Embed Size (px)
MAO INHIBITION AND DEPRESSION-DUNLOP ET AL
SUMMARY
Intravenous modaline sulfate was evaluatedin six hospitalized depressed patients over athree-week course of therapy. The results obtained are consistent with the hypothesis thatthe degree of MAO inhibition is related toclinical improvement of depression. Therewere no significant side effects noted and noevidence of systemic toxicity due to modalinesulfate therapy. Data presented are preliminary in nature and should be interpreted accordingly.
BIBUOGRAPHY
1. Loomer, H. P., Saunders, J. C. and Kline, N. S.:A clinical and pharmacodynamic evaluation ofiproniazid as a psychic energizer. Amer. Psychiat.Assoc. Psychiat. Research Rept., 8: 129-135, 1957.
2. Voelkel, A.: Clinical experiences with amineoxidase inhibitors in psychiatry. Ann. N.Y. Acad.Sci., 80:680-686, 1959.
3. Pletscher, A.: Significance of monoamine oxidaseinhibition for the pharmacological and clinicaleffects of hydrazine derivatives. Ann. N.Y. Acad.Sci., 80:1039-1045, 1959.
4. Saunders, J. C., Randinger, N., Rochlin, D. andKline, N. S.: Treatment of depressed patientswith iproniazid and reserpine. Dis. Nerv. Syst.,20( 1) :31-39, 1959.
5. Zeller, E. A.: Some remarks about monoamineoxidase and monoamine oxidase inhibitors. J.Neuropsychiat., 2: 125-130, 1960-1961.
6. Resnick, 0.: The influence of amine oxidase inhibitors on epinephrine metabolism in man.Ann. N. Y. Acad. Sci., 80:726-733, 1959.
7. Resnick, 0., Hagopian, M., Hoagland, H. andFreeman, H.: An in vivo test for measuringmonoamine oxidase inhibition in human subjects.A.M.A. Arch. Gen. Psychiat., 2:459-461, 1960.
8. Feldstein, A., Hoagland, H., Rivera, M. andFreeman, H.: A preliminary report on MAO inhibition and clinical effectiveness in the treatment of depressed patients with phenelzine. ].Neuropsychiat., 2: 12-14, 1960.
9. Gylys, J. A., Muccia, P. M. R. and Taylor, M. K.:Pharmacological and toxicological properties of2-methyl-3-piperidinopyrazine, a new antidepressant. Ann. N. Y. Acad. Sci., 107:899-913,1963.
10. Dubnick, B., Morgan, F. and Phillips, G. E.: Inhibition of monoamine oxidase by 2-methyl-3piperidinopyrazine. Ann. N. Y. Acad. Sci., 107:914-923, 1963.
ll. Goldstein, L., Murphree, H. B. and Pfeiffer, C.C.: Quantitative electroencephalography in manas a measure of CNS stimulation. Ann. N. Y.Acad. Sci., 107:1045-1056, 1963.
12. Dunlop, E.: Antidepressant effects of MAO inhibitors. Ann. N. Y. Acad. Sci., 107:1107-1116,1963.
13. Feldman, P.: Comparison of effect of 2-methyl3-piperidinopyrazine on target symptoms of anergic schizophrenics. Ann. N. Y. Acad. Sci.,107:1117-1130, 1963.
14. Hamilton, M.: A rating scale for depression. ].Neurol. Neurosurg. and Psychiat., 23:56-62,1960.
15. Sjoerdsma, A., Oates, J. A., Zaltzman, P., andUndenfriend, S.: Identification and assay ofurinary tryptamine: application as an index ofmonoamine oxidase inhibition in man. J. Pharmacol. and Exper. Therap., 126:217-223, 1959.
16. Pisano, J. J., Crout, J. R. and Abraham, D.:Determination of 3-methoxy-4-hydroxymandelicacid in urine. Clin. Chemica. Acta., 7 :285-291,1962.
17. Undenfriend, S., Titus, E. and Weissbach, H.:The identification of 5-hydroxy-3-indoleaceticacid in normal urine and method for its assay.J.B.C., 216:499-505, 1955.
(Doctor Dunlop)Fuller Memorial SanitariumAttleboro, Massachusetts
"The average practitioner is quite capable of handling the vast majority of ex-institutionalizedpatients by regulation of medication, reassurance, manipulation of the environment wherenecessary, and ... other technics."
-N. S. KLINE, Postgrad. Med.,27:620, May, 1960.
ERRATUMIn the Editorial of the November-December 1964 issue the editor noted that "Psychoso
matics has now completed its fourth year." This is an understatement of the true facts; sincepublication was commenced in January, 1960; it is therefore corrected to "its fifth year.' Theeditor cannot and will not seek refuge in the possibility of an error that can be traced to hisassistant, nor to the publisher. The best explanation is either that 1960-1964 is a span of fouryears, or hopefully that it is a significant slip indicating his continued interest in the journaland the fact that another year or less is not too significant. WD
January-February, 1965.,.•
