Dr.Ajay - Pharmacokinetic

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    Lx+ @b`w Fn`q`kLjt|+ ca X`v`vn`v|x`

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    Fck|jk|vFck|jk|v

    Gk|xclzf|gck

    Chbjf|gqj

    Ljagkg|gck

    Ljvfxgt|gck ca @LMJ

    Lgvfgtigkjv

    Mcljiv

    @ttigf`|gck

    Cuk xjvj`xfn qgju

    Xjvj`xfn x|gfij

    Vzmm`xw

    Fckfizvgck0:#8#8408 8Tn`xm`fcogkj|gf @f|gck

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    Gk|xclzf|gck

    Exjjo tn`xm`ock (lxze( `kl ogkj|gocv |c lc

    ug|n mc|gck(

    G| lj`iv ug|n |nj x`|jv ca mcqjmjk| ca lxze `kl

    g|v mj|`hcig|j gk |nj hclw `kl acxfjv `f|gke ck

    |nj txcfjvv+

    X`|jv ca mcqjmjk| ca lxzev ugii j~ti`gk ug|n |nj

    njit ca vzg|`hij M`|njm`|gf`i Mclji+

    0:#8#8408 6Tn`xm`fcogkj|gf @f|gck

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    Fck|l Fckfjk|x`|gck ca ` lxze gk ti`vm` cx `kw

    tnwvgcicegf`i aizgl vzfn `v zxgkj) v`igq`) mgio)

    j|f+) gv lj|jxmgkjl ug|n xjvtjf| |c |gmjaciicugke g|v `lmgkgv|x`|gck+

    H`vjl ck |nj nwtc|njvgv |n`| |nj `f|gck ca `

    lxze xjpzgxjv txjvjkfj ca ` fjx|`gk

    fckfjk|x`|gck gk |nj |`xej| |gvvzj+

    0:#8#8408

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    Chbjf|gqj

    Hxgja cqjxqgju |c zkljxv|`kl xje`xlgke

    Tn`xm`fcogkj|gf `f|gck

    0:#8#8408 :Tn`xm`fcogkj|gf @f|gck

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    Ljagkg|gck Tn`xm`fcogkj|gfv gv |nj v|zlw ca un`| |nj

    hclw lcjv |c ` lxze+

    \nj pz`k|g|`|gqj v|zlw ca |nj @hvcxt|gck)

    Lgv|xghz|gck) Mj|`hcigvm `kl J~fxj|gck calxzev `kl |njgx mj|`hcig|jv+

    0:#8#8408 1Tn`xm`fcogkj|gf @f|gck

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    @hvcxt|gck

    G| gv `k `mczk| ca lxze |n`| jk|jxv gk hiccl

    `a|jx g|v `lmgkgv|x`|gck gk hclw+

    A`f|cx `aajf|gke `hvcxt|gck2

    0' K`|zxj ca Lxze

    A`|-Vcizhij lxzev `xj m`~gm`iiw `hvcxhjl

    U`|jx-Vcizhij lxzev `xj ijvv `hvcxhjl

    0:#8#8408 >Tn`xm`fcogkj|gf @f|gck

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    Fck|l8' Xcz|j

    Cx`i

    Vzhigkez`i

    Xjf|`i

    \x`kvfz|`kjczv

    Gkn`i`|gck2 @hvcxt|gck |nxczen mzfczvmjmhx`kjv

    \ctgf`i

    T`xjk|jx`iiw2

    Gk|x`qjkczv2

    Gk|x`mzvfzi`x2

    Vzhfz|`kjczv2

    0:#8#8408 7Tn`xm`fcogkj|gf @f|gck

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    0:#8#8408 04

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    Lgv|xghz|gck

    @k `mczk| ca lxze |n`| xj`fnjv |c fjii) `a|jx

    `hvcxt|gck+

    @a|jx `hvcxt|gck gk|c |nj vwv|jmgf fgxfzi`|gck)lxzev `xj lgv|xghz|jl |nxczencz| |nj hclw+

    Ngeniw tjxazvjl cxe`kv vzfn `v hx`gk) nj`x|v)

    izkev) igqjx `kl oglkjwv xjfjgqj mcv| ca |nj lxze

    vcck `a|jx gkbjf|gck+

    0:#8#8408 00Tn`xm`fcogkj|gf @f|gck

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    Txcfjvvjv ca Lgv|xghz|gckG| gkqciqjv |uc v|jtv2

    0+ Tjxmj`|gck ca axjj cx zkhczkljl lxze

    txjvjk| gk hiccl |nxczen |nj f`tgii`xw u`ii `kl

    jk|xw gk|c JFA+

    8+ Tjxmj`|gck ca lxze txjvjk| gk JFA|nxczen mjmhx`kj ca |gvvzj fjiiv `kl gk|c |nj

    GFA+

    0:#8#8408 08Tn`xm`fcogkj|gf @f|gck

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    A`f|cxv @aajf|gke Lxze

    Lgv|xghz|gck

    0+\gvvzj tjxmj`hgig|w+

    8+Cxe`k cx |gvvzj vgrj `kl tjxazvgck x`|j+

    6+Hgklgke ca lxzev |c |gvvzj fcmtckjk|v+

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    Mj|`hcigvm

    \nj gxxjqjxvghij |x`kvacxm`|gck ca t`xjk|

    fcmtczklv gk|c l`zen|jx mj|`hcig|jv+

    @ mjfn`kgvm hw ungfn) mcv|iw igqjx `i|jx

    fnjmgf`i v|xzf|zxj ca lxze+

    G| hjfcmj kck-|c~gf) u`|jx vcizhij `kl j`vgiw

    j~fxj|j cz|vglj hclw |nxczen zxgkj cx a`jfjv

    0:#8#8408 0

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    Fck|l

    Hw |ngv) mcv|iw a`|-vcizhij lxze `xj fckqjx|

    gk|c u`|jx-vcizhij ungij u`|jx-vcizhij mcv|iw

    xjm`gk zkfn`kejl+

    Igqjx f`k lc mj|`hcigvm hw Fckbze`|gck)

    Xjlzf|gck) Nwlxc~wi`|gck j|f

    0:#8#8408 0:Tn`xm`fcogkj|gf @f|gck

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    J~fxj|gck

    \nj jigmgk`|gck ca |nj vzhv|`kfjv axcm |nj

    hclw+ Gk x`xj f`vjv) vcmj lxzev gxxjqjxvghiw

    `ffzmzi`|j gk hclw |gvvzj+

    U`|jx vcizhij lxze gv j~fxj|jl cz|vglj mcv|iw

    |nxczen zxgkj cx a`jfjv+

    0:#8#8408 01Tn`xm`fcogkj|gf @f|gck

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    Fck|l

    J~fxj|jl lxze m`w fn`kejv fcicx `kl

    k`|zxj ca zxgkj cx a`jfjv+

    Vcmj lxze `ivc j~fxj|jl |nxczen vuj`|gke)

    i`fxwm`|gck) hxj`v| mgio

    0:#8#8408 05Tn`xm`fcogkj|gf @f|gck

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    Lgvfgtigkj

    v

    0+ Figkgf`i Tn`xm`fcogkj|gfv

    8+ Tctzi`|gck Tn`xm`fcogkj|gfv

    6+ \c~gfcogkj|gfv

    Tn`xm`fcogkj|gf @f|gck

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    Figkgf`i Tn`xm`fcogkj|gfv

    Gv |nj `ttigf`|gck ca tn`xm`fcogkj|gf

    mj|nclv |c lxze |njx`tw+

    G| gkqciqjv ` mzi|glgvfgtigk`xw `ttxc`fn |c

    gklgqglz`iiw ct|gmgrjl lcvgke v|x`|jegjv h`vjl

    ck |nj t`|gjk|%v lgvj`vj v|`|j `kl t`|gjk|-

    vtjfgagf fckvgljx`|gckv+

    0:#8#8408 07Tn`xm`fcogkj|gf @f|gck

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    Tctzi`|gck Tn`xm`fcogkj|gfv

    Zvj gk |nj lxze ljqjictmjk| txcfjvv |c njit

    gljk|gaw lgaajxjkfjv gk lxze v`aj|w `kl jaagf`fw

    `mcke tctzi`|gck vzhexcztv+

    \nj v|zlw ca tn`xm`fcogkj|gf lgaajxjkfjv ca

    lxzev gk q`xgczv tctzi`|gck excztv gv |jxmjl

    `v tctzi`|gck tn`xm`fcogkj|gfv+

    0:#8#8408 84Tn`xm`fcogkj|gf @f|gck

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    Fck|l

    @ej) ejkljx) ejkj|gf) `kl j|nkgf lgaajxjkfjv

    f`k `ivc xjvzi| gk tn`xm`fcogkj|gf lgaajxjkfjv

    |n`| m`w `aajf| |nj cz|fcmj ca lxze |njx`tw+

    0:#8#8408 80Tn`xm`fcogkj|gf @f|gck

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    \c~gfcogkj|gfv

    Gv |nj `ttigf`|gck ca tn`xm`fcogkj|gf

    txgkfgtijv |c |nj ljvgek) fcklzf|) `kl

    gk|jxtxj|`|gck ca lxze v`aj|w jq`iz`|gck

    v|zlgjv+

    \c~gfcogkj|gfv l`|` `glv gk |nj gk|jxtxj|`|gck ca|c~gfcicegf agklgkev gk `kgm`iv `kl j~|x`tci`|gck

    ca |nj xjvzi|gke l`|` |c nzm`kv+

    0:#8#8408 88Tn`xm`fcogkj|gf @f|gck

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    Figkgf`i\

    c~gfcicew

    Gv |nj v|zlw ca `lqjxvj jaajf|v ca lxzev `kl

    |c~gf vzhv|`kfjv .tcgvckv' gk |nj hclw

    0:#8#8408 86Tn`xm`fcogkj|gf @f|gck

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    Tn`xm`fcogkj|gf Mcljiv

    Q`xgczv m`|njm`|gf`i mcljiv `xj zvjazi gk |nj

    ljqjictmjk| ca jpz`|gckv |c ljvfxghj lxze

    fckfjk|x`|gckv gk |nj hclw+

    Lxze fckfjk|x`|gckv `xj ljtjkljk| ck |gmj)

    |nj |uc q`xg`hijv lxze fckfjk|x`|gck `kl |gmj`xj f`iijl ljtjkljk| `kl gkljtjkljk|

    q`xg`hijv xjvtjf|gqjiw

    0:#8#8408 8

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    Fck|lZvjazi gk 2

    Fn`x`f|jxgrj |nj hjn`qgcx ca lxze gk t`|gjk|+

    Txjlgf|gke fckf+ ca lxze gk q`xgczv hclw aizglv

    ug|n lcv`ej xjegmjk+

    F`ifzi`|gke ct|gmzm lcv`ej xjegmjk acx

    gklgqglz`i t`|gjk|+

    Jq`iz`|gke hgcjpzgq`ijkfj hj|ujjk lgaajxjk|acxmzi`|gck+

    J~ti`gkgke lxze gk|jx`f|gck+0:#8#8408 Tn`xm`fcogkj|gf @f|gck 8:

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    Fck|l

    Tn`xm`fcogkj|gf mcljiv `xj lgqgljl gk|c

    0+ Fcmt`x|mjk| mcljiv

    8+ Tnwvgcicegf`i tn`xm`fcogkj|gf mclji .aicu mclji'

    6+ Kck Fcmt`x|mjk|`i Tn`xm`fcogkj|gfv mclji

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    Fcmt`x|mjk|`i Mclji

    Mcljiv `xj h`vjl ck |nj fckfjt| |n`| |nj hclw

    m`w hj qgjujl `v ` vjxgjv ca fcmt`x|mjk|v gk

    ungfn |nj lxze gv lgv|xghz|jl+

    G| lgqgljl gk|c

    0+ Ckj Fcmt`x|mjk| Mcljiv

    8+ \uc Fcmt`x|mjk| Mcljiv

    0:#8#8408 85Tn`xm`fcogkj|gf @f|gck

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    Fck|l

    Ckj Fcmt`x|mjk| Mcljiv2

    Jk|gxj hclw gv fckvgljxjl `v ckj zkg|

    Lxze gv `lmgkgv|jxjl gk|c |nj fcmt`x|mjk|

    `kl lgv|xghz|jl |nxczencz| |nj fcmt`x|mjk|.|nj hclw' gkv|`k|`kjczviw

    0:#8#8408 8>Tn`xm`fcogkj|gf @f|gck

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    0:#8#8408 Tn`xm`fcogkj|gf @f|gck 87

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    Fck|l \uc Fcmt`x|mjk| Mcljiv2

    Gk |ngv mclji) lxze gv `lmgkgv|jxjl gk|c |njfjk|x`i fcmt`x|mjk| `kl |njk |njxj gv `

    |gmj i`e lzj |c vicujx lgv|xghz|gck gk|c

    c|njx |gvvzjv `kl cxe`kv+

    \njvj c|njx cxe`kv `xj xjtxjvjk|jl hw |nj

    tjxgtnjx`i fcmt`x|mjk|

    0:#8#8408 64Tn`xm`fcogkj|gf @f|gck

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    Tnwvgcicegf`i Mcljiv

    @k `i|jxk`|j mj|ncl ca hzgilgke ` tn`xm`fcogkj|gf

    txcagij ca ` lxze gk |nj hclw gv |c z|gigrj `k`|cmgf

    `kl tnwvgcicegf`i gkacxm`|gck+ G| ljfglj unj|njx lxze lgv|xghz|gck gk|c ` t`x|gfzi`x

    |gvvzj gv hw tjxazvgck x`|j cx mjmhx`kj |x`kvtcx|+

    \nj c|njx t`x`mj|jxv igoj qjkczv lxze

    fckfjk|x`|gck `kl |nj t`x|g|gck fcjaagfgjk|

    0:#8#8408 60Tn`xm`fcogkj|gf @f|gck

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    Kckfcmt`x|mjk|`i

    G| gv ngeniw ljtjkljk| ck jv|gm`|gck ca |c|`i

    lxze j~tcvzxj+

    \c|`i lxze j~tcvzxj gv mcv| ca|jk jv|gm`|jlhw `xj` zkljx |nj fzxqj .@ZF' mj|nclv+

    0:#8#8408 68Tn`xm`fcogkj|gf @f|gck