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Eyelids, Orbit and Lacrimal System Hernando L. Cruz Jr., EyeMD Section of Ophthalmic Plastic, Reconstructive, Lacrimal & Orbital Surgery Department of Ophthalmology

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Eyelids, Orbit and Lacrimal

System

Hernando L. Cruz Jr., EyeMDSection of Ophthalmic Plastic, Reconstructive,

Lacrimal & Orbital Surgery

Department of Ophthalmology

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Eyelids, Orbit and Lacrimal

System

Eyelids

Basic Anatomy and Physiology

Eyelid Lesions

Disorders of the Eyelashes

Entropion

Ectropion

Ptosis

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Eyelids, Orbit and Lacrimal

System

Orbit

Applied Anatomy

Clinical Evaluation of Orbital Diseases Diagnostic Modalities in Orbital Diseases

Graves’ Ophthalmopathy

Orbital Infections

Orbital Tumors

Orbital Fractures

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Eyelids, Orbit and Lacrimal

System

Lacrimal System

Applied Anatomy and Physiology

Epiphora and Lacrimation

Clinical Evaluations of Tearing

Infections of the Lacrimal Passages

Treatment of Lacrimal Obstructions

Surgical Techniques

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Eyelids and Periorbital Structures

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Anatomy & Physiology

Eyelids

Globe Protection

• 1. Screening and Sensing action of the Cilia• 2. Secretion of the glands of the Eyelids

• 3. Movements of the Lids

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Anatomy & Physiology

Cilia “Eyelashes” 

first line of Defense

2 rows of about 100 - 150 in the upper and 50 -

75 in the lower lid

nerve plexuses in each follicle

glands in each follicle

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Anatomy & Physiology

Secretion of the Glands of the Eyelids

Oily layer of the meibomian glands

Forms the superficial element of the precorneal

tear film which prevents tear evaporation

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Eyelid Margin Anatomy

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Anatomy & Physiology

Movements of the Lids

3rd and most important element

levator palpebrae superioris, orbicularis oculi

and Muller ’s muscle

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Anatomy & Physiology

7 structural layers of the eyelid

1. Skin and Subcutaneous Tissue

2.Muscle of Protraction

3.Orbital Septum

4. Orbital Fat

5. Muscle of retraction

6. Tarsus

7.Conjunctiva

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Upper Eyelid Anatomy

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Lower Eyelid Anatomy

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Anatomy & Physiology

I. Skin and Subcutaneous Tissue

thinnest of the body

no subcutaneous fat

Upper lid crease

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Anatomy & Physiology

II. Muscles of protraction

orbicularis oculi

CN VII

Pre-tarsal, Pre-septal, Orbital parts

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Orbicularis Oculi Muscle

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Anatomy & Physiology

III. Orbital Septum

multilayered sheet of fibrous tissue

fuses with the aponeurosis to form the lidcrease

serves as a barrier between the eyelid and the

orbit

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Anatomy & Physiology

IV. Orbital Fat

lies posterior the orbital septum and anterior the

levator aponeurosis with age-related attenuation - “eyebag” 

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Anatomy & Physiology

V. Muscles of Retraction

Upper Eyelid

• Levator Muscle and its Aponeurosis

• Muller ’s Muscle

Lower Eyelid

• Capsulopalberal Fascia

• Inferior Tarsal Muscle

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Anatomy & Physiology

Levator Palpebrae Superioris

muscular portion 40 mm

aponeurosis 14-20 mm

whitnall’s ligament - functions as a suspensory

support of the upper eyelid

innervated by CN III

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Whitnalls ligament

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Anatomy & Physiology

Muller ’s Muscle

originates at the undersurface of the

aponeurosis sympathetically innervated

 provides app. 2 mm of eyelid elevation

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Anatomy & Physiology

Lower lid retractors

Capsulopalpebral Fascia - analogous to levator 

aponeurosis Lockwood’s ligament - analogous to whitnall’s

ligament

Inferior tarsal Muscle- analogous to Muller ’smuscle

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Lower Eyelid Anatomy

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Anatomy & Physiology

Tarsus

firm, dense plate

skeleton of the eyelid

Conjunctiva

non-keratinizing squamous epithelium

contains goblet cells & acc. Lacrimal glands

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Anatomy & Physiology

Vascular Supply

Arterial Supply

ICA - supraorbital and lacrimal artery

ECA - angular and temporal artery

Venous Drainage

Pretarsal - angular vein (medially); superficialtemporal vein (laterally)

Posttarsal - orbital vein

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Anatomy & Physiology

 Nerve Supply

Sensory

• Supraorbital Nerve (V1)- innervates the foreheadand lateral periocular area

• Maxillary Nerve (V2)- innervates lower eyelid and

Cheek 

Motor • CN III

• CN VII

• Sympathetic Nerves

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Eyelid Lesions

Benign Eyelid Lesions

Chalazion

Hordeolum

Miscellaneous

Malignant Lesions

BCCa

SCCa

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Cross section of the Eyelid

Margin

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Benign Eyelid Lesions

Chalazion - chronic

granulomatous

inflammation of themeibomian glands.

It is a painless round

lesion within the

tarsal plate

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Benign Eyelid Lesions

External Hordeolum-

infection of the

glands of Moll andZeiss. Usually caused

 by staphylococcus.

Tender inflamed

swelling in the lidmargin

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Benign Eyelid Lesions

Internal Hordeolum-

acute staphylococcal

infection of themeibomian glands.

Tender inflamed

swelling within the

tarsal plate

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Benign Eyelid Lesions

Treatment

Oral Antibiotics

Topical Antibiotics Warm compress

Surgical: I & C

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Benign Eyelid Lesions

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Miscellaneous Eyelid Lesions

Molluscum contagiosum - pox virus;

 painless umbilicated nodule

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Miscellaneous Eyelid Lesions

Strawberry Nevus  – flat

red lesion within 6

months of birth;involute spontaneously

Inc. in size during

straining or crying butno pulsation and bruit

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Miscellaneous Eyelid Lesions

Port Wine Stain -

nevus flammeus;

well demarcated pink patch that

darkens with age

45% incidence of 

glaucoma 5% sturge weber 

syndrome

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Miscellaneous Eyelid Lesions

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Miscellaneous Eyelid Lesions

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Xanthelasma

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Malignant Eyelid Lesions

Basal cell Carcinoma

most common human malignancy

90% of cases occur in head and neck, 10% of these involved the eyelid

most common eyelid malignancy(90% of cases)

 predilection: lower lid, medial canthus, upper lid, lateral canthus

SLOW GROWING, LOCALLY INVASIVE

BUT NON-METASTASIZING

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Basal Cell Carcinoma

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Basal Cell Carcinoma

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Malignant Eyelid Tumors

Squamous Cell Carcinoma

hard nodule or a scaly patch which develops

crusting erosions and fissures over a fewmonths.

clinically, it may be indistinguishable from

BCCa but it is important to differentiate the

two in view of its metastatic potential of SCC

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Squamous Cell Carcinoma

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Malignant Eyelid Lesions

Treatment: complete excision is a must!

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Malignant Eyelid Lesion

Treatment:

Surgical Excision - complete removal of the entire

tumor • Fresh frozen section

• MOH’s technique

• Eyelid reconstruction

Exenteration

Radiotherapy

Cryotherapy

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Disorders of Eyelashes

Trichiasis

Distichiasis

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Disorders of Eyelashes

Trichiasis

posterior misdirection of previously normal

lashes usually associated with trachoma and severe

chronic staph. Blepharitis

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Disorders of Eyelashes

Trichiasis

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Disorders of Eyelashes

Distichiasis

- abnormal row of lashes

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Disorders of Eyelashes

Treatment

Epilation

Electrolysis

Cryotherapy

Laser thermoablation

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Entropion

Inversion of the Eyelid

4 Types

Involutional

Cicatricial

Congenital

Acute Spastic

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Entropion

Involutional entropion

most common and affects only the lower lid

Pathogenesis 1. Overriding of the orbicularis muscle

2. Horizontal lid laxity

3. Weakness of the lower lid retractors

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Entropion

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Involutional Entropion

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Entropion

Treatment

1. Cautery

2. Transverse Lid-everting sutures

3. Weiss procedure

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Entropion

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Entropion

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Entropion

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Entropion

Cicatricial entropion

- usually caused by scarring of the palpebral

conjunctiva, which pulls the lid margin towardsthe globe

causes: cicatricial pemphigoid, SJ syndromes,

trachoma, & chemical burns

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Cicatricial Entropion

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Entropion

Treatment

contact lenses, epilation

surgical correction

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Entropion

Congenital entropion

due to improper development of the retractor 

aponeurosis into the inferior border of thetarsal plate

inward turning of the entire lower eyelid and

lashes

absence of lower lid crease

DDX: Congenital epiblepharon

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Entropion

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Ectropion

outward turning of the eyelid

usually associated with epiphora and

conjunctivitis Types

Involutional

Cicatricial

Congenital

Paralytic

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Ectropion

Pathogenesis

Involutional (Senile) - excessive eyelid length;

weakness of the pretarsal orbicularis; laxity of the medial and canthal ligaments

Cicatricial - caused by scarring and contracture

of skin and underlying tissues; e.g. trauma,

 burns, tumors

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Ectropion

Pathogenesis

Paralytic Ectropion - facial nerve palsy

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Ectropion

Treatment

Involutional Ectropion

determined by the position and amount of Horizontal lid Laxity.

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Ectropion

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Ectropion

Treatment

Mild Medial Ectropion

Medial Canthoplasty

Severe Medial Ectropion

Lazy T- procedure

Extensive Ectropion

Bick procedure

Kuhnt-Szymanowski procedure

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Ptosis

Drooping of the eyelids

Types (My NAMe )

N eurogenic

A poneurotic

• Involutional

Post-operative Me chanical

My ogenic

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Ptosis

 Neurogenic Ptosis - caused by acquired or 

congenital innervation defect.

Horner ’s syndrome

Marcus Gunn jaw winking syndrome

Misdirection of CN III

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 Neurogenic Ptosis

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Isolated CN III Paralysis

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Ptosis

Aponeurotic Ptosis - defect in the levator 

aponeurosis. It could be due to disinsertion

or stretching.

Involutional Ptosis - degenerative changes in

the levator aponeurosis Post-operative Ptosis - occurs in 5% of patients

following intraocular surgery (SR bridle)

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Involutional Ptosis

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Involutional Ptosis

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Ptosis

Mechanical Ptosis

physical obstruction

impeding eyelid elevation in

the presence of an otherwise

normal levator muscle and

CN III

E.g. Tumors,deramtochalasis, edema

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Ptosis

Myogenic ptosis

congenital or acquired myopathy of the

Levator muscle 2 Types

Simple congenital Ptosis

Blepharophimosis Syndrome

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Ptosis

Simple Congenital Ptosis

may be unilateral or bilateral

during downgaze, the ptotic eyelid is higher than the normal eyelid

weakness of the superior rectus (some cases)

head tilt with chin elevation high EOR and astigmatism

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Ptosis

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Ptosis

Blepharophimosis syndrome

Telecanthus

Epicanthus Other features: ectropion, poorly developed

nasal bridge, hypoplasia of the superior orbital

rims

Amblyopia 50% of cases

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Ptosis

Blepharophimosis Syndrome

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Ptosis

Clinical Evaluation:

Excellent history taking

Is it a true ptosis or pseudoptosis ?

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Ptosis

Causes of Pseudoptosis

1. Decrease vertical fissure height

2. Contralateral lid retraction

3. Ipsilateral hypotropia

4. Dermatochalasis

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Ptosis

Parameters

1. Marginal Reflex distance

 NV 4-5mm; Mild +3 Mod. +2 Severe 0 to -1

2. Vertical Fissure height

 NV male 7-10mm female 8-12mm

3. Levator Function good 12mm; fair 6-11mm poor 5mm or less

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Anatomy and Physiology

Orbit

 bony cavities : globes, EOM, nerves, fat and

 blood vessels  pyramidal or conical in shape

consists of an apex, a base and 4 sides: roof 

floor,medial wall and lateral wall

7 bones: frontal, zygomatic, maxillary,

sphenoid, ethmoid, lacrimal, & palatine

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Anatomy and Physiology

The Bony Orbit:

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Anatomy and Physiology

Roof of the Orbit

frontal bone and lesser wing of the sphenoid

located adjacent to anterior cranial fossa andfrontal sinus

Lateral wall of the Orbit

zygomatic bone and greater wing of thesphenoid

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Anatomy and Physiology

Orbital Roof 

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Anatomy and Physiology

Medial Wall

ethmoid, lacrimal, maxillary and sphenoid

 bones forms the lateral wall of the sphenoid sinus

Floor of the Orbit

maxillary, palatine,& zygomatic bones

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Anatomy and Physiology

Medial Wall

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Anatomy and Physiology

Orbital Apertures

1. Optic Canal

Optic Nerve, Ophthalmic Artery, Sympathetic Nerves

2. Superior Orbital Fissure

CN III,IV,VI, V1, Sympathetic Nerves 3. Inferior Orbital Fissure

CN V2,

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Anatomy and Physiology

Clinical Evaluation of Orbital

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Diseases

6 P’s

Pain

Proptosis Progression

Palpation

Pulsation Periorbital Changes

Clinical Evaluation of Orbital

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Diseases

Proptosis

Axial Displacement - retrobulbar lesions like

cavernous hemangioma, glioma, meningioma,AV mal, lesions with in the muscle cone

Clinical Evaluation of Orbital

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Diseases

 Non Axial Displacement - outside the muscle

cone

Superior Displacement - maxillary tumor 

invading the floor of the orbit

Inferomedial displacement - dermoid cyst and

lacrimal gland tumor 

Bilateral proptosis Grave’s disease andlymphoma, pseudotumor 

Clinical Evaluation of Orbital

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Diseases

Progression

Days to weeks - inflammatory diseases.

Infectious diseases, metastatic tumors

Months to years - dermoids, benign mixed

tumors, lymphomas

Clinical Evaluation of Orbital

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Diseases

Palpation

superonasal - Mucoceles, neurofibromas dermoids

superotemporal - lacrimal gland tumor pseudotumor 

Pulsations

with bruit - CCS Fistula

without bruit - meningoencephalocoeles

Diagnostic Modalities in Orbital

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g

Diseases

Primary Studies

CT scan

MRI Ultrasonography

Histopathology

Secondary Studies Venography

Arteriography

Clinical Evaluation of Orbital

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Diseases

Clinical Evaluation of Orbital

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DiseasesCT Scan

Good for most orbital

conditions, esp fractures

Good view of bone & Ca

Degraded image of orbital

apex due to bony artifact

Less soft tissue detail

Good for metallic foreign

 body

Less expensive

Shorter Scanning time

MRI Better for orbitocranial

lesions

 No view of bone & Ca

Good view of Orbital Apex

More soft tissue detail

Contraindicated for Metallic

Foreign Body

More expensive

Longer Scanning time

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Graves’ Ophthalmopathy

Autoimmune disorder that is related to

excess secretion of thyroid hormone

10-25% occurs in the absence of anythyroid dysfunction

Female/male ratio 8:1

4th to 5th decades of life most common cause of adult unilateral and

 bilateral exophthalmos

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Graves’ Ophthalmopathy

Pathogenesis

1. Hypertrophy of 

Extraocular 

Muscles

2. Cellular Infiltration

3. Proliferation of 

orbital fat,connective tissue

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Graves’ Ophthalmopathy

Main Clinical Manifestation

1. Eyelid retraction

2. Soft Tissue involvement

3. Proptosis

4. Optic Neuropathy

5. Restrictive Myopathy

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Graves’ Ophthalmopathy

Eyelid Retraction

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Graves’ Ophthalmopathy

Soft Tissue

Involvement

1. Conjunctival

Injection

2. Chemosis

3. Eyelid Fullness

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Graves’ Ophthalmopathy

Proptosis

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Graves’ Ophthalmopathy

Restrictive Myopathy

IR>MR>SR>LR 

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Graves’ Ophthalmopathy

CT Scan EOM

Hypertrophy

with tendonsparing

Key Points in Graves’ 

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Ophthalmopathy Eyelid retraction is the most common clinical feature; Graves’ 

ophthalmopathy is the most common cause of eyelid retraction.

Graves’ Ophthalmopathy is the most common cause of unilateral and

 bilateral proptosis.

Graves’Ophthalmopathy is 6 more times more common in female thanmale.

This condition is associated with hyperthyroidism in 90% of cases, but 6%

are Euthyroid.

Severity of Ophthalmopathy may not parallel serum levels of T3 or T4.

Ophthalmopathy may be asymmetric. Urgent care may be required for optic Neuropathy or severe proptosis

If surgery is needed the usual order of surgery is DECOMPRESSION

followed by SQUINT SURGERY followed by EYELID SURGERY

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Orbital Infections

Preseptal Cellulitis

Infection confined to the eyelids and periorbital

tissues anterior to the orbital septum Globe is uninvolved,

Pupillary rxn, VA, & EOM’s are NORMAL

no chemosis, no pain

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Orbital Infections

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Orbital Infections

Orbital Cellulitis

active infection posterior to the septum

90% occurs as a 2ndary extension of bacterialsinusitis

fever, proptosis,chemosis, EOM restrictions,

 pain on eye movement

decrease VA, pupillary abnormalities

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Orbital Infections

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Orbital Tumors

Vascular 

capillary hemangioma

cavernous hemangioma

lymphangioma

Lacrimal Gland

Benign Mixed Tumor 

Malignant Tumor  Rhabdomyosarcoma

Cystic Lesions

dermoid cyst

mucocele

 Neural

optic nerve glioma

Metastatic

Tumor invasion fromadjacent structures

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Capillary Hemangioma

Most common

tumor of the orbit in

childhood

increase in tumor size during crying

and straining

absent bruit and

 pulsation involute

spontaneously

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Cavernous Hemangioma

Most common benign

orbital lesion in adults

middle-aged women

commonly affected enhanced well-

encapsulated mass on

CT scan

Tx: Surgical Excision

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Rhabdomyosarcoma

Most common primary

orbital malignancy of 

childhood

age-onset is 7-8 y/o rapid onset of proptosis

Tx: Exenteration,

Radiation Therapy

combined withsystemic chemotherapy

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Pleomorphic Adenoma

Most common

epithelial tumor of the

lacrimal gland

4th -5th decades of 

life, mostly men

 progresssive, painless,

downward & inwarddisplacement

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Epidermoid / Dermoid Cyst

Dermoid is a benign

cystic teratoma

well-encapsulated lined

 by stratified squamous

& contain dermal

appendages

Epidermoid - does notcontain dermal

appendages

f h bi

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Fractures of the Orbit

Orbital floor 

Fracture

Most frequentlyinvolve wall

Usually along the

infraorbital canal

O bi l l

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Orbital Floor Fracture

Clinical Features

Periocular Changes  – ecchymosis, edema,

subcutaneous emphysema

Enophthalmos

Infraorbital nerve anesthesia

Diplopia

F f h O bi

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Fractures of the Orbit

F f h O bi

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Fractures of the Orbit

F f h O bi

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Fractures of the Orbit

F f h O bi

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Fractures of the Orbit

F t f th O bit

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Fractures of the Orbit

L i l S t

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Lacrimal System

Puncta

Ampullae

canaliculi lacrimal sac

nasolacrimal duct

T Fl Ph i l

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Tear Flow Physiology

E l ti f T i

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Evaluation of Tearing

Lacrimation vs Epiphora

Lacrimation - reflex over production of 

tears from stimulation of CN V byirritation of the cornea and conjunctiva

Epiphora - normal tear production but there

is physical obstruction on the drainagesystem

I f ti f L i l P

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Infections of Lacrimal Passages

Canaliculits -

unilateral epiphora

with mucopurulent

discharge. “Pouting of the punctum” on slit

lamp exam.

I f ti f L i l P

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Infections of Lacrimal Passages

Dacryocystitis infection

of the lacrimal sac.

Presents as a painfulswelling at the medial

canthal area.

S i l T h i

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Surgical Techniques

External DCR 

Endoscopic Laser-Assisted DCR 

Transcanalicular Endoscopic DCR 

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Thank you for your kind attention!