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Drug
Discovery
Drug
Delivery
Drug
Target
Analysis
Chemistry + Biology + Genetics = Advancing Human Health
College of Pharmacy
Genome to Drug Discovery Group
The Bacterial Extracellular Proteome as Potential Therapeutic Target
m/z
Inte
nsi
ty
carB is important for cell growth in rich media
wt T2S mutant1.010 00
1.010 02
1.010 04
1.010 06
1.010 08
CF
Us
/mo
us
e
Aleksandra Sikora
What makes Chlamydia…Chlamydia?
Vacuole bacteria
Host nucleus
Chlamydia trachomatis-infected cells
Dan Rockey
Skin Wound Healing Head and neck cancer Healing of Chronic , diabetic, burn wounds is a major health concern
Cancer is a wound that does not heal
Diagnosis & Prevention 1. Patented Biomarker (Collaborator: A.Indra & M.Leid)
2.New anticancer drugs (Collaborator: T. Mahmud)
Identify gene targets
Validating targets Patient’s biopsies & cancer cell lines
Identify factors to mobilize stem cells
New Drug Targets
C U R E
C U R E
Gitali Ganguli-Indra [email protected]
Ide
ntify p
athw
ays
Collaborators : A.Indra & M.Leid)
Taifo Mahmud Laboratory http://people.oregonstate.edu/~mahmudt/
Drug Discovery and Development
Infectious diseases and cancers
Biosynthetic engineering
Natural product discovery
Department of Pharmaceutical Sciences
Chemical synthesis
Genome mining and metabolomics
OSU Natural Products as Probes to study
Autophagy and Cell Death in cancer cells
Jane Ishmael Pharmacology
Coibamide A discovered by Kerry McPhail
in Panama
Mandelalide A discovered by Kerry McPhail in South Africa
Coibamide A induces
autophagy "self eating"
in glioblastoma cells as a survival response
…but the cell still dies
Molecular CancerTherapeutics Siva Kolluri
Molecular Therapeutics
A new generation of
drugs designed to
interfere with a specific
molecular target
New Molecular Targets
For Breast Cancer
Our Focus:
II. Conversion of Bcl-2 from
a Protector to a Killer
Protein
I. Dioxin Receptor from a
mediator of toxic responses
to an Anti-Cancer Target
Novel inhibitors of the Receptor-tyrosine-kinase-like Orphan Receptor 2 (ROR2) enzyme for cancer treatment
GENERAL RESEARCH FUND AWARD
Rasmussen et al. JBC 2013
Artim et al. Biochem J 2012
Wright et al. Oncogene 2009
tissue
A375 skin
HCT116 colon
RCC4 kidney
U2OS-3 bone
Significance
Innovation
Interdisciplinarity
Successful data drive publications
and NHI grant submissions
- URISC UNDERGRAD AWARD
CADD
Andrey Morgun
Assistant Professor College of Pharmacy
(541) 737-8047
Usp
Drivers of cervical cancer
Host transcriptome microbiome
Trans-kingdom network
GERM FREE animals
• To identify the cell signals that regulate cell differentiation through gene activation.
• To understand how enzymatic modifications of transcription factors change gene activation in development and disease.
• To reveal new drug targets that regulate gene activation in disease.
Cell Signaling in Organ Development and Disease
Theresa Filtz, Ph.D.
Pharmaceutical Sciences, College of Pharmacy
323 Pharmacy; 541-737-5802; [email protected]
Pharmacy Practice Research
• What is pharmacy practice research? • Examines how and why people access pharmacy
services, the associated costs, and resulting patient outcomes
• My areas of interest include: • Impact of clinical pharmacy services on quality metrics
and patient outcomes
• Primary care
• Dynamics of federally qualified health centers (FQHC)
Adriane Irwin
Nano-therapy for cancer treatment • Drug solubilization • Controlled release • Drug targeting • Combinatorial drug therapy
– Ease of administration – Synergy/additive drug effects
• Imaging • Radiotherapy
Adam Alani
Multifunctional Nanomedicine Platforms for Cancer Treatment
Gene Therapy Hyperthermia Photodynamic Therapy Chemotherapy
Theranostic : Photodynamic Therapy and Image-Guided Drug Delivery
Phthalocyanine
No light
Light
Photodynamic Therapy
Image-Guided Drug Delivery
rsTu
mo
r
Oleh Taratula
Reduced Lymph Node invasion after targeted drug delivery
Vehicle Drug
Leung et. al, Journal of Clinical Investigation, 2004
“Skin” - Dr. Jekyll and Mr. Hyde
Dial @ 75775 [email protected]
TK inhibitor controls melanocyte survival
+vehicle +Ack2 +
Cause
Cause
Cure
Cure
Ctip2-/- Ctip2ep-/-
Ctip2-/-
Eczema : itch
Melanoma :beast
XN
Leid
and
Ind
ras
Alani and Indra
Stevens and Indra
Chambon and Indra
NIA
MS
(R
01)
NIE
HS
(R0
1)
eczema
Arup Indra