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COUGHCOUGH
A cough is an action your body takes to get rid of substances that are irritating to your air passages, which carry the air you breathe in from the nose and mouth to the lungs.
A cough occurs when special cells along the air passages get irritated and trigger a chain of events. The result? Air in your lungs is forced out under high pressure; an explosive expiration
You can choose to cough (a voluntary process), or your body may cough on its own (an involuntary process).
Anatomic causes of coughAnatomic causes of cough
Extra-thoracicExtra-thoracic İntra-thoracicİntra-thoracic
CNSCNS Head and neckHead and neck
Lower airways Lower airways diseasesdiseases
Lung ParenchymaLung Parenchyma
MediastinumMediastinum
CardiovascularCardiovascular
Upper GISUpper GIS
PleuraPleura
DiaphragmDiaphragm
StomacStomac
Cough receptors and related nervesCough receptors and related nerves
Regions Afferent nerves
Paranasal Trigeminal (V)
Pharynx Glossofaringeus (IX)
Larynx/tracheobronchial sys. Vagus (X)
External ear way/ thympanic membrane
Vagus (X)
Eusophagus, stomac, pleura Vagus (X)
Diaphragm, pericard Phrenic nerve
Simpson CB. et al. Otolaryngology–Head Neck Surg 2006; 134: 693-700Simpson CB. et al. Otolaryngology–Head Neck Surg 2006; 134: 693-700
Anamnesis: History
While ? When ?Characteria ?Productive/non productiveAdditional symptoms?Risk factors: tabacco smoke
additional diseases or use of drugs ?
Anamnesis: While
Shorter then 3 weeks acute cough
3 to 8 weeks subacute cough
Longer then 8 weeks chronic cough
Irwin RS et al. Chest 1998, 114:2 supplIrwin RS et al. Chest 1998, 114:2 suppl
Causes of acute cough
Respiratory Causes:
Inhaled gases or particuleMucus secretionInflammatory exudate Foreing bodyEndobronchial lesionBronchial boosts
Other causes of acute cough
-acute heart failure
-acute rhinosinusitis
-Eusephageal reflux
-Middle ear patologies and infections
-Diaphragm, pleura and pericardium irritations
Chronic cough causes in adultChronic cough causes in adult
PNDS Allergic rhinitis chronic sinusitis
GER cough-variant asthma ACE Inhibitors tabacco smoke Whoopping Neurogenic
Travmatic vagal injury After upper respiratory tract infection
Psychogenic chronic aspiration Zenker diverticule
Foreign body Tracheobronchial tree Laryngopharingeal Sinonasal External ear way
Chronic bronchitis, COPD Bronchiectasis Lung Cancer Subglottic stenosis Tracheomalasia Tracheosephageal fistula Tuberculosis Sarkoidosis Congestive heart disease
Simpson CB. et al. Otolaryngology–Head Neck Surg 2006; 134: 693-700Simpson CB. et al. Otolaryngology–Head Neck Surg 2006; 134: 693-700Chung KF, Pavord ID Lancet 2008; 371: 1364-1374Chung KF, Pavord ID Lancet 2008; 371: 1364-1374
Patogenic TriadPatogenic Triad
Irwin RS et al. Chest 1998, 114:2 supplIrwin RS et al. Chest 1998, 114:2 suppl
Palombini BC et al. Chest 1999, 116:2,279-284Palombini BC et al. Chest 1999, 116:2,279-284
Anamnesis: Characteria
Like barking Larynx tm, inf. Metalic cough Trachea, brochies.
Cow cough V.Chord paralisis
Vomitig cough Whoopping cough
Smoking cough tabacco smoke
Irrıtative cough URTI
Anamnesis: Characteria
In prospective adult studies time and character of the coughing cannot guide the diagnosis.
Mello CG et al. Arch Intern Med 1996,156; 997-1003Mello CG et al. Arch Intern Med 1996,156; 997-1003
Anamnesis: Productive/Nonproductive
Productive Airway diseases
Non productive Pleura, pericardium, Ear, GIS, heart, ACEI usage, diaphragm, mediastinum, thyroid…
Irwin RS et al. Chest 1998, 114:2 supplIrwin RS et al. Chest 1998, 114:2 suppl
Anamnesis: Additional symptoms
Specific Dyspnea, wheezing, sputum, pyrosis, retronasal discharge…..
Non specific Eshaustion, insomnia, sweating, muscular pain, urine incontinence, headache, loss of appetite, axiety
Anamnesis: Specific additional symptoms
PNDS post nasal drip, throat clearing runny nose, nasalcongestion, sputum
Asthma Dispnea, thightness of breath, wheezing
GER Burning, regurgitation,COPD sputum, effort dispneaBronchiectasia SputumHeart failure Effort dispnea, tachycardia,
edema
Anamnesis: Risk factors
Smoking cases Lung cancer, COPD, asthma, irritation
Irwin RS et al. Chest 1998, 114:2 supplIrwin RS et al. Chest 1998, 114:2 suppl
Additional diseases AIDS, cancer, viral URI
Drug usage ACEI, Nitrofurantoin, Immunosupresives
LaboratoryLaboratory
Chest X Ray Pulmonary function tests Paranasal sinus X-Ray Blood analysis Sputum examination Bronchoscopy ECG, ECO Thorax CT, HRCT Rhinoscopy Barium eseuphagography Allergy prick tests
Treatment of cough
NON SPECIFICNON SPECIFIC SPECIFICSPECIFIC
ANTITUSSİVEANTITUSSİVE PROTUSSIVEPROTUSSIVE TARGET TARGET THERAPYTHERAPY
CodeinCodein
DekstrometorfanDekstrometorfan
DifenhidraminDifenhidramin
PseudoephedrinePseudoephedrine
DekstrobromfeniraminDekstrobromfeniramin
İpratropium Bromidİpratropium Bromid
NaproxenNaproxen
Hipertonic salineHipertonic saline
ErdosteinErdostein
AmiloridAmilorid
N acetylcysteineN acetylcysteine
TerbutalineTerbutaline
PhisiotherapyPhisiotherapy
Postural drenagePostural drenageIrwin RS et al. Chest 1998, 114:2Irwin RS et al. Chest 1998, 114:2
SPUTUM
Mucus glands and goblet cells of lower respiratory tract secrete 10ml mucus every day
Exess of lower respiratory track expectoration is called sputum
General causes of sputum
Exess of mucus production
Changement in the quality of mucus
Lacking activity of mucociliar clearance
Sputum:Anamnesis:
Quantity of sputum
Quality of sputum; density, calour
Odor of sputum
Time of expectoration
Sputum: Anamnesis
Sputum Quality Suspect diseases
Purulent; yellow-green mucoid Pneumonia, asthma with eosinophilia
Rusty Pneumonia (pneumoccocus)
Cherry Pneumonia (klebsiella)
Melanopthisis (black-grey) Air pollution, coal worker
Rock water vomic Eccinoccocus cystes
Chocolate Amibe abscess
Putrefactive; faol smelling Lung abscess (anaerobic infections)
< 600cc/day, morning expect. Bronchiectsasis
Sputum: Diagnosis
Physical examination of the lungs
Chest X-ray, CT, HRCT
Sputum analysis
Blood analysis
Bronchoscopy
HEMOPTYSIS
Lower respiratory track bleeding below epiglottis
Differential diagnosis with ENT ve GIS must be evaluated before saying hemoptysis
Causes of hemoptysis:
Chest X Ray: Anormal
I.Infections: -Pneumonia -Tbc -Lung abcess -Bronchiectasis -Fungal infections
II.Lung tumours: -Bronchial Cancers
-Metastatic cancers
-B.adenoma
Causes of hemoptysis:
III. Alveolar hemorrhage: -Vasculitis -Goodpasture’s syndrome -Wegener granulomatosis -Behçet Disease -SLE -Drugs (penicillamine)
IV.Other -Thorax trauma
-A-V malformations
-P.E
-Disorders of coagulation
Causes of hemoptysis
Normal X-Ray
-Chronic bronchitis-Pulmonary Embolism-Bronchiectasis-Lung cancer-Mitral stenosis-Endometriosis
Massive hemoptysis
Hemoptysis > 600 mL /24 h Cause is % 90 bronchial arteries
causes:1-Tbc 2-Bronchiectasis 3-Malignity
4.Behçet disease
Hemoptysis: Physical examination
-Vital signs -Telengiectasia (Osler-Weber-rendu Syndrome) -Clubbing -Deep venous thrombosis -ENT (URT haemorrhage) -Oral ulcer =>Behçet ? -Chest exanination -Cardiovascular system examination (mitral
stenosis)
Hemoptysis: Diagnosis
Radiology:PA, Lat chest X-ray,
BT, HRCT if needed
PA Chest Xray and CT: normal => Angiography
Hemoptysis: Diagnosis
Laboratory: -Blood analysis, blood goup -Electrolytes, liver and kidney
function tests -PFT, ABG -PT, aPTT -ECG, Urine analysis
- Bronchoscopy