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Immunobiology Editors E. D. ALBERT, Munchen . H. BRANDIS, Bonn' H. DEICHER, Hannover' A. DE WECK, Bern·M. P. DIERICH, Innsbruck· K. EICHMANN, Freiburg . M. FELDMANN, London' E. GLEICHMANN, Amsterdam' K. HAVEMANN, Marburg· H. KIRCHNER, Heidelberg· E. KLEIN, Stockholm· W. KOHLER, Jena' J. P. LEVY, Paris' K. RESCH, Hanno- ver . G. RIETHMOLLER, Munchen . K. O. ROTHER, Heidelberg· V. SCHIRRMACHER, Heidelberg . C. SORG, Munster . R. TIMPL, Munchen . R. VAN FURTH, Leiden . H. WAGNER, Ulm . G. WICK, Innsbruck . R. ZINKERNAGEL, Zurich Editor-in-Chief D. GEMSA, Hannover Editorial Advisory Board R. AVERDUNK, Berlin' J. F. BACH, Paris' H. BALNER, Rijswijk· R. BENNER, Rotterdam' D. BITTER-SUERMANN, Mainz . H. v. BOEHMER, Basel . G. BONNARD, Bern . D. G. BRAUN, Basel . V. BRAUN, Tubingen . J. BROSTOFF, London . A. COUTINHO, Paris . T. DIAMANTSTEIN, Berlin' W. DROGE, Heidelberg' P. DUKOR, Basel· P. ERB, Basel· O. GOTZE, Gottingen . E. GONTHER, Freiburg . U. HADDING, Mainz . H. HAHN, Berlin' K. HALA, Innsbruck . G. J. HAMMERLING, Heidelberg' K. U. HARTMANN, Marburg . H. ZUR HAUSEN, Freiburg . M. HESS, Bern . J. KALDEN, Erlangen . B. KINDRED, Tubingen . T. J. KINDT, New York . U. KOSZINOWSKI, Tubingen . E. KOWNATZKI, Freiburg . P. KRAMMER, Heidelberg· W. LEIBOLD, Erlangen . K. LENNERT, Kiel . F. LILLY, New York . J. LINDEMANN, Zurich . E. MACHER, Munster . H. METZGER, Bethesda . V. TER MEULEN, Wurzburg . H. J. MOLLER-EBERHARD, La Jolla . W. MOLLER-RuCH- HOLTZ, Kiel . H. H. PETER, Hannover' H. PETERS, Gottingen . E. PICK, Tel Aviv' O. PROKOP, Berlin . M. QUASTEL, Beer Sheva . J. P. REVILLARD, Lyon . E. P. RIEBER, Munchen . M. ROLLINGHOFF, Mainz . E. RODE, Mainz . E. SCHOPF, Freiburg . H. G. SCHWICK, Marburg . K. SETHI, Bonn' G. SUNSHINE, London' N. TALAL, San Francisco' G. TILL, Ann Arbor' G. UHLENBRUCK, Koln . M. WAGNER, Jena . H. WEKERLE, Wurz- burg' P. WERNET, Tubingen Gustav Fischer Verlag . Stuttgart . New York . 1983 Terms of delivery 5 issues form one volume. Subscription rate DM 228,- per volume plus postage. All business correspondence should be made with: Gustav Fischer Verlag GmbH & Co KG . Stuttgart (Register HR Nr. A7591 / HR B 4976). Stuttgarter Volksbank 45290 (BLZ 600901 00), Deutsche Bank 8020000 (BLZ 60070070), Postscheck Stuttgart 13556-709 (BLZ 60010070). © Gustav Fischer Verlag· Stuttgart· New York All rights reserved Printed by Ungeheuer+Ulmer KG GmbH+Co, Ludwigsburg Printed in Gennany Valid price Jist as advertised in March, 1982. The articles published in this journal are protected by copyright. All rights are reserved, especially the right to translate into foreign No part of the journal may be reproduced in any form- photocopying, microfilming or other processes - or converted to a machme language, especially for data processing equipment - without the written permission of the publisher. The rights of reproduction by lecture, radio and television transmission, magnetic sound recording or similar means are also reserved. Photocopies for personal and other individual use may only be made as single copies of single articles or portions thereof. Every copy made within the realm of a commercial enterprise serves a commercial purpose in accordance with § 54 (2) of the copyright law of the Federal Republic of Germany and obliges payment of a fee to VG WORT, Abteilung Wissenschaft, GoethestraBe 49; 8000 Miinchen 2, to whom requests for the modalities of payment should be addressed. Please notice: This issue contains the insert «Ortho-mune':- monoclonal antibodies» by Ortho Diagnostic Systems GmbH, Heidelberg

Editorial Board

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Immunobiology

Editors

E. D. ALBERT, Munchen . H. BRANDIS, Bonn' H. DEICHER, Hannover' A. DE WECK, Bern·M. P. DIERICH, Innsbruck· K. EICHMANN, Freiburg . M. FELDMANN, London' E. GLEICHMANN, Amsterdam' K. HAVEMANN, Marburg· H. KIRCHNER, Heidelberg· E. KLEIN, Stockholm· W. KOHLER, Jena' J. P. LEVY, Paris' K. RESCH, Hanno­ver . G. RIETHMOLLER, Munchen . K. O. ROTHER, Heidelberg· V. SCHIRRMACHER, Heidelberg . C. SORG, Munster . R. TIMPL, Munchen . R. VAN FURTH, Leiden . H. WAGNER, Ulm . G. WICK, Innsbruck . R. ZINKERNAGEL, Zurich

Editor-in-Chief

D. GEMSA, Hannover

Editorial Advisory Board

R. AVERDUNK, Berlin' J. F. BACH, Paris' H. BALNER, Rijswijk· R. BENNER, Rotterdam' D. BITTER-SUERMANN, Mainz . H. v. BOEHMER, Basel . G. BONNARD, Bern . D. G. BRAUN, Basel . V. BRAUN, Tubingen . J. BROSTOFF, London . A. COUTINHO, Paris . T. DIAMANTSTEIN, Berlin' W. DROGE, Heidelberg' P. DUKOR, Basel· P. ERB, Basel· O. GOTZE, Gottingen . E. GONTHER, Freiburg . U. HADDING, Mainz . H. HAHN, Berlin' K. HALA, Innsbruck . G. J. HAMMERLING, Heidelberg' K. U. HARTMANN, Marburg . H. ZUR HAUSEN, Freiburg . M. HESS, Bern . J. KALDEN, Erlangen . B. KINDRED, Tubingen . T. J. KINDT, New York . U. KOSZINOWSKI, Tubingen . E. KOWNATZKI, Freiburg . P. KRAMMER, Heidelberg· W. LEIBOLD, Erlangen . K. LENNERT, Kiel . F. LILLY, New York . J. LINDEMANN, Zurich . E. MACHER, Munster . H. METZGER, Bethesda . V. TER MEULEN, Wurzburg . H. J. MOLLER-EBERHARD, La Jolla . W. MOLLER-RuCH­HOLTZ, Kiel . H. H. PETER, Hannover' H. PETERS, Gottingen . E. PICK, Tel Aviv' O. PROKOP, Berlin . M. QUASTEL, Beer Sheva . J. P. REVILLARD, Lyon . E. P. RIEBER, Munchen . M. ROLLINGHOFF, Mainz . E. RODE, Mainz . E. SCHOPF, Freiburg . H. G. SCHWICK, Marburg . K. SETHI, Bonn' G. SUNSHINE, London' N. TALAL, San Francisco' G. TILL, Ann Arbor' G. UHLENBRUCK, Koln . M. WAGNER, Jena . H. WEKERLE, Wurz­burg' P. WERNET, Tubingen

Gustav Fischer Verlag . Stuttgart . New York . 1983

Terms of delivery

5 issues form one volume. Subscription rate DM 228,- per volume plus postage. All business correspondence should be made with: Gustav Fischer Verlag GmbH & Co KG . Stuttgart (Register HR Nr. A7591 / HR B 4976). Stuttgarter Volksbank 45290 (BLZ 600901 00), Deutsche Bank 8020000 (BLZ 60070070), Postscheck Stuttgart 13556-709 (BLZ 60010070).

© Gustav Fischer Verlag· Stuttgart· New York 19~3 All rights reserved Printed by Ungeheuer+Ulmer KG GmbH+Co, Ludwigsburg Printed in Gennany Valid price Jist as advertised in March, 1982.

The articles published in this journal are protected by copyright. All rights are reserved, especially the right to translate into foreign langua~es. No part of the journal may be reproduced in any form- throug~ photocopying, microfilming or other processes - or converted to a machme language, especially for data processing equipment - without the written permission of the publisher. The rights of reproduction by lecture, radio and television transmission, magnetic sound recording or similar means are also reserved. Photocopies for personal and other individual use may only be made as single copies of single articles or portions thereof. Every copy made within the realm of a commercial enterprise serves a commercial purpose in accordance with § 54 (2) of the copyright law of the Federal Republic of Germany and obliges payment of a fee to VG WORT, Abteilung Wissenschaft, GoethestraBe 49; 8000 Miinchen 2, to whom requests for the modalities of payment should be addressed.

Please notice: This issue contains the insert «Ortho-mune':- monoclonal antibodies» by Ortho Diagnostic Systems GmbH, Heidelberg