Cutaneous Neoplasms

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Text of Cutaneous Neoplasms

Early Detection and Treatment of Cutaneous Neoplasms

Janet Wong, M.D.

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Skin Cancer

Skin cancer can come from any part of the cutaneous surface whether it be epidermis, dermis, neural crest, any appendage, sebaceous glands, apocrine glands, the cutaneous nerves or vascular supply. The most common, of course, are the nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma and melanoma. The three most common types of skin cancer really arise from within the epidermis; squamous cell carcinoma within the spinous layer of the epidermis, basal cell carcinoma within the basal layer of the epidermis and hair follicles, and melanoma from the pigmented cells of the epidermis.

Arises from any part of the skin

Skin cancer may involve the epidermis, dermis, neural crest, epidermal appendages, nerves, blood vessels, or any specialized cellular elements within these structures

Most common

non-melanoma skin cancer (NMSC)

basal cell carcinoma

squamous cell carcinoma

melanoma

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IncidenceThe incidence in skin cancer is actually hard to predict. There are not tumor registries for all non-melanoma skin cancers - for most melanomas there are - and we are trying to get tumor registries for all squamous cell carcinomas. There are approximately 800,000 non-melanoma and non-melanoma skin cancers in the US per year and there are 40,000 melanomas annually in the US Just to give you an idea of the magnitude, about one-third of all cancers diagnosed are skin cancers and one out of every five individuals, or in your case, one out of every five patients you could cite will actually have a skin cancer at some point in their lifetime. This just reinforces why it is so imperative to be able to detect these since primary care physicians and internists are usually the front line of people that see patients.

Difficult at accurately access, not all recorded

Approximately 800,000 new NMSC annually in the US

Approximately 36,000 new Melanoma annually in the US

Skin cancer comprises 1/3 of all cancers diagnosed

1 out of 5 individuals will have a skin cancer in their lifetime

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EpidemiologyPatients at higher risk. Anybody can get a skin cancer, but it is those who are fair-skinned Celtic, blond hair, red hair, freckles, very fair skin. Whenever they go out into the sun, they burn. Those are the people who are going to be at the highest risk. Those people who have a significant photo-exposure, whether it be people that work outside, people that have homes maybe down in the lower latitudes who get intermittent severe burns, those are the people that are going to be at higher risk. There are also some genetic syndromes you all have probably heard about; basal cell nevus syndrome, albinism, xeroderma pigmentosa. Rare genetic syndromes. However, those are people that really get showered with skin cancers. Of course, people that live in the lower latitudes, those people who live down south - Australia - they get real significant constant sun exposure.

More common in:

-fair skinned individuals

-outdoor workers or those with significant UV exposure

-certain genetic syndromes

Albinism

Basal Cell Nevus Syndrome

Xeroderma Pigmentosa

Incidence increased with decreasing latitude

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PathogenesisUltraviolet light plays a significant role in causing skin cancer but over the last five to ten years we've found that it is really multifactorial. There is a lot of genetic component of skin cancer. There are some genes that have recently been studied and it seems that it has to do with your cutaneous immunosuppression as well as sort of genetic factors and constant ultraviolet light exposure that cause skin cancer.

Multifactorial

Ultraviolet radiation especially UVB and UVA

-causes cutaneous immunosuppression and DNA damage

-clonal expansion of malignant cells

Genotype and phenotype

-skin color

-genetic inability to repair DNA damage by UVR

-inability to stop malignant cell cycles

-defective tumor suppressor proteins

-defective oncogene

Environmental exposure

-intermittent severe burns more associated with melanoma

-chronic sun exposure more associated with NMSC

-arsenic

-immunosuppression

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Death RatesDeath rates for skin cancer. For basal cell carcinoma, it is essentially nonexistent. There are case reports of huge basal cell carcinomas when they are diagnosed around 10 cm or so that have been shown to have metastases and eventually the patients die. But, I usually tell my patients to reassure them since you are giving them the diagnosis of "cancer" that this really is a type that just about never and I really could fairly confidently say for a small basal cell carcinoma that it would never metastasize or cause death whereas squamous cell carcinoma, it is a little bit more likely. Probably 2 to 5% of the time it can metastasize and there are about 2,000 deaths per year from cutaneous squamous cell carcinoma. Melanoma, as we all know, has a higher death rate and it is climbing annually.

Basal cell carcinoma

-very rare, only with tumors > 10cm with rodent ulcers

Squamous cell carcinoma

-approximately 2100 annually in US

Melanoma

-approximately 7300 annually in US

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Non-melanoma Skin Cancer Basal Cell CarcinomaThe first thing we will focus in on is the non-melanoma skin cancers which are the most common. Basal cell carcinoma is the most common. It comes from the basal layer of the epidermis and from hair follicles. About 85% of them are on the head and neck but certainly not all of them. You can get them on the trunk and extremities, especially the legs and distal arms. They have just about a nonexistent metastatic rate. However, they can cause quite extensive local destruction and that is the reason for removing them. Sometimes it is hard to justify to a patient doing surgery on their face on a relatively small lesion that maybe wasn't even noticed by the person but if left alone it is unpredictable how long it will take but really it can cause a lot of destruction. There are four main types of basal cell carcinoma. Essentially, it is not by degree of cellular differentiation. It is more by the architecture of the lesion. The epidermis is where nodules of a nodular basal cell carcinoma form. A superficial basal cell carcinoma hugs the lower part of the epidermis. A more aggressive basal cell carcinoma, once again, not so much on a cytology but on the architecture is small wisps of islands down here lower in the dermis that really have quite a capacity to dissect through the dermis and cause a lot of destruction. These are sometimes even hard to see because as you can see the epidermis is relatively normal above these nests of tumor cells.

Malignant neoplasm of germinative epithelial cells -basal layer of epidermis -germinative cells of hair follicles

600,000 cases per year in US

Rarely metastasize (2.5cm -grows radially -marked by variability in color

Nodular melanoma -papule or nodule -grown vertically -intense dark color can rarely be amelanotic or pink -most common: trunk-men, legs-women

Acral lentiginous melanoma -palms, soles, nail beds -equal distribution in all races -more common >65 years old

Lentigo maligna melanoma -ill defined atypically pigmented patch -areas of intense sun exposure such as face - >50 years old

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Melanoma Staging and PrognosisThe millimeter depth is the most important prognostic factor. There are certainly other prognostic indicators as far as site, agent, sex that can lead you to a slightly better or worse prognosis but the only thing you want to know from your pathologist is how deep it is. As you can see, a melanoma caught early - melanoma in situ - which is confined to the epidermis, is essentially a 100% cure. Down only 4 mm in the skin, where certainly it doesn't seem very deep, has a much, much worse prognosis so the name of the game with melanoma is early recognition.

Stage in situ IA IB IIA IIB III IV

Criteria confined to epidermis localized melanoma, 4mm

5-year survival 100% 96% 87% 65-75% 47% 36% 5%

limited nodal mets or, 5 in-transit mets distant or advanced regional mets

Vertical tumor thickness is best prognostic indicator for melanoma confined to the skin

Other prognostic indicators

-site

hands and feet have poorer prognosis

-age/sex

older patients and males have poorer prognosis

-mitotic index

-others

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Diagnosis of Skin Cancer Nonmelanoma Skin CancerHow do you diagnose skin cancer? Diagnosing non-melanoma skin cancer - basal cells and squamous cells - is relatively easy and it is something that I think a lot of internists and primary care physicians are doing in their office now. Numbing up the area with a little bit of local and just doing a little shave biopsy off the top is a very easy way to diagnose non-melanoma skin cancer. You only need a representative sample.

Biopsy

-shave or punch

Need only enough tissue to get representative sample

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Melanoma

Excisional biopsy

Melanoma, however, needs to come completely off. You have no idea from a biopsy how deep the entire lesion is. The surgical treatment as well as any adjuvant treatment depends upon its millimeter depth. So, if you see a melanoma, it doesn't get biopsied. Either you or somebody needs to just plain take the whole thing off telling the patient that this is for the diagnosis and the definitive surgery will be after you figure out how deep it is.

-removing