Craniofacial Development & Disorders1

8/20/2019 Craniofacial Development & Disorders1

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Craniofacial Development &

Disorders

Yani Corvianindya Rahayu


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Perkembangan kepala & leher


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Minggu ke 4 pembentukan cranial (head)

& cervical (neck) kira2 ½ panjang embrio


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3 mgg IU

!el"#el berdi$eren#ia#i dalam 3 germ la%er# 'he#e #pecialied la%er# o$ cell# are ectoderm

($orming all nerve and #ome epithelial ti##ue)

me#oderm ($orming all connective mu#cle and

#ome epithelial ti##ue) and endoderm ($orming

#ome epithelial ti##ue)

*khir mgg ke 3 ectoderm di$$erentiate# into

neuroectoderm and epidermi# +euroectoderm$orm# the neural tube (eventuall% becoming the

brain and #pinal cord) and neural cre#t


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neural cre#t cell# and lateral plate me#odermmembentuk phar%ngeal arche# bakalpembentukan rongga mulut & dige#tive #%#tem


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Me#oderm migra#i ke peri$er mulai mgg ke ,lateral

plate me#oderm +eural cre#t cell# produk#i tulang cranial

(neurocranium) diantara phar%ngeal arche#

neural cre#t cell# and lateral plate me#odermmembentuk tulang rahang dan lo-er $ace(vi#cerocranium)


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'anda panah menunjukkan arah

tujuan #el neural cre#t ke #keletal &

jar ikat


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+eural cre#t membentuk

tulang $a#ial (kuning) & cranial (pink)


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pembentukan palatum antara

prominence mak#ila & mandibula


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Pembentukn palatum sekunder padaprominen maksila


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Pembentukan palatum primer padaprominen medial nasal


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CLEFT PALATE (palato#chi#i#)

.egagalan $u#i pro#e#u# lateral palatina

Uvula #plit

Menghubungkan rongga mulut dengan

na#al


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/01' 0IP (/heilo#hi#i#)

/elah pada bibir %ang berlanjut ke daerah

na#al

Unilateral incomplete unilateral complete

& bilateral complete


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2 tipe pro#e# o##i$ika#i

endochondral o##i$ication and

intramembranou# o##i$ication


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!kull development

'ulang tengkorak tumbuh pe#at #mpai

u#ia th

'he neonate $ace at birth i# compri#e#

onl% appro5imatel% one"eighth o$ the total

cranium a ratio -hich b% adulthood

become# one"hal$


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Cranial sutures are various facialsutures

points of skull growth and epansion


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Cranios!sostosis

a di#order that involve# premature $u#ion

o$ the cranial vault #uture# pertumbuhan

abnormal & adi#propo#ional tulang

kranium

http://www.hopkinsmedicine.org/craniofacial/LynmProject/GLOSSARY/GLOSS4.HTMhttp://www.hopkinsmedicine.org/craniofacial/LynmProject/GLOSSARY/GLOSS4.HTM


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#%ndromic cranio#%no#to#i#

$u#ion o$ #uture# i# combined -ith other

#%#temic abnormalitie# #uch a# hearing

lo## or pol%#%ndact%l%

'hi# t%pe o$ cranio#%no#to#i# ha# a

genetic ba#i# and i# o$ten $amilial

http://www.hopkinsmedicine.org/craniofacial/LynmProject/GLOSSARY/GLOSS3.HTMhttp://www.hopkinsmedicine.org/craniofacial/LynmProject/GLOSSARY/GLOSS3.HTM


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Tongue L!mphatic "alformation


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#kull malformation'he Inca practiced ritual #kull mal$ormation b% -rapping the head# o$ babie# o$

the nobilit% to create other"-orldl% #hape# that rein$orced their #pecial #tatu#


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/ranio$acial mal$ormation cau#ed b%

hidrocephalu#


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$ab! girl born with l!mphatic

malformation


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/ranio$acial di#order#

6gene mutation# and chromo#omal

2#tructural or numerical anomalie#

3 #peci$ic inheritance pattern


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Critical stages during development

cell division and implantation occur and are

vital $or $uture development

672 and 273 o$ all human conception# do notdevelop #ucce##$ull% to term (/hromo#omalerror# )

#pontaneou#l% congenitalaborted de$ect


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2 " 8 minggu IU

pathogene#i# congenital mal$ormation# embr%o i# more #u#ceptible to teratogen#

that produce congenital mal$ormation#

'eratogen# (environmental agent#) in$ectiou# agent# drug# or

pharmaceutical# chemical# and ph%#ical

agent# and maternal di#ea#e


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9 mgg : birth ($etu#)

gro-th and di$$erentiation o$ organ#

continue#

Major #tructural de$ect# are le## likel% to

occur

environmental $actor# including

mechanical $orce# va#cular di#ruption#

drug# and maternal di#ea#e can alter

normal development


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;i$$erent organ# have di$$erent critical

period#

da% 6, through to da%


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Deformations

mechanical $orce# intrauterine con#traintand lack o$ $etal movement

de$ect# during the la#t trime#ter

15trin#ic $orce#di#tortion o$ $acial#tructure# abnormal po#itioning o$ thee5tremitie# and head alteration# in joint

mobilit% joint di#location# nerve pal#ie# contraction o$ the cervical mu#cle

altered head po#ition


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Disruptions

de#truction o$ normall% developed ti##ue#

or organ#

birth de$ect# a##ociated -ith rupture o$ the

amnion

$ibrou# ti##ue made to repair the amnion""

that adhere# to the developing individual

and can lead to circulator% compromi#e

and $urther necro#i# later in development


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"alformations

are intrin#ic de$ect# in the developing humanthat re#ult in locali#ed abnormalitie# during thedevelopment o$ organ# and bod% part#

Major mal$ormation# are tho#e that inter$ere -ithnormal $unction

Minor mal$ormation#o$ten have onl% co#meticimplication#

the cle$t palate lip $ail# to clo#e de$ect# in toothdevelopment and incomplete gro-th o$ theno#tril#


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Craniofacial Development & Disorders1