employment ^W O P P D R T I I M I T I F Q FOR 9007

C&EN

OPPORTUNITIES FOR 2007 AND BEYOND

DRUG DISCOVERY AND DEVELOPMENT

To succeed in the PHARMACEUTICAL INDUSTRY, chemists must have special skills and work across disciplines

BETTE HILEMAN, C&EN WASHINGTON

FULFILLING CAREERS are available for chemists in the pharmaceutical industry. But to be successful, candidates must have very special skills, aptitudes, and personal qualifications.

In general, chemists are much more likely to be hired and to pursue a satisfying career if they have at least some training in biology and computational chemistry,

as well as in synthetic organic chemistry and other traditional fields. Nearly all work in drug firms involves multidisciplinary groups, so chemists must enjoy functioning in a team setting.

C&EN contacted pharmaceutical industry recruiters, current and former executives of drug companies who have been deeply involved in research, and scholars

who study the industry. They describe promising, unexplored areas where chemists can contribute to the discovery of new drugs. They also note problems in today's R&D environment that may short-circuit research before it has a chance to come to fruition.

Some observers also call attention to interesting new opportunities to develop

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EMPLOYMENT

drugs outside profit-making firms. Over the past few years, nonprofit drug companies and groups have started to fund research on medicines to cure the most deadly neglect-ed diseases in developing countries.

CHEMISTRY is central to modern drug dis-covery and development. For most of the 20th century, the majority of drugs were found either by identifying the active in-gredient in traditional remedies or by ser-endipity. The newer approach devised over the past two decades is to try to understand how disease is controlled in the body at the molecular level and find specific com-pounds that block progress of an illness or stop it in its tracks.

"In the early phase of drug discovery, we try to identify a target where a biomolecule is causing disease, and then we try to invent an approach to prevent it from causing disease," says Magid Abou-Gharbia, senior vice president for chemical and screen-ing sciences at Wyeth Research. "First, biochemists work hand-in-hand with biologists to identify the target," which is usually a protein, he says. Then, biochem-ists and biologists turn those targets into assays or screens, he explains. Chemical engineers and analytical chemists, along with biochemists, next take those lab-scale screens and convert them into automated screens for high-throughput selection of potential drug compounds, he says.

During high-throughput screening, many compounds chosen from a large collection or library of chemicals owned by the drug firm are tested for their ability to inhibit or stimulate the target, Abou-Gharbia says. Medicinal and computational chemists select the compounds from the large library, which often consists of 100,000 to 1 million chemicals, he says.

"After you have identified the molecules that work on the target, analytical chemists make sure these are the right molecules that they have not been degraded from sit-ting in the library for 20 or 30 years," Abou-Gharbia says. But even if a compound has decomposed to some extent, analytical chemists maybe able to determine what part of it is still active, he says.

In the second phase of discovery, medic-

inal chemists turn the early leadscalled "hits"identified through high-through-put screening into optimized leads, Abou-Gharbia notes. Initial screening is unlikely to identify an ideal drug candidate. Generally, it turns up several compounds that have some degree of activity against the target. So medicinal chemists use structure-activity relationships to improve the candidates by increasing their activity against the target and reducing their activ-ity against nontargets.

The improved compounds are then test-ed with in vitro assays and in lab animals to determine if they are active against the dis-ease. A compound that passes these assays then goes on to clinical testing.

During animal testing and later clinical trials in humans, analytical chemists play an important role, Abou-Gharbia says. "We try to understand the effects of the compound on the body as well as the effects of the body on the compoundthe changes the chemi-cal undergoes inside the body, which we call the pharmacokinetics." This involves mea-suring absorption, distribution, metabo-lism, and excretion of the candidate drug.

"When you want to do toxicology stud-ies and clinical trials, process chemists are needed," he says. "They use synthetic chemistry and chemical engineering skills to produce 100-g to kilogram quantities of the candidate drug." If the compound is successful in clinical trials and is approved by the Food & Drug Administration, chemi-cal engineers design a pilot plant for even larger production.

Abou-Gharbia has advice for chemistry students who aim for careers in the drug industry: "Choose a discipline based on your interest in analytical or synthetic or-ganic chemistry and try to get an internship with a pharmaceutical firm to expand your horizons. Internships at pharmaceutical firms help students acquire skills during their undergraduate years. The drug dis-covery centers at some institutions, such as Northeastern University in Boston and Rensselaer Polytechnic Institute, can also provide valuable experience."

Wyeth's drug discovery division employs chemists at all degree levels, but it has a high concentration of Ph.D.s, says Martin C.

Coyle, human resources director for the di-vision. "We are typically looking for people whose Ph.D. research has relevance to drug discovery or development," he says. To be hired at Wyeth, Coyle says, a chemist must have a "deep passion for science and in-novation" and be willing to work on teams with scientists from other disciplines. In addition, the employee must set productiv-ity goals and strive to meet them.

There is an active postdoc program across the whole discovery organization, Coyle says. "At any one time, about 40 postdocs, including about a dozen chem-ists, are employed there." Each year, Wy-eth's drug discovery division hosts about 12 interns who assist with chemical research.

At AstraZeneca, Boston, chemists work primarily in three different areas, says Jeffrey H. Hanke, vice president of cancer research. One is medicinal chemistry. "Chemists who have specialized in organic synthetic chemistry or have industry ex-perience in synthetic medicinal chemistry may work on one or two specific drug dis-covery projects at any one time," he says. Over the course of a few years, they tend to work on many different projects involv-ing a variety of chemical series. Chemists "have the job basically of taking early drug leads from high-throughput screening or deduced from other information and op-timizing these early leads against quite a broad range of parameters, including drug metabolism," he explains.

"WE ALSO HIRE computational chem-ists," who focus on computational model-ing of structures, Hanke says. Using com-puter modeling, they dock some of the drug leads onto the protein structure of a target and help the synthetic medicinal chemists optimize the early drug leads, he explains.

Hanke describes one example of opti-mization. "If we are working on epidermal growth-factor receptor, the computational chemist has an X-ray crystal structure of that protein in the computer," he says. Within that structure, which looks like a moonscape, are pockets or holes or clefts. A small-molecule drug candidate is bound to this receptor and crystallized. In the crystal structure visualized on the computer, the computational chemist may then see a pock-et right next to where the small molecule is bound. He or she can then advise the me-dicinal chemist on a way to add something to that small molecule that will get into the pocket and increase its activity. "Compu-tational chemists tend to be Ph.D.-trained

What is generally needed to invent truly innovative drugs is patience and

intense efforts over many years. WWW.CEN-0NLINE.ORG Q X NOVEMBER 20, 2006

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chemists who also have a background in computational structure," he says.

"Analytical chemists are a third specialty we hire," Hanke says. They help determine the structures and properties of compounds and assist with their purification. Astra-Zeneca employs analytical chemists with bachelor's, master's, and Ph.D. degrees. One of the most important qualifications for researchers at the company is the ability to work on teams, he says.

Roche Palo Alto is trying to develop drugs, particularly biologies, for a large variety of health problems, says Hans Maag, vice president of chemistry at the firm. These include viral diseases, such as HIV and hepatitis G; inflammatory and im-mune system diseases, such as rheumatoid arthritis; and neurological problems, such as depression and peripheral nervous sys-tem diseases. "At the start of their careers, chemists should recognize that they will encounter many types of diseases and mo-lecular agents over time," Maag says. In the future, drug targets are likely to become more complex, he explains.

Most of the small molecules that have al-ready been investigated in pharmaceutical research either stimulate or inhibit the tar-gets they interact with, Maag explains. But in coming years, he says, chemists will be studying more challenging target classes, such as receptors that are modulated by small-molecule drugs, rather than being di-rectly stimulated or inhibited. To succeed in this research, organic chemists will need to interact closely with computational chemists and protein crystallographers, he says. "To be best prepared for research at Roche Palo Alto, a strong foundation in synthetic organic chemistry is essential," Maag says.

According to Steve Bertram, director of human resources for Amgen's research division, R&D there focuses on serious ill-ness. Rather than limiting itself to only one type of therapeutic agent, such as small or large molecules, it develops agents that best fit the target. After testing a potential drug for efficacy in lab animals and healthy human volunteers, Amgen also conducts clinical trials in patients.

"Amgen believes it has to have the full armamentarium of therapeutic choices to interact with biological systems," Bertram says. "If it limited itself to one modality whether that be small or large molecules it would limit its potential to cure disease. Amgen scientists choose the best therapeu-tic agent to block a specific disease process.

It is studying the use of proteins, monoclo-nal antibodies, and small molecules."

Currently, Amgen's chemistry organiza-tion employs about 600 people, including medicinal, process, and analytical chem-ists, as well as chemical engineers, Bertram says. To be hired there, candidates must be outstanding in several respects, he ob-serves. "In addition to core chemistry and science curriculum courses, we look for

a blend of studies in strategic and project planning, general courses in biotechnology, management and leadership courses, and courses requiring team projects," he ex-plains. Also, "the quality of the candidate's research and postdoc experience is very important to our selection process."

Today, chemists will probably find more employment opportunities in the biotech sector than in traditional large pharmaceu-tical companies, says Paul S. Anderson, a former ACS president who held executive research positions at drug firms for four de-cades. "My sense is that hiring at big pharma is relatively flat. When people retire, they are replaced, but the industry is not in an expansion mode," he notes. "Although there is a little more activity in the biotech sector, it is not hiring as aggressively as it was a few years ago. Because chemists must compete very hard for a limited number of positions in the drug industry, how well they perform in their graduate work and what their refer-ences say are very important."

DRUG COMPANIES have mixed views about whether chemists should have formal training in medicinal chemistry before they seek employment, Anderson

says. "The most common philosophy is to try to hire people who have very strong training in organic chemistry and then let them learn medicinal chemistry after they join the company," he says. But other firms prefer that chemists study medicinal chemistry as part of their formal university training, he explains.

Experts described some of the biggest challenges in pharmaceutical research to-day. Gaining a more complete understand-ing of pharmacokinetics is an important issue, says Daniel F. Veber, a drug industry consultant who directed medicinal chem-istry at GlaxoSmithKline for many years. "How the body clears and handles drugs is a very complicated system that we don't understand," he says.

The greatest successes are going to be from people who learn something about how to transform a potent compound to one that has good pharmacokinetics, Veber explains. "That is a very multidisciplinary issue. We need to understand what it is in the body that causes drug clearance, what's involved in drug distribution, and the na-ture of the molecules that control those factors. Some researchers think that if you've got a potent compound, you've got a drug, and that's not true at all," he says. 'When you tell them they have to make the drug long-lasting, they ask, 'What do I have to do, to do that?' That's where the big gap in information is."

In terms of constraining the price of therapeutic drugs, "there is a huge oppor-tunity for chemists and medicinal chemists who can take large molecules identified through biological screening and turn them into small-molecule drugs," says Arthur Daemmrich, director of the Center for Contemporary History & Policy at the Chemical Heritage Foundation.

Complex large molecules such as inter-leukins and interferons that are now used as drugs are extremely expensive. Their production, shipment, and administration to patients are very complex processes. They have short storage lives and often must be given through intravenous infu-sion. Some biologies sell for $50,000 per month for therapies that might extend life by far less than year, Daemmrich says.

"But if chemists could find a way to engineer small-molecule chemicals that bind to the same receptors and bring about the same sequence of biological events induced by complex, large-mol-ecule drugs, that could be a huge contribu-tion," Daemmrich says.

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EMPLOYMENT

New thinking and approaches are also needed on the regulatory side of drug development, Daemmrich says. He says FDA officials have told him they need chemists who have more of an interdisciplinary background than most. For example, reviewing drug-eluting stentsimplants that release medicines into the bodyrequires expertise from broadly trained chemists. Reviewers must be able to evaluate the drugs delivered by the stents, as well as the stents' performance as materials and as devices.

INTERESTING NEW opportunities are also emerging for chemists to do research outside of profit-driven firms, yet still be involved in drug development, Daemmrich says. Some chemists are now working on research projects supported by the Institute for OneWorld Health and the Drugs for Neglected Diseases initiative (DNDi), for example.

The Institute for OneWorld Health, a nonprofit pharmaceutical company in San Francisco, is working to find potential new medicines for diseases disproportionately

affecting developing countries. It has already identified a new cure for visceral leishmaniasis, the second most deadly parasitic disease in the world after malaria. The medicine has been approved by the Indian government and is being manufactured in India.

On Nov. , the institute was awarded a $46 million grant by the Bill & Melinda Gates Foundation to develop new treatments for pediatric diarrhea, the leading cause of death in children under the age of five worldwide.

DNDi was established in 2003 by seven organizations around the world, including a United Nations/World Bank special program on tropical diseases. So far, it has begun 20 projects aimed at inventing medicines for diseases that are common in the developing world. Ten of the medicines DNDi is working on are in the discovery phase, four are in preclinical development, and six are in the clinical phase. "For the right chemist who is really passionate about curing malaria and other neglected diseases, working for organizations like OneWorld Health could

probably be exciting," Daemmrich says. But Veber warns that these nonprofit

initiatives are placing too much emphasis on the cost of potential drugs and on "trying to apply known drugs to Third World diseases." A more productive tactic would be to think about the best way to approach a disease and later worry about cost, he says. "The problem is even people who are very altruistic aren't very excited about going back to the basics to try to figure out how to cure diseases that are common in the developing world. They want to achieve a quick outcome," Veber says.

What led to good drugs in the past, Veber explains, was researchers "beating away over a long period of time and finally coming to understand what it would take to contribute to a disease." Although HIV protease inhibitors were developed over a relatively short period, he explains, they in fact resulted from "an incredible effort within the pharmaceutical industry to reach a conclusion." What is generally needed to invent truly innovative drugs is patience and intense efforts over many years, he says.

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Advertising Rate Information CLASSIFICATIONS Positions open and academic positions. Situations wantedmembers, nonmembers, student and national affiliates, retired members.

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ACS MEMBER RATES "Situations Wanted" advertisements will be classified by the chemical field designated by the members. If not designated, placement will be determined by the first word of the text submitted.

EMPLOYED MEMBERS "Situations Wanted" advertisements placed by employed ACS members and affiliates are accepted at $6.60 a line per insertion, no minimum charge. State ACS membership status and email to m_mccloskey@acs.org.

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POSITIONS OPEN

BIOCHEMIST Amgen has an opportuni ty for a Scientist to perform protein purification, protein characterization and crystallization target proteins, including co-crystallization with ligands. Reqs. include PhD; l y r . related exp.; and exp. with crystallographic software including Denzo/ Scalepack, HKL2000, Mosflm, CCP4, CNX, 0, COOT, Pymol; and synchroton X-ray data collection. Job site: S. San Francisco, CA. Applicants send resume and reference #6K4SJ7 to: Kyle Foster, Amgen, Inc., One Amgen Center Drive, Mai lstop 19-1-A, Thousand Oaks, CA 91320. No phone calls or e-mails please. Must be legally authorized to work in the U.S. without sponsorship. EOE.

CHEMICAL ENGINEER Amgen has an opportunity for an Engineer I to perform optimization, characterization and troubleshooting of formulation, filling and finishing processes for protein parenteral products. Reqs. include related Master's; 2 yrs related exp.; and exp. wi th thermodynamics ; fluid mechanics; mass transfer; unit operations; and exp. with peptides/proteins. Job site: Thousand Oaks, CA. Send resume referencing #5V72WL to: Kyle Foster, Amgen, Inc., One Amgen Center Drive, Mailstop 19-1-A, Thousand Oaks, CA 91320. No phone calls or e-mails please. Must be legally authorized to work in the U.S. without sponsorship. EOE.

BIOTECHNOLOGY Amgen has an opportuni ty for a Senior Associate to identify and validate novel drug targets through over-expression and functional knockdown studies. Reqs. include related Bachelor's; 4 yrs related exp.; and exp. in the development of biochemical and cell-based assays; VectorNTI; GraphPad Prism; molecular biology skills including PCR, clong, DNAand RNA isolation, gel electrophoresis, site-directed muagenesis, and bacterial transformations; and exp. in cell biology including mammalian cell culture, protein isolation, chromatography, western blott ing, silver staining, immunopre-cipi tat ions, t ransient and stable t ransfect ions, microscopy and immunohistochemical staining. Job site: Thousand Oaks, CA. Applicants send resume and reference #6EF276 to: Kyle Foster, Amgen, Inc., One Amgen Center Drive, Mailstop 19-1-A, Thousand Oaks, CA 91320. No phone calls or e-mails please. Must be legally authorized to work in the U.S. without sponsorship. EOE.

CHEMICAL ENGINEER Amgen has an oppor tun i ty for an Engineer to be responsible for day-to-day manu fac tu r ing suppor t , inc lud ing process pe r f o rmance mon i t o r i ng , implementation of process improvement strategies, development of process models, and technology transfer. Reqs. include related Master's; 2 yrs. related exp.; and exp. in a cGMP biopharmaceutical, pharmaceutical or medical devise manufactur ing environment; exp. with mammal ian cell cul ture for recombinant protein production; commercial scale bioreactor; process modeling; process simulation; automation systems; and exp. troubleshooting, reliability and uptime enhancements, design and implementat ion, validation and change control methodology. Job site: West Greenwhich, Rl. Appl icants send resume and reference #6LLUHL to: Kyle Foster, Amgen, Inc., One Amgen Center Drive, Mailstop 19-1-A, Thousand Oaks, CA 91320. No phone calls or e-mails please. Must be legally authorized to work in the U.S. without sponsorship. EOE.

SENIOR CHEMIST Serina Therapeutics, Inc. (Huntsvi l le, Alabama) is a new company formed by the founders of Shearwater Polymers. We are lookingfor a Ph.D. Organic/Polymer Chemist with min. 2 years of post-doctoral or industrial experience. Working knowledge of HPLC, MALDI, NMR and PC software is desired. Must have excellent oral and wri t ten communicat ion skills and the ability to participate in a small team environment. Send resume, cover letter and salary history to HR c/o tavie-gas@bellsouth.net.

TAKATA CORPORATION, a $4 bil l ion annual company and leader in automotive safety seeks a Chemist or Chemical Engineer. This posit ion is located in our Research and Development center in a Northern Metro Detroit suburb. Individuals will be working with airbag propellant and inflators. Candidates will have advanced degrees or exper ience in pyrotechnics, combust ion, solid propellant or related field to develop energetics for our products. Send resumes to jeff. douma@takata.com.

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W. R. Grace is a leading global supplier of catalysts and other products and services to petroleum refiners; catalysts for the manufacture of plastics; silica-based engineered and specialty materials for a wide-range of industrial applications; specialty chemicals, additives and materials for commercial and residential construction; and can sealants and coatings for food packaging. With annual sales of more than $2.5 billion, Grace has employees in nearly 40 countries. More

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salary and benefits, we also offer equity participation and participation &^ stock purchase program. No agencies, please. ;Sa%?-

Apply online at: www.vrtx.com. EOE ' 'vt^mi

We Enjoy Big Lead in Small Molecules,

Computational Drug Design Opportunities at D. E. Shaw Research

Extraordinarily gifted scientists with expertise in protein structural modeling or computer-aided drug design are sought to join a rapidly growing New York-based research group that is pursuing an ambitious, long-term strategy aimed at fundamentally transforming the process of drug discovery.

Candidates should have world-class credentials in computational chemistry or biology and substantial experience in commercial structure-based drug design. Relevant areas of experience might include the computation of protein-ligand binding affinities, the study of biologically important systems using molecular dynamics simulation, and the development and/or application of bioinformatics-based tools for studying protein structure-function relationshipsbut specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Successful hires will extend practical experience and perspective in structure-based drug design to the group's initiatives in this area, while potentially also contributing to other research areas that include molecular dynamics simulation of functionally significant globular and membrane proteins, the prediction of protein structures and binding free energies, and the development of algorithms for biomolecular simulations.

This research effort is being financed by the D. E. Shaw group, a global investment and technology development firm with approximately US $25 billion in aggregate investment capital. The project was initiated by the firm's founder, Dr. David E. Shaw, and operates under his direct scientific leadership.

We are eager to add both senior- and junior-level members to our world-class team, and are prepared to offer above-market compensation to candidates of truly exceptional ability. Please send your CV (including list of publications) to cenews-mdl@career.deshawresearch.com.

D. E. Shaw Research, LLC does not discriminate in employment matters on the basis of race, color, religion, gender, national origin, age, military service eligibility, veteran status, sexual orientation, marital status, disability, or any other protected class.

DEShaw&Co

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CHEMISTRY F A C U L T Y POSITION, D R U G DISCOVERY PROGRAM The College of Medicine and the H. Lee Mofffit Cancer Center & Research Institute, a comprehensive NCI designated center at the University of South Florida, is seeking applications from Assistant, Associate and Full Professor level individuals to participate in the Department of Interdisciplinary Oncology and the Drug Discovery Program. Structure-based drug design and focused combinatorial chemistry library approaches will be strongly supported by the current and developing research infrastructure. The Moffitt Cancer Center has several core lab facilities and services available such as: NMR, structural biology, molecular modeling, high throughput screening, proteomics and microarray shared facilities.

Synthetic organic chemists looking for strong biological collaborators with outstanding core facilities or industrial synthetic organic chemists looking for a wide open research agenda are encouraged to apply. Successful candidates must possess a PhD in synthetic organic chemistry or related areas with preferred experience in molecular recognition and/or bioorganic/synthetic/medicinal chemistry.

Candidates for the rank of Assistant Professor must have at least two years postdoctoral experience. Candidates for the rank of Associate Professor must have a proven track record of independent federal funding and research and at least five years experience at the Assistant Professor level. Candidates for Full Professor must have a proven track record of independent research and a national/international reputation in their field and at least five years experience at the Associate Professor level. Academic rank and salary will be commensurate with experience and qualifications. These tenure track positions will be assigned to the Department of Interdisciplinary Oncology within the College of Medicine.

Please reference position no. 11911. Send curriculum vitae, statement of research interests, and the names and addresses of three or more references to Professor Said Sebti, Drug Discovery Program, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, MRC-DRDIS, Tampa, Florida 33612. Electronic CVs preferred to sebti@moffitt.usf.edu. The selection committee will begin reviewing applications December 1,2006 and will continue until suitable candidates are hired.

USF Health is committed to increasing its diversity and will give individual consideration to qualified applicants for this position with experience in ethnically diverse settings, who possess varied language skills, or who have a record of research that supports/benefits diverse communities or teaching a diverse student population.

A National Cancer Institute Comprehensive Cancer Center At fie University of South Florida

\ U$F For disability accommopaions,

(813) 745-1451 a minimiimk five According to FL law, applications

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ASSISTANT/ASSOCIATE/ F U L L PROFESSORS CHEMISTRY, STRUCTURAL BIOLOGY & PROTEOMICS The College of Medicine and the H. Lee Moffitt Cancer Center & Research Institute, a comprehensive NCI designated cancer center at the University of South Florida, is seeking applications from Assistant, Associate and Full Professor - level individuals to participate in the Department of Interdisciplinary Oncology and the Drug Discovery Program. The Drug Discovery Program (httpy/vmw.moffittusf.edu/research/molecular/dmg is expanding Synthetic Organic Chemistry, Structural Biology and Proteomics components to synergistically grow with its outstanding Cancer Biology/Signal Transduction/Gene Regulation components. Structure-based drug design and focused combinatorial chemistry library approaches will be strongly supported by the current and developing research infrastructure. The Moffitt Cancer Center has several core lab facilities and services available such as: NMR, structural biology, molecular modeling, high throughput screening, proteomics and microarray shared facilities.

Chemistry, position #11911: Synthetic organic chemists looking for strong biological collaborators with outstanding core facilities or industrial synthetic organic chemists looking for a wide open research agenda are encouraged to apply. Successful candidates must possess a PhD in synthetic organic chemistry or related areas with preferred experience in molecular recognition and/or bioorganic/synthetic/medicinal chemistry.

Structural biology, position #14600: Applicants must possess a PhD in Structural Biology or related area and have a demonstrated track record in X-ray crystallography and the elucidation of stractiire-function relationships. Areas of research focus could include protein structure-function relationships, protein/drug interactions and protein/protein interactions. Experience in the areas of growth factor signal transduction, proteins involved in oncogenesis or tumor suppression, and cell cycle regulation preferred. Applicants should have a strong desire to interact with scientists engaged in drug discovery and design, including synthetic organic chemists and computational chemists.

Proteomics. position #13301: Successful candidates must possess a PhD degree and a demonstrated expertise in Proteomics in the cancer area with a minimum of five years experience in this area We are looking for individuals with proven experience in utilizing or developing proteomics techniques. The individual will be expected to develop independent, fiindable research projects and collaborate with other investigators at Moffitt

Candidates for the rank of Assistant Professor must have at least two years postdoctoral experience. Candidates for the rank of Associate Professor must have a proven track record of independent federal funding and research and at least five years experience at the Assistant Professor level. Candidates for Full Professor must have a proven track record of independent research and a national/international reputation in their field and at least five years experience at the Associate Professor level. The Moffitt Cancer Center and Research Institute, a National Cancer Institute-designated comprehensive cancer center, and USF offer an outstanding salary, benefits and relocation package. Academic rank and salary will be commensurate with experience and qualifications. These tenure track positions will be assigned to the Department of Interdisciplinary Oncology within the College of Medicine.

Please send curriculum vitae, statement of research interests, and the names and addresses of three or more references to Professor Said Sebti, Drug Discovery Program, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, MRC-DRDIS, Tampa, Florida 33612. Electronic CVs preferred to sebti@moffittusf.edu. The selection committee will begin reviewing applications December 1,2006 and will continue until a suitable candidate is hired. Important: Please state on your cover letter which of the 3 positions you are applying for by indicating the actual position number.

FITTiH r Center &Research Institute

The End Of Cancer Begins Here.

A National Cancer Institute Comprehensive Cancer Center At lie University of South Florida

USF

www.moffitt.usfiedu &cdu

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Merck Et Co. Inc., established in 1891, is a global research-driven pharmaceutical company dedicated to putting patients first. Join us and experience our culture first-hand-one of strong ethics St integrity, diversified experiences and a resounding passion for improving human health. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Sr. Research Chemist This position will support Merck's drug discovery and preclinical development effort in the Department of Drug Metabolism at West Point, PA. Specific duties will include: design, execution and interpretation of Pharmacokinetic/Absorption-Distribution-Metabolism-Excretion (PK/ADME) studies, to gain better understanding of the mechanism of disposition of a drug candidate. Other responsibilities include representing the Department in a cross-functional project team, and preparation of documentation for regulatory submissions. The successful candidate should possess strong bioanalytical (LC-MS/MS) skills, either qualitative or quantitative, or both, and knowledge in one or more of the following areas: pharmacokinetics, in vitro techniques, in vivo metabolism and ADME. Experience in drug discovery and development is highly desirable. To be considered for this position, please visit our career site at www.merck.com/careers to create a profile and submit your resume for requisition # CHE001017.

Chemometrician We currently have an exciting opportunity for a Chemometrician to join our Analytical Sciences Et Quality Testing Department located at our West Point, PA site. Employee will be responsible for the development and implementation of statistical models for PAT methods supporting the development and manufacture of products within Merck. Will work closely with various teams and departments across the company to assist with novel in-line, on-line, and at-line measurement of critical process parameters in the drug product, vaccines/biologies, and bulk chemical areas. A particular focus of the position will be the development and implementation of multivariate process models and controls using a variety of raw material, process and testing data. The ideal candidate has a strong background in chemometrics (multivariate data analysis) for both analyzer calibration, as well as process data analysis and process control. A current knowledge of state-of-the-art applications in these areas are highly desired. A proven record of accomplishment, as well as strong academic achievements, communication skills, and recommendations are also desired. U.S. work eligibility and M.S. in relevant field (Chemistry, Mathematics or Engineering) with 7-10 years of experience are required. Ph.D in relevant field (Chemistry, Mathematics or Engineering) with 0-7 years of experience desired. To be considered for this position, please visit our career site at www.merck.com/careers to create a profile and submit your resume for requisition # CHE001020.

Our work is someone's hope. Join us.

MERCK Where patients come first.

www.merck.com/careers Merck is an equal opportunity

employer-proudly embracing diversity in all of its manifestations. 2005

Merck ft Co., Inc. All rights reserved.

CHEMIST Amgen has an oppor tun i ty for a Scientist to design and synthesize new chemical entities for test ing and considerat ion as new pharmaceutical agents. Reqs. include related PhD; and exp. in planning & executing multi-step organic reaction schemes resulting in complex target synthesis; and publications in top-peer reviewed chemistry journals. Job site: S. San Francisco, CA. Send resume referencing #69W2UL to: Kyle Foster, Amgen, Inc., One Amgen Center Drive, Mailstop 19-1-A, Thousand Oaks, CA 91320. No phone calls or e-mails please. Must be legally authorized to work in the U.S. without sponsorship. EOE.

THEOFFICEOFSCIENCE, DEPARTMENT OF ENERGY is seeking a motivated and highly qualified individual to serve as the Associate Director, Office of Biological and Environmental Research. As such, you will provide leadership and direction in establishing vision, strategic plans, goals, and objectives for the research activities supported. You may apply through two different methods - one is for a Senior Executive Service appointment and the second is for an Intergovernmental Personnel Act appointment. The announcement number is SES-SC-HQ-005. The announcement opens on November 6 and closes on December 21. Visit h t t p : / / www.usajobs.opm.gov/ for more information and for instructions concerning application procedures.

When responding to a position please mention you saw the ad in

CHEMICAL & ENGINEERING NEWS

ACADEMIC POSITIONS TENURE TRACK FACULTY POSITIONS. The Chem istry Department at East Tennessee State University (www.e tsu .edu /chemis ts / ) invites applications for tenure-track positions; one in Analyt ical Chemistry, with a preference in electrochemistry or separations, and one in Chemist ry Educat ion, each at the Assistant Professor level to start August, 2007. Candidates must have finished requirements for the Ph.D. in their fields by hire date, and post-doctoral experience is desirable. A commi tment to excellence and innovation in teaching and a high potential for seeking external fundingfor research at the undergraduate and MS levels are expected. The position in chemical education will also be active in our newly established Center of Excellence in Mathemat ics and Science Education, which will develop outreach and support for K-12. Review of applications will begin December 15,2006. Applicants should send vita, official transcripts, three letters of recommendat ion and statements of teaching and research goals to: Chair, Chemistry Department, Box 70695, East Tennessee State University, Johnson City, Tennessee 37614-1710. Position contingent on funding. AA/EOE

TWO YEAR POSTDOCTORAL POSITIONS available Jan. 1, 2007: (1) Development of protein and DNA mi-croarrays. Must be trained in surface modif ication of glass and gold, surface initiated polymerization, SPR, ell ipsometry XPS, and bioconjugation. Knowledge of thermodynamic and kinetic modeling of binding data a plus. (2) Surface initiated polymerization of novel polymer architectures: monomer synthesis (essential), desirable skills include surface modification, NMR, SPR, and XPS. Send cover letter (specify position applying for), CV and contact information of 3 references as single PDF attachment to: chilkoti@duke.edu. Duke University is an EO/AA employer.

ACADEMIC POSITIONS DEPARTMENT OF CHEMISTRY & BIOCHEMISTRY

SETON HALL UNIVERSITY Seton Hall University, one of the largest Diocesan Universities in the country, seeks a tenure track faculty member in Biochemistry for the Department of Chemistry and Biochemistry beginning in the Fall semester of 2007. Successful applicants will be expected to conduct research at the doctoral and undergraduate level, seek external funding and have a strong commitment to teaching graduate and undergraduate courses. The position is for a biochemist specializing in nucleic acid biochemistry, biophysics and/or related molecular science. Applicants whose research complements the current faculty interests and who demonstrate interest in collaborating with the significant local chemical and pharmaceutical industries will be given preference. For more information aboutthe Department and faculty research interests, please visit h t t p : / / a r t s c i . shu.edu/chemis t ry / . Applicants should submit curriculum vitae, research plans and three letters of recommendat ion to: Chair, Faculty Search Commit tee, Department of Chemistry and Biochemistry, Seton Hall Universi ty, 4 0 0 South Orange Avenue, South Orange, NJ 07079-2694. Applications sent via email should be addressed to: chemistry@shu.edu and the subject line should read: Biochemistry Position - SHU. Review of applications will begin on December 11. Seton Hall, the Catholic University of New Jersey, founded in i8$6, is an Equal Opportunity/Affirmative Action Employer. Applicants must possess an understanding of and will ingness to support the Seton Hall University Catholic mission.

UNIVERSITY OF MARYLAND The Department Of Chemistry And Biochemistry at the University of Maryland, College Park invites applications for a ful l-t ime Lecturer in our Chemistry and Biochemistry Programs. The Programs are responsible for the chemical and biochemical education of students in chemistry, biological sciences and engineering. Annual enrollments are more than 3000 students. Successful candidates must be outstanding teachers who have a strong commitment to undergraduate science education. Duties include teaching undergraduate lecture courses, managing laboratory courses, and advising undergraduate students. Participation in course development and other efforts aimed toward improving undergraduate education is also expected. A Ph.D. Degree in Chemistry, Biochemistry or related disciplines is required. Start Summer or Fall 2007. This is a renewable 12-month, non-tenured position with a history of continuity. Applicants should submit a cover letter, curriculum vitae, teaching philosophy, and contact information for three persons f rom whom letters of recommendation can be requested. Electronic submission of application through department's webpage is required: ( h t t p : / / w w w . c h e m . u m d . e d u / e m p l o y -ment /6 .h tml ) . Review of applications will begin about January 15 and will continue until the position is fil led. Information about the University of Maryland can be found at www.umd.edu and the department at www. chem.umd.edu. The University of Maryland is an Affirmative Action/Equal Opportunity Employer. Women and members of minority groups are encouraged to apply.

INSTRUCTOR POSITIONS ORGANIC CHEMISTRY AND GENERAL CHEMISTRY The Department of Chemistry at Bowling Green State University invites appl icat ions for two (2) fu l l - t ime non-tenure track Instructor positions start ing August 2007. The Organic Instructor (3 year term) will teach in the organic chemistry area with duties including the supervision of the organic laboratories, experiment development, and direct ion of teaching assistants. The General Chemistry Instructor (2 year term) will be involved inteachingcourses ingeneral, physical, a n d / or analytical chemistry. Both positionscan be renewed for additional terms and additional activities such as the development of lecture and on-line courses, a n d / or new chemical pedagogy would be encouraged and supported. Both positions require a Ph.D. in chemistry and college teaching experience is desired. A curriculum vita, statement of teaching philosophy, academic t ranscr ipts and three letters of recommendat ion should be sent to: Instructor Search, Department of Chemistry, Bowling Green State University, Bowling Green, OH 43403 . The review of applications will start December 15, 2 0 0 6 and continue until the positions are filled. BGSUis an Affirmative Action/'Equal Employment employer and encourages applicationsfrom women, minorities, veterans and individuals with disabilities.

WWW.CEN-0NLINE.ORG 1 6 NOVEMBER 20, 2006

http://www.merck.com/careershttp://www.merck.com/careershttp://www.merck.com/careershttp://http://www.usajobs.opm.gov/http://www.etsu.edu/chemists/mailto:chilkoti@duke.eduhttp://artscihttp://shu.edu/chemistry/mailto:chemistry@shu.eduhttp://www.chem.umd.edu/employ-http://www.umd.eduhttp://chem.umd.eduhttp://WWW.CEN-0NLINE.ORG

ACADEMIC POSITIONS

@PC^ Why not '-M change the world?

FACULTY OPENINGS Department of Chemical and Biological Engineering

Rensselaer Polytechnic Institute (RPI) invites applications for faculty appointments at the assistant, associate and professor levels in the Howard P. Isermann Department of Chemical and Biological Engineering. These faculty members will join the Department at a time of unprecedented growth, with eight new faculty hired over the past eight years. Current research strengths include molecular engineering, biochemical engineering, bioseparations, materials processing, interfacial phenomena, nanotechnology, polymers, microelectronics processing and process systems engineering. New faculty will have the opportunity to conduct multidisciplinary research associated with a large number of centers on campus, including Future Energy Systems, Biotechnology and Interdisciplinary Studies, Nanotechnology, and Polymer Synthesis, among many others. Qualified individuals should send a complete CV, research/teaching plans, and the names of three references to: Chair, Faculty Search Committee, Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th St., Troy, NY 12180-3590. Email: CHBE-L@lists.rpi.edu.

Rensselaer We welcome candidates who will bring diverse intellectual, geographical, gender and

ethnic perspectives to Rensselaer's work and campus communities. Rensselaer Polytechnic Institute is an Affirmative Action/Equal Opportunity Employer.

STMAPyS UNIVERSITY

Fostering Academic Excellence And Spiritual Growth

ASSISTANT PROFESSOR IN ANALYTICAL CHEMISTRY

beginning August 2007

St. Mary's University seeks applications for a tenure-track Assistant Professor in Analytical Chemistry, beginning August 2007. Required: Ph.D. and a strong commitment to undergraduate teaching. Teach analytical chemistry and instrumental analysis, and laboratories, and other areas as needed. Participation in undergraduate research is encouraged.

St. Mary's University is a Catholic Marianist Liberal Arts University. Send CV, statement of teaching philosophy, transcripts, and three letters of reference to:

Dr. Kenneth Pohlmann, Chair Department of Chemistry/Biochemistry

St. Mary's University One Camino Santa Maria San Antonio, TX 78228

Application deadline is 12/31/06. St. Mary's University is an equal opportunity/affirmative action employer, and women and minorities are encouraged to apply.

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The School of Engineering and Applied Sciences (SEAS) at Washington Uni- ^ , versity invites applications for five faculty positions at all levels in the newly constituted Department of Energy, Environmental and Chemical Engineering in 1 the following areas:

Bioenergy & Environmentally Benign Energy Production - (Up to 3 positions) This is an ambitious program to employ systems-level research approaches to investigate alternate forms of energy production. This program [ will allow productive interactions between members of SEAS, the College of Arts and Sciences, and the School of Medicine. Preference will be given to individuals with expertise in the following areas: Systems Biology, Bio-Transformation, Metabolic Engineering, Environmentally Benign Energy Production, I and Nano-Biotechnology. Applications must be submitted by e-mail as a single 1 file, editable pdf format to energyfaculty@seas.wustl.edu.

Environmental Engineering Science - (1 position) This search is open to all areas of aquatic science and technology; however, preference will be given to individuals with expertise in the following areas: Environmental Organic Chemistry, Physical-Chemical Processes in Natural and Engineered j Aquatic Systems, Environmental Biotechnology, Environmental Nanotechnol- 1 ogy. Applications must be submitted by e-mail as a single file in editable pdf format to environmentalfaculty@seas.wustl.edu.

Advanced Materials - (1 position) The School of Engineering and Applied Sciences and the Center for Materials Innovation invite applications for the McKelvey chair in interdisciplinary materials research. Outstanding candidates whose interests fall within a broad range of materials disciplines that include but are not limited to nanoscopic, bio, inorganic & organic semiconducting, opto-electronic, energy-related, smart, environmental, magnetic and ferroelectric materials. Applications must be submitted by e-mail as a single file in editable pdf formatto materialsfaculty@seas.wustl.edu.

Review of applications will begin immediately, but applications will be received until the postions are filled. Washington University is an Equal Opportunity and 1 Affirmative Action Employer. Applications from women and under-represented minority groups are strongly encouraged. 1

Department of Energy, Environmental and Chemical Engineering 1 Campus Box 1180, One Brookings Drive, St. Louis, M0 63130 ~ 314-935-6070 J?

Last "Recruitment Issues"

for 2006 Issue

Date

Dec. 4 Pharmaceutical Year I n Review

Dec. 11 Careers in Genomics/Proteomics

Dec 18 Chemical Year in Review

Don't miss these issues to get your recruitment

message to the 300,000+ readers oiCdfEN.

Contact M a t t McCloskey at

6 1 0 - 9 6 4 - 8 0 6 1 to place your recrui tment ad today.

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The School of Engineering and Applied Sciences (SEAS) at Washington Uni- ^ , versity invites applications for five faculty positions at all levels in the newly constituted Department of Energy, Environmental and Chemical Engineering in 1 the following areas:

Bioenergy & Environmentally Benign Energy Production - (Up to 3 positions) This is an ambitious program to employ systems-level research approaches to investigate alternate forms of energy production. This program [ will allow productive interactions between members of SEAS, the College of Arts and Sciences, and the School of Medicine. Preference will be given to individuals with expertise in the following areas: Systems Biology, Bio-Transformation, Metabolic Engineering, Environmentally Benign Energy Production, I and Nano-Biotechnology. Applications must be submitted by e-mail as a single 1 file, editable pdf format to energyfaculty@seas.wustl.edu.

Environmental Engineering Science - (1 position) This search is open to all areas of aquatic science and technology; however, preference will be given to individuals with expertise in the following areas: Environmental Organic Chemistry, Physical-Chemical Processes in Natural and Engineered j Aquatic Systems, Environmental Biotechnology, Environmental Nanotechnol- 1 ogy. Applications must be submitted by e-mail as a single file in editable pdf format to environmentalfaculty@seas.wustl.edu.

Advanced Materials - (1 position) The School of Engineering and Applied Sciences and the Center for Materials Innovation invite applications for the McKelvey chair in interdisciplinary materials research. Outstanding candidates whose interests fall within a broad range of materials disciplines that include but are not limited to nanoscopic, bio, inorganic & organic semiconducting, opto-electronic, energy-related, smart, environmental, magnetic and ferroelectric materials. Applications must be submitted by e-mail as a single file in editable pdf formatto materialsfaculty@seas.wustl.edu.

Review of applications will begin immediately, but applications will be received until the postions are filled. Washington University is an Equal Opportunity and 1 Affirmative Action Employer. Applications from women and under-represented minority groups are strongly encouraged. 1

Department of Energy, Environmental and Chemical Engineering 1 Campus Box 1180, One Brookings Drive, St. Louis, M0 63130 ~ 314-935-6070 J?

WWW.CEN-0NLINE.ORG \Y1 NOVEMBER 20, 2006

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ACADEMIC POSITIONS

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TENURE-TRACK FACULTY POSITION The Chemistry Department at California State Polytechnic University, Pomona is seeking applications for a tenure-track position in organic chemistry to star t September 2007. Individuals who combine interdisciplinary interests with organic chemistry are also encouraged to apply. Minimum qualifications are a Ph.D. in Organic Chemistry. ABD status at t ime of application is acceptable. Rank and salary are at the Assistant Professor level. Under exceptional c i rcumstances, qualified individuals might be considered for Associate Professor. The successful candidate will be expected to exhibit the potential for: Instruction of freshman chemistry, Excellence In Teaching Organic Chemistry Lecture, Laboratory, And Computat ional Courses At The Junior, Senior And M.S.-Level, professional development directed toward enhancement of the organic chemistry program, leadershipforthe department and university community, and responsiveness to the educational equity goals of the university and its increasing ethnic diversity and international character. Applicants Should Submit Curriculum Vitae, Graduate And Undergraduate Transcripts (Unofficial Acceptable For Initial Screening), A Brief Statement Of TheirTeaching Philosophy And Research Plans, Three Letters Of Recommendation And Two Additional Names With Phone Numbers Of References To: Chair, Organic Chemistry Search Committee, Chemistry Department, California State Polytechnic University, 3801 West Temple Ave., Pomona, CA 91768; 909-869-3653. This posit ion is open until f i l led, but f irst consideration will be given to applicants who have completed their applications before January 15, 2007. Cal Poly Pomona is dedicated to building a diverse and multicultural working environment and the University encourages applications from women, minorities, individuals with disabilities and covered veterans. Cal Poly Pomona is an affirmative action, equal opportunity employer. A university application form will be automatically sent to all applicants and must be completed prior to final screening. EO/ AAE. http://www.csupomona.edu/~chemistry

JOHNS HOPKINS UNIVERSITY DEPARTMENT OF CHEMICAL AND BIOMOLECU-

LAR ENGINEERING The Department of Chemical and Biomolecular Engineering at the Johns Hopkins University announces a search for tenured/ tenure- t rack faculty at the Assistant or Associate Professor level. The department seeks outstanding engineers and scientists who will create an innovative, high-impact research program, and who will excel at teachingand motivatingtalented undergraduate students. A doctorate in Chemical Engineering or a related field is required. Preference will be given to applicants in the fields of Fundamentals of Nanotechnology, Colloidal and Interface Science, Biomolecular and Cellular Engineering. Appl icat ionsfrom candidates with interdisciplinary interests spanning more than one area are encouraged. The Chemical and Biomolecular Engineering Department provides a highly collaborative environment with departments in the School of Engineering, Arts & Sciences, Medicine, and Public Health, as well as the Institute for NanoBio-Technology. Additional information about the department and this position may be found at www.jhu.edu/ chembe. Candidates Should Submit A Curriculum Vitae, Reprints Of Recent Papers, A Statement Of Research Interests And Teaching Plans, And The Names Of Three References To: Chair, Search Committee, Department of Chemical and Biomolecular Engineering, Johns Hopkins University Maryland 221, 3 4 0 0 North Charles Street, Baltimore, MD 21218. To Ensure Full Consideration, Applications Should Be Submitted By January 1, 2007. The Johns Hopkins University is an Equal Opportunity/Affirmative Action Employer.

ALBERTSON COLLEGE OF IDAHO IDAHO'S LIBERAL ARTS COLLEGE

ASSISTANT PROFESSOR OF CHEMISTRY Alber tson College invites appl icat ions for a tenure t rack posi t ion beginning September 2007. Ph.D. in chemis t ry requi red, inorganic, organometa l l ic , or bioinorganic is preferred. Candidates must have a s t rong c o m m i t m e n t to breadth of undergraduate teaching in a liberal arts environment. For a complete descript ion of the posit ion, visit http://www.albert- son.edu/jobs. Send curr iculum vita, undergraduate and graduate transcripts, statement of teaching philosophy, an overview of research plans, and three letters of recommendation to Chemistry Search, Albert-son College, 2112 Cleveland Blvd., Caldwell, ID 83605. Application review will begin December 15 and continue until position is filled. EOE

ACADEMIC POSITIONS

THE DEPARTMENT CHEMICAL AND PETROLEUM ENGINEERING AT THE UNIVERSITY OF WYOMING has an opening for a distinguished Professor of Chemical and Petroleum Engineering. This position is for a senior level faculty member in the newly created University of Wyoming School of Energy Resources (SER). The successful candidate will also be a tenured faculty member in the Department of Chemical & Petroleum Engineering. We seek an individual who has a national reputation in some aspect of coal conversion or utilization. The successful candidate will be expected to be a national leader in his/her area of scholarship and bring a significant externally funded research program to the University of Wyoming. Responsibilities will include teaching at the undergraduate and graduate levels in chemical engineering as well as providing leadership on campus for coal related research. As the only public four-year institut ion of higher learning in Wyoming, the University enjoys a distinctive leadership role in the state and region. The main campus is in Laramie, a city of 27,000 people perched in a scenic valley between the Laramie and Medicine Bow Mountains of the Rocky Mountains. Laramie is a two-hour drive north of Denver, Colorado. More information about the University and its regional setting is available on the University's Web site, http://www.uwyo.edu. Candidates who possess an earned doctorate in chemical engineering or a closely related field and a demonstrated record of excellence in teaching and scholarship are invited to mail or email their appl icat ion, resume, statements of teaching and research interests, and contact information for at least three referees to Dr. Brian Towler, Head, Department of Chemical and Petroleum Engineering, Dept. 3295 ,1000 University Avenue, University of Wyoming, Laramie, WY 82071. Email to mar-gep@uwyo.edu. Tel: (307) 766-2500. We will begin the application review process in early January 2007. The University of Wyoming is an AA/EEO employer.

ALLEGHENY COLLEGE DEPARTMENT OF CHEMISTRY invites application for a two-year sabbatical replacement position at the assistant professor level beginning August 2007. We seek a person with a Ph.D. in organic chemistry. Teaching responsibilities will be in organic and first-year chemistry. Opportunit ies exist to work with undergraduates on independent research projects. Allegheny College is a highly selective private liberal arts college with a dedicated faculty of teacher-scholars. Send resume, undergraduate and graduate transcripts, statement of teaching philosophy, and three letters of recommendation to Dr. Alice Deckert, Department of Chemistry, Allegheny College, Mead-ville, PA 16335. Review will begin December 15 and continue until the position is fil led. Allegheny College is an Equal Opportunity Employer, with a strong institutional commitment to develop a diverse faculty and staff. Women and members of other under-represented groups are encouraged to apply.

ASSISTANT PROFESSOR OF BIOCHEMISTRY Washburn University's Chemistry Department invites appl icat ionsfora biochemistry tenure track, assistant professor position beginning August 1, 2007. Requirements: Ph.D. in chemistry and strong commitment to excel lent/ innovat ive teaching and scholarship in an undergraduate liberal arts environment. Responsibilities: primarily teaching biochemistry lectures, biochemistry laboratories, and freshman courses. Ability to work with undergraduates in research very important. Send application letter, vitae, undergraduate/ graduate t ranscr ip ts , s tatement of personal teaching philosophy, outline of research plans involving undergraduates, 3 recent letters of recommendation to Dr. Stephen Angel, Chair, Department of Chemistry, Washburn University, 1700 College Ave., Topeka, KS 66621. Application review begins December 12, 2006 and continues until posit ion is f i l led. Washburn University is an EOE. Women and minorities are encouraged to apply. For more information about the chemistry department, please visit: http://www.washburn. edu/cas/chemistry/

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ACADEMIC POSITIONS

MONTCLAIR STATE UNIVERSITY COLLEGE OF SCIENCE AND MATHEMATICS

DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY

MARGARET AND HERMAN SOKOL CHAIR IN MEDICINAL CHEMISTRY

The College of Science and Mathemat ics at Mont-clair State University is pleased to invite applications for the Margaret and Herman Sokol Chair in Medicinal Chemistry f rom outstanding scientists whose research is focused on the chemistry of living systems in the areas of pharmaceutical or medicinal chemistry. The person selected for the Sokol Chair must demonstrate a strong commitment to conducting a vigorous research program, seeking external funding for his or her research program, building linkages to the pharmaceutical industry in New Jersey, and teaching and mentoring graduate and undergraduate science students. The individual appointed to the Sokol Chair will be placed simultaneously in a tenure track faculty position at the rank appropriate to his or her experience and qualif ications. Appointment to the Sokol Chair is for a five year term and is renewable. The Sokol Chair endowment will provide support for two graduate students, start-up funds, and annual research support . Appointment to the Sokol Chair will be effective September 1, 2007. In addit ion to the pr imary duties of teaching and research, contr ibut ions in areas such as curr icu lum and program development, community outreach, and other service areas are expected. Applications should include a cover letter, full curriculum vitae, summary of research plans, a brief statement of teaching philosophy and at least three supporting letters of reference. Letters of nomination are also welcome. Application materials, nominations, or inquiries should be received at the earliest possible date and directed to: Dr. Jeffrey Toney, Sokol Professor and Chairperson, Department of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043. Women and minorities are strongly encouraged to apply. Montclair State University is an EEO/AA employer.

INORGANIC CHEMISTRY FACULTY Full-time, tenure track faculty position atthe assistant/ associate professor level. Teach courses in advanced inorganic chemistry, instrumental analysis&quantita-tive analysis in the ACS-certified BS in chemistry, and inorganic spectroscopy in the MS in analytical chemistry. Assignment may include service courses, other chemistry lectives, graduate courses, and opportuni-ty to direct undergraduate & graduate research. Abil-ity to teach methods development desirable. Division instrumentation includes a Bruker FT-NMR, new Elec-troThermo FTIR, new Agilent LC/MS, Varian Ion Trap GC/MS, Perkin-Elmer FL/GFAAS, Dionex ion chro-matograph, assorted GC's, and electrochemical in-strumentat ion. Ph.D. in Inorganic Chemistry or relat-ed field required. Demonstrated commitment to both teaching and research; post-doctoral research exp. and recent chemist ry teaching at the post-second-ary level preferred. Review of applications begins im-mediately & continues until position is fil led. Send let-ter of application, curr iculum vita, brief statement of teaching philosophy, transcripts of all college/univer-sity work, and 3 letters of professional reference to: Dr. Gary Lyon, Chair; Inorganic Chemistry Search Com-mittee; Division of Science, College of Arts and Sci-ences; Governors State University; 1 University Park-way, University Park, IL 60466 . AA/EOE. Governors State University

UMASS BIOENGINEERING FACULTY POSITION: Ph.D. in Bioengineer ing, Chemical Engineering or equivalent; outstanding record of accomplishments; and commi tmen t to excellence in teaching and re-search are required. Rank and salary commensurate with qualifications. Preference will be given to mid-ca-reer candidates with leadership potential. Preferred areas of research are cellular/tissue engineering, with stem cell engineering being of special interest. Ex-pected star t ing date: September 1, 2007. Send cur-riculum vitae, research plan, statement of teaching in-terests, and arrange for three letters of reference to be sent directly to: Chair, Faculty Search Committee, Department of Chemical Engineering, University of Massachusetts Amherst, 686 North Pleasant Street, Amherst, MA 01003-9303. Reviews will begin Decem-ber 1, 2006 . Applications accepted until the position is fi l led. The University of Massachusetts is an Affirma-tive Action/Equal Opportunity Employer. The Universi-ty, College, and Department seek to promote diversity, and welcome applicationsfrom women and other underrepre-sentedgroups.

WWW.CEN-0NLINE.ORG ] _ 8 NOVEMBER 20, 2006

http://www.csupomona.edu/~chemistryhttp://www.jhu.edu/http://www.albert-http://son.edu/jobshttp://www.uwyo.edumailto:gep@uwyo.eduhttp://www.washburnhttp://WWW.CEN-0NLINE.ORG

ACADEMIC POSITIONS TEXAS A&M UNIVERSITY AT QATAR The Depart ment of Chemistry at Texas A&M University invites applications for one or more faculty positions at our campus in Doha, Qatar (www.qatar.tamu.edu). Texas A&M University at Qatar (TAMUQ) is a partnership with Qatar Foundation. Now in its four th year of operat ion, TAMUQ offers Bachelor of Science degrees in Chemical, Electrical and Computer, Mechanical, and Petroleum Engineering. The degree programs are identical to those of the main campus at College Station, Texas, and a Texas A&M University diploma is awarded to graduates. A new, state-of-the-art buildingfor teaching and research will open in 2007. TAMUQ offers classes in general, organic, analytical, and physical chemistry, all of which form an integral part of the engineering curricula. Teaching loads are kept low (usually two or three small classes per academic year) to promote faculty-student mentoring and to al lowt imefor faculty to pursue research. Salary rates are competit ive and, in general, average 3 0 % higher than comparable salary rates of similar positions here in the U.S. In addition, summer salary is guaranteed. Liberal allowances for professional travel and for relocation to Qatar are provided. Fringe benefits include free furnished housing in one of several gated communit ies, K-12 education for dependents, group health insurance, annual leave allowance, and a car allowance. Appointment is expected to begin in the Fall 2007. The successful candidate is expected to hold a Ph.D. inChemistryoraclosely related field, with demonstrated experience in teaching and strong potential for establishing a research program involving undergraduate students. Expected duties include teaching general chemistry as well as one of the upper level undergraduate courses. Faculty research is encouraged, and is expected to grow significantly in the coming years. TAMUQ is equipped with a broad array of modern analytical instrumentat ion, including a new 4 0 0 MHz NMR spectrometer. Candidates should submit a curr iculum vita, a brief narrative description of teaching experience and philosophy and research interests (not to exceed 4 pages), and arrange for three letters of recommendation to be sent to: Dr. David H. Russell, Head, Department of Chemistry, Texas A&M Universi ty, P.O. Box 30012 , College Stat ion, TX 77843-3012. Review of applications will begin on December 1, 2006 and will continue until the position is fil led. The successful applicant may be asked to spend t ime on TAMU's College Station campus this summer to become acquainted with our programs. Texas A&M University is an Equal Opportunity/ Affirmative Action employer, and applications from under represented groups are especially encouraged.

GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (GIST) DEPARTMENT OF ENVIRONMENTAL

SCIENCE AND ENGINEERING Faculty Posit ions (Ass is tan t , Assoc ia te and Full Pro fessor ) at Depar tmen t of Env i ronmenta l Science & Engineering, Gwangju Insti tute of Science & Technology(GIST) in Korea. GIST seeks candidates whose interest lies in Environmental Biotechnology, Renewable Energy Technology (Photovoltaics, Biofu-el), Environmental Nanotechnology and Ecological Engineering. Candidates must possess a Ph.D. degree in a pertinent field. Candidates with postdoctoral experience are preferred. Korean citizenship is Not required for these positions. At GIST all lectures are conducted in English. GIST started in 1993 as a government-funded science and engineering oriented graduate school and has performed numerous research projects sponsored by thegovernment and private sectors. More information about GIST can be found on our web page: ht tp: / /www.gis t .ac.kr . We seek dynamic and superb scient ists or engineers for these facul ty posit ions. GIST will offer internat ional ly compet i t ive salaries and housing benefits. GIST offers an electronic version of its application forms in Microsoft Word format at h t t p : / / w w w . g i s t . a c . k r / h i n d e x . h t m l . Appl icants should submit all appl ication materials by e-mail or fax to the following address: Section of Academic Affairs, Gwangju Inst i tute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea. (Tel:82-62-970-2043, Fax:82-62-970-2059, e-mail:admis@gist.ac.kr)

COLORADO STATE UNIVERSITY - PUEBLO offers two tenure-track Assistant Professor positions, one in Analytical chemistry and one in Organic chemistry, to begin August 2007. Requirements include: a Ph.D. in chemistry; acommi tment to teach ingand undergrad-uate/MS-level research; a commitment to seek external funding. For full position descriptions, department and facility information, and application instructions, go to ht tp : / /csm.colostate-pueblo.edu/chem/.

ACADEMIC POSITIONS SENIOR FACULTY OPENING

The Department of Chemical and Biomolecular Engineering at the University of Illinois of Urbana-Cham-paign invites applications for a full-time faculty position at the Associate Professor or Full Professor level. Candidates are expected to have demonstrated research leadership and scholarly excellence in chemical engi-neeringor related fields with national and international recognition. A Ph.D. with a distinguished academic record is required. Duties include teaching undergraduate and graduate courses, direction of M.S. and Ph.D. theses, and service to the University and profession. The depar tment is part of the School of Chemical Sciences in the College of Liberal Arts and Sciences, while maintaining close ties with the College of Engineering, which has been consistently ranked among the top five in the nation in recent years by deans at engineering schools, according to surveys conducted by U.S. News & World Report. The Department faculty supervise 100 graduate students enrolled in chemical engineering and additional graduate students in various departments of science and engineering across campus (h t t p : / /www.scs .u i uc .edu / chem_eng / i n -dex.html). A preferred start ing date for this position is August 16, 2007. In order to ensure full consideration, applications must be received by December 1, 2006 . Interviews may be conducted during the application period, but all appl icat ions received by December 1 will receive full consideration: salary will be commensurate with experience. Send an up-to-date curriculum vitae, a detailed research statement, and the names of five references to: Professor Richard D. Braatz; Chair of Faculty Search Commit tee; Department of Chemical and Biomolecul