Genetic DiseasesL.O: To understand how some

genetic diseases can be inherited

Starter: list as many inherited diseases that you can think of

In groups of 4 then split into two pairs

Each pair need to create an information leaflet (1 A4 side only) cystic fibrosis and polydactyly. You will also need to create a 5 question quiz.In the leaflet include:-How it is inherited, a genetic diagram e.g. punnet square would be good (include alleles of parents)-What the symptoms are and organs affected-What the treatments are-What embryo screening is

A change in a single gene can cause problems:

A mutation in just one gene can change a characteristic. Sometimes this change has a harmful effect on the body and can lead to disease.

This type of condition is called an inherited disease.

What is an inherited disease?

Examples of inherited diseases

- An inherited disease that affects many body organs, (mainly lungs and digestive system).

What is cystic fibrosis?

- In a person with cystic fibrosis the mucus in air passages (which trap and remove bacteria) is thicker than normal.

The effects of cystic fibrosis

TREATMENT:•Need daily physiotherapy•Antibiotics help to treat and control lung infections

•breathing difficulties

•Risk of repeated chest infections which can lead to lung damage.

Other treatment of cystic fibrosis?

•Special inhalants

•In severe cases, a lung transplant

•Most take enzyme pills when they eat to supply missing enzymes and allow digestion.

There is no cure but embryos can be screened.

Over 7,500 people in the UK are affected by cystic fibrosis.

The quality of life for people with cystic fibrosis is much better than in earlier times, due to improved treatment and understanding of this inherited disease.

Children born with cystic fibrosis do not have a normal life expectancy, although this is improving all the time.

Living with cystic fibrosis

Cystic fibrosis is caused by a recessive allele.

How is cystic fibrosis inherited?

A person with cystic fibrosis has the genotype cc. They have inherited a cystic fibrosis gene from both parents.

normal allele normal allele==CC

cystic fibrosis allele=cc

cc cc

disease allele

disease allele

How is cystic fibrosis inherited?

A heterozygous person (Cc) is called a carrier. They do not have the disease but they do carry the cystic fibrosis allele which they might pass on to their children.

In the UK, 2.3 million people carry the cystic fibrosis gene.

If both parents are carriers of the faulty gene, what is the chance that their children will have cystic fibrosis, the chance of their children being carriers and the chance of them having the disease? Use a genetic cross to work it out.

CC cc

Cystic fibrosis inheritance activity

Cystic fibrosis inheritance activity

21/04/23

Cystic Fibrosis Cystic Fibrosis

Cystic fibrosis is a RECESSIVE genetic disease affecting the cell membranes especially in the lungs and pancreas

Sufferers have problems with creating too much mucus in their lungs and also with digestion

Treatments – enzyme tablets with each meal and physiotherapy to remove mucus

As the disease is recessive BOTH parents must carry the gene for the child to be a sufferer