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Editorial Board
Editor-in-ChiefProf. M. S. Bhatia, India (Bharati Vidyapeeth College of Pharmacy, Kolhapur, India) Email: manish.b[email protected] Email: [email protected]
Associate Editors
Dr. Avijeet Jain, IndiaTIT College of Pharmacy, Bhopal, MP, India Email: [email protected]
Dr. Diah Ayu Maharani, Indonesia (Department of Preventive and Public Health, Dentistry Faculty of Dentistry, University of Indonesia,Indonesia) Email: [email protected]
Dr. Subhash C Mandal, India (Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India) Email: [email protected]
Dr. Lokesh Deb, India (Medicinal Plants and Horticultural Resources Division, Institute of Bioresources and SustainableDevelopment (IBSD), Department of Biotechnology, Government of India, Takyelpat Institutional Area,Imphal, Manipur, India) Email: [email protected]
Dr. Wong Tin Wui, Malaysia (Non-Destructive Biomedical and Pharmaceutical Research Center, University of Technology MARA,Malasiya) Email: [email protected]
Assistant Editors
Dr. Idress Hamad Attittala, Libya (Omar El-Mukhtar University, Faculty of Science, Botany Department, El-Beida, Libya) Email: [email protected]
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Dr. Alok Nahata, Malaysia (Alor Star, Malaysia) Email: [email protected]
Executive EditorMr. Niranjan Pathak, India (Dept. of Pharmaceutical Sciences, Dr H S Gour Central University, Saugor, India) Email: [email protected]
Editorial Board Members
Dr. Furhan Iqbal Bahauddin Zakariya University Multan, Pakistan
Dr. Ebtessam Ahmed Mohammed Essa Department of Pharmaceutical Technology,Faculty of Pharmacy, Tanta University, Tanta,Egypt
Dr. Syed Muhammad Farid Hasan Faculty of Pharmacy, University of Karachi,Karachi, Pakistan
Dr. Abdel Raheim Mohammed Ahmed Donia College of Pharmacy – Salman Bin abdul AzizUniversity, Egypt
Dr. Pranay Jain Institute of Engineering & Technology,Kurukshetra University, Kurukshetra, Haryana,India
Dr. Dr. Niaz Ali Institute of Basic Medical Sciences, KhyberMedical University, Peshawar, Pakistan
Dr. M. Saeed Arayne Chairman, Department of Chemistry, University ofKarachi, Pakistan
Dr. Wanzala Wycliffe School of Pure and Applied Sciences, SouthEastern Kenya University, Kenya
Dr. Mayuree Tangkiatkumjai Faculty of Pharmacy, Srinakharinwirot University,Ongkharak, Nakhonnayok, Thailand
Dr. Anup Naha Dept. of Pharmaceutic, MCOPS, Manipal,Karnataka, India
Dr. Jagdish Labhubhai Kakadiya Indubhai Patel College of Pharmacy and ResearchCentre, Petlad-Khambhat Road, Dharmaj, Anand,Gujarat, India
Dr. Maha Ali Eissa Ahmed Department of Pharmacology, Faculty of
Dr. Javed Intekhab G. F. College (Rohilkhand University),Shahjahanpur, U.P., India
Dr. Manish P. Patel Dept. of Pharmaceutics and PharmaceuticalTechnology, Nootan Pharmacy College, Visnagar,Gujarat, India
Dr. Narendra Babu Shivanagere Nagojappa J.N. Medical College, KLE University, Belgaum,Karnataka, India
Dr. C. Chellaram Vel Tech Multi Tech Engg. College, Chennai, India
Dr. Mehdi Shafiee Ardestani Department of Medicinal Chemistry andRadiopharmacy, Tehran University of MedicalSciences, Tehran, Iran
Dr. Amal Amin Mohamed Plant Biochemistry Department; AgricultureDivision -National Research Center, Dokki, Cairo,Egypt
Dr. Rabab Kamel Mahmoud National Research Center, Cairo, Egypt
Dr. Syed Adnan Ali Shah Universiti Teknologi MARA (UiTM), Puncak AlamCampus, Bandar Puncak Alam, Selangor D. E.,Malaysia
Dr. Sat Pal Singh Bisht Roland Institute of Pharmaceutical SciencesBerhampur, Orissa, India.
Dr. Shahu Ingole Smt. Kashibai Navale Medical College & Hospital,Pune India
Dr. Gina Samy El-Feky Pharmaceutics Department, Faculty of Pharmacy,Modern Science and Arts University, Egypt
Dr. Abdalla Ahmed Elbashir Ahmed Khartoum University, Sudan
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Pharmacy, MISR University for Science andTechnology (MUST), Giza Governorate, Egypt.
Dr. Rajesh Mukthavaram Health Science Drive, University of California, SanDiego, Lajolla, CA, California, USA
Dr. Saifullah Khan International Islamic University, Malaysia
Norhaniza Aminudin Institute of Biological Sciences, Faculty of Science,University of Malaya, Kuala Lumpur, Malaysia.
Dr. Shazia Jamshed Kulliyyah of Pharmacy, International IslamicUniversity Malaysia (IIUM), Kuantan, Pahang,Malaysia
Dr. Mayuree Tangkiatkumjai Department of Clinical Pharmacy and SocialPharmacy Faculty of Pharmacy, SrinakharinwirotUniversity, Nakhonnayok, Thailand
Dr. İsmail Murat Palabiyik Faculty of Pharmacy, University of Ankara, Tandoğan, Ankara, Turkey
Nadeem A. Kizilbash Faculty of Medicine, Northern Border UniversityArar, Saudi Arabia
Dr. Debajit Kalita Department of Botany, Morigaon College, Assam,India
Dr. Seyed Mohammad Department of Biology, Faculty of Basic Sciences,University of Mazandaran, Babolsar, Iran
Dr. Shalini Sivadasan Faculty of pharmacy, AIMST University, Semeling,Kedah, Malaysia
Dr. Sujimon Tanvichien Srinakharinwirot University Nakornayok Rd. A.Ongkarak T.Ongkarak, Nakornayok, Thailand
Prof. Dr.-Ing. habil. Dr. h. c. Lothar Mörl Institute für Apparate- und Umwelttechnik Otto-von-Guericke-Universität Magdeburg, Germany
Dr. V. Ravichandran Faculty of Pharmacy, AIMST University, Semeling,Kedah, Malaysia
Dr. Zahid Hussain Department of Pharmaceutics andPharmaceutical Technology, College of Pharmacy,University of Sharjah, Sharjah 27272, United Arab Emirates
Dr. Ajay Kumar Meena Department of AYUSH, Ministry of Health &
Dr. Yesudass Dominic Ravichandran School of Advanced Sciences, VIT University,Vellore, Tamil Nadu, India
Dr. Seema Akbar Research Institute of Unani Medicine, TheUniversity of Kashmir Campus, Srinagar, J. & K.,India
Dr. P. Thillai Arasu Department of Chemistry, Wollega University,Nekemta, Ethiopia
Dr. Sooraj S. Nath Safi Institute of Advanced Study, Kozhikode, India
Dr. Erum Shireen Dept. of Biochemistry, University of Karachi,Pakistan
Dr. M. M. Gupta School of Pharmacy, Faculty of Medical Sciences,The University of The West India, India
Dr. Najma Sultana United Biotechnologies, Karachi, Pakistan
Dr. Sivakumar P Department of Petroleum Engineering, JCTCollege of Engineering and Technology, Pichanur,Tamil Nadu, India
Dr. Evren Algin Yapar Department in Ministry of Health, TurkishMedicines and Medical Devices Agency, Ankara,Turkey
Dr. Vishal Vijay Pandey Jayawantrao Sawant College of Pharmacy &Research, Hadapsar, Pune, India
Dr. Shamkuwar Prashant Babarao Government College of Pharmacy, Thiba Palace,Ratnagiri, India
Dr. S. K. Starling Department of Chemistry, Mewar UniversityChittorgarh, Rajasthan, India
Dr. Syed Sajjad Hussen Manipal College of Pharmaceutical Sciences,Manipal University, India
Dr. Ahmed Osman Department of Psychology, Faculty of Education,Assiut University, Malaysia
Dr. Abdel-Tawab Halim Mossa Abd El-Aziz Department of Pesticide Chemistry, NationalResearch Centre (NRC) Dokki, Cairo, Egypt
Dr. V. Vinod Prabhu Department of Biochemistry, University ofMadras, Guindy campus, Tamil Nadu, India
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Family Welfare, Government of India, India
Dr. Ashish C. Suthar Herbal R & D, Piramal Life Sciences Ltd., Mumbai,India
Dr. Manish A. Rachchh Pharmacological Research and IPR Universityroad, Rajkot, Gujarat, India
Kiran Kumar Chereddy Manager at Novartis Pharma AG Postfach 4002, Basel Switzerland
Dr. Fahd M. Abd Al Galil Department of Zoology, Faculty of AppliedScience,Thamar University, Yemen
Dr. Priyanka Bhatt Department of Pharmaceutical Sciences, Collegeof Pharmacy, University of South Florida, USA
Dr. Beril Anilanmert Istanbul University-Cerrahpasa Institute ofForensic Sciences, Cerrahpasa/İstanbul
Dr. Andleeb Shahzadi Istanbul University Cerrahpasa-Fatih Istanbul, Turkey 34098
Dr. Mohd Masih Uzzaman Khan Unaizah College of PharmacyUnayzah 56264,Saudi Arabia
Dr. Ching Siew Mooi University Putra, Malaysia
Dr. Asif Husain Jamia Hamdard University, New Delhi, India
Dr. Muhammad Shahzad Aslam School of Bioprocess Engineering, UniversitiMalaysia Perlis, Kompleks Pusat PengajianJejawi, Arau, Perlis
Dr. Gláucio Diré Feliciano State University Center Foundation of the WestZone / Rio de Janeiro, Brazil
Dr Dilipkumar Pal Department of Pharmaceutical Sciences, GuruGhasidash Vishwavidyalaya, Bilaspur, C.G., 495009, India
Ali Abdullah Ali Al-yahawi Assistant Professor of Clinical Pharmacy &Therapeutics, Yemen
Dr. Maha Zaki Rizk National Research Center, Therapeutic ChemistryDept., National Research Center, Dokki, Cairo,Egypt
Online ISSN: 0975-1491
Print ISSN: 2656-0097
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Source Normalized Impact per Paper (SNIP): 2.029
SCImago Journal Rank (SJR): 0.23
ISSN: 0975–1491
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Vol6,Issue1,2014
ReviewArticles JAK/STATASANOVELTARGETFORTREATMENTOFLEUKEMIA 1-7SUGANDHACHAUDHARI,JIGARS.DESAI,ADITYAADAM,PREETESHMISHRA PHOSPHOLIPIDSASVERSATILEPOLYMERINDRUGDELIVERYSYSTEMS 8-11SURIYAKALAP.C,SATHEESHBABUN,SENTHILRAJAND,PRABAKARANL TASTEMASKINGOFPEADIATRICFORMULATION:AREVIEWONTECHNOLOGIES,RECENTTRENDSANDREGULATORYASPECTS 12-19JIJOABRAHAM,FLOWERLETMATHEW CANASPIRINBECONTINUEDDURINGDENTALEXTRACTION? 20-23DR.MADHULAXMI.MANDDR.P.U.ABDULWAHAB APPLICATIONOFHEATEXCHANGERSINBIOPROCESSINDUSTRY:AREVIEW 24-28PADMAKSHIAGARWAL,ADHIRATHSIKANDSHANTHIV QUALITYBYDESIGN(QBD):ACOMPREHENSIVEUNDERSTANDINGOFIMPLEMENTATIONANDCHALLENGESINPHARMACEUTICALSDEVELOPMENT 29-35SHASHANKJAIN CAMYLOFINDIHYDROCLORIDE–AREVIEWOFANALYTICALMETHODS 36-37K.S.KOKILAMBIGAI,K.S.LAKSHMI TOBACCO–APOTENTIALTHREATTOTHEORALCAVITY 38-40HARISHSANTHOSHPILLAI,NITHYAJAGANNATHAN PROBIOTICS:ANOVELAPPROACHINIMPROVINGTHEVALUESOFHUMANLIFE 41-43PRAVEENKUMARVEMURI,RAMYAHARIPRIYAVELAMPATIANDSRILAASYATIPPARAJU DEVELOPMENTOFANORALSUBMUCOUSFIBROSIS-SPECIFICHAPLOTYPICSIGNATURE–HOWFARAREWE? 44-47SURESHP.K. TEAK(TECTONAGRANDISLINN.):ARENOWNEDTIMBERPLANTWITHPOTENTIALMEDICINALVALUES 48-54RAMESHB.NIDAVANI,MAHALAKSHMIAM. ResearchArticle FORMULATIONANDEVALUATIONOFSILIBININLOADEDSOLIDLIPIDNANOPARTICLESFORPERORALUSETARGETINGLOWERPARTOFGASTROINTESTINALTRACT 55-67
ABATHERA.SADIQANDALAAA.ABDULRASSOL ANTIULCERACTIVITYOFPTEROSPERMUMACERIFOLIUM(L.)WILLD.STERCULIACEAE 68-72RASIKAD.BHALKE,SEEMAA.GOSAVI,SARITAS.PAWAR,RAOSAHEBS.SHENDGE,ANDSUBODHC.PAL TYPE2DIABETES:INTERACTIONBETWEENCINNAMONPOLYPHENOLANDHUMANSERUMPROTEIN 73-74ANISHABRIGITSHAJAN EVALUATIONOFANTIBACTERIALACTIVITYOFSEEDEXTRACTSOFVIGNAUNGUICULATA 75-77DOPPALAPUDISANDEEP INVITRORELEASEANDINVIVOTISSUELOCALIZATIONOF5-FLUROURACILLOADEDMICROSPHERES 78-83RATHODSUDHAS.,KUMBHARRASIKAB. IDENTIFICATIONOFINHIBITORSFORRNDEFFLUXPUMPOFPSEUDOMONASAERUGINOSAUSINGSTRUCTURE-BASEDPHARMACOPHOREMODELINGAPPROACH 84-89
VASUDEVANAPARNA,NARASUMANIMOHANALAKSHMI†,KESAVANDINESHKUMARANDWAHEETAHOPPER DEVELOPMENTANDVALIDATIONOFAREVERSE-PHASELIQUIDCHROMATOGRAPHICMETHODFORRELATEDSUBSTANCESOFPRASUGRELFOR5AND10MGTABLETS 90-94
M.NARESHCHANDRAREDDY,K.B.CHANDRASEKHAR,A.KAVITHA,E.SASIKIRANGOUD DEVELOPMENTANDVALIDATIONOFAREVERSE-PHASELIQUIDCHROMATOGRAPHICMETHODFORDETERMINATIONOFRELATEDSUBSTANCESOFPITAVASTATINFOR2AND4MGTABLETS 95-100
E.SASIKIRANGOUD,DR.V.KRISHNAREDDY,M.NARESHCHANDRAREDDY ANTIMICROBIALEFFECTSOFMEDICINALPLANTSANDTHEIRCOMPARATIVECYTOTOXICEFFECTSONHEPG2CELLLINE 101-105SHIRISHARAO,BIBECHANATIMSINAANDVARALAKSHMIKILINGARNADUMANE DEVELOPMENTANDVALIDATIONOFRP-HPLCMETHODFORSIMULTANEOUSESTIMATIONOFTERBINAFINEHYDROCHLORIDEANDMOMETASONEFUROATEINCOMBINEDDOSAGEFORM 106-109
MEHULM.PATEL,HETAD.PATEL BIO-PROSPECTINGOFCATFISHSTINGVENOMARIUSMACULATUSAVAILABLEALONGSOUTHEASTCOASTOFINDIA 110-115P.ABIRAMI,M.ARUMUGAM,S.GIJI,S.NAGARAJAN ANTISPASMODICSTUDIESONLEAFANDROOTEXTRACTOFBLUMEALACERA 116-119ASHISHDIXIT,PAWANTIWARI,DEEPESHPARASHER,SARVESHBHARGAVA
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FORMULATIONANDCHARACTERIZATIONOFTELMISARTANSELFMICROEMULSIFYINGDRUGDELIVERYSYSTEM 120-125HYMA.P,ANUSHACHANDRA,ABBULUK DEVELOPMENTANDVALIDATIONOFSTABILITYINDICATINGHPLCMETHODFORCLOTRIMAZOLELOZENGESFORMULATION 126-129PRASHANTHKUMAWAT,JAGADISHPC,MUDDUKRISHNA&KRISHNAMURTHYBHAT PREFORMULATIONSTUDYOFPOLOXAMER407GELS:EFFECTOFADDITIVE 130-133UPENDRAC.GALGATTE,PRAVEEND.CHAUDHARI PRELIMINARYPHYTOCHEMICALSCREENINGOFLIMONIAACIDISSIMALINN. 134-136PRATIMAVIJAYVARGIA,SONIYACHOUDHARYANDREKHAVIJAYVERGIA PEGYLATIONOFRECOMBINANTMUTEINSTREPTOKINASEFROMOVERPRODUCTIONINESCHERCHIACOLIBL21ANDSTUDYONTHEFIBRINOLITYCACTIVITYINVITRO 137-141
HENIRACHMAWATI,FERRYDAMANHURI,IRFANAGUSTIANDARFIANSYAH,DEBBIES.RETNONINGRUM POTENTIALSOFPINEAPPLEWASTEASGROWTHMEDIUMFORLACTOBACILLUSSPECIES 142-145HASSANPYAR,MIN-TZELIONGANDK.KPEH IN-VIVOSCREENINGOFANTI-INFLAMMATORYACTIVITYINMETHANOLICEXTRACTOFCORBICHONIADECUMBENS(FORSK.)USINGVARIOUSANIMALMODELSOFPAWOEDEMA 146-148
UMA.GBALASUBRAMANIAM.VANDJAGATHESKUMAR.S OPTIMIZATIONOFSTABILITY-INDICATINGCHROMATOGRAPHICMETHODSFORTHEDETERMINATIONOFROXATIDINEACETATEINTHEPRESENCEOFITSDEGRADATIONPRODUCTS 149-157
HALAE.ZAAZAA,SAMAHS.ABBAS,ZEINABA.EL-SHERIF,DALIAA.ELـHADDADANDBADREL-ZEANY
PHYTOCHEMISTRYANDANTIMICROBIALEFFICACYOFINDIGOFERALONGIRACEMOSA(FABACEAE) 158-160DHARMASAMYPREMALATHA,RAMASAMYKAMARAJ,ARUMUGAMECHANEMOUGAMETANGAVELOU INVESTIGATINGANTINOCICEPTIVEACTIVITYOFPOLYCARPAEACORYMBOSALAM.(CARYOPHYLLACEAE)INSTANDARDEXPERIMENTALANIMAL 161-163SINDHUSANDSMANORAMA EVALUATIONOFANTICANCERACTIVITYOFVETIVERIAZIZANIOIDESAGAINSTHUMANBREASTCANCERCELLLINE 164-166CHITRAT,SJAYASHREEANDJRATHINAMALA ASTUDYONSTRUCTURALASPECTSANDMICROBIALACTIVITYOF(E)-4-PYRIDINECARBOXALDEHYDE-3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYL-OXIMEHYDROCHLORIDE:ANEXPERIMENTALANDCOMPUTATIONALAPPROACH 167-173
K.ESHWARI,P.SAROJA,K.SANDHYA,B.SIREESHA,PALLEPOGURAGHAVAIAH,ANDCH.SARALADEVI ANTIOXIDANTANDANTIFUNGALPROFILESOFPHENOLACIDRICH-FRACTIONSFROMSIDAURENSL.AGAINSTMYCELIAGROWTHINHIBITIONOFSOMEASPERGILLUSANDFUSARIUMSPECIES 174-178
PATRICEZERBO,KIESSOUNKONATÉ,MAURICEOUÉDRAOGO,VANDAMMEPATRICKANDNICOLASBARRO FORMULATIONANDEVALUATIONOFERGOTAMINETARTRATELYOPHILIZEDNASALINSERT 179-184DALIAF.EL-TELBANY,SADIAA.TAYEL,M.A.EL-NABARAWI,RANDATAG,AHMEDA.ABOELWAFA FORMULATIONEVALUATIONANDINVITROPERMEATIONSTUDIESOFTRANSDERMALNIFEDIPINEFROMMATRIXTYPEPATCHES 185-188ARUNRAJ.R CHARACTERIZATIONANDIDENTIFICATIONOFLACTOBACILLUSACIDOPHILUSUSINGBIOLOGRAPIDIDENTIFICATIONSYSTEM 189-193HASSANPYARANDK.KPEH ISOLATIONOFANOVELFEATHER-DEGRADINGBACTERIUMANDOPTIMIZATIONOFITSCULTURALCONDITIONSFORENZYMEPRODUCTION 194-201RADHIKAS.MEHTA,RIDDHIJ.JHOLAPARA,CHHAYAS.SAWANT MARKERBASEDSTANDARDISATIONOFPLANTBASEDFORMULATIONSCONTAININGBRAHMIUSINGBACOSIDEABYHPTLC 202-207SUPRIYAJIRGE,S.Y.GABHE,PRATIMATATKE SIMULTANEOUSSPECTROPHOTOMETERICESTIMATIONOFLAFUTIDINEANDDOMPERIDONEINSOLIDDOSAGEFORMS 208-211P.KALAISELVI,KG.LALITHA FORMULATIONDEVELOPMENTANDEVALUATIONOFMETOCLOPRAMIDEHYDROCHLORIDENASALSPRAY 212-216M.MENAKA,V.P.PANDEY EFFECT0FBIOLOGICALCOMPETITIONOFWEEDSONGROWTHANDVOLATILEOILYIELDOFMARIGOLD(CALENDULAOFFICINALISL.)ASMEDICINALPLANTUSEDINHERBALMEDICINEOFIRAQ 217-219
IBRAHIMS.ABAAS UV-SPECTROPHOTOMETRICANDRP-HPLCMETHODSFORTHEESTIMATIONOFPRASUGRELHYDROCHLORIDEINBULKANDTABLETFORMULATION 220-225RANJITHKUMARRAJENDIRAN,VINOTHKUMARSEKAR,BHARATHADEVINAMADEVAN,JAIKUMARANNAMALAI,SARAVANANDEVARAJAN GC-MSANALYSISOFVARIOUSEXTRACTSOFCLERODENDRUMPHLOMIDISLEAF 226-232K.BALAJI,D.KILIMOZHI HEPATOPROTECTIVEACTIVITYOFETHANOLICEXTRACTOFAERIALPARTSOFALBIZIAPROCERAROXB(BENTH.)AGAINSTPARACETAMOLINDUCEDLIVERTOXICITYONWISTARRATS 233-238
S.SIVAKRISHNAN,A.KOTTAIMUTHU SYNTHESISOFNEWDICLOFENACDERIVATIVESBYCOUPLINGWITHCHALCONEDERIVATIVESASPOSSIBLEMUTUALPRODRUGS 239-245SAMERA.HASANANDAMERN.ELIAS BOTANICALSTUDY,DNAFINGERPRINTING,TOTALPROTEINPROFILING,NUTRITIONALVALUESANDCERTAINPROXIMATESOFV.ERVILIAL. 246-253MONAM.OKBA,MIRIAMF.YOUSIF,KADRIYAS.ELDEEBANDFATHYM.SOLIMAN ANTI-DIABETICACTIVITYOFMETHANOLICEXTRACTOFCALOTROPISGIGANTEASEEDSONSTZINDUCEDDIABETICRATS 254-257JATINJAISWAL,HEMANTBHARDWAJ,SHRUTISRIVASTAVA,HEMENDRAGAUTAM,SURABHISHARMA,CH.VRAO COMPACTIBILITYASSESSMENTOFDIRECTCOMPRESSIONEXCIPIENTS:PROSOLVEASYTAB 258-264JESÚSANDRÉSRODRÍGUEZVALADEZ,LEOPOLDOVILLAFUERTEROBLES PREPARATIONANDSOLIDSTATECHARACTERIZATIONOFSIMVASTATINANOSUSPENSIONSFORENHANCEDSOLUBILITYANDDISSOLUTION 265-269P.AMSA,S.TAMIZHARASI,M.JAGADEESWARAN,T.SIVAKUMAR RP-HPLCMETHODDEVELOPMENTANDVALIDATIONFORTHESIMULTANEOUSQUANTITATIVEESTIMATIONOFPREGABALIN,MECOBALAMINANDALPHALIPOICACIDINCAPSULES 270-277
J.ANILMOHAN,B.RAJKUMAR,T.BHAVYA,A.ASHOKKUMAR SIMULTANEOUSESTIMATIONANDVALIDATIONOFNEBIVOLOLANDVALSARTANINTABLETDOSAGEFORMBYRP-HPLC 278-282C.MADHAVI,B.SIDDARTHA,C.PARTHIBAN SIMULTANEOUSESTIMATIONOFLOSARTAN,HYDROCHLOROTHIAZIDEANDATENOLOLFROMSOLIDDOSAGEFORMBYRP-HPLC 283-288
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SAVITASYADAVANDJANHAVIR.RAO DEVELOPMENTANDVALIDATIONOFSTABILITYINDICATINGHPLC-UVMETHODFORTHEDETERMINATIONOFAMPHOTERICINBINBULKANDDOSAGEFORM 289-293
“ARTICLEHASBEENWITHDRAWNFROMPUBLICATIONONAUTHOR’SREQUEST” FORMULATIONANDEVALUATIONOFTRIFLUOPERAZINEHYDROCHLORIDEORODISPERSIBLETABLETS 294-300EBTIHALA.DAKHILANDNIDHALK.MARAIE SOLUBILITYANDDISSOLUTIONOFPHYSICALMIXTURECARBAMAZEPINEANDAMINOACIDS 301-306DEWIISADIARTUTI,TUTUKBUDIATI,SUWALDIMARTODIHARDJO REVERSEPHASEHPLCMETHODDEVELOPMENTANDVALIDATIONFORTHESIMULTANEOUSQUANTITATIVEESTIMATIONOFALPHALIPOICACIDANDALLOPURINOLINTABLETS 307-312
B.RAJKUMAR,T.BHAVYA,A.ASHOKKUMAR SEPARATIONANDDETERMINATIONOFTRITERPENEACIDSBYUSINGHIGHPERFORMANCETHINLAYERCHROMATOGRAPHYFROMSTEMBARKOFMIMUSOPSELENGILINN. 313-317
VIDYADIGHEANDDHANASHRIMESTRY COMPARATIVEEVALUATIONOFFREERADICALSCAVENGINGACTIVITYOFCLEOMEVISCOSEANDTRICHODESMAINDICUM 318-325SANGEETHA,S.,MARYSHOBADAS,C.ANDGAYATHRIDEVI,S. GLUTATHIONE-S-TRANSFERASEAND CATALASEACTIVITYINDIFFERENTTISSUESOFMARINECATFISHARIUSARIUSONEXPOSURETOCADMIUM 326-332R.MANI,B.MEENA,K.VALIVITTANANDA.SURESH REVERSEPHASEHPLCMETHODDEVELOPMENTANDVALIDATIONFORTHESIMULTANEOUSQUANTITATIVEESTIMATIONOFTROXERUTINANDCALCIUMDOBESILATEINTABLETS 333-339
N.J.R.HEPSEBAH,D.NIHITHA,A.ASHOKKUMAR INVITROANTIMICROBIALACTIVITYOFDIFFERENTPARTSOFSTACHYTARPHETAURTICIFOLIA(SALISB)SIMS 340-343SREELATHAR,MURALIMOHANCH,ASHOKPHANIKIRANK,SUDESHKUMARE PHYTOCHEMICALSANDANTIOXIDANTACTIVITYINBOERHAVIADIFFUSA 344-348RICHABHARDWAJ,ANKITAYADAVANDRASHARMA SUSTAINEDRELEASEOFRAMIPRILFROMAMMONIOMETHACRYLATECOPOLYMERMATRIXPREPAREDBYHIGHPRESSUREHOMOGENIZER 349-353
SATISHPANDAV,JITENDRANAIK NEUROPROTECTIVEEFFECTSOFPOLYHERBALFORMULATION(INDIANNONI)ONSCOPOLAMINE-INDUCEDMEMORYIMPAIRMENTINMICE 354-357G.UMA,S.UMAMAHESWARI THEMODULATINGEFFECTOFMETHANOLICSEEDEXTRACTOFNIGELLASATIVAONETHANOLANDHIGHFATDIETINDUCEDPANCREATICINJURYINRATS 358-363
PERIYANAYAGAMSUGUNA,ARUMUGAMGEETHA,RAVIKUMARARUNA,GANESANVIJAIYANSIVA IN-VITROANTI-OXIDANTACTIVITYOFCITRUSMACROPTERA(VARANNAMENSIS)FRUITPEELSEXTRACTS 364-371HABIBURRAHMAN,M.CHINNAESWARAIAH,A.M.DUTTA ACOMPARATIVESTUDYONBIOSYNTHESISOFSILVERNANOPARTICLESUSINGFOURDIFFERENTFUNGALSPECIES 372-376RAVINDRA.B.KANDA.H.RAJASAB METALLOTHIONEININDUCTIONINFRESHWATERCATFISHCLARIASGARIEPINUSONEXPOSURETOCADMIUM 377-383SUMITROSE,S.VINCENT,B.MEENA,A.SURESHANDR.MANI ACTIONOFTRICHLOROETHENEANDTETRACHLOROETHENEONFURFURALDEHYDEDI-N-BUTYLACETALATLOWTEMPERATURE 384-386M.EASURAJA EVALUATIONOFDIURETICANDANTI-INFLAMMATORYPROPERTYOFETHANOLICEXTRACTOFSOLANUMSURATTENSEINEXPERIMENTALANIMALMODELS 387-389
R.V.RAMANARAYANAREDDY,K.UMAMAHESHWARARAO,YAKAIAHVANGOORI,J.MOHANASUNDHARAM RP-HPLCMETHODDEVELOPMENTANDVALIDATIONFORTHESIMULTANEOUSESTIMATIONOFAMLODIPINEANDATENOLOLINBULKANDTABLETDOSAGEFORMS 390-394
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MULLASAIRA,MUKHOPADHYAYRAJENDRANATH,KULKARNISUHASRAMKRISHANA,BHURESUDESH,IYERKRISHNAN ANTIPROLIFERATIVEACTIVITYOFPIPERBETELLEAFEXTRACTSONHUMANLUNGCANCERCELLLINE(A549) 432-435DEVJANIBANERJEE&BARKHASHAH SPASMOLYTICANDHYPOGLYCEMICEFFECTSOFDIFFERENTFRACTIONSISOLATEDFROMMETHANOLICEXTRACTOFWHOLEPLANTOFHYGROPHILAAURICULATAINWISTARALBINORATS 436-439
RAMESHAPRAVEENKUMARP,SILVIAN,NARENDRARAJUJ,PRASADK SYNTHESISOFSUBSTITUTEDPIPERDIN-4-ONESWITHDICHLORO(CYCLOOCTADIENE)PALLADIUM(II)ANDANTIMICROBIALACTIVITY 440-444NALININAMASIVAYAMANDCHINNIAGOUNDERTHEIVARASU EFFECTOFDESFLURANEANAESTHESIAONBISPECTRALINDEXANDPOST-OPERATIVERECALL 445-448
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Research Article
IN VITRO ANTIMALARIAL ACTIVITY OF CHALCONE AND ITS DERIVATIVES
MELANNY IKA SULISTYOWATY*, KHOLIS AMALIA NOFIANTI, SUZANA, AND TUTUK BUDIATI
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia 60286.
Email: [email protected]
Received: 11 Nov 2013, Revised and Accepted: 9 Dec 2013
ABSTRACT
Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives.
Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced
by Trager and Jensen (1976).
Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 µg/ml.
Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.
Keywords: Chalcones, In vitro, Antimalarial activity, Plasmodium falciparum.
INTRODUCTION
Malaria is a major parasitic infectious disease in the world, caused by Plasmodium falciparum. It continues to be one of the major public health problems in many tropical countries leading to widespread morbidity and mortality [1,2].According to the annual report of World Health Organization, the malaria incidence in Indonesia in 2010 is still fairly high, about 37% from 242.7 million people. It is a threat to over 2 billion people living in areas of high incidence [3,4]. The available medicines such as Chloroquine is no longer effective to treat malaria, due to the increasing of multi drug resistance [1,5].Nowadays, Artemisinin and its derivatives have become the only available drugs to treat malaria. Resistance to these drugs have not been clinically encountered so far [1,6].In fact, synthesize of those compounds are delicate and very expensive. Moreover, sooner or later, resistance of that medicine will be arising. Therefore, it is important to develop some alternative compounds which have better antiplasmodial activity.
Chalcones are precursor of numerous plant metabolites with
distinctive scaffold owing exceptional biological properties [1,7].
Their main structure is 1,3-diphenyl-2-propene-1-ones, wherein two
benzene rings are associated by highly electrophillic three carbon
α,β-unsaturated carbonyl configuration [10,12]. In past few years, it
had been reported Morachalcone A (figure 1), a naturally occurring
substance from Artocarpus champeden Spreng, belonging to the
family Moraceae, is a native plant of Indonesia which significantly
inhibited the in vitro growth of the human malaria parasite
Plasmodium falciparum [8,15]. Due to its simple structure and
effortless to synthesize clarify the substantial interest of chemist in
this particular group of compounds. There are various methods for
the syntheses of chalcones have been discovered, including Claisen-
Schmidt condensation [11,12], photo-Fries rearrangement [13],
Suzuki coupling reaction [13,14], Friedel-Craft acylation [13], and
also green chemistry method via microwave irradiation [11,13].
In our previous work, we have been synthesized chalcone (KTS 11)
and some derivatives via Claisen-Schmidt condensation, namely 3-
(4-methoxyphenyl)-1-phenylprop-2-en-1-one (KTS 12), 3-(2-
methoxyphenyl)-1-phenylprop-2-en-1-one (KTS 13) and 3-(3-
hydroxyphenyl)-1-phenylprop-2-en-1-one (KTS 16) in a good yields
(73 - 93%)[9,16]. Figure 1 shows structure of chalcone and its
derivatives which have been used in this experiment. In this report,
we evaluated in vitro antimalarial activity of chalcone and its
derivatives against parasite Plasmodium falciparum 3D7 strain.
O
O
HO OH
OH
HO
Morachalcone A
O
OH
OO
Chalcone (KTS 11)
O CH3
OCH3
3-(2-methoxyphenyl)-1-phenylprop-2-en-1-one(KTS 13)
3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one(KTS 12)
3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one(KTS 16)
Fig. 1: Chalcone and Its Derivatives
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN- 0975-1491 Vol 6, Issue 1, 2014
AAccaaddeemmiicc SScciieenncceess
Sulistyowaty et al.
Int J Pharm Pharm Sci, Vol 6, Issue 1, 669-671
670
MATERIALS AND METHODS
Antiplasmodial activity of chalcones was basically conducted by
using candle jar method of Trager and Jensen [17]. Briefly, Stock
solution of tested compounds were arranged in DMSO and diluted
with complete medium, which consist of RPMI 1640 supplemented
with 10% human plasma, 25 mM HEPES and 25 mM NaHCO3, to the
required concentrations of samples in culture plate wells were 100;
10; 1; 0.1; and 0.01 µg/ml. The final DMSO concentration in the
culture media had no effect on parasite growth.
Asexual blood stage parasite of Plasmodium falciparum (3D7 strain)
were tested to graded concentration of each compound in 24-well
culture plates in duplicates for 48 h at 37 οC. Growth of the parasite
was observed by preparing a blood smear fixed with methanol and
stained with Giemsa stain. The antimalarial activity of each
compound was stated as an IC50 value, defined as the concentration
of the compound causing 50% inhibition of parasite growth relative
to untreated control. Concentration versus response curve was set
up to figure out IC50 value of each compound [1,2].
RESULTS AND DISCUSSION
Plasmodium is an intracellular parasite for most part of its life cycle
in the vertebrate host. The intraerytrocytic parasite grows and
reproduces asexually by converting the toxic heme molecules into
nontoxic hemozoin. Inhibition of hemoglobin degradation process
proves fatal for the parasite. It is envisaged that malarial aspartic
proteases and cysteine protease mediate the haemoglobin
degradation to release amino acids that are entailed for
intraerythrocytic parasite growth and multiplication
[18,19].Structure-based studies expected antimalarial of chalcone
derivatives inhibition on trophozoite cysteine protease as most
likely mode of action [20, 21].Availability of continues cultivation of
human malaria parasite, Plasmodium falciparum [17]affords an
interesting in vitro system for preliminary screening to recognize
antiparasitic action of compounds in the absence of immune
substances [18].
The tested compounds were evaluated its antimalarial activity
against Plasmodium falciparum (3D7 strain). Chalcone gave IC50
0.242 µg/ml, while compound with methoxy group on para
position of 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one gave
IC50 value 54.316 µg/ml. The presence methoxy group on ortho
position of 3-(2-methoxyphenyl)-1-phenylprop-2-en-1-one gave
undesired result with IC50 value >100 µg/ml, which means it has
no antimalarial activity. Other chalcone derivative with hydroxyl
group on meta position, 3-(3-hydroxyphenyl)-1-phenylprop-2-en-
1-one gave IC50 value 14.136 µg/ml. Figure 2 shows the graph of
concentration versus response of chalcone and its derivatives
against blood stages of Plasmodium falciparum (3D7 strain). In this
experiment, the standard antimalarial drug, Chloroquine
diphosphate was also examined and gave IC50 value 0.006 µg/ml.
From this result, it can be concluded that chalcone which has no
substituent at its both ring gave the greatest IC50 value among the
tested compounds. And also they all have lower antimalarial
activity than commercially available antimalarial medicine,
Chloroquine. The table 1 shows IC50 values of the Chalcones as
described below:
From literature, it was reported that the IC50 value of Morachalcone
A, that isolated from Artocarpus champeden Spreng was 0.002
µg/ml [8].The absence of isoprenyl group and multi-hydroxyl group
of chalcone-skeleton is decreasing its ability to inhibit parasite
growth. Therefore, it needs to be designed furthermore to develop
innovative strategies to synthesis other new chalcone derivatives,
which have better antimalarial potency.
Table 1: Antimalarial activity of Chalcone and its derivatives (IC50 value)
Structure Compound IC50
(µg/ml)
Substituent
R1 R2 R3
KTS 11 0.242 H H H
KTS 12 54.316 H OCH3 H
KTS 13 > 100 OCH3 H H
KTS 16 14.136 H H OH
Standard-antimalarial agent Chloroquin diphosphate 0.006 - - -
Fig. 2: Concentrations-Response Curve of the Chalcones
0
20
40
60
80
100
120
Cons 0.01 Cons 0.1 Cons 1 Cons 10 Cons 100
% in
hibi
tion
(mea
n)
Concentrations (µg/ml)
KTS 11
KTS 12
KTS 13
KTS 16
Sulistyowaty et al.
Int J Pharm Pharm Sci, Vol 6, Issue 1, 669-671
671
CONCLUSIONS
Chalcone and its derivatives have been tested for its antimalarial
activity against Plasmodium falciparum (3D7 strain). All the tested
compounds have lower antimalarial activity than commercially
available antimalarial drug, Chloroquine, with IC50 value range from
>100 to 0.242 µg/mL.
ACKNOWLEDGMENT
This research was financially funded by Directorate General of
Higher Education (DGHE) or DIKTI through Penelitian Unggulan
Perguruan Tinggi’s scheme of 2013.
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International Journal of Pharmacy and PharmaceuticalSciencesDiscontinued in Scopus as of 2016
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SUBJECT AREA ANDCATEGORY
Pharmacology,Toxicology andPharmaceutics
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Year Documents2009 772010 3102011 573
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Cites per document Year ValueCites / Doc. (4 years) 2009 0.000Cites / Doc. (4 years) 2010 0.558Cites / Doc. (4 years) 2011 1.261Cites / Doc. (4 years) 2012 1.947Cites / Doc. (4 years) 2013 1.169Cites / Doc. (4 years) 2014 0.796Cites / Doc. (4 years) 2015 0.659Cites / Doc. (4 years) 2016 0.686Cites / Doc. (4 years) 2017 0.800Cites / Doc. (4 years) 2018 0.970
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800
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2009 2011 2013 2015 2017 2019
0
0.4
0.8
1.2
1.6
2
2009 2011 2013 2015 2017 2019
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2k
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2009 2011 2013 2015 2017 2019
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1
2
2009 2011 2013 2015 2017 2019
0
5
10
2009 2011 2013 2015 2017 2019
0
2k
4k
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Bimala Subba 13 hours ago
Dear Elena Corera
Please help me to publish this comment. It will save the future of many innocent researchers like
me. This journal International Journal of Pharmacy and Pharmaceutical Sciences is published by a
predatory publishershttps://predatoryjournals.com/publishers/, We are unable to use any
publication published by Innovare Academic Sciences as it is listed in the predatory list. I have
been suffering a lot, as though this is a good journal with the SCImigo impact factor.
I have a humble request with the SCImigo team, to remove this journal from your list as it is
misleading.
Dr. Bimala Subba
Central Department of Chemistry, TU, Kirtipur, Nepal
reply
VINAY PANWAR 1 year ago
This journal is scopus/sci
Ratio of a journal's items, grouped in three yearswindows, that have been cited at least once vs. thosenot cited during the following year.
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