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Lindell R. Gentry, M.D. Facial Paralysis: Objectives: Discuss the anatomy of the facial nerve Look at common patterns of facial nerve palsy Discuss imaging appearance of lesions that lead to facial paralysis. Facial Nerve Anatomy: Facial Nerve Anatomy: Facial Nerve Anatomy: Facial Nerve Anatomy:

Gentry Facial Nerve - 2017 ASHNR - Educational SymposiaLindell R. Gentry, M.D. Facial Paralysis: Objectives: • Discuss the anatomy of the facial nerve • Look at common patterns

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Lindell R. Gentry, M.D.

Facial Paralysis: Objectives: •  Discuss the anatomy of the facial nerve

•  Look at common patterns of facial nerve palsy

•  Discuss imaging appearance of lesions that lead to facial paralysis.

Facial Nerve Anatomy: Facial Nerve Anatomy:

Facial Nerve Anatomy: Facial Nerve Anatomy:

Branchial Motor (Main Facial Nerve) - Muscles of facial expression

Greater Superficial Petrosal Nerve - Autonomic (parasympathetic)

Chorda Tympani Nerve - Taste to anterior 2/3 tongue

Posterior Auricular Nerve - Periauricular region

Facial Nerve Anatomy:

Muscles of Facial Expression

Greater Petrosal Nerve

Motor Root

Facial Nerve

Chorda Tympani

Sensory Root

Nerve to Stapedius

Facial Nerve Anatomy:

•  Loss of Function –  Central Facial Palsy –  Peripheral Facial Palsy

• Hyperactive Function –  Hemifacial Spasm

Facial Nerve: Symptoms Facial Nerve: Symptoms •  Facial Weakness (Muscles of Facial Expression)

•  Loss of Taste –  Anterior 2/3 of the tongue

• Hyperacusis

•  Loss of Lacrimation

Central Palsy 1. Suprabulbar - Supranuclear

–  Sparing of the upper face

2. Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

Facial Nerve Palsy: Location

Optimal imaging workup: - depends on location of offending lesion - depends on pathology - depends on acuity

Facial Nerve Palsy: Location Central Facial Palsy Peripheral Facial Palsy

Left Facial Palsy with Sparing of the Upper Face

Facial Nerve Palsy: Location Central Palsy

1.  Suprabulbar - Supranuclear –  Sparing of the upper face

2.  Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

Facial Nerve Palsy: Location Central Palsy

1.  Suprabulbar - Supranuclear –  Sparing of the upper face

2.  Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

Lymphoma

6th and 7th CN Palsy

Meningoencephalitis

57 Y/O diabetic with HA, hearing loss, facial pain and lower facial palsy

Central Palsy 1.  Suprabulbar - Supranuclear

–  Sparing of the upper face

2.  Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

Facial Nerve Palsy: Location Central Palsy

1.  Suprabulbar - Supranuclear –  Sparing of the upper face

2.  Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

Facial Nerve Palsy: Location

Parotid Adeno Ca

CN 7 Schwannoma

Facial Nerve Palsy: Location Central Palsy

1.  Suprabulbar - Supranuclear –  Sparing of the upper face

2.  Brainstem –  Other CN Palsies (CN 5-6) –  May or may not spare upper face

Peripheral Palsy 1.  Intratemporal

–  Loss of lacrimation –  Hyperacusis –  Loss of taste to anterior 2/3 of tongue

2.  Intraparotid –  Pure motor

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants CN 7 Schwannoma

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

CN 7 Schwannoma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants CN 7 Schwannoma

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants CN 7 Schwannoma

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants CN 7 Schwannoma

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

CN 7 Schwannoma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants CN 7 Schwannoma

Peripheral Facial Nerve Palsy:

Courtesy of Michelle Michel CN 7 Schwannoma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Plexiform Neurofibroma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

V1

V2 V3

V3

V2

V3

CN 7 CN 7

V2

Auriculotemporal Nerve

CPA Meningioma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Nasopharyngeal SCCA

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Smoker

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Renal Cell Met Smoker

“Dropped” Metastasis

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

SCCA of Cheek

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Adenoid Cystic Ca

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Adenoid Cystic Ca

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Glomus Jugulare Smoker

Glomus Faciale

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: Progressive facial paralysis secondary to a rare temporal bone tumor: Glomus faciale. Parker, NP & Huang, TC. Archives of Oto- HNS, 137:712-715. DOI: 10.1001/archoto.2011.96-a

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Intraosseous Venous Malformation

Idiopathic -  Bell’s Palsy -  Other Viral

Specific -  Bacterial (strep, H Flu, staph, pseudomonas)

-  Spirochete (syphilis, Lyme) -  Fungal (blastomycosis, mucormycosis, aspergillosis)

-  Viral (herpes zoster) -  TB

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: Demographics

-  Very common cause of facial paralysis -  Afflicting 1 in 65 individuals -  More common (elderly, DM, pregnancy, immunosuppressed)

Etiology -  Viral prodrome (60%) -  Unknown, probably viral (HSV 1)

Features -  Abrupt, isolated, unilateral, paralysis entire face -  Hyperacusis, decreased tearing, dysgeusia -  Symptoms peak within days -  No imaging required with these typical features

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Herpetic (Bell’s) Palsy

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: Imaging

–  Herpetic (Bell’s) Palsy is a clinical diagnosis –  Imaging only required in atypical presentations –  MRI to exclude other causes (CVA, neoplasm, TB infection)

Treatment –  Observation –  Nerve regenerates at 1-2 millimeters per day –  Steroids, antivirals may slightly improve outcome –  Surgical decompression controversial

Prognosis –  Recovery = 85% Full recovery

= 10% Partial deficit = 5% Complete deficit

–  Duration = 50% few months = 35% within a year

–  Recurrence = 10 - 20%

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Herpetic (Bell’s) Palsy

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Herpetic (Bell’s) Palsy

Background –  J. Ramsay Hunt (1907)

Clinical Triad –  Otalgia (+/- before paralysis) –  Facial paralysis –  Herpetic eruptions

Etiology –  Varicella zoster (HV-3)

Features –  CN 8 dysfunction (> Bell’s) –  Vertigo, hearing loss, tinnitus –  Peri-auricular edema –  < 50% complete recovery

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: Role of Imaging

– Limited – Exclude other lesions

CN 7 Enhancement – Geniculate ganglion – Labyrinthine segment facial nerve –  IAC meninges – Degree enhancement not prognostic – Peri-auricular soft tissue edema > Bell’s

Treatment –  IV acyclovir and steroids – No role for nerve decompression

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Acute Pre-eruption Phase

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Cholesteatoma

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Cholesteatoma

Aggressive Otitis Externa

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Blastomycosis

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Wegener’s Granulomatosis

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Incidence –  Intralabyrinthine Fxs 30- 50% –  Extralabyrinthine Fxs 10- 20%

Location of Injury –  Perigeniculate 80% –  Proximal mastoid 12% –  Multiple sites 20%

Etiology

–  Bony spicules 46% –  Contusion / edema 36% –  Transection 9% –  Intraneural hematoma 9%

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Degree 1.  Immediate Onset 2. Delayed Onset

Management questions 1. Location Injury 2. Etiology Injury? 3. Surgical Guidance

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: •  Neoplasm

-  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy:

Facial Nerve Prolapse

•  Neoplasm -  Primary -  Metastasis - Meningeal -  Perineural Spread (H&N) -  Vascular

•  Infection-Inflammatory -  Herpetic (Bell’s) Palsy -  Herpes Zoster Oticus -  Mastoiditis - Cholesteatoma -  Other

•  Trauma •  Other

-  Normal Variants

Peripheral Facial Nerve Palsy: Objectives: •  Reviewed the anatomy of the facial nerve

•  Looked at common patterns of facial nerve palsy

•  Discuss imaging appearance of common and uncommon lesions that lead to facial paralysis.

Facial Paralysis:

Lindell R. Gentry, M.D.

Central Facial Palsy Peripheral Facial Palsy