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Cellular Signalling L. Birnbaumer (UCLA, CA, USA) J. Bockaert (CCIPE-INSERM, Montpellier, France) M. Caron (Duke University, Durham, NC, USA) L. Cocco (University of Bologna, Italy) J. E. Dumont (Vrije Universiteit Brussel, Belgium) P. Greengard (Rockefeller University, NY, USA) T. Hébert (McGill University, Québec, Canada) J. Heller-Brown (University of California at San Diego, CA, USA) R. Irvine (University of Cambridge, UK) K. H. Jakobs (Universitätsklinikum Essen, Germany) B. E. Kemp (University of Melbourne, VIC, Australia) A. Levitzki (Hebrew University of Jerusalem, Israel) I. G. Macara (University of Virginia, Charlottesville, VA, USA) T. F. J. Martin (University of Wisconsin at Madison, WI, USA) S. Nakanishi (Kyoto University, Japan) J. Pouyssegur (CNRS, Nice, France) E. Rozengurt (UCLA, CA, USA) J. Scott (HHMI, Vollum Institute, Portland, OR, USA) S. B. Shears (NIH/NIEHS, Research Triangle Park, NC, USA) M. Ui (The University of Tokyo, Tokyo, Japan) EDITOR-IN-CHIEF MILES D. HOUSLAY, Professor of Pharmacological Innovation, Institute of Pharmaceutical Science, King’s College London, 5th Floor, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK E-mail: [email protected] EDITOR NIGEL PYNE, Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK Tel.: (+44) 141-548-2659, Fax: (+44) 141-552-2562 E-mail: [email protected] CO-EDITORS GEORGE S. BAILLIE, Molecular Pharmacology Group, Gardiner Laboratory, Wolfson Link Building, Division of Biochemistry and Molecular Biology, IBLS, The University of Glasgow, University Avenue, Glasgow G12 8QQ, UK Tel.: (+44) 141-330-2821, Fax: (+44) 141-330-4365 E-mail: [email protected] SUSAN PYNE, Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK Tel.: (+44) 141-548-2012, Fax: (+44) 141-552-2562 E-mail: [email protected] EDITORIAL BOARD Aims and Scope Description. This journal publishes full-length, original papers covering all aspects of mechanisms, actions and structural components of cellular signalling systems. The emphasis is on effector systems, such as protein kinases, lipid signalling pathways, cyclic nucleotide signalling processes, NO signalling and ion channels; the production, regulation, degradation and action of second messengers; the structure, regulation, degradation and action of receptors; guanine nucleotide regulatory proteins; bio-informatic studies related to cell signalling mechanisms; compartmentalisation/compartmentation of signalling systems; anchor/scaffold signalling proteins; the effect of cellular signalling events on the functioning, growth and differentiation of cells in normal and pathological states and also cellular oncogenes. Within the scope of the journal, manuscripts dealing with biochemistry, protein structure, cell biology, molecular biology, pharmacology, neurobiology, molecular endocrinology and molecular oncology are welcomed. The journal also publishes original reviews on topical subjects. Audience. Biochemists, Cell Biologists, Molecular Biologists, Pharmacologists, Neuroscientists, Endocrinologists and Cancer Scientists. Author enquiries For enquiries relating to the submission of articles (including electronic submission) please visit this journal’s homepage at http://www.elsevier.com/locate/cellsig. For detailed instructions on the preparation of electronic artwork, please visit http://www.elsevier.com/artworkinstructions. Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher. You can track accepted articles at http://www.elsevier.com/trackarticle. You can also check our Author FAQs at http://www.elsevier.com/authorFAQ and/or contact Customer Support via http://support.elsevier.com. For a full and complete Guide for Authors, please go to http://www.elsevier.com/locate/cellsig

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Cellular Signalling

L. Birnbaumer (UCLA, CA, USA)J. Bockaert (CCIPE-INSERM, Montpellier, France)M. Caron (Duke University, Durham, NC, USA)L. Cocco (University of Bologna, Italy)J. E. Dumont (Vrije Universiteit Brussel, Belgium)P. Greengard (Rockefeller University, NY, USA)T. Hébert (McGill University, Québec, Canada)J. Heller-Brown (University of California at San Diego, CA, USA)R. Irvine (University of Cambridge, UK)K. H. Jakobs (Universitätsklinikum Essen, Germany)

B. E. Kemp (University of Melbourne, VIC, Australia)A. Levitzki (Hebrew University of Jerusalem, Israel)I. G. Macara (University of Virginia, Charlottesville, VA, USA)T. F. J. Martin (University of Wisconsin at Madison, WI, USA)S. Nakanishi (Kyoto University, Japan)J. Pouyssegur (CNRS, Nice, France)E. Rozengurt (UCLA, CA, USA)J. Scott (HHMI, Vollum Institute, Portland, OR, USA)S. B. Shears (NIH/NIEHS, Research Triangle Park, NC, USA)M. Ui (The University of Tokyo, Tokyo, Japan)

EDITOR-IN-CHIEF

MILES D. HOUSLAY, Professor of Pharmacological Innovation, Institute of Pharmaceutical Science, King’s College London, 5th Floor, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK E-mail: [email protected]

NIGEL PYNE, Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK Tel.: (+44) 141-548-2659, Fax: (+44) 141-552-2562 E-mail: [email protected]

GEORGE S. BAILLIE, Molecular Pharmacology Group, Gardiner Laboratory, Wolfson Link Building, Division of Biochemistry and Molecular Biology, IBLS, The University of Glasgow, University Avenue, Glasgow G12 8QQ, UK Tel.: (+44) 141-330-2821, Fax: (+44) 141-330-4365 E-mail: [email protected]

SUSAN PYNE, Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK Tel.: (+44) 141-548-2012, Fax: (+44) 141-552-2562 E-mail: [email protected]

EDITORIAL BOARD

Aims and ScopeDescription. This journal publishes full-length, original papers covering all aspects of mechanisms, actions and structural components of cellular signalling systems. The emphasis is on effector systems, such as protein kinases, lipid signalling pathways, cyclic nucleotide signalling processes, NO signalling and ion channels; the production, regulation, degradation and action of second messengers; the structure, regulation,degradation and action of receptors; guanine nucleotide regulatory proteins; bio-informatic studies related to cell signalling mechanisms; compartmentalisation/compartmentation of signalling systems; anchor/scaffold signalling proteins; the effect of cellular signalling events on the functioning, growth and differentiation of cells in normal and pathological states and also cellular oncogenes. Within the scope of the journal, manuscripts dealing with biochemistry, protein structure, cell biology, molec ular biology, pharmacology, neurobiology, molecular endocrinology and molecular oncology are welcomed. The journal also publishes original reviews on topical subjects.

Audience. Biochemists, Cell Biologists, Molecular Biologists, Pharmacologists, Neuroscientists, Endocrinologists and Cancer Scientists.

Author enquiriesFor enquiries relating to the submission of articles (including electronic submission) please visit this journal’s homepage at http://www.elsevier.com/locate/cellsig. For detailed instructions on the preparation of electronic artwork, please visit http://www.elsevier.com/artworkinstructions. Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher. You can track accepted articles at http://www.elsevier.com/trackarticle. You can also check our Author FAQs at http://www.elsevier.com/authorFAQ and/or contact Customer Support via http://support.elsevier.com.

For a full and complete Guide for Authors, please go to http://www.elsevier.com/locate/cellsig