General Pharmacology EDITOR

Professor G. A. KERKUT, Department of Physiology and Biochemistry, University of Southampton, Southampton SO9 3TU, England

ASSISTANT EDITOR

Dr. G. N. WOODRUFF, Department of Physiology and Biochemistry, University of Southampton, Southampton SO9 3TU, England

HONORARY EDITORIAL ADVISORY BOARD

M. H. APRISON (Indianapolis) R. W. BRIMBLECOMBE (Welwyn) B. B. BRODIE (Tucson) G. BURNSTOCK (Melbourne) V. ERSPAMER (Rome) E. FLOREY (Konstanz) H. M. GERSCHENFELD (Paris) L. I. GOLDBERG (Chicago) M. J. GREENBERG (Tallahassee)

G. B. KOELLE (Philadelphia) G. D. H. LEACH (Bradford) L. LYTLE (Cambridge, Mass.) M. J. MICHELSON (Leningrad) G. PETERS (Lausanne) J. W. PHILLIS (Winnepeg) M. ROCHA E SILVA (S&o Paulo) D. W. STRAUGHAN (London) R. WERMAN (Jerusalem)

Published Bi-monthly

Copyright 0 1976 Pergamon Press

No part of this publication may be produced, stored in a retrieval systemor transmitted in any form or by any means:electronic,electrostatic magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers.

Annual Subscription Rates 1976

For libraries, research departments and all other multipIe reader institutions $75.00.

Specially Reduced Rates to Individuals In the interests of maximising the dissemination of the research results published in this important

international journal we have established a two-tier price structure. Any individual, whose institution takes out a library subscription, may purchase a second or additional subscription for personal use at the reduced rate of $25.00 per annum.

All subscription orders should be addressed to the Subscription Fulfillment Manager, Pergamon Press, Ltd., Headington Hill Hall, Oxford OX3 OBW.

Microform Subscriptions and Back Issues

Current subscriptions and back files on microfilm as well as back issues in the regular editions of all previously published volumes are available from Microform International Marketing Company, a Division of Pergamon Press Inc. at the most convenient address:

Fairview Park, Elmsford, Cowper House, Olney, New York 10523, U.S.A. Bucks, England.

PERGAMON PRESS

HEADINGTON HILL HALL, OXFORD OX3 OBW

MAXWELL HOUSE, FAIRVIEW PARK, ELMSFORD, NEW YORK 10523