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1. Excitation 2. Excitation-contraction coupling 3. Contraction 4. Regulation of contraction 5. Metabolism of contraction Smooth muscle

Excitation Excitation-contraction coupling Contraction Regulation of contraction

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Excitation Excitation-contraction coupling Contraction Regulation of contraction Metabolism of contraction Smooth muscle. Excitation. Excitation-contraction coupling. dihydropyridine. ryanodine. Andrew HUXLEY 1953. TITIN. actinin. ACTIN. - PowerPoint PPT Presentation

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Page 1: Excitation Excitation-contraction coupling Contraction Regulation of contraction

1. Excitation2. Excitation-contraction coupling3. Contraction4. Regulation of contraction5. Metabolism of contraction

Smooth muscle

Page 2: Excitation Excitation-contraction coupling Contraction Regulation of contraction

1. Excitation

Page 3: Excitation Excitation-contraction coupling Contraction Regulation of contraction

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Excitation-contraction coupling

Page 5: Excitation Excitation-contraction coupling Contraction Regulation of contraction

Page 6: Excitation Excitation-contraction coupling Contraction Regulation of contraction

ryanodine

dihydropyridine

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TITIN

actinin

Andrew HUXLEY 1953

Page 8: Excitation Excitation-contraction coupling Contraction Regulation of contraction

ACTIN

Page 9: Excitation Excitation-contraction coupling Contraction Regulation of contraction

Actin together with Mg a ATP se binds to myosin, When tropomyosin is added binding releases

In presence of Ca the efekt of troponin on tropomyosin complex on A - M interaction disapears

Ca binds to troponin C – binding sites of actin arc uncovered

Page 10: Excitation Excitation-contraction coupling Contraction Regulation of contraction

MYOSIN

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http://harveyproject.science.wayne.edu/development/muscle/proteol.html

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Page 13: Excitation Excitation-contraction coupling Contraction Regulation of contraction

CONTRACTION

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Regulation of contraction

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2 um

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Force gradation:a. Recruitment (spacial sumation)b. temporal sumation

tetany

Page 20: Excitation Excitation-contraction coupling Contraction Regulation of contraction

A cartoon diagram of myosin and its

A cartoon diagram of myosin and its

http://harveyproject.science.wayne.edu/development/muscle/proteol.html

http://harveyproject.science.wayne.edu/development/muscle/proteol.html

http://harveyproject.science.wayne.edu/development/muscle/lever.html

http://harveyproject.science.wayne.edu/development/muscle/lever.html

http://harveyproject.science.wayne.edu/development/muscle/proteol.html

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Page 22: Excitation Excitation-contraction coupling Contraction Regulation of contraction

Metabolism of contraction

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MYOGLOBIN

10 sec min

Page 24: Excitation Excitation-contraction coupling Contraction Regulation of contraction

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