HIV/TB CLINICAL RESEARCH DURBAN

Reid Rubsamen

PheZulu Safari Park

Zulu Hut Zulu Tribe Performers

Caprisa Research and Treatment ClinicParallel work on TB and HIV

Tour Guides

Ayesha Kharsany

Lulu Nair

Caprisa Clinic Intake Waiting RoomAll charts are electronic

On the Roof N95 respirator required for clinic tour

Neighborhood Across the StreetAmbulance driver training school

Caprisa Clinic Placards

Education Facility Safety

Sample Collection TB screening is primarily via sputum collection. PPD not useful in patients over five years old because of prevalence of BCG vaccination.

Counseling AreaLay counselors enroll patients in VOICE trial.

Counseling Session For VOICE TrialVaginal gel with anti-viral agents. >30% signal in 600 patient Phase IIb with peri-coital administration. Sponsor wants daily dosing in Phase III. Quintiles is overseeing the Phase III study for Conrad Pharmaceuticals.

Study RegistrationFingerprint scanner eliminates possibility of co-enrollment (which was a problem with the VOICE Phase IIb trial).

Fingerprint Acquisition

Fingerprint Scanner Reid’s Thumbprint

Clinic-Based Data Management

Data-FAX system used.

All HPP data sent to SHARP

Clinic has read-only access to OCR translated CRFs for QC

Fingerprint scanner eliminates possibility of unauthorized co-enrollment

Clinical Trial ManagementAudits by NIH and Quintiles

Caprisa Clinic

Operations Infrastructure Clinic Video

The Medical SchoolMain Entrance

Medical School NeighborhoodLooking East Looking West

Medical School Facility - HHMRIHoward Hughes Medical Research Institute under construction. P3 lab will be included for TB research.

Medical School Facility Focus HIV and TB

Facility Directory Detail

Medical School FacilityCaprisa Offices

Medical School Facility

Reid and Salim Abdool Karim Slim’s Office Entrance

Medical School Facility

News clipping display Bruce walker detail

Medical School Facility

Bruce walker Lab corridor

HIV Pathogenesis Programme

HPP Entity Poster HPP Process Outline

Flow CytometryClinical FACS 4 wavelength FACS machineExpanded wavelength research FACS in same facility

All Positive Samples Frozen

Medical School Facility

Parallel TB Research

Study in-progress is evaluating the optimal timing of co-delivery of anti infective and anti viral agents in patients infected with HIV and TB

HPP Enabled StudiesSystematic tracking of patient cohorts in various HIV infection states allows for wide range of hypothesis testing