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Dansk Selskab for Farmakologi, Toksikologi og Medicinalkemi DSFTM.dk ! [email protected] DSFTM Annual Meeting 2015 19.-20. October, 2015 at Sandbjerg Manor in Sønderborg, Denmark Pharmacokinetics: Driving Research at the Interface between Pharmacology, Toxicology and Medicinal Chemistry The Danish Society for Pharmacology, Toxicology and Medicinal Chemistry (DSFTM) hereby announces its 2015 Annual meeting, which will take place over two days in October at the scenic Sandbjerg Manor near Sønderborg. The meeting is open to members and non- members alike. The DSFTM 2015 Annual Meeting aims to bring researchers together across traditional scientific disciplines, but also to serve as a meeting place for students, young researchers and more established experts from academia and industry alike. The meeting includes an Early Careers Session with a chance to present own research (posters and short oral presentations). Best poster and oral contributions will be awarded the DSFTM Annual Meeting Award including a 1000 kr. cash prize. Program is subject to change - Day 1 - Session 1 Chair: Eva Cecilie Bonefeld-Jørgensen Aarhus University President of DSFTM Plenary Session 11.30 – 11.40 Welcome 11.40 – 12.25 Plenary Lecture (35 + 10 min): Pharmacokinetics - state of the art Dino Montanari H. Lundbeck A/S 12.25 – 13.30 Lunch Session 2 Chair: Niels Svenstrup H. Lundbeck A/S Transport through biological barriers – Two sides of a coin 13.30 – 14.45 Modulation of Intestinal Membrane Transporters: In vitro mechanisms to in vivo impact Carsten Uhd Nielsen Southern University of Denmark Placental transport (and transporters) Line Mathiesen University of Copenhagen Assessing the permeability of new drugs across the BBB: An industry perspective Lassina Badolo H. Lundbeck A/S 14.45 – 15.15 Coffee and Check-In

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Dansk Selskab for Farmakologi, Toksikologi og Medicinalkemi DSFTM.dk ! [email protected]

DSFTM Annual Meeting 2015

19.-20. October, 2015 at Sandbjerg Manor in Sønderborg, Denmark

Pharmacokinetics: Driving Research at the Interface between Pharmacology, Toxicology and Medicinal Chemistry

The Danish Society for Pharmacology, Toxicology and Medicinal Chemistry (DSFTM) hereby announces its 2015 Annual meeting, which will take place over two days in October at the scenic Sandbjerg Manor near Sønderborg. The meeting is open to members and non-members alike.

The DSFTM 2015 Annual Meeting aims to bring researchers together across traditional scientific disciplines, but also to serve as a meeting place for students, young researchers and more established experts from academia and industry alike.

The meeting includes an Early Careers Session with a chance to present own research (posters and short oral presentations). Best poster and oral contributions will be awarded the DSFTM Annual Meeting Award including a 1000 kr. cash prize.

Program is subject to change

- Day 1 -

Session 1 Chair: Eva Cecilie Bonefeld-Jørgensen Aarhus University President of DSFTM

Plenary Session 11.30 – 11.40 Welcome 11.40 – 12.25 Plenary Lecture (35 + 10 min):

Pharmacokinetics - state of the art Dino Montanari H. Lundbeck A/S

12.25 – 13.30 Lunch

Session 2 Chair: Niels Svenstrup H. Lundbeck A/S

Transport through biological barriers – Two sides of a coin

13.30 – 14.45 Modulation of Intestinal Membrane Transporters: In vitro mechanisms to in vivo impact Carsten Uhd Nielsen Southern University of Denmark

Placental transport (and transporters) Line Mathiesen University of Copenhagen

Assessing the permeability of new drugs across the BBB: An industry perspective Lassina Badolo H. Lundbeck A/S

14.45 – 15.15 Coffee and Check-In

   

 

 

 

Dansk Selskab for Farmakologi, Toksikologi og Medicinalkemi DSFTM.dk ! [email protected]

Session 3 Chair: Christiane Beer Aarhus University

Early Careers Session 15.15 – 16.30 Early Careers Session - Short oral presentations (10 minutes plus 5 minutes discussion each) 16.30 – 16.45 Break 16.45 – 17.30 Poster session with short poster presentation (3-5 min each) 17.30 – 18.30 DSFTM General Assembly (For the members of DSFTM) 19.00 – 22.00 Dinner 22.00 – Social activities

- Day 2 -

Session 4 Chair: Harrie C.M. Boonen University of Copenhagen

Predicting human pharmacokinetics and human biomonitoring

9.00 – 10.15 Plenary Lecture (35 + 10 min): ADME: Toxicokinetics as a key to the integrated toxicity risk assessment (non-animal approach) Emanuella Testai European Union Reference Laboratory for Alternatives to Animal Testing, Italy

In silico modelling of pharmacokinetics and metabolism for safety assessment of chemicals - where are we right now? Svava Ósk Jónsdóttir Technical University of Denmark, DTU

10.15 – 10.30 Coffee

Session 5 Chair: Gunnar Vase Toft Aarhus University

Metabolism

10.30 – 12.15 Bioactivation of carboxylic acid drugs – focus on CoA conjugation Lars Weidolf AstraZeneca

Clinical aspects of genetic and environmental differences in drug oxidation Kim Brøsen University of Southern Denmark

Polymorphism in P450 genes versus breast cancer risk Mandana Ghisari Aarhus University

Fate of nanomaterials – in vitro and in vivo Christiane Beer Aarhus University

12.15 – 13.10 Lunch

   

 

 

 

Dansk Selskab for Farmakologi, Toksikologi og Medicinalkemi DSFTM.dk ! [email protected]

Session 6 Chair: Trond Ulven University of Southern Denmark

Case stories

13.10 – 14.50 Xultophy Discovery and Development Morten Schlein Novo Nordisk A/S

The importance of integration between human dose predictions and discovery toxicology in the selection of the right development candidate - a case story Tomas Mow H. Lundbeck A/S

Physiologically based pharmacokinetic modeling of environmental contaminants in Greenlanders Christian Sonne Aarhus University

SorCS1 – a new principle for the treatment of type 2 diabetes? Anders Nykjær Aarhus University

14.50 – 15.00 Prize Announcement: Best oral and poster 15.00 – 15.15 Thanks and Goodbye

15.15 – 15.45 Coffee

Concerning transportation Train from Copenhagen: Connection (IC825) from Copenhagen (departure 7:28) to Sønderborg (arrival 11:07) costs kr. 825,- round trip incl. seat reservation. Shuttle buses will operate between Sønderborg railway station and Sandbjerg Conference Centre. Reservations to be made on www.dsb.dk. Flight from Copenhagen: Alsie Express runs a convenient flight service from Copenhagen Airport to Sønderborg (we recommend arrival Monday at 9:15 AM, departure Tuesday at 4:30 PM). Prices by online booking are currently around kr. 2.000-2.500 for a return ticket depending on ticket class. Flight time is around 40 minutes. Shuttle buses will operate between Sønderborg Airport and Sandbjerg Conference Centre. Please book soon due to a limited number of seats. Bookings can be made at www.alsieexpress.dk. Bus/car from Århus: By discretion of the board, there may be established a return bus service between Aarhus to Sandbjerg Conference Centre, depending on the number of participants from this area. Please inform us of your travel plans at the time of registration and we will arrange for transport between Sønderborg railway station / Sønderborg Airport and Sandbjerg Conference Centre. Registration On first come, first served basis - the meeting is limited to 100 participants. Abstract submission deadline is August 15th. Registration fee: 400 kr (DSFTM members - membership is free for students)* 750 kr (non-members) Please navigate to www.DSFTM.dk to register.