Gaby Weissman MD Washington Hospital Center Georgetown University Hospital

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Overview of Adult Cardiovascular Disease Social Security Administration Compassionate Allowances Outreach Hearing on Cardiovascular Disease and Multiple Organ Transplants November 9 th 2010 University of Maryland Baltimore County. Gaby Weissman MD Washington Hospital Center - PowerPoint PPT Presentation

Text of Gaby Weissman MD Washington Hospital Center Georgetown University Hospital

  • Overview of Adult Cardiovascular Disease

    Social Security Administration Compassionate Allowances Outreach Hearing on Cardiovascular Disease and Multiple Organ Transplants

    November 9th 2010University of Maryland Baltimore County

    Gaby Weissman MDWashington Hospital CenterGeorgetown University HospitalAssistant Professor Clinical Medicine

  • Burden of CVD - MortalityWorld Health Organization - https://apps.who.int/infobase/Mortality.aspx

  • Burden of CVD - MortalityWorld Health Organization - https://apps.who.int/infobase/Mortality.aspx

  • Burden of CVD Risk Factors - HypertensionAmerican Heart Association - http://www.americanheart.org/downloadable/heart/1261003279882FS14HBP10.pdf

  • Burden of CVD Risk Factors - Diabetes MellitusAmerican Heart Association - http://www.americanheart.org/downloadable/heart/1236357007811FS12DIAB08.pdf

  • Burden of CVD Risk Factors - ObesityAmerican Heart Association - http://www.americanheart.org/downloadable/heart/1236358025411OVRWGHT.pdf

    ACC/AHA/ASNC Guidelines for the clinical use of cardiac radionuclide imaging 2003.Schinkel A, et al. Noninvasive evaluation of ischemic heart disease: Eur Heart J 2003;24:789-800.Uchechukwu K. et al. Diagnostic accuracy of Rb-82 myocardial perfusion. JACC;49:1052-58Nandalur KR. et al. Diagnostic performance of stress cardiac MRI- a meta analysis. JACC;50:1343-53.Accuracy Trial: Budoff MJ. et al. JACC 2008.CORE-64 Trial: Miller JM. et al. Circulation. 2007;116:2627-2633.Evaluating IHD

  • Burden of CVD: Heart FailureLloyd-Jones D. et al Circulation. Published online Dec 15, 2008.

  • Burden of CVD: Heart FailureLloyd-Jones D. et al Circulation. Published online Dec 15, 2008.

  • Heart Failure : Common CausesDickstein K. et al . Eur Heart J 2008. 29, 2388-2442.

  • Heart Failure Classification

  • Heart Failure : Prognosis Based on StageAmmar KA et al . Circulation 2007 115, 1563-1570.

  • Heart Failure : BNPChange in NT-Pro BNP predicts re-hospitalization

  • Evaluating Heart FunctionAnatomyHeart StructureCoronary Anatomy/stenosisFunctionLVEFRVEFCoronary FlowStress testingExercise CapacityStress testingCardiopulmonary testing

  • Evaluating Heart FunctionTests of AnatomyEchoMRICTTests of coronary perfusionStress nuclearStress echoStress MRI

    Tests of exercise capacityETTCPET6 minute walk

  • Prognosis - LVEFCurtis JP et al J Am Coll Cardiol. 2003; 736-42.

  • Cardiopulmonary stress testingLavie CJ. et al Am J Cardiol. 2004; 93:588-593.

  • Prognosis - Exercise stress testingHsich E. et al Am J Cardiol. 2004; 93:588-593.

  • Heart Failure : Prognosis ModelsLevy WC. et al. The Seattle heart failure model: prediction of survival in heart failure. Circulation. 2006;113:1424.

  • Heart Failure : Prognosis ModelsLee DS et al. Predicting mortality among patients hospitalized for heart failure. J Am Medical Association. 2003;290:2581-87.

  • Future of Testing in HFmIBG - Evaluation of the sympathetic nervous systemcMR - fibrosis imagingMyocardial strain measurements1.Karamitos TD. Et al. The role of cardiovascular magnetic resonance imaging in heart failure. J Am Coll Cardiol. 2009;54;1407-1424.2.Jacobson AF. et al. Myocardial Iodine-123 Meta-Iodobenzylguanidine Imaging and cardiac events in heart failure. J Am Coll Cardiol. 2010;55:2212-21.3.Cho GY. et al. Global 2-Dimensional strain as a new prognosticator in patients with heart failure. J Am Coll Cardiol. 2009;54;618-24.