120 VeggieCaps per bottle. Suggested retail price: $34.95 Typically, lectins can bind to many of the carbohydrate antigens found in the gut and immune system, causing a variety of health problems. This is usually accomplished by direct agglutination ofthe target cells. Lectins can occur in very common foods in the diet, and the majority is specic for the carbohydrates of the ABO blood typing system. Clinical Indications • Intestinal dysbiosis • Bowel hyperpermiabil ity • Immune dysfunction • Food sensit ivities a nd systemic inammation • Metabolic Syndrome • Carbohydrate intolerant individuals who typically gain weight on high carbohydrate diets. In one study, the edible parts of 29 of 88 foods tested, including common salad ingredients, fresh fruits, roasted nuts, and processed cereals were found to possess signicant lectin-like activity as assessed by hemagglutination and bacterial agglutination assays. Several common lectins, in particular , wheat germ agglutinin, are known to bind to the insulin receptor and mimick the hormonal effects of insulin on adipose tissue, an under-appreciated action which can account for why individuals on high carbohydrate diets often have difculty contolling their weight. Thus, lectin blocking is a safe and rational method for enhancing weight loss. In the words of one lectin researcher: “Most lectins in our diet are resistant to breakdown during gut passage andare bound and endocytosed by epithelial cells. These lectins are powerful exogenous growth factors for the small intestine, can induce dramatic shifts in its bacterial ora and interfere with its hormone secretion. In addition, lectins that are transported across the gut wall into the systemic circulation can modulate the body’s hormone balance, metabolism andhealth. Although these physiological effects are mediated or reinforced byimmune responses, they are primarily the result of the specic chemical reactivity of lectins with cell surface receptors of the gut.” Actions and Indications The Deect ® formula provides a source of free blocking amino sugars which bind and block lectins before they can attach to the cells. Since each blood type is succeptible to lectins with different carbohydrate specicities, Dr . D’Adamo designed formulas to block lectins by using mono and polysaccharides specic foreach blood type. The amino sugars in Deect ® encourage healthy bowel ora, although they do not provide a source of ora themselves. These same amino sugars are healthy enhancers of joint gliding surface and synovia as well. One way this repair mechanism works is by ‘prying off’ lectins which have already adhered to cellular receptors, such as insulin. Since insulin blockage by dietary lectins has been linked to both insulin resistance and obesity , using Deect ® can help accelerate weight reduction in diet-compliant individuals by speeding up the time it takes for the regeneration of new insulin receptors or the ‘cleansing’ of the old ones. This can take upwards of one year in some individuals who just follow the diet, and explains why some dieters do not see weight loss in the early stages of the program. It is because ofthis ‘lectin-locking’ function that many other diets (which do have accelerated weight loss in their early stages) cause theirfollowers to lose muscle mass and fat -when what we want is to lose only the fat. If the weight loss in the Blood Type Diet is occasionally slow, at least it is healthy: Losing only body fat means that a person’s weight loss can sometimes be only 50% as rapid as other programs which are destroying muscle and fat. The problem is that muscle is hard to get back, and any drop in muscle mass results in a lower metabolic rate, leaving the dieter more likely to gain back the weight, but this time only in body fat. Many lectins can amplify the effects of auto-immune disease, such as thyroiditis, rheumatoid arthritis, schleroderma, bromylagia and pemphigus. Research shows that some of the lectins that can cause this may actually be manufactured by the body itself (serum lectins). By acting as sacricial molecules, Deect ® can block this action. Many people with ‘food sensitivities’ or ‘leaky gut’ have a phenomena called ‘active endocytosis’ where prior lectin damage results in an intestinal absorption surface that actively scoops up macromolecules. Because these larger molecules are very antigenic, they tend to increase local inammation and thus increase the leaky gut. Again, by acting like ‘sacrical molecules ’ Deect ® can block this, while also inhibiting bacterial D’ADAMO NAP PROFESSIONAL SERVICES Deect ® (ABO Specifc Lectin Blocker Formula)
adhesion to the gut as well (bacteria use their own lectins to attachto the intestines) a secondary cause of leaky gut. The amino sugars
in Deect® can also help prevent re-infection by H. pylori and
many gram-negative bacteria which cause bladder infections, by
ooding their own lectin receptors, thereby preventing adhesion,the rst step needed for infection.
The amino sugars in Deect® encourage healthy bowel ora,although they do not provide a source of ora themselves. These
same amino sugars are healthy enhancers of joint gliding surface
and synovia as well.
• Redoxa, Quercetin (Leaky gut support in all types)
• Itaru’s Tea (Weight management in all types)
• Polyora O, Polyora A, Polyora B, Polyora AB (Dysbiosis
in all types)
• Bromelain (Joint dysfunction in all types)
Dosage• Weight management and anti-lectin support: 1-2 capsules
• Other conditions: 1-2 capsule twice daily away from meals
See Also• Boyd’s Report of Lectin Specicity
• Dietary lectins are metabolic signals for the gut and modulate
immune and hormone functions
• Dietary lectins can induce in vitro release of IL-4 and IL-13
from human basophils
• Lectins, Mitogen and Blastogenic Effects
• Lectins, Resistance to Degradation
• Lectins in the United States Diet
References1. Basso, D. (1995). Living calcareous algae by a paleontological approach:
1. Freed DJ. British Medical Journal, 1999 Apr 17;318(7190):1023-4.
2. Pusztai A. Dietary lectins are metabolic signals for the gut and modulateimmune and hormone functions. Eur J Clin Nutr 1993 Oct;47(10):691-9
3. Irache JM, Durrer C, Duchene D, Ponchel Bioadhesion of lectin-latexconjugates to rat intestinal mucosa. Pharm Res 1996 Nov;13(11):1716-9
4. Acarin L, Vela JM, Gonzalez B, Castellano B Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramied microglial cellsin rat brain by tomato lectin binding. J Histochem Cytochem 1994Aug;42(8):1033-41
5. Hussain N, Jani PU, Florence AT Enhanced oral uptake of tomatolectinconjugated nanoparticles in the rat. Pharm Res 1997 May;14(5):613-8
7. Tariq SM, Stevens M, Matthews S, Ridout S, Twiselton R, Hide DWCohort study of peanut and tree nut sensitisation by age of 4 years. BMJ1996 Aug 31;313(7056):514-7
8. Gan RL[Peanut lectin-binding sites in gastric carcinoma and the adjacentmucosa]. Chung-hua Ping Li Hsueh Tsa Chih 1990 Jun;19(2):109-11
9. Lin M, et al Peanut lectin-binding sites and mucins in benign andmalignant colorectal tissues associated with schistomatosis. HistolHistopathol. 1998 Oct;13(4):961-6.
10. Melato M, et al The lectin-binding sites for peanut agglutinin ininvasive breast ductal carcinomas and their metastasis. Pathol Res Pract.1998;194(9):603-8.
11. Jordinson M, Playford RJ, Calam Effects of a panel of dietary lectins oncholecystokinin release in rats. Am J Physiol 1997 Oct;273(4 Pt 1):G946-50
12. Jordinson M, et al Soybean lectin stimulates pancreatic exocrine secretionvia CCK-A receptors in rats Am J Physiol. 1996 Apr;270(4 Pt 1):G653-9.
13. Mikkat U, Damm I, Schroder G, Schmidt K, Wirth C, Weber H, Jonas LEffect of the lectins wheat germ agglutinin (WGA) and Ulex europaeusagglutinin
14. (UEA-I) on the alpha-amylase secretion of rat pancreas in vitro and invivo. Pancreas 1998 May;16(4):529-38
15. Burks AW, et al Identication of peanut agglutinin and soybean trypsininhibitor as minor legume allergens. Int Arch Allergy Immunol. 1994
16. Buchanan and Higley : The relationship of blood groups to disease. Br. J.Exp. Path. (1921) 2;227
17. Springer GF. Relation of blood group active plant substances to humanblood groups. Acta Haem. 20 (1958) 147-55
18. Alderman S, Kailas S, Goldfarb S, Cholestatic hepatitis after ingestion of chaparral leaf: conrmation by endoscopic retrogradecholangiopancreatography and liver biopsy. Clin Gastroenterol 1994Oct;19(3):242-7
19. Okada Y, Jinno K, Moriwaki S, Shimoe T, Tsuji T, Murakami M, ThurinJ, Koprowski H Blood group antigens in the intrahepatic biliary tree. I.Distribution in the normal liver. J Hepatol 1988 Feb;6(1):63-70
20. Jordinson M, Playford RJ, Cala Am J Physiol Effects of a panel of dietarylectins on cholecystokinin release in rats 1997 Oct;273(4 Pt 1):G946-50
21. Pusztai A Dietary lectins are metabolic signals for the gut and modulateimmune and hormone functions. Eur J Clin Nutr. 1993 Oct;47(10):691-9.Review
22. Ruhlmann J, Sinha P, Hansen G, Tauber R, Kottgen E Studies on theaetiology of coeliac disease: no evidence for lectin-like componentsnwheat gluten. Biochim Biophys Acta 1993 Jun 19;1181(3):249-56
23. Freed DJ Dietary Lectins in Food Allergy and Intolerance Brostoff andCallacombe Editors Bailliere Tindall Publishers, London
24. Gendel, Steven M. (1998) Sequence Databases for Assessing thePotential Allergenicity of Proteins Used in Transgenic Foods. Advancesin Food and Nutrition Research 42; 63-92.
25. Forssell F, Wieser H [Spelt wheat and celiac disease]. Z Lebensm UntersForsch 1995 Jul;201(1):35-9
26. Falth-Magnusson K, et al. Elevated levels of serum antibodies to the lectinwheat germ agglutinin in celiac children lend support to the gluten-lectintheory of celiac disease. Pediatr Allergy Immunol. 1995 May;6 (2):98-102.
27. Brady PG, Vannier AM, Banwell JG Identication of the dietary lectin,wheat germ agglutinin, in human intestinal contents. Gastroenterology 1978Aug;75(2):236-9
28. Pusztai A, Ewen SW, Grant G, Brown DS, Stewart JC, Peumans WJ, VanDamme EJ, Bardocz S Antinutritive effects of wheat-germ agglutinin andother N-acetylglucosamine-specic lectins. Br J Nutr 1993 Jul;70(1):313-21
29. Deschodt-Lanckman M, Robberecht P, Camus JC, Christophe J Wheat germagglutinin inhibits basal- and stimulated-adenylate cyclase activity as well as
the binding of [3H] caerulein to rat pancreatic plasma membranes J CyclicNucleotide Res 1977 Jun;3(3):177-87
30. Ponzio G, Debant A, Contreres JO, Rossi B Wheat-germ agglutinin mimicsmetabolic effects of insulin without increasing receptor autophosphorylationCell Signal 1990;2(4):377-86
31. Wu AM, Wu JH, Song SC, Tsai MS, Herp A. Studies on the binding of wheatgerm agglutinin (Triticum vulgaris) to O-glycans. FEBS Lett 1998 Dec4;440(3):315-9
32. N, Taminato T, Ida T, Seno M, Seino Y, Matsukura S, Kuno S, Imura HDetection of antibodies against wheat germ agglutinin bound glycoproteinson the islet-cell membrane. Diabet Med 1988 Mar;5(2):139-44
33. Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI Increased intestinal permeability in patients with Crohn’s disease and their relatives. A possible etiologic factor. Ann Intern Med 1986 Dec;105(6):883-5
34. Nachbar MS, Oppenheim JD Lectins in the United States diet: a survey of
lectins in commonly consumed foods and a review of the literature. (SV)Am J Clin Nutr 1980 Nov;33(11):2338-45 Prog Food Nutr Sci 1989;13(3-4):317-48
35. Erickson RH, Kim J, Sleisenger MH, Kim YS Effect of lectins on the activityof brush border membrane-bound enzymes of rat small intestine. J Pediatr Gastroenterol Nutr 1985 Dec;4(6):984-91
36. Weinman MD, Allan CH, Trier JS, Hagen SJ Repair of microvilli in the ratsmall intestine after damage with lectins contained in the red kidney bean.Gastroenterology 1989 Nov;97(5):1193-204
37. Greer F, Pusztai A Toxicity of kidney bean (Phaseolus vulgaris) in rats:changes in intestinal permeability. Digestion 1985;32(1):42-6
38. Grant G Anti-nutritional effects of soyabean: a review. J Anim Sci 1982Nov;55(5):1087-98
39. Aletor VA Effect of dietary sub-lethal doses of lima bean lectin onrelative organ weights, pancreatic and intestinal trypsin (EC 220.127.116.11) and
chymotrypsin (EC 18.104.22.168) in the rat. Nahrung 1989;33(4):355-60
40. Toro F, Benshimol AL, Gonzalez Elorriaga M, Soyano A Spleen and thymushistology and proliferative response of splenic cells in rats fed raw and cookedPhaseolus vulgaris beans. (SJ)Arch Latinoam Nutr 1992 Dec;42(4):395-402
41. Henney L, Ahmed EM, George DE, Kao KJ, Sitren HS Tolerance to long-term feeding of isolated peanut lectin in the rat: evidence for a trophic effecton the small intestines J Nutr Sci Vitaminol (Tokyo) 1990 Dec;36(6):599-607
42. Myer RO, Froseth JA, Coon CN Protein utilization and toxic effects of rawbeans (Phaseolus vulgaris) for young pigs. J Anim Sci. 1982 Nov;55(5):1087-98.
43. Grant G, More LJ, McKenzie NH, Stewart JC, Pusztai A A survey of thenutritional and haemagglutination properties of legume seeds generallyavailable in the UK. Br J Nutr 1983 Sep;50(2):207-14
44. Chiba M, et al Anti-erythrocyte antibodies in ulcerative colitis: case reportand discussion on the pathophysiology of anti-erythrocyte antibody.Gastroenterol Jpn. 1988 Oct;23(5):564-9.
45. 4Vesely KT. Frequency of blood groups of the ABC and Rho(D) system inpatients with viral hepatitis,
46. Springer GF Importance of blood-group substances in interactions betweenman and microbes. Ann NY Acad Sci. 1970 Feb 13;169(1):134-52.
47. Variyam EP, Hoskins LC Mucin degradation in human colon ecosystems.Degradation of hog gastric mucin by fecal extracts and fecal cultures.Gastroenterology 1981 Oct;81(4):751-8
48. Springer GF. Role of human cell surface structures in interactions betweenman and microbes. Naturwissenschaften. 1970 Apr;57(4):162-71.
49. Yang N, Boettcher B Development of human ABO blood group A antigenon Escherichia coli Y1089 and Y1090. Immunol Cell Biol 1992 Dec;70 (Pt 6):411-6
50. Lindstedt R, Larson G, Falk P, Jodal U, Lefer H, Svanborg C The receptorepertoire denes the host range for attaching Escherichia coli strains tharecognize globo-A. Infect Immun 1991 Mar;59(3):1086-92
51. Essery SD, et al Detection of microbial surface antigens that bind Lewis(aantigen. FEMS Immunol Med Microbiol. 1994 Jun;9(1):15-21.
52. Tosh FD, et al Characterization of a fucoside-binding adhesin of Candidalbicans. Infect Immun. 1992 nov;60(11):4734-9.
53. Osipova SO, et al [The ABO system and Lamblia infection. 2. The secretionof ABO system antigens and level of the specic humoral response inpersons with Lamblia infection and the presence of group-specic antigensin Lamblia].
54. Med Parazitol (Mosk). 1985 Nov-Dec;(6):16-9. Russian.
55. Jordinson M, et al Vicia faba agglutinin, the lectin present in broad beansstimulates differentiation of undifferentiated colon cancer cells. Gut. 1999May;44(5):709-714.
56. Itzkowitz SH Blood group-related carbohydrate antigen expression inmalignant and premalignant colonic neoplasms. J Cell Biochem Supp1992;16G:97-101
57. Denk H, Holzner JH, Obiditsch-MayrEpithelial blood group antigens incolon polyps. I. Morphologic distribution and relationship to differentiationJ Natl Cancer Inst 1975 Jun;54(6):1313-7
58. Li R, et al [Subcellular localization of blood group substances ABH in humangastrointestinal tracts]. Chung KuoHsueh Ko Hsueh Yuan Hsueh Pao. 1996Feb;18(1):49-53. Chinese.
59. Itzkowitz SH, Dahiya R, Byrd JC, Kim YS Blood group antigen synthesiand degradation in normal and cancerous colonic tissues. Gastroenterology1990 Aug;99(2):431-42
60. Vowden P, Lowe AD, Lennox ES, Bleehen NM Thyroid blood groupisoantigen expression: a parallel with ABH isoantigen expression in thedistal colon. Br J Cancer 1986 Jun;53(6):721-5
61. Schumacher U, Higgs D, Loizidou M, Pickering R, Leathem A, TaylorCance1994 Dec 15;74(12):3104-3107 Helix pomatia agglutinin binding is a usefuprognostic indicator in colorectal carcinoma.
62. Campbell BJ, et al Direct demonstration of increased expression oThomsen-Friedenreich (TF antigen in colonic adenocarcinoma andulcerative colitis mucin and its concealment in normal mucin. J Clin Invest1995 Feb;95(2):571-6.
63. Datta PK, et al Enhancement of lectin-erythrocyte agglutination by gumsBiochim Biophys Acta. 1988 Nov 2;957(1):164-7.
64. Melito C, et al Vegetable gums modify lectin hemagglutinability. Acta Cien
Venez. 1992;43(5):312-4.65. Clausen H, et al . Monoclonal antibodies directed to the blood group A
associated structure, galactosyl-A: specicity and relation to the ThomsenFriedenreich antigen. Mol Immunol. 1988 Feb;25(2):199-204.
66. Wu AM, et al Binding studies on the combining site of a GalNAc alpha1-->-specic lectin with Thomsen-Friedenreich activity prepared from greenmarine algae Codium fragile subspecies tomentosoides.
67. Murayama T, et al. Colon carcinoma glycoproteins carrying alpha 2,6-linkesialic acid reactive with Sambucus nigra agglutinin are not constitutivelyexpressed in normal human colon mucosa and are distinct from sialyl-Tnantigen. Int J Cancer. 1997 Mar 4;70(5):575-81.
68. Boland CR, et al Use of the lectin from Amaranthus caudatus as ahistochemical probe of proliferating colonic epithelial cells Cancer Res1991 Jan 15;51(2):657-65.
69. Poola I, et al. Purication and saccharide-binding charcteristics of a rice
lectin. Carbohydr Re. 1986 Feb 1;146(2):205-21770. Springer GF. Relation of blood group active plant substances to human blood
groups. Acta Haem. 20 (1958) 147-55
71. Freed DL, et al Letter: Do dietary lectins protect against colonic cancer?Lancet. 1975 Dec 20;2(7947):1261-2.
72. Bardocz S, et al. Reversible effect of phytohaemagglutinin on the growth andmetabolism of rat gastrointestinal tract. Gut. 1995 Sep;37(3):353-60.
73. Pusztai, A. (1995) Proc. Int. Symp. Control. Rel. Bioact. Mater. 22, 161-162
74. Tchernychev B, et al Natural human antibodies to dietary lectins. FEBS Lett1996 Nov 18;397(2-3):139-42.
75. Seaweeds and Their Uses (Levring, Hoppe and Schmid, 1969) by V.JChapman (Professor of Botany, Auckland University) 1970.