Reactions 552 - 27 May 1995 Contrast agents interact with thrombolytics? The possibility of an interaction between contrast agents and thrombolytics has been identified by investigators from the US. An in vitro study conducted by the investigators showed that the contrast agents sodium amidotrizoate [‘Hypaque 76’] and iohexol [‘Omnipaque’] delayed the onset of lysis induced by streptokinase, urokinase and alteplase, and that ioxaglate sodium/ioxaglate meglumine [‘Hexabrix’] delayed the onset of lysis by alteplase and urokinase, but not streptokinase. The impairment of fibrinolysis was reduced by increasing the concentration of thrombolytic agent. In vivo data from patients undergoing angiography using iohexol also showed delays in the onset of lysis by alteplase and urokinase, but not streptokinase. According to the investigators, these findings may have considerable clinical relevance when thrombolytic agents are used during angiography. Dehmer GJ, et al. Impairment of fibrinolysis by streptokinase, urokinase and recombinant tissue-type plasminogen activator in the presence of radiographic contrast agents. Journal of the American College of Cardiology 25: 1069-1075, Apr 1995 800357403 1 Reactions 27 May 1995 No. 552 0114-9954/10/0552-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Contrast agents interact with thrombolytics?

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Reactions 552 - 27 May 1995

Contrast agents interact withthrombolytics?

The possibility of an interaction between contrastagents and thrombolytics has been identified byinvestigators from the US.

An in vitro study conducted by the investigatorsshowed that the contrast agents sodium amidotrizoate[‘Hypaque 76’] and iohexol [‘Omnipaque’] delayed theonset of lysis induced by streptokinase, urokinase andalteplase, and that ioxaglate sodium/ioxaglatemeglumine [‘Hexabrix’] delayed the onset of lysis byalteplase and urokinase, but not streptokinase. Theimpairment of fibrinolysis was reduced by increasing theconcentration of thrombolytic agent.

In vivo data from patients undergoing angiographyusing iohexol also showed delays in the onset of lysis byalteplase and urokinase, but not streptokinase.

According to the investigators, these findings mayhave considerable clinical relevance when thrombolyticagents are used during angiography.Dehmer GJ, et al. Impairment of fibrinolysis by streptokinase, urokinase andrecombinant tissue-type plasminogen activator in the presence of radiographiccontrast agents. Journal of the American College of Cardiology 25: 1069-1075,Apr 1995 800357403