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Assessment of Physiological Age in Humans
Physiological age depends onPhysiologic competence: good to
optimal function of all body systems
&Health status: absence of disease
Physiological age may or may not coincide with chronological age
Laboratory Values in Old Age:
1. Most values unchanged (e.g. hepatic, coagulation, electrolytes, renal, thyroid, blood count, etc.)
2. Some values decreased (e.g. HDL in women)
3. Some values increased (e.g. LDL in men, glucose)
**See Table 3.2**
Geriatric AssessmentInvolves a multi-dimensional diagnostic process
designed to qualify an elderly individual in terms of:
• Functional capabilities• Disabilities
• Medical & Psychological characteristics
A list of typical assessments is summarized in Table 3.3
For our discussion, we will consider particularly:
• Activities of Daily Living (ADL) • Instrumental Activities of Daily Living (IADL)
**See Table 3.4**
Multi-Factorial Aspects of Aging
Assessment criteria for measurements:• Variables must be indicative of a
function important for the general health of the individual
• Must correlate with chronological age
• Must change sufficiently, and with regularity, over time to show differences over 3-5 year intervals
• Must be easily measured without discomfort for the individual (without great expense & excessive labor) Page
31
Assessment Programs include tests that are
grouped into three categories:
1. Tests examining general physical health
2. Tests measuring ability to perform basic self care (ADLs)
3. Tests measuring ability to perform more complex activities (IADLs), reflecting the ability to live independently in the community
Table 3-4 Categories of Physical Health Index MeasuringPhysical Competence
ACTIVTIES INSTRUMENTAL ACTIVITIESOF DAILY LIVING OF DAILY LIVING
Feeding CookingBathing CleaningTo ileting Using telephoneDressing WritingAmbulation ReadingTransfer from toilet LaundryVisual acuity Driving a carOthers Others
The severity of the disability may be measured in terms of
whether a person:
• Does not perform the activity at all
• Can only perform the activity with the help of another
person• Can perform the activity with the help of special equipment
Figure 3. 6: % of persons 70 years & older having difficulty/inability to perform ADLs & IADLs
With advancing age, 1) disability intensity increases in men & women; 2) disability intensity is higher in women than in men at the same age (esp. at later ages); 3) females live a longer average life span but live longer with disability
Why do women have more disability?
Women have more chronic disabling diseases than men but less life threateningExamples of conditioning limiting
ADL (% indicate number of people affected in a given population):
• Arthritis (10.6%)• Heart disease (4.0%)
• Stroke (2.6%)• Respiratory (2.5%)• Diabetes (1.5%)
Some disabilities of aging resemble with those of physical inactivity
(disuse)
**The following table shows some examples of
physiological changes in aging, physical inactivity,
and weightlessness**
Table 3-6 Physiologic Parameters in Aging, Physical Inactivity Weightlessness (In Space)
Reduced Increased
Maximum oxygen consumption Systolic blood pressure andperipheral resistance
Resting and maximum cardiac output Vestibular sensitivityStroke volume Serum total cholesterolSense of balance Urinary nitrogen and creatinineBody water and sodium Blood cell massLean body massGlucose tolerance test VariableSympathetic activity and neurotransmission Endocrine changesThermoregulation Altered EEGImmu ne responses Altered sleep
Changes in specific senses
Maximum Oxygen Consumption Systolic blood pressure and peripheral resistance
Urinary and Fecal Calcium
Table 3.7: Holistic view of the Elderly
In geriatrics, it is necessary:
1. To differentiate the aging process from disease
2. To correlate physical state with psychological environment
Aging is associated with increased incidence of:
• Diseases• Accidents• Stress
The increased susceptibility to stress and disease in old age may
be related to cell senescence.
Table 3.3 “Simple” Functional Assesment of Ambulatory Elderly
PHYSICAL EXAMINATION including: neurologic and musculoskeletal evaluation of arm and leg, evaluation of vision, hearing and speech
NUTRITIONdental evaluation body weight laboratory tests depending on nutritional status and diet
HISTORY
INCONTINENCE (eventually fecal incontinence)presence and degree of severity
MENTAL STATUSNumber of tests are available
DEPRESSIONIf Geriatric Depression scale is positive:- check for adverse medications - initiate appropriate treatment
ADL and IADL (see Table 3-4)
HOME ENVIRONMENT AND SOCIAL SUPPORTEvaluation of home safety and family and community resources
Table 3.3 “Simple” Functional Assesment of Ambulatory Elderly (Cont)