9/1/2009 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar) Page 1

COURSE OUTLINE

SCHOOL: School of Engineering Technology and Applied Science

DEPARTMENT: Applied Biological and Environmental Science (ABES)

PROGRAM: Medical Laboratory Technician

COURSE TITLE: Applied Chemistry for the Medical Laboratory

COURSE CODE: MLAB 103

TOTAL COURSE HOURS: 60 (15 weeks x 4 hours)

PRE-REQUISITES/CO-REQUISITES: N/A

COURSE ELIGIBILITY FOR PRIOR LEARNING ASSESSMENT AND RECOGNITION (PLAR): Yes

ORIGINATED BY: Margaret Faye

REVISED BY: Margaret Faye

DATE: May, 2009

APPROVED BY: __________________________________ Chairperson/Dean Semester: 2009 Fall Students should keep all course outlines for each course taken at Centennial College. These may be used to apply for transfer of credit to other educational institutions. A fee may be charged for additional or replacement copies.

Course Title: Applied Chemistry for the Medical Laboratory CENTENNIAL COLLEGE Course Code: MLAB103

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COURSE DESCRIPTION: This course will assist the student in developing his/her knowledge of chemistry as a basis to understand chemical compounds and enzyme reactions. This course will begin with atoms and compounds and chemical nomenclature. This course will continue to explore more complex structures such as organic compounds and function of enzymes. COURSE LEARNING OUTCOMES: Upon successful completion, students will be able to: 1. Demonstrate knowledge of chemical symbols 2. Understand the concept of atoms, ions and molecules 3. Understand the significance of pH and buffer systems 4. Demonstrate knowledge of the basic structure of the major classes of organic compounds 5. Understand enzyme function and factors influencing enzyme activity 6. Demonstrate competency in the calculation and mixing of chemical solutions including:

a. Preparation, standardization, and storage of molar, isotonic and percentage solutions b. Calculation and preparation of dilutions using concentrated and diluted reagents c. Relate the following terms for grades of chemicals and their practical use: analytical,

technical, commercial, CP, USP, BP, certified ACS d. Use of deionized water vs distilled water

7. Demonstrate competency in use of analytical balances, the pH meter and spectrophotometer 8. Evaluate equipment and methods with regard to accuracy, precision and effects of potential

sources of error. ESSENTIAL EMPLOYABILITY SKILLS (EES): This course supports the students’ ability to:

Communicate clearly, concisely, and correctly in the written, spoken, and visual form that fulfills the purpose and meets the needs of the audience.

Execute mathematical operations accurately.

Apply a systematic approach to solve problems.

Locate, select, organize, and document information using appropriate technology and information systems.

Interact with others in groups or teams in ways that contribute to effective working relationships and the achievement of goals.

Manage the use of time and other resources to complete projects.

Take responsibility for one’s own actions, decisions, and consequences. PRIOR LEARNING ASSESSMENT & RECOGNITION PROCESS (ES): This course is eligible for PLAR through the Registrar and SETAS offices. Assessment of portfolio and/or testing may be discussed with faculty. EVALUATION & GRADING SYSTEM: Lecture Tests 20% Final Exam 30% Laboratory Tests 20% Laboratories Reports 30% Total 100% Students must obtain at least 60% of the theory grade (lecture tests, and final exam), at least 60% of the laboratory report marks and at least 60% of lab test marks.

Course Title: Applied Chemistry for the Medical Laboratory CENTENNIAL COLLEGE Course Code: MLAB103

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Students must complete laboratory maintenance and monitoring duty to the satisfaction of the professor and lab technologist. A failing (U) grade will be assigned if lab duties are not completed satisfactorily. This course is prerequisite for MLAB121, MLAB122, and MLAB124. Final Grade: Final grades will be assigned according to the following definitions. Grade Description Mark Range A+ Outstanding Achievement 90 - 100 A Excellent Achievement 80 - 89 B+ Very Good Achievement 75 - 79 B Good Achievement 70 - 74 C+ Satisfactory Achievement 65 - 69 C Acceptable Achievement 60 - 64 D+ Pass 55 - 59 D Pass 50 - 54 F Unsatisfactory 0 - 49

STUDENT ACCOMMODATION: All students have the right to study in an environment that is free from discrimination and/or harassment. It is College Policy to provide accommodation based on grounds defined in the Ontario Human Rights Code. Accommodation may include changes or modifications to standard practices. Students with disabilities who require academic accommodations must register with the Centre for Student with Disabilities. Please see the Centre for Students with Disabilities for details.

Students requiring accommodation based on human rights grounds should talk with their professors as early as possible. Details are available on the Centennial College website (www.centennialcollege.ca ). If students are unable to write an examination due to a medical problem or unforeseen family problems, they should immediately contact their professor or program Chair for advice. In exceptional and well documented circumstances (e.g. unexpected family problems, serious illness, or death of a close family member), students should be able to write a make-up examination to replace an examination missed. TEXT AND OTHER INSTRUCTIONAL/LEARNING MATERIALS: Sackheim,G, An Introduction to Chemistry for Biology Students 9th ed, Addison Wesley, 2007, ISBN 0805395717 Estridge B., Basic Medical Laboratory Techniques 5th ed, Thomson Learning. ISBN 1418012793 Laboratory Manual for Applied Chemistry for the Medical Laboratory, College Prepared Laboratory Kit for the Medical Laboratory Technician Program and Lab Coat. USE OF DICTIONARIES Dictionary use is not permitted in test or examination settings.

Course Title: Applied Chemistry for the Medical Laboratory CENTENNIAL COLLEGE Course Code: MLAB103

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Week Topic/Content Readings Instructional Objectives Instructional Strategies/ Tests and Assignments

1 Introduction, atomic structure Apply knowledge of atomic structure to understand the nature of matter

Lecture; read text and answer problems

2 Chemical symbols and periodic table

Use the atomic symbols of biologically important elements; use a periodic table to find information on atoms

Lecture; read test and answer problems; make a periodic table of the biologically important elements

3 Molecules, ionic compounds, acids and bases

Apply knowledge of atoms, ions and bonding to determine how ions and molecules are formed and how acids and bases act in solution

Lecture; read text and answer problems

4 Electrolytes, pH and buffers Identify the biologically important ions, electrolytes and buffers; to able to predict changes in pH

Lecture; read text and answer problems

5 Solutions, suspension and colloids; diffusion

Describe the properties of different types of liquid mixtures and their biological significance

Lecture; read text and answer problems

6 Chemistry of nerve and muscle activity. Term Test 1

Discus the importance of ions in nerve and muscle activity and be able to apply this knowledge to ECG’s

Lecture; read text and answer problems; discuss handout Tested on weeks 1-6

7 Covalent bonds and Hydrogen bonds

Use knowledge of bonding to complete small molecules. Apply knowledge of bonds to biological molecules and their biological activity.

Lecture; read text and answer problems

8 Functional groups in organic molecules

Recognize functional groups and discuss their properties; categorize molecules according to their functional groups

Lecture; read text and answer problems; discuss handout

9 Carbohydrate Recognize the structures and discus the properties of sugars and other carbohydrates

Lecture; read text and answer problems; discuss handout

10 Lipids Recognize the structures and discus the properties of biologically important lipids

Lecture; read text and answer problems; discuss handout

11 Proteins, Nucleotides Recognize the structures and discus the properties of proteins and nucleotides.

Lecture; read text and answer problems

12 Enzymes Term Test 2

Discus the activity of enzymes, the role of coenzymes and enzyme inhibitors

Lecture; read text and answer problems Tested on weeks 7-12

13 Biological Oxidation and respiration

Discus biological oxidation, energy storing molecules and cellular respiration

Lecture; read text and answer problems

14 Blood gases Discus the transport of oxygen and carbon dioxide in blood Lecture; read text and answer problems

15 Final exam Examined on weeks 1-15

Course Title: Applied Chemistry for the Medical Laboratory CENTENNIAL COLLEGE Course Code: MLAB103

9/1/2009 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar) Page 5

Laboratory Outline

Week

Topic/content Instructional Objectives

1 Laboratory Safety To learn the safety rules of a lab; to learn the proper use and maintenance of safety equipment.

2 Use of Laboratory Glassware To identify common lab glassware; to learn properly use and care of lab glassware

3 Use of Balances To properly use lab balances; to learn care and maintenance of balances

4 Calibration of Glassware To accurately use glassware and balances; to check the calibration of volumetric glassware.

5 Grades of Water and Chemicals To learn proper use of grades of chemicals and water; to learn water purification techniques

6 Measuring pH To measure pH using pH paper, indicators and pH meter; to calibrate and maintain a pH meter

7 Spectroscopy To learn the proper use and maintenance of a Spectrophotometer

8 Lab Test 1 To evaluate knowledge and basic use of safety equipment, water, chemicals, balance, pH meter and Spec20

9 Solutions I To prepare solutions using appropriate glassware, grades of chemicals and water; to calculate concentration

10 Solutions II To accurately prepare solutions; to prepare a buffer and adjust its pH using a pH meter.

11 Titration I: Measuring Buffer Capacity

To perform a titration using a burette and pH meter.

12 Titration II: Standardizing Acid Solutions

To accurately prepare a dilute acid solution from a concentrated acid; to standardize it by titration.

13 Standard Curve To accurately use a micropipette and Spec 20; to prepare a graph

14 Lab Test 2 To evaluate accurate use of volumetric glassware, balances, pH meter and Spec 20.

The above is a tentative schedule of laboratories and activities depending on the availability of cultures and other materials.

Course Title: Applied Chemistry for the Medical Laboratory CENTENNIAL COLLEGE Course Code: MLAB103

9/1/2009 THIS COURSE ADHERES TO ALL COLLEGE POLICIES (See College Calendar) Page 6

POLICY STATEMENTS College Policies The following statements are selected from Centennial College policies approved by the Board of Governors. Student Responsibilities Students are expected to know the contents of the course outline and to discuss with the professor any areas where clarification is required. Students should keep all course outlines for each course taken at Centennial College. These may be used to apply for transfer of credit to other educational institutions. A fee may be charged for additional or replacement copies. Other Policies Students should familiarize themselves with all College Policies that cover students’ rights, responsibilities, and the Academic Appeal process. For further information, consult the Academic Matters Section in the full-time and Continuing Education calendars. The Academic Appeal Application form is available from any Enrolment Services Office. Proof of Student Status Students must produce official photo identification at any time during the semester when requested to do so by any professor. (The official piece is the Centennial Student Card.) Continuing Education students do not have Centennial Student Cards, and so they may use other forms of photo identification, such as a driver’s license, health card, or other government-issued photo identification. Final Examinations When writing a test or examination, students must put their official photo-ID cards in full view for review by the invigilator. Students who do not have official photo-ID will be permitted to write the examination with a substitute photo-ID, but they will be required to produce photo-ID at the program or department office within 24 hours or the next business day following the examination, or else the examination results will be void. More Final Examination Policies are available at http://my.centennialcollege.ca. Academic Progression Policy for Diploma and Certificate Programs: College Academic Standings will be applied. Please see Academic Policies and Procedures, Full-Time Calendar.

Faculty Consultation Professors are available to see students outside of class time. Students can contact professors via voice mail, email, or through their program or department office. Information regarding how to contact teachers will be provided at the beginning of the course and is also available in the program or department office.

Human Rights Statement It is the policy of the College that all programs will strive for a learning, teaching, and working environment that promotes inclusion, understanding, and respect for all students and employees, consistent with the Ontario Human Rights Code and Centennial College's Statement of Diversity.