EPIC Biophotonics Workshop Translating Biophotonics Technologies to Clinical Oncology:Perspectives & Challenges

1−2 December 2016 | Villejuif (Paris), France

Hosted by Gustave Roussy, the 1st cancer research centre in Europe

PROGRAMME AT A GLANCE

SESSION 1 – Biophotonics to refine clinical decision-making

Topic 1: How can photonics improve tissue preservation?

Topic 2: How far can per-operative optical imaging improve surgical navigation?

SESSION 2 – Standardization and quantification in clinical photon imaging: where are we, what’s neededand how to proceed?

SESSION 3 – Future trends: new imaging tools, targeted imaging, and prediction of treatment efficacy

With the support of

www.epic-assoc.com/epic-biophotonics-oncology-workshop

“EPIC has built an amazingly strong network of companies focused on collaborationto reach the synergy effect. A very valuable resource for our company and the Photonics industry.” Dr. Viacheslav Artyushenko, President, art photonics

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EPIC Biophotonics Workshop

Useful ...

ADDRESSESVenueEspace Maurice Tubiana – Gustave Roussy rue du Docteur Pinel – 94800 VillejuifFrance

Hotel Mercure paris centre tour Eiffel20 Rue Jean Rey – 75015 ParisFranceT. +33 825 80 17 17

Restaurant 58 Tour Eiffel (Thursday dinner)Located in the Eiffel towerChamp de Mars, Eiffel Tower – 75007 ParisFranceT. +33 1 45 55 20 04

ONSITE CONTACTSCarmen Ferrari, Events and Marketing Manager at EPIC, T. +31 6 14 544 255

Jose Pozo, Director of Technology and Innovation at EPIC, T. +31 6 26 978 312

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Participants

FIRST NAME LAST NAME JOB TITLE COMPANY COUNTRY

Muriel Abbaci Research engineer Gustave Roussy FranceOdile Allard CEO Fluoptics FranceViacheslav Artyushenko President and CEO Art Photonics GermanyAntoine Azan PhD student Gustave Roussy FranceMichel Belleil Sales manager France Benelux Renishaw FranceEmilie Benoit R&D project manager LLTech FranceFlorent Berteau Sales manager Clinic - France NOVADAQ GermanyIngrid Breuskin Medical doctor Gustave Roussy FranceOdile Casiraghi Medical doctor - pathologist Gustave Roussy FranceEdoardo Ceci Ginistrelli PhD student Politecnico di Torino ItalyJacques Cochard Associate, founder TEMATYS FranceKevin Contreras CTO Condor Photonics FranceFrédéric de Leeuw Research engineer Gustave Roussy FranceRonald Dekker CTO XiO Photonics The NetherlandsDaphné Descarpentries Medical doctor Gustave Roussy FranceJouke Dijkstra Associate prof. Vascular and Molecular Imaging Leiden University Medical Center The NetherlandsJean-Marc Dinten Head of Imaging and acquisition systems lab CEA-LETI FranceCarmen Ferrari Events and marketing manager EPIC - European Photonics Industry Consortium The NetherlandsMarie Pierre Fontaine-Aupart Director of research CNRS FranceWahib Ghanem ORL chirurgie Cervico Faciale Gustave Roussy FranceSylvain Gioux Professor ICube Laboratory FrancePhilippe Gorphe Head and neck oncologic surgeon Gustave Roussy FranceStephanie Guillermet Application specialist clinic Fluoptics FranceDana Hartl Surgeon Gustave Roussy FranceJean-François Honart Plastic Surgeon Gustave Roussy FranceJean-Marc Hyvelin Responsible technology scouting Bracco SwitzerlandMartin Isabelle Senior applications scientist for life sciences Renishaw United KingdomDavid Kallweit Project manager CSEM SwitzerlandShadi Katou Medical doctor Charite university medicine Berlin GermanyMichael Kempe Senior director Research Carl Zeiss GermanyKrishna Khakurel PhD student Hokkaido university JapanSven Kiontke CEO Asphericon GermanyJustine Klonowski Contract lawyer Gustave Roussy FranceSenada Koljenovic Consultant Pathologist Erasmus Medical Center The NetherlandsCorinne Laplace-Builhe Imaging & cytometry lab manager Gustave Roussy FranceCamille L'Epine Project manager Gustave Roussy FranceGabriel Liberale Surgical oncologist Institut Jules Bordet BelgiumClemens Lowik Prof. Radiology, Head Optical molecular imaging Erasmus Medical Center The NetherlandsHuihui Lu Researcher Tyndall National Institute IrelandChristian Matthaeus Research assistant Leibniz Institute of Photonic Technology GermanyChafika Mazouni Breast surgeon Gustave Roussy FranceLluis M. Mir Director of research CNRS FranceJanet Mulle Sales manager Europe Asphericon GermanyIoan Notingher Professor University of Nottingham United KingdomMehmet Ozturk PhD student Rensselaer USAAnne Planat-Chretien Project manager LETI/DTBS CEA-LETI FranceMarie-Christine Pouchelle Director of research CNRS FranceJose Pozo Director of technology and innovation EPIC - European Photonics Industry Consortium The NetherlandsGerwin Puppels Managing director RiverD International The NetherlandsQuentin Qassemyar Surgeon Gustave Roussy FranceMatthias Reif General manager EMEA NOVADAQ GermanyNicolas Reyns Neurosurgeon Inserm FranceClemens Scholz CEO WOM - World of Medicine GermanyGunter Seewald Project engineer WOM - World of Medicine GermanyDustin Shipp Researcher University of Nottingham United KingdomMira Sibai PhD student Princess Margaret Cancer Centre CanadaPaulien Stegehuis PhD candidate Leiden University Medical Center The NetherlandsPetteri Uusimaa CEO Modulight FinlandAlexander Vahrmeijer Surgeon Leiden University Medical Center The NetherlandsGareth Williams Medical device designer Queens Medical Research Institute United Kingdom

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EPIC Biophotonics Workshop

Programme

Thursday 1 December 2016

12:00-13:00 Registration and light lunch

13:00-13:10 Opening of the workshop by Jose Pozo, Director of technology and innovation, EPIC

13:10-13:40 KEYNOTE: Near infrared fluorescent imaging; towards clinical translation. Alexander L. Vahrmeijer, Leiden University Medical Center, The Netherlands

13:40-14:00 EPIC member pitches

14:00-18:00 SESSION 1: Biophotonics to refine clinical decision-making

SESSION CHAIRS Jose Pozo, EPIC Philippe Gorphe & Corinne Laplace-Builhé, Gustave Roussy

TOPIC 1 HOW PHOTONICS CAN IMPROVE TISSUE PRESERVATION?

14:00-14:20 Glioblastoma surgery using Fluorescence Guided Resection. Nicolas Reyns, INSERM 1189 - ONCO THAI, Lille, France 14:20-14:40 FFOCT for nerve transplant and ovarian tissue auto-transplantation (Fertility rescue). Paulien Stegehuis, Leiden University Medical Center, The Netherlands 14:40-15:00 Optical biopsies in head and neck cancer: How far are we from the clinic? Muriel Abbaci & Frédéric de Leeuw, Gustave Roussy, France 15:00-15:10 Industry presentation 1: Next generation illumination system for photodynamic therapy of glioblastoma. Petteri Uusimaa, CEO, Modulight, Finland 15:10-15:20 Industry presentation 2: Miniaturization of Optical Coherence Tomography (OCT) using Photonic Integrated Circuits (PICs). Ronald Dekker, CTO, XiO Photonics, The Netherlands

15:20-16:00 Networking break and exhibition visit

TOPIC 2 HOW FAR PER-OPERATIVE OPTICAL IMAGING CAN IMPROVE SURGICAL NAVIGATION?

16:00-16:20 Raman technology for intra-operative tumor margin assessment. Gerwin Puppels, MC Erasmus Rotterdam, The Netherlands 16:20-16:40 NIR imaging for peroperative assessment of peritoneal carcinomatosis. Gabriel Liberale, Institut Jules Bordet, Bruxelles, Belgium 16:40-17:00 Lymph nodes mapping using NIR imaging in breast cancer: A step ahead. Chafika Mazouni, Gustave Roussy, Villejuif, France 17:00-17:10 Industry presentation 3: Innovations in ICG Fluorescence. Matthias Reif, NOVADAQ, Germany 17:10-17:20 Industry presentation 4: Far infrared tissue imaging: a step beyond visible and NIR modalities. Jacques Cochard, TEMATYS, Market report 17:20-17:30 Industry presentation 5: Clinical indications of the Fluobeam® device: Be part of the surgical workflow. Fluoptics, France

17:30 Transfer to restaurant 58 Tour Eiffel

18:30-20:30 Networking Dinner

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Programme

Friday 2 December 2016

07:45 Bus transfer from Mercure Paris Centre Tour Eiffel to Gustave Roussy. Meeting point: lobby

09:00-10:20 SESSION 2: Standardization and quantification in clinical photon imaging: where are we, what’s needed, and how to proceed?

SESSION CHAIRS Jose Pozo, EPIC Ingrid Breuskin & Luis Mir, Gustave Roussy

09:00-09:20 Dynamic control of surgical flaps perfusion using fluorescence imaging: how important is the quantification? Quentin Qassemyar, Gustave Roussy, France 09:20-09:40 A case of NIR tissue autofluorescence: the parathyroids. Why quantification can help? Dana Hartl, Gustave Roussy, France 09:40-10:00 Towards real-time quantitative fluorescence image-guided surgery. Sylvain Gioux, ICube- Télécom Physique, Strasbourg, France 10:00-10:10 Industry presentation 6: From multispectral tissue diagnostics to spectral fiber sensors required for customized theranostics in clinics. Viacheslav Artyushenko, President Art Photonics, Germany 10:10-10:20 Industry presentation 7: 2PM FlySCAN: Innovative approach for wide field high resolution imaging of skin tissue volumes. Gunter Seewald, W.O.M., Germany

10:20-11:00 Networking break and exhibition visit

11:00-12:40 SESSION 3: Future trends: new imaging tools, targeted imaging, and prediction of treatment efficacy

SESSION CHAIRS Jose Pozo, EPIC Odile Casiraghi & Antoine Azan, Gustave Roussy

11:00-11:20 Multimodal (Raman and auto-fluorescence) spectral imaging for intra-operative assessment of surgical margins. Ioan Nottingher, University of Nottingham, United Kingdom 11:20-11:40 Fiber based Raman probes: From a point to an image. Christian Matthäus, Institute of Photonic Technology, Jena, Germany 11:40-11:50 Industry presentation 8: The road map towards providing a robust Raman spectroscopy-based cancer diagnostic platform and integration into clinic. Dr. Martin Isabelle, Renishaw, UK 11:50-12:10 Can ex-vivo assessment in photonics reveals in-vivo response to drug efficacy. Marie Pierre Fontaine-Aupart, Institute of Molecular Sciences, France) 12:10-12:30 Necrosis as target for diagnostic imaging and drug deliver: a new theranostic platform. Clemens Lowik (Erasmus Medical Center Rotterdam, The Netherlands 12:30-12:50 From a pathologist’s point of view. Senada Koljenovic, Erasmus Medical Center Rotterdam, The Netherlands 12:50-13:30 Discussion Panel Sessions 2 & 3 and closing of the meeting

13:30-14:30 Networking lunch and exhibition visit

14:30-15:30 Gustave Roussy visit

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