H7N9)

virus.Read more

UPCOMING EVENTS

5thInternational Conference on Stem Cells and Cancer 2014, JNU

Convention Centre, New Delhi, India from 8-10 November, 2014

DRUGS UPDATES

FDA Approves Keytruda (pembrolizumab) for

Advanced Melanoma:(4thSeptember, 2014)The U.S. Food and Drug Administration granted accelerated

approval toKeytruda (pembrolizumab) for treatment of patients

with advanced or unresectable melanoma who are no longer

responding to other drugs.Read more

CAMPUS NEWS

Today, on 5th September, 2014 the students of GNIPST havearranged a wonderful Teachers Day Programme. On behalf of all

the teachers of GNIPST I would like to thank our beloved

students.

The Freshers welcome programme was held on 14thAugust, 2014.Welcome 1styear students.

We congratulate the following M.Pharm. final year students whohave made their positions in different pharmaceutical companies.


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http://www.who.int/csr/don/2014_09_04_avian_influenza/en/http://www.who.int/csr/don/2014_09_04_avian_influenza/en/http://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.drugs.com/keytruda.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/newdrugs/fda-approves-keytruda-pembrolizumab-advanced-melanoma-4079.htmlhttp://www.drugs.com/keytruda.htmlhttp://d/Jeenat/Bulletin%2034.3_1/New%20Folder/UPCOMING%20EVENTS.docxhttp://www.who.int/csr/don/2014_09_04_avian_influenza/en/


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Anirban Banerjee (Emami Ltd.)

Mahender Roy (Stadmed private Ltd.)

We congratulate the following B.Pharm. final year students for

their success.Samadrita Mukherjee (Abbott India Ltd.)

Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)

Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)

Avishek Naskar (Glaxo SmithKline-Marketing)

Bappaditya Manik (USV Limited)

Sarbani Das (Nutri Synapzz-Marketing)

Ankita Roy (Nutri Synapzz-Marketing)

Rahul Mitra (B M Pharmaceuticals-Production)

The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all.

Utsha Sinha

Satarupa Bhattacharya

Sandipan Sarkar

Purbali Chakraborty

Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 inCollege campus ground.

An industrial tour and biodiversity tour was conducted in Sikkimfor B.Pharm and B.Sc. students under the supervision of Mr. Asis

Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm 2nd

year. Deep Chakrabortywas the only scorer of the final.


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STUDENTS SECTION

WHO CAN ANSWER FIRST????

Which day is celebrated as World

Teachers Day?

From which year teachers day is

celebrated in India?

Answer of Previous Issues Questions

A) DRDO

B) Afghanistan

Identify the person

Answer of Previous Issues Image

Richard Martin Willsttter

Send your thoughts/

Quiz/Puzzles/games/write-ups or any other

contributions for Students Section

answ ers of this Section at

[email protected]


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EDITORS NOTE

It is a great pleasure for me to publish the 2nd

issue of 37th

Volume

of GNIPST BULLETIN. All the followers of GNIPST BULLETIN

are able to avail the bulletin through facebook account GNIPSTbulletin I am very much thankful to all the GNIPST members and

readers who are giving their valuable comments, encouragements

and supports. I am also thankful to Dr. Abhijit Sengupta, Director

of GNIPST for his valuable advice and encouragement. Special

thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar

and Mr. Soumya Bhattacharya for their kind co-operation and

technical supports. Thank you Mr. Soumya Bhattacharyafor thequestionnaires of the student section. An important part of the

improvement of the bulletin is the contribution of the readers. You

are invited to send in your write ups, notes, critiques or any kind of

contribution for the forthcoming special and regular issue.

ARCHIVE

Students of GNIPST organized pre puja celebration programme,Saaranya on 7thOctober, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28thSeptember, 2013 at Dakshineswar Kali Temple and Adyapith,

Kolkata. On this remarkable event about hundred people have

received garments. More than hundred students and most of the

faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) andPharmacists Day (25thSeptember)on 25thand 26thSeptember,

2013 in GNIPST Auditorium. A seminar on Violence against


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recent development of Pharmacy, Genetics and Microbiology and

their correlation with Life Sciences. On the post lunch session,

Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the

recent development and career opportunities in Biotechnology

and Hospital Management. The programme was concluded with

valedictory session and certificate distribution.

About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district of

West Bengal participated in this programme. A good interactive

session between participants and speakers was observed in the

seminar. The seminar was a great success with the effort of

faculties, staffs and students of our Institute. It was a uniquediscussion platform for school teachers and professional of the

emerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started

with a nice presentation by Dr. Pulok Kr. Mukherjee, School of

Natural Products, JU on the skill to write a good manuscript for

publication in impact journals. It was followed by nearly two hourlong discussion among more than thirty participants on different

aspects of pharmacy education. Five nonmember participants

applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm)

in PHARMACOLOGY.The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to

120.


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AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-13to

GNIPST as per the details below:

a. Beneficiary Institution:Guru Nanak Institution of PharmaceuticalScience & Technology.

b.Principal Investigator:Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d.Approved duration: 3 years

e. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal

with respect to diseases such as diabetes, rheumatism, Jaundice,hypertension and developing biotechnological tools for enhancing

bioactive molecules in these plants.


Documents

GNIPST Bulletin 37.2