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CANCER: SOME CELLS DON'T KNOW WHEN TO STOP AND DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTSLaura Barrientos
Third semester
Medical student
INTRODUCTION
Central dogma of genetic information:
DNA replication:
ProteinsRNADNA
DNA is replicated from
its same moldRNA is replicated from a
DNA`s mold
Proteins are synthesized from RNAm`s mold
In this process a
DNA molecule
synthesize a new DNA molecule
This process
occurs in the phase S of the cell
cycle
This is important because if there is a mistake, occurs a mutation
CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
Cancer arises from DNA damage in
fragile sites in the genome, like
repetitive sequences.
CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
B cells lymphocytes are the cells that have more
risk to have DNA damage.
Also by the AID
The rason is because they divide rapidly.
CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
Early replicating frgile sites (ERFSs)
are AID-independient
ERFSs are associeted with the DNA breaks.
ERFSs are the principal cause of
alteration in B cells lymphoma
CANCER: SOME CELLS DON'T KNOW WHEN TO STOP
The replication of DNA damage helps to adpat and survive to the cells when there is a metastasis.
PEERSONAL COMMENT
This new is very importante becuase now there is a better knowledge about the mechanism of the cancer, so the scientists can improve treatment and this will improve the quality of life.
DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Some cells can resist these drugs.
Chemoterapy drug stop DNA replication in the cancer cells
DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
There are checkpoints mutants that create damaged DNA, this can cause cancer
DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Normally cells can recognize when they loss nucleotides, but checkpoints mutants dont recognize this signal.
DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS
Some cells continue with the replication of damaged
DNA.
There is a collapse
point where strands break.
PERSONAL COMMENTWith this investigation scientists know what are the failures in the treatment, and other cause of cancer. So now they can create other methods to trear this disease.
MEDICAL BENEFIT
With these knowledges the cancer´s treatment can improve, and this probably will save many lifes.
MEDICAL BENEFIT
In cancer and helthy cells we can find problems in the replication, so now scientists must to create methods to control and supervise these problems.
MEDICAL BENEFIT
Scientists can create a method to identify which cells have problems in the replication, and the way to stop them.
MEDICAL BENEFIT
To understand the consequences of the chemotherapy, and know why this can not traet cancer by 100%, but this can improve it.
BIBLIOGRAPHY
Martínez S, Lina Maria. Biología Molecular. 5 ed Medellín: UPB. Facultad Medicina.
Cancer: Some Cells Don't Know When to Stop. Science Daily. November 19, 2012
Discovery of New Class of Damage-Prone DNA Regions Could Lead to Better Cancer Treatments. Science Daily. January 24
GRACIAS