Ersin Yavuz - Third Generation Bio Medical Materials

8/8/2019 Ersin Yavuz - Third Generation Bio Medical Materials

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Che 439 - Biomaterials

by Ersin Yavuz 130202021

F a l l, 2010


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1960s and 1970s

Goal achieve physical properties-replacement tissue immune response in

host1980s 50 implantable devices 40

different materialsCommon feature -biological inertness


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1 st generation Bio-inert

2nd generation bioactive

Mechanism of bonding of bioactive glass with living tissue


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Bioactiveglass

SiOHbond

Adsorption -bio moieties

Si-O-Si

Crystal- HCA

Adsorption

Ca+Po 4+Co 3

ActionMacrophages

Stem cells

DifferntiationMatrixformation

Crystalmatrix

BoneFormation

Reactions in forming a bond between tissue and bioactive glasses


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http://www.bb.ustc.edu.cn/ocw/OcwWeb/Materials-Science-and-Engineering/3-051JSpring2004/CourseHome/index.htm


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In mid 1980s and 1990sdevelopment of HA,bioactive glasses andglass ceramics, bonefixation, middle-earprostheses, replacementof vertebra

Another advancement:Resorbable biomaterials

No difference betweenimplant site and hosttissue http://www.spine-health.com/treatment/artificial-disc-replacement


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S urvival analysis - skeletalprostheses & artificial heart

valves Failure 10-25 years revision surgery

Main disadvantage:Living tissue changes withphysiological load andbiochemical stimuli but notimplanted biomaterials

http://inventors.about.com/library/inventors/blartificialheart.htm


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S timulatespecific cellularresponses at themolecular level

Twoalternativeroutes of repair

1. Tissueengineering

http://www.tissue-engineering.net/index.php?seite=whatiste


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2.In situ tissue engineeringForm of powders, solutions, or dopedmicroparticles to stimulate local tissue repair.

ionic dissolution products, or growth factors(BMP)

Activate the cells

Cells S timulate multiple generations of growing cells to self-assemble into the

required tissues in situ


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Human osteoblasts ionic dissolution

products of bioactive glasses up

regulates seven families of genes

Activated genes stimulates

differentiation and proliferation of

osteoblasts

Genetic control and activation


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(i) transcription factors and cellcycle regulators;(ii) signal transduction molecules;

(iii) proteins involved in DNA synthesis, repair,

and recombination;


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(iv) growth factors and cytokines that influence theinflammatory response to the material;

(v) cell-surface antigens and receptors;

(vi) extracellular-matrix components;

(vii) apoptosis regulators.

Genetic control and activationGenetic control and activation


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Immobilizing specific proteins,

peptides, and other biomolecules- material - mimic ECM

environment - multifunctional celladhesive surface

PLA/PGA copolymers were usedto incorporate nerve growthfactor (NGF)

Molecularly tailored polymers

regeneration of nerves

http://scicom.ucsc.edu/scinotes/0001/nerves.htm


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Third-generationbiomaterials moleculardesign of scaffolds fortissue engineering andfor in situ tissueregeneration and repair,

with minimally invasivesurgery.

Economic advantagePatient specific

treatmenthttp://www.medpagetoday.com/MeetingCoverage/AAPM/18300


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Thanks for your attention


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D . Yamanouchi, J. Wu, A.N. Lazar, K.C. Kent, C.C. Chu, and B. Liu. 2008.Biodegradable arginine-basedpoly(ester-amide)s as non-viral gene delivery reagents. Biomaterials 29(22):3269-3277.

N.W. Choi, M. Cabodi, B. Held, J.P. Gleghorn, L.J. Bonassar, and A. D . S troock. 2007. Microfluidicscaffolds for tissue engineering. Nature Materials 6: 908-915.

S .Y. Wong, J. Pelet, and D . Putnam. 2007. Polymer systems for gene delivery - Past, present, and future.Progress in Polymer S cience (invited) 2:799-837.

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Ersin Yavuz - Third Generation Bio Medical Materials