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10/5/2019 Our Focus - California Oncology Research Institute | CORI
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CORI ResearchCORI believes that when doctors and researchers work together, we can create innovative and
“After climbing a great hill, one only finds that thereare many more hills to climb.”
— Nelson Mandela
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10/5/2019 Our Focus - California Oncology Research Institute | CORI
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effective treatments improving the chance for cure. We provide the opportunity for doctors tocollaborate internationally, working with institutions in countries such as Israel and Serbia, to better
understand less researched cancers. We recognize the value in personalized medicine, recognizingthat every patient is unique in how they should be treated. CORI looks to expand our partnerships as we look towards the future of cancer research and moreeffective treatments. CORI supports education and research in the following cancers:ColonPancreas and LiverMelanomaBreast CancerProstate CancerGynecologic malignancies (ovary, uterus, and cervix)
Research ProjectsCompleted and Ongoing Research Projects Funded by CORI
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10/5/2019 Our Focus - California Oncology Research Institute | CORI
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General Cancer Research
Redefine staging systems in cancer to improve the selection of patients for different therapies.Evaluate the impact of age on adherence to quality measures in cancer care.Establish predictive statistical models to improve the selection of patients for chemotherapy.Study stem cells as biomarkers in cancer.Examine whether community hospitals are meeting the same standards as academic hospitals for the multimodalmanagement of cancer.Examine the role of tumor infiltrating immune cells in tumor invasion and metastases.Establish evidence-based guidelines for precision risk stratification in cancer.
Liver Cancer
Describe the benefits and risks of novel anti-angiogenesis therapies after liver resection.Develop novel, minimally invasive ways to destroy liver tumors.Examine the effects of long-acting somatostatin analogues plus aggressive cytoreductive surgery in patients withmetastatic neuroendocrine carcinoma.
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Colon Cancer
Perform international multicenter trials to individualize cancer care in colon cancer.Develop new techniques for targeting lymph node assessment in gastrointestinal neoplasms. Describe a novel primary tumor gene signature in colon cancer when national quality standards are adhered to.Establish an immunoprofile for the prognostic assessment of colon cancer.Study sex-specific differences in colon cancer.
Breast Cancer
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Breast Cancer
Conduct a double-blind randomized controlled trial in breast cancer by adding 1% lidocaine to technetium sulfur colloid forsentinel lymphatic mapping.
Melanoma
Conduct an extensive 45-year review in anorectal malignant melanoma and propose a novel staging classification. Evaluate whether there is an expanding role for hepatic resection and adrenalectomy in metastatic melanoma.
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Stomach
Evaluate whether surgical quality improves staging accuracy in gastric cancer. Determine whether race influences stage-specific survival in gastric cancer. Examine the impact of birthplace in Asian-Americans with gastric cancer.
Gallbladder
Perform a prospective randomized controlled trial comparing standard analgesia with combined intra-operative cystic plateand port-site local anesthesia for post-operative pain management in patients undergoing a laparoscopic cholecystectomy.
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10/5/2019 Our Focus - California Oncology Research Institute | CORI
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Cancer education and training
Evaluate attitudes and perceptions of surgical oncology fellows on ACGME accreditation and the complex general surgicaloncology certification.
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