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Drug Discovery Drug Delivery Drug Target Analysis Chemistry + Biology + Genetics = Advancing Human Health College of Pharmacy Genome to Drug Discovery Group

Drug Discovery Drug Delivery Analysis · PowerPoint Presentation Author: Mark Leid Created Date: 2/26/2014 1:40:50 PM

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Drug

Discovery

Drug

Delivery

Drug

Target

Analysis

Chemistry + Biology + Genetics = Advancing Human Health

College of Pharmacy

Genome to Drug Discovery Group

College

of

Pharmacy

Genome To

Drug Discovery

The Bacterial Extracellular Proteome as Potential Therapeutic Target

m/z

Inte

nsi

ty

carB is important for cell growth in rich media

wt T2S mutant1.010 00

1.010 02

1.010 04

1.010 06

1.010 08

CF

Us

/mo

us

e

Aleksandra Sikora

What makes Chlamydia…Chlamydia?

Vacuole bacteria

Host nucleus

Chlamydia trachomatis-infected cells

Dan Rockey

Skin Wound Healing Head and neck cancer Healing of Chronic , diabetic, burn wounds is a major health concern

Cancer is a wound that does not heal

Diagnosis & Prevention 1. Patented Biomarker (Collaborator: A.Indra & M.Leid)

2.New anticancer drugs (Collaborator: T. Mahmud)

Identify gene targets

Validating targets Patient’s biopsies & cancer cell lines

Identify factors to mobilize stem cells

New Drug Targets

C U R E

C U R E

Gitali Ganguli-Indra [email protected]

Ide

ntify p

athw

ays

Collaborators : A.Indra & M.Leid)

Taifo Mahmud Laboratory http://people.oregonstate.edu/~mahmudt/

Drug Discovery and Development

Infectious diseases and cancers

Biosynthetic engineering

Natural product discovery

Department of Pharmaceutical Sciences

Chemical synthesis

Genome mining and metabolomics

OSU Natural Products as Probes to study

Autophagy and Cell Death in cancer cells

Jane Ishmael Pharmacology

Coibamide A discovered by Kerry McPhail

in Panama

Mandelalide A discovered by Kerry McPhail in South Africa

Coibamide A induces

autophagy "self eating"

in glioblastoma cells as a survival response

…but the cell still dies

Molecular CancerTherapeutics Siva Kolluri

Molecular Therapeutics

A new generation of

drugs designed to

interfere with a specific

molecular target

New Molecular Targets

For Breast Cancer

Our Focus:

II. Conversion of Bcl-2 from

a Protector to a Killer

Protein

I. Dioxin Receptor from a

mediator of toxic responses

to an Anti-Cancer Target

Novel inhibitors of the Receptor-tyrosine-kinase-like Orphan Receptor 2 (ROR2) enzyme for cancer treatment

GENERAL RESEARCH FUND AWARD

Rasmussen et al. JBC 2013

Artim et al. Biochem J 2012

Wright et al. Oncogene 2009

tissue

A375 skin

HCT116 colon

RCC4 kidney

U2OS-3 bone

Significance

Innovation

Interdisciplinarity

Successful data drive publications

and NHI grant submissions

- URISC UNDERGRAD AWARD

CADD

Andrey Morgun

Assistant Professor College of Pharmacy

(541) 737-8047

[email protected]

Usp

Drivers of cervical cancer

Host transcriptome microbiome

Trans-kingdom network

GERM FREE animals

• To identify the cell signals that regulate cell differentiation through gene activation.

• To understand how enzymatic modifications of transcription factors change gene activation in development and disease.

• To reveal new drug targets that regulate gene activation in disease.

Cell Signaling in Organ Development and Disease

Theresa Filtz, Ph.D.

Pharmaceutical Sciences, College of Pharmacy

323 Pharmacy; 541-737-5802; [email protected]

Pharmacy Practice Research

• What is pharmacy practice research? • Examines how and why people access pharmacy

services, the associated costs, and resulting patient outcomes

• My areas of interest include: • Impact of clinical pharmacy services on quality metrics

and patient outcomes

• Primary care

• Dynamics of federally qualified health centers (FQHC)

Adriane Irwin

Nano-therapy for cancer treatment • Drug solubilization • Controlled release • Drug targeting • Combinatorial drug therapy

– Ease of administration – Synergy/additive drug effects

• Imaging • Radiotherapy

Adam Alani

Multifunctional Nanomedicine Platforms for Cancer Treatment

Gene Therapy Hyperthermia Photodynamic Therapy Chemotherapy

Theranostic : Photodynamic Therapy and Image-Guided Drug Delivery

Phthalocyanine

No light

Light

Photodynamic Therapy

Image-Guided Drug Delivery

rsTu

mo

r

Oleh Taratula

Reduced Lymph Node invasion after targeted drug delivery

Vehicle Drug

Leung et. al, Journal of Clinical Investigation, 2004

“Skin” - Dr. Jekyll and Mr. Hyde

Dial @ 75775 [email protected]

TK inhibitor controls melanocyte survival

+vehicle +Ack2 +

Cause

Cause

Cure

Cure

Ctip2-/- Ctip2ep-/-

Ctip2-/-

Eczema : itch

Melanoma :beast

XN

Leid

and

Ind

ras

Alani and Indra

Stevens and Indra

Chambon and Indra

NIA

MS

(R

01)

NIE

HS

(R0

1)

eczema

Arup Indra

College

of

Pharmacy

Genome To

Drug Discovery