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  • University of Michigan College of PharmacyPharmD Curriculum - Summary by Course Series or Curricular Thread

    Updated September 2014

    Academic Year

    Term Course #

    Course Name Course Coordinator(s)

    Course Objectives

    P1 Fall PS508 Drug Delivery & Solutions

    Greg Amidon Basic principles of drug delivery:- biological and physical-chemical barriers to the bioavailability of drugs- routes of drug delivery and related dosage forms- principles and problems in equilibria, transport, and chemical kinetics of drug solutions as they relate to liquid dosage form performance

    P1 Winter PS518 Dispersed/ Solid Forms

    Nair Rodriguez Formulation, Development and Approval Process of Dosage Forms- dispersed phases (suspensions and emulsions)- solid phases (amorphous and crystalline)- integration of physicochemical concepts with quality and performance of topical, oral and inhalation dosage forms- bioequivalence and generics

    P2 Fall PS608 Pharmacokinetic Concepts

    David Smith Absorption, Distribution, Metabolism, Excretion, and Transport of Drugs- physiological and pathophysiological factors that may impact pharmacologic response and dosing- basic pharmacokinetic principles, including absorption and bioavailability, volume of distribution, clearance, half-life, and protein binding- interpret pharmacokinetic data after intravenous bolus, intravenous infusion, and extravascular dosing using both plasma and urine data- variability in patient genetics, age and weight, disease, and drug interactions and how they may affect drug kinetics and response- design an appropriate therapeutic drug regimen and recommend dosing adjustments due to disease progression- linear and nonlinear pharmacokinetics and how they may impact drug levels, dosing and response in patients

    P3 Winter PS718 Biopharm & Pharmacogenetics

    Gus Rosania Modern Biopharmaceutics and Pharmacogenomics- biopharmaceutics and pharmacokinetics in the context of special patient populations- advances in pharmacogenomic and genetic test methods

    Pharmaceutical Sciences

    1

  • University of Michigan College of PharmacyPharmD Curriculum - Summary by Course Series or Curricular Thread

    Updated September 2014

    P1 Winter MC510 Principles of Drug Action I

    George Garcia Basic Concepts Related to Drug Action, I- understanding of drugs as chemical molecules- physiochemical properties and how they influence a drugs biological activity- processes in drug absorption, distribution and elimination- processes in the human body that lead to xenobiotic metabolism and resulting drug-drug interactions- how drugs act at receptors and interfere with endogenous ligand/effect or action- how chemical structure relates to biological activity for peripheral and cardiovascular systems- application of the basic principles of drug action to the autonomic nervous system and the cardiovascular system and the drugs tht affect them

    P2 Fall MC600 Principles of Drug Action II

    Mustapha Beleh Basic Concepts Related to Drug Action, IIContinued application of the basic principles of drug action focusing on the following therapeutic areas and the drugs that affect these systems:- central nervous system- diabetes- endocrine systems- histamine receptors and GI drugs- NSAIDs- vitamins

    P2 Winter MC610 Principles of Drug Action II

    David Sherman Basic Concepts Related to Drug Action, IIIContinued application of the basic principles of drug action focusing on the following therapeutic areas:- anti-infective agents- cancer chemotherapeutic agents- immunolgy and immuntherapies and biologicals

    Medicinal Chemistry and Pharmacology

    2

  • University of Michigan College of PharmacyPharmD Curriculum - Summary by Course Series or Curricular Thread

    Updated September 2014

    P3 Fall MC700 Drug Assay Hank Mosberg Techniques Used to Analyze DrugsDidactic Coursework:- biopharmaceutical analysis and managing biological media (sampling, storage and analysis)- standard analytical techniques and instrumentation (titrations, spectroscopic analysis, protein, enzyme and immunoassays, electrophoresis and chromatography)- concepts related to drug analysis, including chemical equilibrium, buffers, acid base chemistry, chemical ionization and solubility and the terminology of analytical techniques and principles- relate chemical structure and nature of drugs to the experimental results from analytical assays- design a logical and rational protocol for analysis of any given drug based on the chemical nature and analytical techniques - evaluate results and interpret data from qualitative and quantitative analytical assays from the scientific literature- gather, analyze, synthesize related information from the scientific literature and other available toolsLab Coursework:- Plan, prepare and carry out standard analytical techniques (titration, spectroscopy, protein and enzyme assays, genotyping, electrophoresis, and chromatography)- prepare solutions and reagents to support various analytical techniques, including buffers and standard solutions- measure and weigh varying ranges of volumes and weights with accuracy and precision, use serial dilutions, and construct standard curves- working knowledge of concepts/terminology of analytical techniques and statistical concepts - evaluate results/interpret data from qualitative and quantitative analytical assays- maintain a complete, accurate and real-time record of procedures, data and results - relate the chemical structure and nature of drugs to experimental results from corresponding analytical assays- apply acquired knowledge and experimental results from analytical methods conducted in the laboratory to solve and discuss related case studies- demonstrate the ability to operate instrumentation correctly, perform relevant calculations and maintain proper documentation in the process- demonstrate care in the use of equipment and reagents and maintain a professional environment within the laboratory- exhibit professional behavior through attendance, promptness and conducting oneself in an honest, ethical and safe manner- work productively within a team to carry out analytical procedures according to established protocols while assuming appropriate responsibility and cooperation.

    3

  • University of Michigan College of PharmacyPharmD Curriculum - Summary by Course Series or Curricular Thread

    Updated September 2014

    P1 Fall P500 Introduction to Pharmacy

    Peggy Carver Exploring the Profession of Pharmacy- introduction to and history of pharmacy and drug regulation in the US- role of pharmacists and pharmacy practice as they relate to patient care (clinical care, MTM) and other healthcare professionals- State and Federal healthcare issues in pharmacy- professionalism, e-professionalism, and professional organizations- career exploration, networking, career planning, internships, CV, letters of rec & letters of intent

    P1 Winter P516 Health Care Systems Steve Erickson Components of the US Healthcare System- history and overview of delivery of health care in the US (includes government policies that affected health care delivery and health care reform).- drug discovery and development (stages of the US approval process and phases of clinical testing)- manufacturing and marketing of pharmaceuticals, including factors that contribute to increased use and cost- drug distribution chain for pharmaceutical (GPO, wholesalers)- pharmacy practice in various settings (hospital, long-term care, mental health, home care, community)- economics of health care (basic economic concepts of utility, supply, demand, equilibrium price) - managed health care, including fee-for-service and capitated reimbursement- tools to manage pharmaceutical care (P&T, formulary, cost sharing, incentives, step therapy, drug utilization review, medication therapy management)- government's role in health care, health care reform- Medicare and Medicaid- quality in health care- introduction and overview of public health (applied epidemiology for pharmacists, disease prevention, behavioral health, public health services)

    Health Systems and Pharmacy Practice

    4

  • University of Michigan College of PharmacyPharmD Curriculum - Summary by Course Series or Curricular Thread

    Updated September 2014

    P2 Winter P616 Health Systems Kim Redic Best Practices in Health-System Pharmacy- medication distribution and dispensing in a health system environment (oral, controlled substances, pediatrics, oncology, TPN, parenteral)- required elements for sterile technique (USP 797)- producing dose forms for specialty patient populations (pediatrics, geriatrics)- steps necessary to make a cancer chemotherapeutic agent- issues associated with compatibilities of intravenous products- health system calculations- role of pharmacy informatics to improve efficiency, safety, and support the pharmacy practice model- advancement of the pharmacy practice model and clinical pharmacy practice- determination of how resources are deployed to care for patients needs- differences and similarities between quality measures and the provision of safe care

    Pharmacy Leadership and Business Practices- leadership decisions as they relate to safety, quality, efficiency, financial management, and change leadership- process improvement, quality, best practices- Regulatory compliance [The Joint Commission (TJC), Center for Medicaid/Medicare Services (CMS), state boards]- how to plan a patient care service, synthesize a business plan, and develop marketing strategies - principles around facility design and layout

    P3 Fall P706 Health Care Systems Raj Balkrishnan Effectiveness of Pharmaceuticals- pharmacy health care effectiveness, outcomes evaluations and interlink with pharmacy practice- role of the clinical pharmacist in developing populati