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ORIAL2, B-11, BLOK GASTROINTESTINAL SYS
DIAREAcute bloody diarrhoea
FAKULTAS KEDOKTERAN
UNIVERSITAS SUMATERA UTARA
MEDAN 200
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!EMI"U
D# $eora%& a%a' (ere)(ua% u)ur * tahu%#diba+a ibu%ya 'e !u$'e$)a$ de%&a% 'eluha%)e%cret $ela)a , hari- Fre'ue%$i lebih dari .'ali/hari- Ko%$i$te%$i cair# le%dir 1# darah 1-
De)a) 1 3 hari- Me%urut ibu%ya# D# $elalu)eri%&i$ $etia( 'ali a'a% 4A4- Dari(e)eri'$aa% 5$i'# D# terlihat hau$# le)ah#)ata terlihat ce'u%&# 6re'ue%$i %adi
078/)e%it# re&uler# te'a%a%/9olu)e 'ura%&#te)(teratur ,7#3:"- 4erat bada% $e'ara%& 7'&-
Apakah yang terja! paa "#
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MORE INFO
!e)eri'$aa% 5$i' dite)u'a% tur&or $eda%&#(e)eri'$aa% abdo)e% $oe(el# (eri$talti' u$u$)e%i%&'at- 4erat bada%& $ebelu) $a'it ; '&-!e)eri'$aa% a%o&e%ital<terlihat )erah da%
lecet di $e'itar a%u$- !e)eri'$aa% darah ruti%di=u)(ai leu'o$it 2000/)),- !e)eri'$aa% uri%dala) bata$ %or)al- !e)eri'$aa% 6aece$>darah 1# le%dir1# caci%& ?# 'i$ta
Entamoeba histolytica ?- O$ $udah diberi'a%'otri)o'$a@ol $ela)a , hari# %a)u% tida')e)bai'-
Baga!$ana penanganan paa " anpe$er!k%aan apa &ag! yang !per&'kan#
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MORE INFO 2
Kultur 6aece$ di=u)(ai Shi&ella $(-U=i $e%$iti9ita$>Kotri)o'$a@ol R
A$- Nalidi'$at S
A)(icilli% R
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I!OTESA
•A%a' D )e%&ala)i diare a'ut• A%a' D )e%&ala)i dehidra$i
• A%a' D )e%derita di$e%tri
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ANALISIS MASALAFre'ue%$i!eri$talti'Me%cret
Te%e$)u$Leu'o$ito$i$De)a)Fe$e$
De)a)Fre'ue%$iLeu'o$ito$i$
Te%e$)u$!eri$talti'Fe$e$Me%cret
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LEARNINB ISSUE
- A%ato)i da% hi$tolo&i u$u$ halu$ da% u$u$ be$ar
2- Fi$iolo&i u$u$ halu$ da% u$u$ be$arbe$erta hor)o%?hor)o% da% e%@i) ya%& terlibat
,- De5%i$i# e(ide)iolo&i da% 6a'tor re$i'o diare
C- Kla$i5'a$i da% etiolo&i diare
3- !ato&e%e$i$ diare ya%& di$ebab'a% Entamoebahistolytica da% Shigella spp.
*- !ato5$iolo&i diare
.- Dia&%o$i$ da% (e)eri'$aa% (e%u%=a%& diare
7- Dia&%o$i$ ba%di%& di$e%tri;- Dehidra$i da% (e%atala'$a%aa%%ya
0-!e%atala'$a%aa% diare $ecara u)u)
-Ko)(li'a$i diare
2-!e%ce&aha% da% (ro&%o$i$ diare
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ANATOMI USUS ALUS
•Duode%u)• e=u%u)
• Ileu)
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DUODENUM The 5r$t (ortio% o6 the $)all i%te$ti%e +hich i$
directly a%d 5r)ly attached to the (o$terior
abdo)i%al +all "o%$i$t > ? (ar$ $u(erior $horte$t (ortio%
? (ar$ de$ce%de%$
? (ar$ i%6erior 4e%d$ arou%d )ar'edly to the ri&ht a%d 6or+ard to
&o o9er i%to the i%te$ti%u) =e=e%u)e8uraduode%o=e=u%ali$
I% the )uco$a (re$e%t a lo%&itudi%al 6old (lica
lo%&itudi%ali$ duode%i a%d $)all (ro=ectio% u(o%+hich o(e% the ductu$ choledocu$ a%d ductu$(a%creaticu$ (a(illa Vateri
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EENUM AND ILEUM
I%6ro%t a%d lateral+ard =e=e%u) a%d ileu) i$ co9eredby the &reat o)e%tu) o)e%tu) )a=u$
The )ucou$ )e)bra%e (re$e%t$ the $(ecial $tructur > !lica circulari$Kerc'ri%& >
? the co%$ta%t 6old
? I% =e=e%u) # they are lo%&er a%d hi&her tha% i%ileu)
Ly)(h %ode
? i% =e=e%u)# they are u$ually $i%&le %odulily)(hatici $olitary
? i% ileu)# they are %u)erou$ a%d hi&her a%d i% (artare cro+ded toðer # Peyer Patcher %odulily)(hatici a&re&ati
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ISTOLOBI USUS ALUS
LAYER "ES(RI)TION
MU"OSA E!ITELIUM SURFA"E A4SOR!TIVE "ELLS#BO4LET "ELLS# DNES "ELLS# M MI"ROFOLD"ELLSLAMINA !RO!RIA "ORE OF VILI# TU4ULAR
BLANDS# STEM "ELLS# !ANET "ELLSMUS"ULARIS MU"OSAE INNERENTER VILI#EGTEND ITS "ORE H OUTER
SU4MU"OSA DENSE# IRREBULAR FI4ROELASTI" "ONNE"TIVE TISSUE IT 4LOOD H LJM! VESSELS
MUS"ULARISEGTERNA SMOOT MUS"LE FI4ERS "IR"ULAR#LONBITUDINAL
SEROSA/ADVENTITIA
TIN SEROSA
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Ba)bar hi$tolo&i u$u$ halu$
• duode%u)• ileu)• =e=u%u)
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MO"I*I(ATIONS
• !LI"AE "IR"ULARESVALVES OF KER"KINB – TRANSVERSE FOLD OF
MU"OSA H SU4MU"OSA TAT FORM SEMI"IR"ULAR
TO ELI"AL ELEVATIONS• VILI
– E!ITELIALLJ "OVERED#FINBER?LIKE OR OAK LEAF?LIKE !ROTRUSIONS OFLAMINA !RO!RIA
• MI"ROVILI – A!I"AL INTESTINAL
E!ITELIUM "ELLMEM4RANE
S)E(I*I( *EATURES
• DUODENUM – 4RUNNERS
DUODENAL BLANDSIN SU4MU"OSA
• EUNUM – !LI"AE "IR"ULARES
• ILEUM – !EJERS !AT"ES
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"ELLS FUN"TION
SUR*A(E ABSOR)TI+E (ELLSENTERO(YTES
• TALL "OLUMNAR "ELLS#OVAL NU"LEUS ALF4ASALLJ LO"ATED
• A!EG> OMOBENOUSLAJER4RUS 4ORDER
• FOR TERMINAL DIBESTIONH A4SOR!TIONS OF O H
NUTRIENT• SE"RETEDISA""ARIDASES H!E!TIDASES
GOBLET (ELLS
• INTERS!ERSED 4ETEENA4SOR!TIVE "ELLSUN"ELLULAR BLANDS
• IN DUODENUM# ILEUM
• !RODU"E BLJ"O!ROTEINMU"IN MU"US
• MU"US> !ROTE"T HLU4RI"ATE LININB OFINTESTINE
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M MI(RO*OL"(ELLS
• SUAMOUS LIKE
"ELLS S!E"IALIPEDA4OVE TE LJM!OIDNODULE
• IM!ORTANT FOR
DEFENSE ME"ANISM• 4ASEMENT UNDER
TESE "ELLS ARE!OROUS FA"ILITATE
TRANSIT OF "ELLS
)ANET. (ELLS
• LO"ATED AT 4ASAL
!ORTION OFINTESTINAL "RJ!TS#!JRAMID?SA!E
• EGO"RINEQ LARBE#
EOSINO!ILI"SE"RETORJBRANULESA!I"AL"JTO!LASM
LJSOPOME#!OS!OLI!ASE A#DEFENSINS
• INNATE IMMUNITJ
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ANATOMI USUS 4ESAR
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LARBE INTESTINE
- Follo+i%& u(o% the $)all i%te$ti%e# it$ be&i%$ a$ thei%te$ti%u) caecu) i% the 6o$$a iliaca de8tra
2- !art o6 lar&e i%te$ti%e>•. "aecu)
•. "olo% a$ce%de%$
•. "olo% tra%$9er$u)
•. "olo% de$ce%de%$
•. "olo% $i&)oideu)
,- The (ortio% 6ro) the caecu) to the rectu) i$ called thecolon
C- The lar&e i%te$ti%e i$ caracteri@ed# it$ $ur6ace i$ %ot $)oothly
cyli%drical# but (re$e%t$ a %odular a((eara%ce due to thethree ro+$ o6 irre&ular# a$' li'e (ro=ectio%Q haustra
3- The$e ro+$ o6 hau$tra are $e(arated 6ro) o%e a%other bythree ba%d$? li'e $tri($ o6 the lo%&itudi%al )u$cleQ taenia coli
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"AE"UM
The bli%d?$ac?li'e (ortio% o6 the lar&e i%te$ti%e$ituated belo+ the o(e%i%& o6 the ileu) i%to the
lar&e i%te$ti%eI% the 6or)atio% o6 thi$ the ter)i%al (ortio% o6 the$)all i%te$ti%e i$ i%9a&i%ated i%to the lar&e i%te$ti%eca9ity
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A!!ENDIG VERMIFORMIS
A%arro+ # &e%erally cyli%drical# hollo+# bli%d e%di%&o6 the caecu)-
Le%&th a9era&e 7#3 c)
"OLON AS"ENDENS
• 4e&i%$ at the 6re%ula 9al9ulae coli a$ the directco%ti%uatio% o6 caecu)
"OLON TRANSVERSUM
Ru%$ out to the le6t a%d $o)e+hat u(+ard 6ro) thee8ura coli de8tra o9er the )eedia% (la%e i% acur9e co%9e8 6or+ard a%d at the $a)e ti)edo+%+ard a%d &oe$ o9er i%to the colo% d$ce%de%$
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"OLON DES"ENDENS
A de$ce%di%& li)b o6 colo%
"OLON SIBMOIDEUM
Ter)i%al (ortio% o6 colo% # ha%&$ a$ a loo( &e%erallydo+% i%to the ca9ity o6 $)all (el9i$ a%d &oe$ o9er i%6ro%t o6 the $acru) i%to the rectu)
RE"TUM
Ter)i%al (ortio% o6 the di&e$ti9e tube +hich e8te%d$6ro) the colo% $i&)oideu) throu&h the i%6erior +all
o6 the $)all (el9i$ to the i%6erior o(ei%& a%u$
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ISTOLOBI USUS 4ESARA))EN"I/ (AE(UM0(OL
ONANAL (ANAL
MU"OSA E!I > SIM!LE"OLUMNARLAMINA !RO!RIA
E!I > SIM!LE"OLUMNARLAMINA > ENDOED"RJ!TS OFLIE4ERKUN# NO
!ANET"ELLS#A4SOR!
TIVE# BO4LET HDNES "ELLS
E!I>SIM!LE"U4OIDAL# STRS NONKERATINIPED#STR SKERATINIPED
LAMINA> ANALBLANDS#"IR"UMANALBLANDS
SU4MU"OSA FI4ROELASTI" TISSUE# VENOUS!LEGUS
MUS"ULARIS OUTER LAJERBATERED 4J
TAENIA "OLI
TI"KENEDINNER LAJER
SEROSA/
ADVENTITIA
A!!ENDI"ES
E!I!LOI"AEQ FATFILLED !OU"ES
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Ba)bar hi$tolo&i u$u$ be$ar da% a(e%di'$
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DEFENISI DAN E!IDEMIOLOBI DIARE
• Me%urut O# diare adalah bua%& air be$ar, 8/2C =a)# de%&a% 'o%$i$te%$i cair- Ja%&(ali%& (e%ti%&> 'o%$i$te%$i ti%=a cair# 1/?le%dir atau darah-
• E(ide)iolo&i diare>? * =uta a%a' )e%i%&&al/tahu%
? . 'e)atia% a%a' di du%ia a'ibat diare
? Di I%do%e$ia> Diare adalah (e%yebab'e)atia% a%a' terba%ya' C2
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FAKTOR RESIKO DIARE
- U)uri%$ide%$ terti%&&i u$ia *? bula%
2- I%6e'$i a$i)(to)ati'
,- Mu$i)
C- y&ie%e
3- I%tolera%$i la'to$a
*- Va'$i% rota9iru$
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ETIOLOBI DIARE
• Tida' 'ura%& dari 23 =e%i$ )i'roor&a%i$)eda(at )e%yebab'a% diare (ada bayi da%a%a'-
• !e%yebab uta)a> 9iru$# ba'teri# da% (ara$it
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DIARROEA
INFLAMMATION
NONINFLAMMATION
INFE"TION ? VIRAL? FUNBAL
? 4AKTERIA? !ARASITE
NON INFE"TION ? ALLERBJ? etc
? ORMONAL? ANATOMI"AL? etc
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Bolo%&a% ba'teri
• Aero)o%a$
• 4acillu$ $ereu$
• "a)(ylobacter =e=u%i
• "lo$tridiu) (er6ri%&e%$
• "lo$tridiu) decile
• E$cherichia coli
• !le$io)o%a$ $hi&eloide$
• Sal)o%ella
• Shi&ella• St(hylococcu$ aureu$
• Vibrio cholera
• Vibrio (arahae)olyticu$
• Jer$i%ia e%terocolitica
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Bolo%&a% 9iru$
• A$tro9iru$
• "alci9iru$%oro9iru$#$a(o9iru$
• E%teric ade%o9iru$
• "oro%a9iru$
• Rota9iru$
• Nor+al' 9iru$
• er(e$ $i)(le8 9iru$
• "yto)e&alo9iru$u)u)%ya ter=adi ha%ya (ada (e%derita
i)u%oco)(ro)i$ed
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Bolo%&a% (ara$it
• 4ala%tidiu) coli
• 4la$tocy$ti$ ho)o%i$
• "ry(to$(oridiu) (ar9u)
• E%ta)oeba hi$tolytica
• Biardia la)blia
• I$o$(ora belli
• Stro%&yloide$ $tercorali$
• Trichuri$ trichiura
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• Diare 'ar%a 9iru$ > 9iru$ )e%&i%6e'$i da%)e%&ha%cur'a% $el?$el u=u%&?u=u%& 9illu$
(ada u$u$ halu$• Diare 'r% ba'teri yer=adi )elalui $alah $atu
)e'a%i$)e ya%& berhubu%&a% de%&a%
(e%&atura% tra%$(or io% dala) $el $elu$u$ cAM!#cBM!#da% "a de(e%de%
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!e%yebab diare %o% i%6e'$i• Ke$ulita% )a'a%
• De6e' a%ato)i$
?)alrota$i? (e%ya'it hirch$(ru%&
? $hort bo+el $y%dro)e
? atro5 )i'ro9illi
? $tricture
• Malab$or($i
? de5$ie%$i di$a'arida$e? )alab$orb$i &lu'o$a?&ala'to$a
? cy$tic 5bro$i$
? chole$to$i$
? (e%ya'it celiac
• E%do'ri%o(ati
? thyroto'$i'o$i$
? (e%ya'it addi$o%
? $i%dro)a adre%o&e%ital
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• Keracu%a% )a'a%a%
? lo&a) berat
? )u$hroo)$
• Neo(la$)a
? %eurobla$to)a
? (haeochro)ocyto)a
? $i%dro)a @olli%&er elli$o%
• Lai%2? i%6e'$i %o%&a$troi%te$ti%al
? aler&i $u$u $a(i
? (e%ya'it croh%
? de5$ie%$i i)u%? coliti$ ul$ero$a
? &a%&&ua% )otilita$ u$u$
? (ella&ra
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Diare 'ro%i$
Di %e&ara )a=u lebih 'are%a i%tolera%$i (rotei%$u$u $a(i/'eledaiQceliac di$ea$e&lute%?$e%$iti9e e%tero(athyda% cy$tic 5bro$i$
T( da(at ber)ula dari diare a'ut a'ibat i%6e'$i
$alura% cer%a-
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KLASIFIKASI DIARE
• U)ur
• O%$et
• Etiolo&i
• Ke(araha%
• o$t de6e%$e
• !ato&e%e$i$
• Su)ber i%6e'$i
• Te)(at (atolo&i• O 2003
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Me%urut u)ur
• Neo%atal diare > diare (ada %eo%atu$ 27hari
• I%6a%tile diare > diare (ada bayi
• "hildhood diare > diare (ada a%a'2 tahu%
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Me%urut o%$et
• Diare a'ut > .hari ;0?;3
• Diare (rolo%&ed )e%eta(> .?C hari
• Diare 'ro%i$ > C hari
)e%urut etiolo&i• I%a)a$i > i%6e'$i da% %o% i%6e'$i
• No% i%a)a$i
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Me%urut 'e(araha%%ya
• Diare ri%&a% > 8/2 =a) atau 3)l/'&bb/=a)
• Diare berat > =a) atau 3 )l/'&bb/=a)
Me%urut ho$t de6e%$e• I)u%oco)(ote%t
• I)u%oco)(ro)i$ed> AIDS# Leu'e)ia
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Me%urut(ato&e%e$i$%ya
A4SOR!TIVE/OSMOTI"SE"RETORJ- FASTINB STO!S
"ONTINUES
2- STOOLS OSM- C00270
,- Na 1 ,000
C- K 1 ,0C0
3- Na1K8 2 20270
*- SOLUTE BA! 270
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Me%urut $u)ber i%6e'$i%ya
• No$o'o)ial> i%6e'$i%ya 'e%a di RS
• "o))u%ity> dari li%&'u%&a%/)a$yara'at
Me%urut e(ide)iolo&i
• E%de)i'> $elalu ada tia( $aat• E(ide)i'> 'e=adia% )elebihi 'e=adia% bia$a
• ca)(ura%
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Me%urut te)(at (atolo&i%ya
• U$u$ halu$> cholera#rota9iru$
• U$u$ be$ar > $hi&olo$i$#a)oeba$i$
• Kedua dua%ya >ca)(hylobacterio$i$#$al)o%ello$i$
Me%urut O tahu% 2003• Diare a'ut
• Diare (er$i$te%t
• 4e%tu' di$e%tri• Diare de%&a% 'e(araha%
• )al%utri$i
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Ti(e Ti(e
!ATOBENESIS DIARE AKI4AT Shigella spp.
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Shigella spp.
• Shigella spp. )eru(a'a% )odi5'a$i dari E.coli- E.coli )e%&ala)i e9olu$i (ada &e%oti(e da% 6e%oti(e 9irule%$i%yada% )e%=adi Shi&ella- Shi&ella adalah ba'teri bata%& &ra)%e&ati6 %o% )otil $ehi%&&a ha%ya )e)ili'i a%ti&e% O# tida')e)ili'i a%ti&e% Fa&el-
• Fe$e$ ora%& ya%& teri%6e'$i Shi&ella bi$a )e%&a%du%& 0*?07 Shi&ella (er &ra)- Shi&ella a'a% taha% (adali%&'u%&a% luar $ela)a , hari? )i%&&u-
• !ort de%tre Shi&ella>
? La%&$u%&> dari ora%& 'e ora%&
? Tida' la%&$u%&> 6e'al?oral )elalui )a'a%a% ya%&
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SaatMa'ro6a&e
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SaatMa'ro6a&e
Rea'$i i%a)a$i da% to'$i% Shi&ella ber$a)a?$a)a )e%yebab'a% 'eru$a'a% =ari%&a% ya%& lebih
(arah la&i
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Vi l i
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Virule%$i
!ATOBENESIS DIARE AKI4AT
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!ATOBENESIS DIARE AKI4ATEntamoeba histolytica
• 4e%tu' i%6e'ti6> 'i$ta )ata%& ya%& terda(at(ada ora%& $ehat- Ki$ta da(at hidu( la)adala) air0?C hari# li%&'u%&a% le)bab2hari da% )ati (ada $uhu 30:" da% dala)
'eadaa% 'eri%&-• 4e%tu' (ato&e%> hi$toliti'a-
• 4e%tu' dia&%o$ti'> 'i$ta beri$i e%ta)oebadala) 6e$e$-
Ki$ta
4e%tu'
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4e%tu'
!ATOFISIOLOBI DIARE
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!ATOFISIOLOBI DIARE
• Diare o$)oti'
• Diare $e'retori'
• Diare e'$udati6
• Diare 'are%a &a%&&ua% )otilita$
Di ti'
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Diare o$)oti'
• 4aha% ya%& tida' da(at di$era(
)e%i%&'at'a% o$)olarita$ dala) ro%&&a u$u$hi%&&a a'a% )e%ari' air da% ele'trolit dari(la$)a 'e ro%&&a u$u$- Ma'a #=adilah diare
• "o%toh > I%tolera%$i )a'a%a%# +a'tu(e%&o$o%&a%la)bu%& ya%& ce(at# de5$ie%$i e%@i)la'ta$e#
la'$a% o$)oti'
Di ' t i'
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Diare $e'retori'
• To'$i% ya%& di'eluar'a% ba'teri to'$i% 'olera#
(e%&aruh &ara) e)(edu# hor)o% i%te$ti%al$e(erti &a$tri% 9a$oacti9e i%te$ti%al (oli(e(tide VI!)e%yebab'a% &a%&&ua% tra%$(ort caira% ele'trolit # di)a%a ab$or($i 'ura%& dari $e're$i-
• To'$i% )e%$ti)ula$i cAM! da% cBM! hi%&&a)e%$ti)ula$i $e're$i caira% da% ele'trolit-
• A'ti6> &a%&&ua% alira%ab$or($i dari lu)e% u$u$ 'edala) (la$)a atau (erce(ata% caira% air dari (la$)a'e lu)e%-
• !a$i6> te'a%a% hidro$tati' dala) =ari%&a% 'are%a ter=adie'$(a%$i air dari =ari%&a% 'e lu)e% u$u$- "o%toh >(e%i%&&ia% te'a%a% 9e%a )e$e%terial# ob$tru'$i $i$te)li)6ati'# i$'e)ia u$u$# (ro$e$ (erada%&a%-
Di ' d ti6
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Diare e'$udati6
• Keru$a'a% )u'o$a u$u$ halu$ atau u$u$
be$ar a'ibat (ro$e$ i%a)a$i-
• I%a)a$i H e'$uda$i da(at ter=adi a'ibati%6e'$i ba'teri# %o% i%6e'$i &lute% $e%$iti9e
e%tero(athy# I4D# atau a'ibat radia$i-• "o%toh > 'oliti6 ul$ero$a# (e%ya'it "roh%#
a)ebia$i$# $hi&ello$i$# i%6e'$i ca)(ylobacter#i%6e'$i yer$i%ia-
Di ' tilit
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Diare 'are%a &a%&&ua% )otilita$
• Ba%&&ua% (ada 'o%trol oto%o)i'
)e%yebab'a% +a'tu ta%$it u$u$ )e%=adilebih ce(at
• Mi$al%ya (ada diabeti' %euro(ati# (o$t
9a&oto)i# (o$t re$e'$i u$u$# hi(ertiroid#tiroto'$i'o$i$# $i%dro)a u$u$ iritabel-
! t 5 i l i Di
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!ato5$iolo&i Diare
DIABNOSIS DAN !EMERIKSAAN !ENUNANB DIARE
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DIABNOSIS DAN !EMERIKSAAN !ENUNANB DIARE
• A%a)%e$i$
• !e)eri'$aa% 5$i'
• !e)eri'$aa% darah ruti%
• !e)eri'$aa% uri%
• !e)eri'$aa% 6e$e$• !e)eri'$aa% radiolo&i
A%a)%e$i$/History Taking
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A%a)%e$i$/History Taking
• Autoa%a)%e$i$ H aloa%a)%e$i$
• Keluha% uta)a
diare >4ua%& air be$ar e%cer/$e)i?$olid ,
'ali/hari atau 200&/hari
Le%dir#darah#)u%tah boleh ada/tida' ada
• Ditelu$uri 'eluha% uta)a ri+ayat (e%ya'itdiare >
La)a%ya $a'it diare
Fre'ue%$i
Volu)e
ar%a H bau
4atu'#(ile'#'e=a%& $ebelu)#$ela)a#$etelah
diare
• Keluha% ta)baha% a'ibat diare da%
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Keluha% ta)baha% a'ibat diare da%dehidra$i >
au$
Le)ahMata terlihat ce'u%&
Meri%&i$ / ce%&e%& / &eli$ah
%a6$u )a'a% )e%uru%Ubu%?ubu% be$ar ce'u%&
To%u$ H tur&or 'ulit berubah
Sela(ut le%dir )ulut H bibir 'eri%&
• Ri+ayat 'e$ehata% )a$a lalu hi$torydiare (ada (a$ie% H (e%ya'it lai%
• Ri+ayat )a'a% / )i%u) (ola H aler&i
•
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!e)eri'$aa% Fi$i'• Te'a%a% darah hi(ote%$i ortho$tati'
• De%yut %adi• Te)(eraturfever moderate to severe)
• 4erat bada%
• !e)eri'$aa% 5$i' abdo)e% (eri$talti'u$u$ )e%i%&'at
• !e)eri'$aa% a%o&e%ital )erah H lecet$e'itar a%u$
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!e)eri'$aa% Laboratoriu)• Darah leu'o$it
• Leu'o$ito$i$ i%6e'$iW• Ele'trolit dala) darah
• Uri%
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!e)eri'$aa% Lai%• "olo%o$co(y (e)eri'$aa%
)e%&&u%a'a% e%do$'o( (ada 'olo%)elalui re'tu)
• !a%=a%& 2)eter
• Me%&e9alua$i i%6e'$i / ab%or)alita$$tru'tur 'olo% =u&a da(at &u%a'a% Gray /"T Sca%
• Hydrogen breath test )alab$orb$i &ula
• Si&)oido$co(y i%$(e'$i colo%)e%&&u%a'a% tube ya%& ti(i$'a)era didala)
• u&a da(at )e%&u)(ul $el/=ari%&a%
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!e)eri'$aa% Ti%=a• Volu)e ti%=a %or)al > 00?,00&/hari
• Ko)(o$i$i
.0 hari#,0 $i$a )a'a%a% H 'u)a%• Ma'ro$'o(i$ bau#'o%$i$te%$i#'eberadaa%
darah#(ara$it
• Mi'ro$'o(i$ $ele(itel#)a'ro6a&#le'o$it#eritro$it#'ri$tal#$i$a )a'a%a%#$el
ra&i#telur H =e%ti' caci%&#(roto@oa• Le%dir di ba&ia% luar ti%=a irita$i u$u$ be$ar
• Le%dir berca)(ur ti%=a irita$i (ada u$u$ halu$
• Malab$orb$i le)a'/(rotei% 9ol-be$ar#berbau
• Si%dro)a (ada u$u$ be$ar
ra(uh de%&a% darah da%le%dir
• E-coli / 'eracu%a% hita)#)udah )ele'at#9olu)ebe$ar#cair
• Shi&ella (erdaraha% ri%&a%/berat#%yeri (erut#berat
bada% )e%uru%
i' i' bi l i
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!e)eri'$aa% Mi'robiolo&i
• Kultur / (e)bia'a% >
S(e$i)e% 6e$e$ di)a$u''a% 'e dala))edia u%tu' )e)beri 'e$e)(ata%'u)a%/(ara$it (atolo&i$ tu)buh H
ber'e)ba%&
ide%ti5'a$i =e%i$ da% =u)lah 'u)a%
• Te$ $e%$iti9ita$ >
Me%&u=i $e%$iti9ita$ 'u)a% (ato&e%
terhada( a%tibioti'aMe)ba%tu dala) (e)iliha% obat a%ti?
'u)a% ya%& terbai' dala) (e%&obata%
i%6e'$i
• !e)eri'$aa% &ra) >
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• !e)eri'$aa% &ra) >
!e)eri'$aa% )or6olo&i 'u)a%/=a)urde%&a% (e+ar%aa% u%tu'ide%ti5'a$i#'u)a% &ra) (o$iti6 atau%e&ati6
• !e)eri'$aa% =a)ur >
!e)eri'$aa% terhada( =e%i$ =a)ur(ato&e% H o((ortu%i$ti'
Te$ 'o)(li)e% ide%ti5'a$i a%tiboditerhada( =a)ur
"a%dida (e)eri'$aa% complementation
• Ide%ti5'a$i 9iru$ >
Te$ $erolo&i$
!ENATALAKSANAAN NON FARMAKOLOBI DIARE
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!ENATALAKSANAAN NON FARMAKOLOBI DIARE
• !erbai'a% &i@i
- !e)beria% )a'a%a% $e(erti bia$a
- Vita)i% A
- a%&a% beri'a% )a'a%a% berle)a'
• 4ed re$t
!ENATALAKSANAAN FARMAKOLOBI
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DIARE• Pi%c
• A%tibioti'a
• Ad$orbe%
• A%ti)otilita$
• 4i$)uth
Pi%c
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Pi%c
• De5$ie%$i @i%c $eri%& di %e&ara ber'e)ba%& )e%uru%%ya 6u%&$i i)u% da%)e%i%&'at%ya 'e=adia% i%6e'$i-
• Mi'ro%utrie% 'o)(o%e% (e%ti%& e%@i) dala)tubuh H u%tu' $i%te$i$ DNA-
• Me%uru%'a% i%$ide% diare $eba%ya' 3-• 20 )& (erhari $ela)a 0 C hari da% (ada
bayi * bula% 0 )& (erhari $ela)a 0 Chari-
A%tibioti'a
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A%tibioti'a
• a%ya $eba&ia% 'ecil ya%& di$ebab'a% oleh
ba'teri (ato&e%-• Kebia$aa% %ya diare i%6e'$i adalah rota9iru$
ya%& tida' da(at dibu%uh de%&a%
a%ti)i'roba-
Penyebab Antibiotik pilihan Alternatif
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y p
Kolera Tetracycline
12,5mg/kg
!" #ehari #elama $ hari
%rythromycin
12,5mg/kg
!" #ehari #elama 5 hari
&higella 'y#entry (iproflo"acin
15mg/kg
2" #ehari #elama $ hari
Pi)mecillinam
2*mg/kg
!" #ehari #elama 5 hari
(eftria"one
5*-1**mg/kg1" #ehari + #elama 2-5 hari
Amobia#i# etroniaole
$" #ehari #elama 5 hari
iaria#i# etroniaole$" #ehari #elama 5 hari
Ad$orbe%
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Ad$orbe%
• "o%toh> 'aoli%# atta(ul&ite# $)ectite#
chole$tyra)i%e-• Me%&i'at da% )e%&i%a'ti9a$i to'$i% ba'teri
atau baha% lai% ya%& )e%yebab'a% diare-
• Ma)(u )eli%du%&i )u'o$a u$u$-
A%ti)otilita$
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A%ti)otilita$
• "o%toh> lo(era)ide hydroclhoride# tu%ctura
o(ii# (are&oric# codei%-• Me%&ura%&i 6re'ue%$i diare (ada de+a$a da%
tida' (ada a%a'-
• Me)(er(a%=a%& i%6e'$i de%&a%)e)(erla)bat eli)i%a$i dari or&a%i$)e(e%yebab-
4i$)uth $ub$alicylate
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4i$)uth $ub$alicylate
• 4ila diberila% $etia( C =a) da(at )e%&ura%&i
'eluara% ti%=a (ada a%a' de%&a% diare a'ut$eba%ya' ,0# a'a% teta(i cara i%i =ara%&di&u%a'a%-
Kotri)o'$a@ol
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Kotri)o'$a@ol
• Obat a%tiba'teri ya%& )e%&a%du%&
$ul6a)etho8a@ole da% tri)etho(ri)-• Sa%&at $eri%& di&u%a'a% u%tu' )e%&obati
i%6e'$i dari uri%ari# re$(iratori da%
&a$troi%te$ti%al-
A$a) %alidi'$at
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A$a) %alidi'$at
• A%tibioti'a $i%teti' $e(erti ci(roo8aci%#
oo8aci%-• 4erti%da' de%&a% i%a'ti9a$i e%@i)# DNA
&yra$e ya%& (e%ti%& u%tu' re(li'a$i
)i'roor&a%i$)e-• Seri%& di&u%a'a% u%tu' or&a%i$)e ya%&re$i$te% (ada a%tibioti'a-
A)(icili%
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A)(icili%
• A%tibioti'a ya%& da(at )e%&obati ba%ya'
)aca) i%6e'$i ter)a$u' di uri%ari#re$(iratory da% $alur i%te$ti%al-
• Di i%a'ti9a$i oleh (e%icilli%a$e da% tida'
boleh di&u%a'a% (ada )i'roor&a%i$)e ya%&bi$a )e)(rodu'$i e%@i) i%i-
KOM!LIKASI DIARE
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KOM!LIKASI DIARE
• Dehydratio% Dehydratio%?e8ce$$i9e lo$t o6 body uid?)o$t 6atal co%ditio%?)ore
da%&erou$ % co)o% i% childre% % i%6a%t$-
Di)i%i$hed uri%e out(ut
'id%ey 6ailure#
"o%6u$io%
*aea& !n3nt!nene4 Failure o6 9olu%tary co%trol o6 the a%al%ph!nter%# +ith i%9olu%tary (a$$a&e o6 5ee% a%d 6at'%
Ma&n'tr!t!3n
A!3%!%
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A!3%!%
E&etr3&yte% $!nera&% a&%3 are &3%t 7!th 7ater7hen !arrhea !% pr3&3nge 3r %e8ere, an
$!nera& 3r e&etr3&yte e9!en!e% $ay 3'r:The $3%t 3$$3n e9!en!e% 3'r 7!th%3!'$ an p3ta%%!'$
.yp3$agne%e$!a4 S';n3r$a& ;&33 %er'$
3nentrat!3n 35 $agne%!'$< $ay a'%e3n8'&%!3n% an 3n'rrent hyp3a&e$!a
-hyp3$g a5ter pr3&3nge !arrhea an a'%etetany
.yp383&e$! %h3k
.yp3ka&e$!a
.yp3a&e$!
(ar!a y%rhyth$!a% 'e t3 hyp3ka&e$!a an
h!p3ka&%e$!
!ROBNOSIS DIARE
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!ROBNOSIS DIARE
• De%&a% (e%&&a%tia% caira% ya%& ade'uat#
(era+ata% ya%& )e%du'u%&# da% tera(ia%ti)i'robial =i'a dii%di'a$i'a%# (ro&%o$i$diare i%6e'$iu$ ha$il%ya $a%&at bai' de%&a%)orbidita$ da% )ortalita$ ya%& )i%i)al-
!EN"EBAAN DIARE
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!EN"EBAAN DIARE
• 4rea$t6eedi%&
• I)(ro9ed 6eedi%& (ractice$
• U$e o6 $a6e +ater
• a%d+a$hi%&
• Food $a6ety
• U$e o6 latri%e$ a%d $a6e di$(o$al o6 $tool$
• Mea$le$ i))u%i@atio%
KESIM!ULAN
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KESIM!ULAN
A%a' D )e%&ala)i !cute bloody diarrhea
a'ibat i%6e'$i Shigella da% berada dala)'eadaa% dehidra$i ri%&a%?$eda%&-
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TERIMA KASI