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Cyclosporin induces remission in steroid- resistant idiopathic nephrotic syndrome Cyclosporin in combination with prednisone for 6 months produced complete remissions in 14/31 children with steroid-resistant idiopathic nephrotic syndrome. However, cyclosporin therapy was thought to precipitate rapid progression to end-stage renal disease in I patient, and treatment was withdrawn in 2 patients because of reductions in creatinine clearance. The children were aged I month to 14.3 years at disease onset, and all had a creatinine clearance of 50 ml/min/ 1. 73m 3 . Partial remission was achieved in 3 patients, and 14 patients failed to respond. Other adverse effects included hypertension (n = 12), hypertrichosis (18) and gum hypertrophy (II) . Niaudet P. and the French Club of Pediatric Nephrology. Steroid- resistant idiopathic nephrotic syndrome and cic1osporin. Nephron 57: 481. Apr 1991 "" ISSN 0156-2703/91/0427-0007/0$01.00/0 e AdiJ Illtertliltiolltll Ltd 7 INPHARMA®27 Apr 1991

Cyclosporin induces remission in steroid-resistant idiopathic nephrotic syndrome

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Page 1: Cyclosporin induces remission in steroid-resistant idiopathic nephrotic syndrome

Cyclosporin induces remission in steroid­resistant idiopathic nephrotic syndrome

Cyclosporin in combination with prednisone for 6 months produced complete remissions in 14/31 children with steroid-resistant idiopathic nephrotic syndrome. However, cyclosporin therapy was thought to precipitate rapid progression to end-stage renal disease in I patient, and treatment was withdrawn in 2 patients because of reductions in creatinine clearance.

The children were aged I month to 14.3 years at disease onset, and all had a creatinine clearance of ~ 50 ml/min/ 1. 73m 3. Partial remission was achieved in 3 patients, and 14 patients failed to respond. Other adverse effects included hypertension (n = 12), hypertrichosis (18) and gum hypertrophy (II). Niaudet P. and the French Club of Pediatric Nephrology. Steroid­resistant idiopathic nephrotic syndrome and cic1osporin. Nephron 57: 481. Apr 1991 ""

ISSN 0156-2703/91/0427-0007/0$01.00/0 e AdiJ Illtertliltiolltll Ltd

7 INPHARMA®27 Apr 1991