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  1. 1. Developing Directions for Translational Biomedical Research at the University of Illinois Town Hall Forum
  2. 2. Agenda 1:00 p.m. Welcome and Introduction Charles Zukoski, Vice Chancellor for Research 1:10 p.m. Overview of Illinois Translational Research Activities Herbert Whiteley, Dean, College of Veterinary Medicine and Chair, Campus Translational Research Advisory Committee 1:20 p.m. NIH Roadmap for Medical Research William Heetderks, Associate Director for Scientific Programs at the National Institute of Biomedical Imaging and Bioengineering, NIH 2:20 p.m. Strategic Planning for Translational Research at Northwestern University Holly Falk-Krzesinski, Director, Life and Biomedical Sciences Strategic Initiatives, Northwestern University 2:30 p.m. Break 2:45 p.m. Panel Discussion with the Campus Translational Research Advisory Committee 4:00 p.m. Illinois Overview and Priorities Richard Herman, Chancellor and Jesse Delia, Acting Provost 4:15 p.m. Wrap-up Charles Zukoski, Vice Chancellor for Research 4:30 p.m. Adjourn
  3. 3. Campus Translational Research Advisory Committee (CTRAC) Committee Members Herbert Whiteley, Chair Sharon Donovan Albert Feng Tanya Gallagher Martha Gillette John Katzenellenbogen Charles Miller Lawrence Schook Bradford Schwartz Bruce Wheeler Jennifer Eardley
  4. 4. Charge of the CTRAC To develop a process for leading the campus toward a strategic plan for present and future investment in translational biomedical research that will impact human health and society.
  5. 5. CTRAC Process Initial Meetings Call for Campus Advice Focus Group Meetings Open Forum/Symposium Recommendations to Vice Chancellor for Research, Provost, and Chancellor
  6. 6. Translational Research Definitions: NIH Studies at the interface of the bench and bedside. Information flow at this interface is bi-directional, requiring close interaction between clinical and bench scientists. In translational research, clinical and bench scientists advance the diagnosis of disease and use their knowledge of natural history and pathogenesis to investigate the effects of novel interventions in early-phase clinical studies. Complementing these clinical studies are laboratory investigations of clinical specimens that contribute to a fuller understanding of the diseases, their etiology, pathophysiology, pathogenesis, diagnosis, and treatment. From Re-engineering the Clinical Research Enterprise NIH Roadmap Initiative www.nih.gov
  7. 7. Translational Research Definitions: UIUC those activities or resources that facilitate the ability of fundamental research to impact biomedical science and human health
  8. 8. Focus Groups Applied Social Sciences Discussion Leader: Tanya Gallagher (11 participants) Biosensors and Devices Discussion Leader: Al Feng (29 participants) Host-Microbe Interactions Discussion Leader: Charles Miller (16 participants) Bio-Imaging Discussion Leader: Bruce Wheeler (29 participants) Therapeutic Agents/Delivery Systems Discussion Leader: John Katzenellenbogen (24 participants) New Directions Discussion Leader: Herbert Whiteley (12 participants) Stem Cell Biology Discussion Leader: Lawrence Schook (15 participants) Medical Informatics Discussion Leader: Brad Schwartz (10 participants)
  9. 9. Questions for assessing Translational Research needs and opportunities What do you need in your area that would move your ideas toward application to the human condition? For example what facilities, resources or expertise are missing? Do you need a mechanism to identify areas of clinical relevance that could be applied to your area of interest? To move forward should we build on existing strengths or invest in new areas? What are our existing strengths? If we pursue new areas, what are the opportunities, is it feasible to pursue these opportunities?
  10. 10. Recommendations Communication Research Resources & Infrastructure People Space Long-term strategy
  11. 11. Communication Create a centralized service to facilitate internal and external interactions and assist faculty with related regulatory and ownership issues Encourage cross-disciplinary exchange through departmental seminars
  12. 12. Research Resources & Infrastructure Develop a strategic process for identifying necessary biomedical research facilities Provide seed funding for evaluating the translational potential of specific projects Develop strategic partnerships with clinical institutions Expand opportunities for partnership with NCSA on life sciences computing projects
  13. 13. People Recruit faculty investigators having the ability to bridge basic and clinical sciences through ongoing translational research programs Determine mechanisms for recognizing impact of translational and interdisciplinary research activities when evaluating faculty achievements Develop educational opportunities and training programs that expose students to the clinical research relevant to their basic science studies
  14. 14. Space Provide project-based swing space for researchers without ready access to wet-lab research space Identify a process to fund and construct a biomedical research building that mixes bioengineers, pathobiologists, clinician scientists, basic biologists, biological chemists and biophysicists
  15. 15. Long-term strategy Make biomedical research a priority for the next fund-raising campaign Fellowships ,facilities, programmatic support, professorships, and a biomedical building
  16. 16. Focus Groups Applied Social Sciences Discussion Leader: Tanya Gallagher Biosensors and Devices Discussion Leader: Al Feng Host-Microbe Interactions Discussion Leader: Charles Miller Bio-Imaging Discussion Leader: Bruce Wheeler Therapeutic Agents/Delivery Systems Discussion Leader: John Katzenellenbogen New Directions Discussion Leader: Herbert Whiteley Stem Cell Biology Discussion Leader: Lawrence Schook Medical Informatics Discussion Leader: Brad Schwartz
  17. 17. Applied Social Sciences Tanya Gallagher and Sharon Donovan Attendees Office of Translational Research Negotiate with clinical facilities Invest funds for faculty release & sponsor seminars Facilities Strengths
  18. 18. Biosensors and Devices Al Feng and Bruce Wheeler Illinois faculty experience in commercializing biosensor technologies Strength in sciences, engineering, computation Need for partnership/input from chemistry, life sciences Need problem definition/refinement from medicine
  19. 19. Host-Microbe Interactions Charles Miller and Larry Schook Support for pilot studies Better clinical interactions Better lines of communication Improved infrastructure Greater recognition for interdisciplinary work in the promotions process
  20. 20. BioImaging Bruce Wheeler and John Katzenellenbogen Great Engineering Strength MRI, ultrasound, biophotonics, image processing Biomolecular Imaging great expansion area Chemistry/pharmacology/pathology needs overlap those for drug delivery, sensors Potential for immediate medical applications Need improved collaborations with Mayo, Carle, Wash U, UIC
  21. 21. Therapeutic Agents/Delivery Systems John Katzenellenbogen & Martha Gillette Seek opportunity to link new chemical entities to animal models for evaluating efficacy and toxicity Marketing potential pharmaceuticals is facilitated by having pre-clinical data Work with IRB and IACUC to assist development and approval of human and animal use protocols Formalize UIUC-Carle/Provena/other partnerships to facilitate research protocol approval and address legal issues Develop a Research Residency Program to provide continuing research exposure/experience A biomedical research building could be a progenitor to an NIH- funded Translational Research Institute
  22. 22. New Directions Focus Group Herb Whiteley and Brad Schwartz Translational research is interdisciplinary issues with department cultures and promotion and tenure Recruitment of clinician scientists physicians/veterinarians Build on campus strengths Partnerships with institutions such as Mayo Clinic
  23. 23. Stem Cell Biology Larry Schook and Martha Gillette Intra-campus communications Regular meetings (every six months) Use IGB Theme for organization mechanism Develop website Seminar program Promote active collaborations/partnerships which link models with methodologies Distinguish ourselves by leveraging our strengths Interface of cells/tissues with biomaterials/substrates Bridging life sciences - chemistry - engineering/biomaterials ID extracellular cues/intracellular signaling Inducing tissue-specific stem cells to regenerate tissues
  24. 24. Medical Informatics Brad Schwartz and Tanya Gallagher Bioinformatics research and education cut across multiple disciplines and illustrate how difficult it is to capitalize on opportunities that do not conform to current departmental structures NCSA could be an important partner in the development of bioinformatics capabilities however, few faculty members understand the resources available through NCSA or how to interact with NCSA researchers
  25. 25. Developing Directions for Translational Biomedical Research at the University of Illinois Town Hall Forum Please send additional input to individual committee members or Vice Chancellor for Research Charles Zukoski http://www.research.uiuc.edu/translational
  26. 26. Developing Directions for Translational Biomedical Research at the University of Illinois Town Hall Forum