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DNA, RNA, and protein purificationCatalog supplement 2016
MACHEREY-NAGEL GmbH & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · GermanyFrance:MACHEREY-NAGEL EURLTel.: +33 388 68 22 68Fax: +33 388 51 76 88E-mail: [email protected]
Switzerland:MACHEREY-NAGEL AGTel.: +41 62 388 55 00Fax: +41 62 388 55 05E-mail: [email protected]
Germanyand international:Tel.: +49 24 21 969-0Fax: +49 24 21 969-199E-mail: [email protected]
www.mn-net.com
www.mn-net.comMACHEREY-NAGEL
EN ISO 9001: 2008CERTIFIED
USA:MACHEREY-NAGEL Inc.Tel.: +1 484 821 0984Fax: +1 484 821 1272E-mail: [email protected]
What’s new?
2
Con
tent
sContents
www.mn-net.com
MACHEREY-NAGEL – Bioanalysis catalog supplement 2016
This Bioanalysis catalog supplement 2016 is an addition to the main Bioanalysis catalog 2014 / 2015. The new MACHEREY-NAGEL products are sorted according to the product chapters in the main catalog.
Product Page
Clean-upNGS clean-up and size selectionNucleoMag® NGS Clean-up and Size Select
Clean-up and tunable size-selection of NGS library preparation reactions
4
RNARNA from cells and tissueNucleoSpin® RNA Plus Ultra-fast isolation of high-quality RNA including lysate
clearing and gDNA removal in one step 5
NucleoZOL High yield RNA isolation from all kind of sample material 6MicroRNAExosome Precipitation Solution (Serum / Plasma), (Urine)
Simple and efficient exosome precipitation for quantitative miRNA isolation
7
Genomic DNAGenomic DNA from blood and biological fluidsNucleoSpin® Blood L Vacuum Convenient and time-saving DNA purification from large
blood volumes under vacuum8
Genomic DNA from microorganismsNucleoSpin® Microbial DNA Isolation of total DNA from hard-to-lyse microbial cultures
with bead-supported homogenization9
Genomic DNA from FFPE samplesNucleoSpin® 96 DNA FFPE NucleoMag® DNA FFPE
Xylene-free high-throughput isolation and decrosslinking of DNA from FFPE samples
10 11
Genomic DNA from forensic samplesNucleoSpin® Forensic Filters Incubation and lysate separation of solid sample carriers in
one tube12
Viral RNA and DNAViral RNA and DNA from serum and plasmaNucleoSpin® Virus Simultaneous isolation of viral RNA and DNA 13
AccessoriesEquipmentNucleoMag® SEP Mini NucleoMag® SEP MaxiNucleoBond® Smart RackStarter Set Midi
Manual separation of magnetic beads in 1.5 mL or 2 mL reaction tubesMagnetic separation in 50 mL tubesFor processing of NucleoBond® Columns by gravity flowFor processing of NucleoSpin® Midi / L Columns under vacuum
14
141414
ConsumablesNucleoSpin® Bead Tubes Efficient cell disruption 14
www.mn-net.com 3
MACHEREY-NAGEL · Company updatesC
ompany updates
MACHEREY-NAGEL – Quality, innovation, and support
Since 1911, MACHEREY-NAGEL stands for highly reliable analytical products made in Germany. Based on more than 100 years of experience, the company has focused on continuous improvement and innovations to offer up-to-date solutions of outstanding quality.
MACHEREY-NAGEL – Facilities and resourcesThroughout MACHEREY-NAGEL’s centennial history, the compa-nyʼs facilities have constantly been adapted and renewed. Just recently the production and the warehouse facilities have been modernized and enlarged. State-of-the-art high-quality equipment meets optimal production and delivery requirements.
To share our long lasting knowledge and expertise with custom-ers and distributors, a new training center has been established at the MACHEREY-NAGEL headquarters in Düren. A dedicated team of scientists and product specialists with extensive practical and theoretical expertise is committed to train our clients and provide maximal support.
MACHEREY-NAGEL – Packaging according to up-to-date standardsTo meet the demands of providing a reliable, high quality product, MACHEREY-MAGEL is always looking for enhancements and continuous optimizations of products and production processes.As of June 2015, all MACHEREY-NAGEL products will be labeled according to the Globally Harmonized System of Classification (GHS), the new world-wide-standardized system for classification and labeling of chemicals on product labels and Material Safety Data Sheets (MSDS). The most noticeable change is the new diamond shaped hazardous icon which replaced the previously labeled orange square symbols.
In addition, all liquids included in the MACHEREY-NAGEL Bioanalysis product line will be provided in new Nalgene® round bottles. These bottles provide better handling and a wider opening, allowing easier and more precise pipetting. The new bottles have shown improved stability and have helped streamline production processes.
MN headquarters in Düren, Germany
MN Training-Center symbol
Nalgene® round bottles
Hazardous icons according to GHS
www.mn-net.com4
NGS clean-up and size selectionC
lean
-up
NucleoMag® NGS Clean-up and Size Select
Applications*Clean-up and size selection of NGS (Next Generation Sequencing) library preparation reactions
Features• Convenient magnetic-bead technology
– easy to adjust for different applications or workflows – optimal scalability for manual and automated processing
• Tunable size selection from 150 bp to 800 bp – highest flexibility for custom-specific applications
Product at a glance
Parameter NucleoMag® NGS Clean-up and Size SelectTechnology Magnetic-bead technologyFormat Highly reactive superparamagnetic beadsProcessing Manual or automatedSample material Reaction mixtures from common NGS library kitsAmount of sample material 7.5 pg–5 μgFragment size Tunable: 150–800 bpInput volume 50–150 μLTypical recovery > 80 %Elution volume 10–100 μLPreparation time 30–45 min/96 preps
Ordering information
Product Pack of Specification REFNucleoMag® NGS Clean-up and Size Select
5 mL 50 mL
500 mL
NucleoMag® NGS Bead Suspension as above as above
744970.5 744970.50 744970.500
Material to be supplied by the user Pack of Specification REFSquare-well Block (separation plate) 4
2496-well blocks with 2.1 mL square-wells as above
740481740481.24
Elution Plate, U-bottom (elution plate) 24 96-well microplates with 300 μL u-bottom wells, including Self-adhering Foil
740486.24
Product accessories Pack of Specification REFNucleoMag® SEP 1 magnetic separator, for use with 96-well
plates744900
NucleoMag® SEP Mini 1 magnetic separator, for use with 1.5 mL or 2 mL reaction tubes (12 positions)
744901
NucleoMag® SEP Maxi 1 magnetic separator, for use with 50 mL tubes (4 positions)
744902
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)
www.mn-net.com 5
MicroRNAR
NA
NucleoSpin® RNA Plus
Applications*New generation of RNA isolation from cells and tissue
Features• NucleoSpin® gDNA Removal Column included – no time-consuming rDNase digestion• Lysate clearing and gDNA removal in one step – quick and convenient handling • New efficient lysis buffer – no ß-mercapthoethanol or TCEP necessary
Product at a glance
Parameter NucleoSpin® RNA PlusTechnology Two column silica-membrane system
1. column for DNA removal 2. column for RNA isolation
Format Mini spin columns Sample material < 1 x 107 cultured cells,
< 109 bacterial cells, < 108 yeast cells, < 30 mg human / animal tissue
Fragment size > 200 nt Typical yield HeLa cells 5 x 106: 40–60 μg
Mouse liver 20 mg: 80–100 μg Mouse kidney 20 mg: 40–70 μg Mouse spleen 5 mg: 30–60 μg
A260/A280 1.9–2.1 A260/A230 1.8–2.5 Typical RIN (RNA integrity number) > 9 Elution volume 30–120 μL Preparation time 20 min/6 preps Binding capacity 200 μg Typical downstream applications Real-time RT-PCR, Northern blotting, primer exten-
sion, array technology, RNase protection assays
Ordering information
Product Preps Specification REFNucleoSpin® RNA Plus 10
50 250
NucleoSpin® RNA Plus Columns with Collection Tubes, NucleoSpin® gDNA Removal Columns with Collection Tubes, Collection Tubes (2 mL and 1.5 mL), buffers as above as above
740984.10 740984.50 740984.250
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)
NucleoSpin® gDNA
Removal Column included
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RNA from cells and tissueR
NA
NucleoZOL
Applications*High yield total RNA extraction from all kind of samples
Features• No use of chloroform, no phase separation needed – easy and safe procedure• Efficient removal of DNA, proteins, and other contaminating compounds – high RNA purity
from any sample material• Isolation of total RNA in one fraction or small and large RNA in two fractions – flexible use• Combination with NucleoSpin® RNA Columns possible
Product at a glance
Parameter NucleoZOL Technology One-phase extractionSample material/mL reagent (scalable)
< 1 x 107 cultured cells, bacteria, and yeast, < 100 mg human / animal / plant tissue, < 0.4 mL (viral) fluids
Fragment size Small RNA: 10–200 nt, large RNA: > 200 nt Typical yield Total RNA:
Liver: Kidney, spleen: Muscle, brain, lung: Cultured cells:
6–8 μg/mg tissue 3–4 μg/mg tissue 0.5–1.5 μg/mg tissue 4–10 μg/106 cells
Large RNA: Liver: Kidney, spleen: Muscle, brain, lung: Cultured cells:
5–7 μg/mg tissue 3–4 μg/mg tissue 0.5–1.5 μg/mg tissue 3–8 μg/106 cells
A260/A280 1.8–2.1 Typical RIN > 9Elution volume Flexible Preparation time < 1 h
Ordering information
Product Pack of Specification REFNucleoZOL 200 mL NucleoZOL Reagent 740404.200 Related products Preps Specification REF NucleoSpin® RNA Clean-up 10
50 250
NucleoSpin® RNA Clean-up Columns with Collection Tubes, Collection Tubes (2 mL and 1.5 mL), buffers as above as above
740948.10 740948.50 740948.250
* Kits to be used for research purposes only (see page 15)
No phase separation
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MicroRNAR
NA
Exosome Precipitation Solution (Serum / Plasma)Exosome Precipitation Solution (Urine)
Applications*Exosome enrichment for most efficient total RNA isolation from serum and plasma samples, urine, other body fluids, and cell culture supernatants (serum-free)
Features• Simple and fast exosome precipitation – avoidance of tedious ultra-centrifugation• Flexibe sample amount – procedure can be scaled up or down depending on sample volume
Product at a glance
Parameter Exosome Precipitation Solution Technology Precipitation solution Sample material Flexible input:
0.1–1 mL serum / plasma (Exosome Precipitation Solution (Serum / Plasma)) 1–10 mL urine (Exosome Precipitation Solution (Urine))
Preparation time 45 min/6 preps Typical downstream application
Total RNA isolation (e.g., with NucleoSpin® miRNA Plasma, see ordering information)
Ordering information
Product Pack of Specification REFExosome Precipitation Solution (Serum / Plasma)
2 mL 12 mL 60 mL
Exosome Precipitation Solution, RNase-free water as above as above
740398.2 740398.12 740398.60
Exosome Precipitation Solution (Urine)
12 mL 50 mL
250 mL
Exosome Precipitation Solution, RNase-free water as above as above
740399.12 740399.50 740399.250
Related products Preps Specification REF NucleoSpin® miRNA Plasma 10
50
250
NucleoSpin® miRNA Columns, Collection Tubes (2 mL), buffers, RNase-free rDNase as above as above
740981.10 740981.50 740981.250
* Kits to be used for research purposes only (see page 15)
www.mn-net.com8
Genomic DNA from blood and biological fluidsG
enom
ic D
NA
NucleoSpin® Blood L Vacuum
Applications*DNA purification from up to 2 mL whole blood using vacuum filtration
Features• Efficient DNA purification – consistent high yields and complete removal of PCR
inhibitors• Adapter set for the NucleoVac 96 Vacuum Manifold available – parallel purification
of 24 samples
Product at a glance
Parameter NucleoSpin® Blood L Vacuum Technology Silica-membrane technology Format Midi spin columns Sample material 1–2 mL whole blood (human or animal, fresh or frozen, treated
with citrate, heparin, or EDTA)Fragment size 200 bp–approx. 50 kbp Typical yield 50–80 μg (2 mL blood) A260/A280 1.6–1.9 Typical concentration 100–130 ng/μL Elution volume 2 x 300 μL Preparation time 75 min/24 preps Binding capacity 250 μg Typical downstream applications
PCR, Southern blotting, enzymatic reactions
Ordering information
Product Preps Specification REFNucleoSpin® Blood L Vacuum 24 NucleoSpin® Blood L Columns with Collection
Tubes, Collection Tubes (1.5 mL), buffers, Proteinase K
740954.24
Product accessories Pack of Specification REF NucleoVac 96 Vacuum Manifold 1 740681NucleoVac Vacuum Regulator 1 for controlling of vacuum 740641 Starter Set Midi 1 for processing NucleoSpin® Midi / L Columns
under vacuum on NucleoVac 96 Vacuum Manifold or similar manifolds, contains 1 Column Holder Midi, 1 Wash Plate Midi, 1 Elution Tube Holder Midi, 24 Dummy Columns Midi
740744
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)
www.mn-net.com 9
Genomic DNA from microorganismsG
enomic D
NA
NucleoSpin® Microbial DNA
Applications*Isolation of total DNA from hard-to-lyse microorganisms
Features• Suitability for a large variety of starting cultures – high-quality DNA from gram-positive /
gram-negative bacteria, yeast, or fungi with one procedure• NucleoSpin® Bead Tubes for efficient cell disruption – compatibility with common disruption
devices• Liquid Proteinase K included – no additional enzyme required
Product at a glance
Parameter NucleoSpin® Microbial DNA Technology Silica-membrane technology Format Mini spin columns Sample material < 40 mg wet weight cell pellet (gram-positive bacteria,
gram-negative bacteria, yeast, fungi) Fragment size 200 bp–approx. 50 kbp Typical yield Depends on sample type and disruption method
Approx. 5–25 μg (30 mg wet weight cell pellet) A260/A280 1.6–2.0 Elution volume 100–200 μL Preparation time 35 min/prep Binding capacity 60 μg Typical downstream applications
PCR, real-time PCR, Southern blotting, enzymatic reactions
Ordering information
Product Preps Specification REFNucleoSpin® Microbial DNA 10
50
NucleoSpin® Microbial DNA Columns, NucleoSpin® Bead Tubes Type B, Collection Tubes (2 mL), buffers, Liquid Proteinase K as above
740235.10 740235.50
Product accessories Pack of Specification REF NucleoSpin® Bead Tubes Type A 50 2 mL tubes with ceramic beads
(as included in the NucleoSpin® Soil kit)740786.50
NucleoSpin® Bead Tubes Type B 50 2 mL tubes with glass beads (as included in the NucleoSpin® Microbial DNA kit)
740812.50
NucleoSpin® Bead Tubes Type C 50 2 mL tubes with corundum (recommended for yeast disruption)
740813.50
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)
www.mn-net.com10
Gen
omic
DN
A
NucleoSpin® 96 DNA FFPE
Applications*Isolation of genomic DNA from formalin-fixed, paraffin-embedded samples (fresh or archived) in 96-well plate format
Features• Blue colored Paraffin Dissolver (patent pending) for easy paraffin removal – no use
of harmful organic solvents• Decrosslinking buffer to eliminate formalin crosslinking – high-quality DNA for im-
proved performance in downstream applications (e.g., PCR)• Processing under vacuum or by centrifugation – suitability for manual and automat-
ed processing
Product at a glance
Parameter NucleoSpin® 96 DNA FFPE Technology Silica-membrane technology Format 96-well plates Processing Manual or automated, vacuum or centrifugation Sample material < 10 mg tissue, < 15 mg paraffin Fragment size 50 bp–approx. 5 kbp Typical recovery Depending on sample amount and quality DNA quality Strongly depending on sample qualityElution volume 100 μL Preparation time 60 min/plate (excl. lysis)Binding capacity 20 μg
Ordering information
Product Preps Specification REFNucleoSpin® 96 DNA FFPE 1 x 96
4 x 96
NucleoSpin® DNA FFPE Binding Plate, MN Wash Plate, MN Square-well Block, Round-well Block, Rack of Tube Strips, Self-adhering Foil, Paraffin Dissolver, buffers, Proteinase K as above
740240.1 740240.4
Product accessories Pack of Specification REFNucleoVac 96 Vacuum Manifold 1 740681NucleoVac Vacuum Regulator 1 for controlling of vacuum 740641For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
Genomic DNA from FFPE samples
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Genom
ic DN
A
NucleoMag® DNA FFPE
Applications*Isolation of genomic DNA from formalin-fixed, paraffin-embedded samples (fresh or archived) with magnetic-bead technology
Features• Blue colored Paraffin Dissolver (patent pending) for convenient paraffin removal – no need for harmful organic
solvents• Removal of formalin crosslinking by efficient decrosslinking buffer – high-quality DNA for improved performance
in downstream applications (e.g., PCR)• Magnetic-bead technology – highest flexibility and easy adaption for automated use
Product at a glance
Parameter NucleoMag® DNA FFPE Technology Magnetic-bead technology Format Highly reactive superparamagnetic beads Processing Manual or automated Sample material < 5 mg tissue, < 15 mg paraffin Fragment size 50 bp–approx. 5 kbp Typical recovery Depending on amount and quality of sampleDNA quality Strongly depending on sample qualityElution volume > 25 μL Preparation time 120 min/96 preps Binding capacity 0.4 μg/μL beads
Ordering information
Product Preps Specification REFNucleoMag® DNA FFPE 1 x 96
4 x 96NucleoMag® B-Beads, buffers, Proteinase K as above
744320.1 744320.4
Material to be supplied by the user Pack of Specification REF E.g., Rack of Tube Strips (lysis tubes) 4 sets
24 sets
1 set consists of 1 rack, 12 strips with 8 tubes each, and 12 cap strips as above
740477 740477.24
Square-well Block (separation plate) 4 24
96-well blocks with 2.1 mL square wells as above
740481 740481.24
E.g., Elution Plate U-bottom (elution plate)
24 96-well microplates with 300 μL u-bottom wells
740486.24
Product accessories Pack of Specification REF NucleoMag® SEP 1 magnetic separator, for use with 96-well plates 744900 NucleoMag® SEP Mini 1 magnetic separator, for use with 1.5 mL or
2 mL reaction tubes (12 positions)740901
NucleoMag® SEP Maxi 1 magnetic separator, for use with 50 mL tubes (4 positions)
740902
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)
Genomic DNA from FFPE samples
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Gen
omic
DN
AGenomic DNA from forensic samples
NucleoSpin® Forensic Filters
Applications*Incubation and lysate separation of swabs, denim, cigarette butts, or other solid sample carriers
Features• Lysis and lysate separation in one tube – no sample transfer, no extra pipetting steps• Special filter design – absolutely leak-proof and compatible with all typical lysis buffers• Complete DNA recovery and maximum process reliability – no DNA loss• Collection Tube with lid – no cross-contamination
Product at a glance
Parameter NucleoSpin® Forensic Filters Technology Semi-permeable basket Sample material Swabs, denim, cigarette butts, others Maximum volume capacity 800 μL Forensic quality Ethylene oxide treated Typical downstream applications DNA purification (e.g., with NucleoSpin® Tissue, NucleoSpin®
Tissue XS, NucleoSpin® 8 / 96 Trace, NucleoMag® Forensic, NucleoMag® 96 Trace)
ProcedureSample preparation DNA purifi cation
Prepare
Place sample into fi lter and add lysis buffer
IncubateNucleic acids are released
without fi lter leakage
SeparateSpin fi lter to separate carrier
and to collect lysate
Follow up (e.g., NucleoSpin® / NucleoMag®
DNA isolation kits)
Ordering information
Product Preps Specification REFNucleoSpin® Forensic Filters 10
50
250
NucleoSpin® Forensic Filters with Collection Tubes (2 mL), blistered, ethylene oxide treated as above as above
740988.10 740988.50 740988.250
NucleoSpin® Forensic Filters (Bulk) 50
250 1000
NucleoSpin® Forensic Filters, Collection Tubes (2 mL), bulk packed, ethylene oxide treated as above as above
740988.50B 740988.250B 740988.1000B
For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.* Kits to be used for research purposes only (see page 15)** For more detailed information regarding the kits, please see the main Bioanalysis Catalog 2014 / 2015 or visit www.mn-net.com.
EO treated plastic materials
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Viral RN
A and DN
AViral RNA and DNA from serum and plasma
NucleoSpin® Virus
Applications*Purification of viral RNA and DNA from cell-free biological fluids (human or animal)
Features• Processing of up to 400 μL starting volume – maximal recovery of viral nucleic acids• Liquid Proteinase K included – convenient and highly efficient sample lysis
Product at a glance
Parameter NucleoSpin® Virus Technology Silica-membrane technology Format Mini spin columns Sample material < 200 μL serum, plasma, cell-free biological fluids
(< 400 μL with two loading steps)Fragment size 100 bp–approx. 50 kbp Elution volume 30 μL Preparation time 50 min/6 preps Binding capacity 25 μg Typical downstream applications qRT-PCR, qPCR, enzymatic reactions
Ordering information
Product Preps Specification REFNucleoSpin® Virus 10
50 250
NucleoSpin® Virus Columns with Collection Tubes, Collection Tubes (2 mL and 1.5 mL), buffers, Carrier RNA, Liquid Proteinase K as above as above
740983.10 740983.50 740983.250
Product accessories Pack of REF Liquid Proteinase K 5 mL ready-to-use liquid Proteinase K, recombinant 740396 For separate kit components see “Accessories” page 149 of the main catalog Bioanalysis 2014 / 2015.
* Kits to be used for research purposes only (see page 15)
One kit for viral RNA and DNA
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Acc
esso
ries
Accessories
EquipmentProduct Pack of Specification REF
NucleoBond® equipment NucleoBond® Smart Rack
1 for use with NucleoBond® Xtra Midi, Xtra Maxi, Xtra BAC, AX 20, AX 100, AX 500, AX 2000, and AX 10000 Columns
740413
NucleoSpin® equipmentStarter Set Midi 1 for processing NucleoSpin® Midi / L Columns
under vacuum on the NucleoVac 96 Vacuum Manifold or similar manifolds, contains 1 Col-umn Holder Midi, 1 Wash Plate Midi, 1 Elution Tube Holder, 24 Dummy Columns Midi
740744
NucleoMag® equipmentNucleoMag® SEP Mini
1 magnetic separator, for use with 1.5 mL or 2 mL reaction tubes (12 positions)
744901
NucleoMag® SEP Maxi
1 magnetic separator, for use with 50 mL tubes (4 positions)
744902
ConsumablesProduct Pack of Specification REF
NucleoSpin® consumablesNucleoSpin® Bead Tubes Type A
50 2 mL tubes with ceramic beads (as included in the NucleoSpin® Soil kit)
744786.50
NucleoSpin® Bead Tubes Type B
50 2 mL tubes with glass beads (as included in the NucleoSpin® Microbial DNA kit)
740812.50
NucleoSpin® Bead Tubes Type C
50 2 mL tubes with corundum (recommended for yeast disruption)
740813.50
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Trademarks used in this supplement
MACHEREY-NAGEL trademarksNucleoBond kits and cartridges for nucleic acid purification (anion-exchange chromatography)NucleoMag kits for purification of DNA and RNA (magnetic-bead technology)NucleoSpin kits for purification of DNA and RNA (silica-membrane technology)
Trademarks of other companiesRegistered trademarksNalgene Thermo Fisher Scientific Inc. (USA) KingFisher Thermo Fisher Scientific Inc. (USA)TrademarksPCR is patented by Hoffmann La Roche
DisclaimerAll used names and denotations can be brands, trademarks, or registered labels of their respective owner – also if they do not have a special denotation. To mention products and brands is only a kind of information, i.e., it does not offend against trademarks and brands and can not be seen as a kind of recommendation or assessment. Regarding these products or services, we can not grant any guarantees regarding selection, efficiency, or operation.
Product use restriction / WarrantyMACHEREY-NAGEL Bioanalysis products and their single components are intended, developed, designed, and sold FOR RESEARCH PURPOSES ONLY, except, however, any other function of the product being expressly described in original MACHEREY-NAGEL product leaflets.MACHEREY-NAGEL products are intended for GENERAL LABORATORY USE ONLY!MACHEREY-NAGEL products are suited for QUALIFIED PERSONNEL ONLY!MACHEREY-NAGEL products shall in any event only be used wearing adequate PROTECTIVE CLOTHING.For detailed information please refer to the respective Material Safety Data Sheet of the product!MACHEREY-NAGEL products shall exclusively be used in an ADEQUATE TEST ENVIRONMENT.MACHEREY-NAGEL does not assume any responsibility for damages due to improper application of our products in other fields of application.Application on the human body is STRICTLY FORBIDDEN. The respective user is liable for any and all damages resulting from such application.DNA / RNA / PROTEIN purification products of MACHEREY-NAGEL are suitable for IN-VITRO-USES ONLY! ONLY MACHEREY-NAGEL products specially labeled as IVD are also suitable for IN-VITRO-diagnostic use. Please pay attention to the package of the product. IN-VITRO-DIAGNOSTIC products are expressly marked as IVD on the packaging.IF THERE IS NO IVD SIGN, THE PRODUCT SHALL NOT BE SUITABLE FOR IN-VITRO-DIAGNOSTIC USE!ALL OTHER PRODUCTS NOT LABELED AS IVD ARE NOT SUITED FOR ANY CLINICAL USE (INCLUDING, BUT NOT LIMITED TO DIAGNOSTIC, THERAPEUTIC, AND / OR PROGNOSTIC USE).No claim or representations are intended for its use to identify any specific organism or for clinical use (included, but not limited to diagnostic, prognostic, therapeutic, or blood banking). It is rather in the responsibility of the user or – in any case of resale of the products – in the responsibility of the reseller to inspect and assure the use of the DNA/RNA/protein purifi-cation products of MACHEREY-NAGEL for a well-defined and specific application.MACHEREY-NAGEL shall only be responsible for the product specifications and the performance range of MN products according to the specifications of MN in-house quality control, product documentation, and marketing material.For detailed information on product use restriction and warranty, please refer to the respective user manuals.
Product use restrictionProduct use restriction
DNA, RNA, and protein purificationCatalog supplement 2016
Service BioanalysisTechnical Support and Customer Service phone
e-mail +49 (0) 24 21 [email protected]
Product Management phone
+49 (0) 24 21 969-275+49 (0) 24 21 [email protected]
Marketing Communication phone
+49 (0) 24 21 969-278+49 (0) 24 21 [email protected]
Sales phone
+49 (0) 24 21 969-274+49 (0) 24 21 [email protected]
OEM Sales phonee-mail
+49 (0) 24 21 [email protected]
Visit our Bioanalysis pages at www.mn-net.com
Your local distributor
MACHEREY-NAGEL GmbH & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · GermanyFrance:MACHEREY-NAGEL EURLTel.: +33 388 68 22 68Fax: +33 388 51 76 88E-mail: [email protected]
Switzerland:MACHEREY-NAGEL AGTel.: +41 62 388 55 00Fax: +41 62 388 55 05E-mail: [email protected]
Germanyand international:Tel.: +49 24 21 969-0Fax: +49 24 21 969-199E-mail: [email protected]
www.mn-net.com
www.mn-net.comMACHEREY-NAGEL
EN ISO 9001: 2008CERTIFIED
USA:MACHEREY-NAGEL Inc.Tel.: +1 484 821 0984Fax: +1 484 821 1272E-mail: [email protected]
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