8
CONTENTS OF VOLUME 16 Vol. 16, No. 1 Minireviews Robert P. Hof F. A. Wali General Papers Arun P. Kulkarni and Ileana Gonzales J. W. Phillis Godfrey Tunnicliff, Kathy L. Welborn and That T. Ngo Hans Kriiger, Regina Gr~itz and Helga Grahn M. Grau and J. Balasch M. Alfonso, M. A. Parafita, M. J. Mancebo and J. Marc6 Unto Nousiainen T. R. Hall, G. Uruefia and H. R. Figueroa H. Meshkinpour, D. Hollander, D. Harmon and S. Koyama M. L. Laorden, J. Hermindez and A. J. Brugger L. Michaiska, G. Nagel, E. Swiniarski and M. M. Zydowo Viviana Tarizzo and Modesto C. Rubio 13 19 25 31 37 43 PY 108-068: a calcium antagonist with an unusual pattern of cardiovascular activity 7 General anaesthetics: effects on transmitter release 49 55 61 65 69 Stimulation of the mouse hepatic microsomal aniline p- hydroxylases by acetone and polyamines Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons Identification of potential GABA-mimetics by their actions on brain GABA recognition sites Influence of ethanol upon the introduction of tyrosine amino- transferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats Protective effects of "cerebroactive drugs" in a model of acute hypoxia Further evidence for effects of ethanol on gonadotrophins and prolactin secretion in female rats Effects of phenobarbital and p,p'-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver Changes in mouse brain serotonin turnover following chronic imipramine administration Colonic absorption of 1,2-dimethyl hydrazine (DMH) in the rat The beta-agonist drug tulobuterol decreases cardiac auto- maticity in the rat: comparison with isoproterenol The effect of ~-solanine on the active calcium transport in rat intestine 71 Effects of cocaine on several adrenergic system parameters A. N. Elias, N. D. Vaziri, L. J. Deftos, R. Shinto and L. J. Valenta 75 Effect of bromocriptine on serum PTH, calcium and phos- phate levels in azotemic rats New Patents i New patents and published patent applications from the United States and over 30 other countries Minireview lan Kitchen 79 Vol. 16, No. 2 Endogenous opioid nomenclature: light at the end of the tunnel iii GP I~ 6,~H

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Page 1: Contents of volume 16

CONTENTS OF VOLUME 16

Vol. 16, No. 1

Minireviews

Robert P. Hof

F. A. Wali

General Papers

Arun P. Kulkarni and Ileana Gonzales

J. W. Phillis

Godfrey Tunnicliff, Kathy L. Welborn and That T. Ngo

Hans Kriiger, Regina Gr~itz and Helga Grahn

M. Grau and J. Balasch

M. Alfonso, M. A. Parafita, M. J. Mancebo and J. Marc6

Unto Nousiainen

T. R. Hall, G. Uruefia and H. R. Figueroa

H. Meshkinpour, D. Hollander, D. Harmon and S. Koyama

M. L. Laorden, J. Hermindez and A. J. Brugger

L. Michaiska, G. Nagel, E. Swiniarski and M. M. Zydowo

Viviana Tarizzo and Modesto C. Rubio

13

19

25

31

37

43

PY 108-068: a calcium antagonist with an unusual pattern of cardiovascular activity

7 General anaesthetics: effects on transmitter release

49

55

61

65

69

Stimulation of the mouse hepatic microsomal aniline p- hydroxylases by acetone and polyamines

Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons

Identification of potential GABA-mimetics by their actions on brain GABA recognition sites

Influence of ethanol upon the introduction of tyrosine amino- transferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats

Protective effects of "cerebroactive drugs" in a model of acute hypoxia

Further evidence for effects of ethanol on gonadotrophins and prolactin secretion in female rats

Effects of phenobarbital and p , p ' - D D T on carboxylesterase activity and hydrolysis of propanidid in rat liver

Changes in mouse brain serotonin turnover following chronic imipramine administration

Colonic absorption of 1,2-dimethyl hydrazine (DMH) in the rat

The beta-agonist drug tulobuterol decreases cardiac auto- maticity in the rat: comparison with isoproterenol

The effect of ~-solanine on the active calcium transport in rat intestine

71 Effects of cocaine on several adrenergic system parameters

A. N. Elias, N. D. Vaziri, L. J. Deftos, R. Shinto and L. J. Valenta

75 Effect of bromocriptine on serum PTH, calcium and phos- phate levels in azotemic rats

New Patents i New patents and published patent applications from the United States and over 30 other countries

Minireview

lan Kitchen 79

Vol. 16, No. 2

Endogenous opioid nomenclature: light at the end of the tunnel

iii G P I~ 6,~H

Page 2: Contents of volume 16

General Papers Cheng S. Tsai and Richard F. Ochillo

Masahiro Aomine and Makoto Arita

George B. Weiss and Phyllis Kutsky

H. R. Figueroa, P. B. Yiirgens, D. K. Newton and T. R. Hall

G. Baifag6n, J. A. Arranz and E. J. Marco

G. liliano, R. Galderisi, A. Di Donato, G. Paofisso and G. F. Draetta

Ritsuko Matsukawa, Mitsuo Hayakawa, Minoru Tanaka and Hisashi Takiguchi

Yoshiaki Akimoto, Hitoshi Nishimura, Masamichi Komiya, Tomomi Shibata, Kenji Kaneko, Akira Fujii and Toyoyuki Tamura

A. Hellegouarch, J. Baran~s, F. Clostre, K. Drieu, P. Braquet and F. V. DeFeudis

Kiyoshi Sakai, Kuniko Higuchi-Nakamura and Masaatsu-Koujiro Uchida

K. F. A. Soliman and N. N. Gabriel

N. D. Vaziri, C. Byrne, C. H. Barton, D. Robertson, K. Jay and L. McDonald

C. A. Taira and M. A. Enero

Lilla Lachowicz and Gra~yna Janiszewska

Birger Kaada and Idar Lygren

Pedro Garz6n, Sonia Roman-Maidonado, Alicia Navarro-Ruiz and Pedro Solis-Camara V

Book Reviews

85

91

97

103

Comparative studies of cardiovascular effects of a new dopamine agonist (SK&F 38393A) and dopamine

Pretreatment with coenzyme Q,0 protects guinea pig ventric- ular muscle from hypoxia-induced deterioration of action potentials and contraction

Effects of manganese on 45Ca mobilization and contractile responses in rabbit aortic smooth muscle

Evidence for negative feedback control of the release of [3H]serotonin from superfused mouse cerebellum slices in- duced by electrical field stimulation

109 Indirect adrenergic effect of histamine in cat right atrium

115

121

125

129

133

137

141

145

149

153

The effects of lidocaine and procainamide on the sarco- lemmal membrane high affinity cyclic AMP phospho- diesterase of rat myocardium

Prostaglandin A 2 receptor in rat intestinal basolateral plasma membranes

Ampicillin concentrations in human serum, gingiva, the mandibular bone, and dental follicle following a single oral administration

Comparison of the contractile effects of an extract of Ginkgo biloba and some neurotransmitters on rabbit isolated vena cava

Calcium reversal: inhibition by Ca ion of sustained con- traction in Ca-free medium induced by various agonists in rat uterine smooth muscle

Brain cholinergic involvement in the rapid development of tolerance to the hypothermic action of ethanol

Prevention of metabolic alkalosis induced by gastric fluid loss using H 2 receptor antagonist

Participation of cholinergic pathways in sinoaortic de- nervated rats

Role of theophylline during the action of SP in vitro on the activity of synaptosomal membrane ATPase (EC 3,6.1.3) from different areas of rat brain

Lower plasma levels of some gastrointestinal peptides m Raynaud's disease. Influence of transcutaneous nerve stimulation

157 Response of rats to seizure stimulus modified by feeding

161

iv

Page 3: Contents of volume 16

Review Edward K. Y. Chiu and 163 J. Steven Richardson

General Papers Jun-lchi Nishijima, 177 Mitsuhiro Okamoto, Kazunori Nakaguchi, Michio Ogawa, Toshio Yamano and Takesada Mori

C. Giunta, M. De Bortoli, 183 M. Sanchini and A. Stacchini

Gregory A. Beumel and 189 Ernest Hodgson

Gregory A. Beumel, Patricia E. Levi 193 and Ernest Hodgson

Kazuhiko Ohishi, Tamiko Suzuki and Masaatsu K. Uchida

Clement Judes, Jean-Jacques Helwig, Claude Bollack and Paul Mandel

199

205

Jiann-Wu Wei and Der-Huey Chiang 211

Kohji Fujii, Ryuji Inoue, Kiyoichiroh Yamanaka and Takeshi Yoshitomi

217

Armand Lione 223

Jan I. M. Drayer, Michael A. Weber and Patricia P. Frankfort

229

A. O. Savage and G. K. Atanga 235

J. G. Auc~lio, J. B. Calixto and A. Jurkiewicz

J. Marin, C. Lazcano, L. Recio, M. Salaices and C. F. Sanchez-Ferrer

Steven G. Kamerling, David J. DeQuick, Timothy J. Weckman and Thomas Tobin

C. Cortinovis, D. Mayer, B. Bouscarel, H. Paris and J. C. Murat

I. Takayanagi and K. Koike

I. Takayanagi, K. Okumura and K. Koike

241

247

253

259

265

Vol. 16, No. 3

Behavioral and neurochemical aspects of prostaglandins in brain function

Inhibitory effect of gabexate mesilate on pancreatic phos- pholipase Az-mediated hydrolysis of ghost membranes

Activatory effect of two cardioglycosides on Cavia cobaya kidney Na+/K+-ATPase activity

The binding of isocyanides to cytochrome P-450 from mouse hepatic microsomes

Spectral interactions of piperonyl butoxide and isocyanides with purified hepatic cytochrome P-450 from uninduced mice

Different effects of local anesthetics on calcium influx into rat mast cells

Isoproterenol-sensitive adenylate cyclase in glomeruli iso- lated from young and adult rat renal cortex

Studies of [3H]nitrendipine binding and KCl-induced calcium uptake in rat cortical synaptosomes

Effects of calcium antagonists on smooth muscle membranes of the canine stomach

Aluminum intake from non-prescription drugs and sucralfate

Disparate responses of blood pressure to adrenergic stimuli during beta blockade

Effect of adenosine 5'-triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama

Evidence for multiple sources of calcium involved on the contractile effects of agonists in the dog uterus. Influence of ovarian sexual hormones

Effect of tetraethylammonium and verapamil on nor- adrenaline release induced by field electrical stimulation and potassium from cat cerebral and femoral arteries

Dose-related effects of fentanyl on autonomic and behavioral responses in performance horses

Study of fl-adrenoceptors and fl-adrenergic responsiveness in cultured "'preneoplastic-like" and neoplastic rat hepatocytes

A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs

269 Interaction of muscarinic drugs with their receptor

Page 4: Contents of volume 16

Yoshiaki Akimoto, Hitoshi Nishimura, Masamichi Komiya, Tomomi Shibata, Kenji Kaneko, Akira Fujii and Toyoyuki Tamura

V. Bocci, G. P. Pessina, A. Pacini, L. Paulesu, M. Muscettola, A. Naldini and G. Lunghetti

Takeshi Katsuragi, Kazuo Furuta, Toshiro Harada and Tatsuo Furukawa

273

277

281

Concentrations of ampicillin and cefadroxil in human serum and mixed saliva following a single oral administration of talampicillin and cefadroxil, and relationships between serum and mixed saliva concentrations

Pharmacokinetics of human lymphoblastoid interferon in rabbits

A possible explanation for a greater discrepant suppression by adenosine and N6-cyclohexyl adenosine of the guinea-pig ileal contraction

S. Evangelista and A. Meli

Jos~ Ram6n Naranjo, Mario Fernandez-Roman, Maria del Carmen Urdin and Jos~ A. Fuentes

Gary B. Giavin

Ewa Turska, Lilla Lachowicz, Wiktor Kozioikiewicz and Tadeusz Wasiak

S. Gottfried~.I~, R. S. Vine and B. Y. C. Wan

B. M. Faggin and J. Palermo-Neto

M. Ubeda, F. Fenoy, L. F. Carbonell, F. J. Salazar, J. Garcia-Estafi, M. G. Salom and T. Quesada

285

287

Influence of antioxidants and radical scavengers on ethanol- induced gastric ulcers in the rat

/~-endorphin: a common factor in the antihypertensive action of clonidine-type imidazolines in spontaneously hypertensive rats

291 Zinc sulphate reduces activity-stress gastric lesions in rats

293 Effects of analogues of substance P fragments on the MAO activity in rat brain

297

299

A quantitative morphological study of the effects of car- benoxolone sodium on duodenal goblet-cells of the rat

Differential alterations in brain sensitivity to amphetamine and pentylenetetrazol in socially deprived mice

303 Effect of captopril on norepinephrine vascular contractility

Minireview

James R. Jauchem 307

Vol. 16, No. 4

Effects of drugs on thermal responses to microwaves

General Papers

P. V. Sulakhe, N. T. Phan and G. Jagadeesh

Terry L. Johnson and Charles O. Knowles

Koki Kato and Hideomi Fukuda

Kazuhiko Ohishi, Tamiko Suzuki and Masaatsu K. Uchida

Sumantra Das and Hemendra N. Bhargava

Thomas Yorio, Ron Royce, Janet Mattern, Larry X. Oakford, A. J. Mia and Nimman Tarapoom

M. F. Kenel and A. P. Kulkarni

311 Comparison of cholinergic inihibition and beta-adrenergic stimulation of adenylate cyclase from rat and guinea-pig hearts: effects of guanine nucleotides and monovalent cations

321 Formamidine-mediated inhibition of rat platelet aggregation

327

335

341

347

355

The non-GABAergic nature of 3H-baclofen binding in rat peripheral tissues

Relation between inhibition of calmodulin and mediator release from rat mast cells

Effect of prolyl-leucyl-glycinamide on blood pressure, heart rate and angiotensin converting enzyme activity in spontane- ously hypertensive and Wistar-Kyoto normotensive rats

Inhibition of the hydro-osmotic response to vasopressin and hypertonicity by phenothiazines and W7, calmodulin antagonists

Ethanol potentiation of carbon tetrachloride hepatotoxicity: possible role for the in vivo inhibition of aldehyde dehydrogenase

Page 5: Contents of volume 16

Markku Pasanen and Olavi Pelkonen 361 Resolution of multiple P-450 forms: separation of aryl hydrocarbon hydroxylase and aminopyrine N-demethylase- associated P-450 isoenzymes by chromatofocusing

D. R. Mottram and P. Saggar 367 Cirazoline, an :~2-adrenoceptor antagonist in guinea-pig ileum

M. H. Hawthorn, K. J. Broadley and C. J. Gibbon

371 Examination of the bronchoconstrictor response of guinea- pig isolated lung to /3-phenylethylamine

Fukio Konno, Yuka Sato, Kunimi Togashi, lssei Takayanagi and Masaaki Hirobe

379 Interactions of codeine-7,8-oxide (codeine-epoxide), as a new metabolite of codeine, with multiple opiate receptors

Minoru Tanaka and Yasuko Shibata 383 The different response of guinea pig peritoneal macrophages to various stimulators

C. Nze. Aguwa 387 Gastrointestinal effects of the extracts of Rhigiocarya racem- (fera ( Menispermaceae )

Nobuhiro Satake, Shoichi Ueda and Shoji Shibata

391 Dopamine-induced potentiation of the contractile response to arachidonic acid in guinea-pig aorta

N. D. Vaziri and C. Byrne 395 Effects of glucose feeding on renal electrolyte and H ~ transport

Jos~ Carlos Gomes and Abilio Antonio 399 Histamine release from the isolated guinea-pig heart by compound 48/80

Maria M. Bernardi, Moacyr L. Aizenstein, Roberto DeLucia and Crist6foro Scavone

403 Influence of phenoxybenzamine on the stereotyped behaviour induced by fencamfamine in rats: evidence for a qualitative alteration

Maria M. Bernardi and Crist6foro Scavone

407 Differential biochemical and behavioral effects of single and chronic administration of amphetamine and apomorphine

P. Garz6n, S. Gonzfilez-Cornejo, S. Romfin-Maldonado and A. Navarro-Ruiz

411 Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients

Francesc Villarroya and Teresa Mampel

415 Glucose tolerance and insulin response in offspring of ethanol-treated pregnant rats

Antonio Chapola, Nelson Villa, Luiz B. S. Valle, Ricardo M. Oliveira-Filho and Conceiq~o A. S. A. Minetti

419 fl-adrenergic stimulation of mouse parotid gland: amylase activity and secretory granules during isoproterenol-induced mitosis

C. Almodovar-Cuevas, A. Navarro-Ruiz, B. E. Bastidas-Ramirez, Ma. R. Mora-Navarro and P. Garz6n

423 Valproic acid effects on leukocytes and platelets of Sprague-Dawley rats

Book Reviews 427

New Patents i New patents and published patent applications from the United States and over 30 other countries

Review

G. Burnstock and C. Kennedy

Minireview

Edward J. Hammond and B. J. Wilder

Vol. 16, No. 5

433 Is there a basis for distinguishing two types of P2-purino- ceptor?

441 Gamma-vinyl GABA

vii

Page 6: Contents of volume 16

General Papers Masaatsn-Koujirou Uchida and Mitsuo Mita

Shunzo Nishibe, Michio Ogawa, Goro Kosaki and Takesada Mori

Antonio R. Granata

C. F. Sfinchez-Ferrer, J. Marin, M. Salaices, M. L. Rico and J. L. Mufioz-Blanco

Lynn Bradley and Sheila A. Doggrell

T. R. Hall, S. Harvey and A. Chadwick

Carlos Beas-Zfirate, Jorge Arauz-Contreras, Anselmo Velazquez and Alfredo Feria-Velasco

M. J. Carmena and J. C. Prieto

I. Takayanagi, F. Konno and M. Kusunoki

J. S. Serrano, F. J. Mifiano, M. Saneibrifin and J. A. Durfin

N. Seiler, S. Sarhan, P. Krogsgaard-Larsen, H. Hjeds and A. Schousboe

Tetsnyuki Nasu, Kazuyoshi Gyobn and Yukio Ishida

S. C. Yeong and A. V. Jnorio

Robin A. Barraco, John W. Phillis and Harvey J. Altman

Charles D. Lox, Dennis M. Lox and M. Wayne Heine

E. Contreras and L. Tamayo

H. De Souza and J. Palermo-Neto

Francesc Villarroya, Teresa Mampel and Emilio Herrera

449

455

463

469

475

483

489

495

501

505

509

513

517

521

Effects of Quin-2, an intracellular Ca chelator, and TMB-8, an intracellular Ca antagonist, on the short-term desensi- tization to histamine in guinea pig taenia caecum

Effects of protease inhibitors and calmodulin inhibitors on Ca 2+ influx and catecholamine secretion in isolated bovine adrenal medullary cells

Prolonged treatment with (_+)propranolol induces super- sensitivity to (L)noradrenaline in mesenteric arteries in the rat

Interference of pentobarbital and thiopental with the vascu- lar contraction and noradrenaline release in human cerebral arteries

Modification of desipramine of the effects of ~-adrenoceptor antagonists on the contractile responses of the trisected rat vas deferens

Effects of putative neurotransmitters on release of prolactin from pituitary glands of the domestic fowl co-incubated with hypothalamic tissue

Monosodium L-glutamate-induced convulsions II. Changes in catecholamine concentrations in various brain areas of adult rats

VIP binding to epithelial cell membranes of rat ventral prostate: effect of guanine nucleotides

Some pharmacological effects of tizanidine on smooth muscle organs and ~:-adrenoceptor

Involvement of bicuculline-insensitive receptors in the hypo- thermic effect of GABA and its agonists

Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor

Analysis of mercury ions binding to the smooth muscle of guinea-pig taenia coli

The effects of estradiol and progesterone on the concen- tration of striatal dopamine and tyramine in ovariectomized mice

Depressant effect of forskolin on spontaneous locomotor activity in mice

525 Effects of acute ethanol intoxication combined with seco- barbital abuse on hemostasis

529 Effects of ethylenediamine on morphine analgesia and tolerance-dependence in mice

533 A biochemical study of cholinergic dopaminergic inter- actions in the central nervous system

537 Similar metabolic response to acute ethanol intake in preg- nant and non-pregnant rats either fed or fasted

viii

Page 7: Contents of volume 16

Ghandi M. Saadeh, Raja E. Ayash, Fadi M. Saadeh and Camille F. Nassar

Book Reviews

541

545

Effect of aminophylline on calcium transport across the rat diaphragm

Minireviews T. B. Ng and H. W. Yeung

F. V. DeFeudis

General Papers

M. S. Dar, P. L. Morselli and E. R. Bowman

Gabriella Coruzzi, Enzo Poli and Giulio Bertaccini

Maria E. M. Oshiro, Antonio C. M. Paiva and Therezinha B. Paiva

Helen Kotsifaki, Vasilios Kapoulas and George Deliconstantinos

Carlo Alberto Maggi, Sandro Giuliani and Alberto Meli

Lorie R. Pelc, Garrett J. Gross and David C. Warltier

Francesc Villarroya and Teresa Mampel

I. N. Stoyanov, K. T. Milenov, A. G. Ter-Margaryan, M. P. Milanov and V. I. Vassilev

R. C. Elliott

J. W. Phillis, A. S. Bender and W. Marszalec

I. Takayanagi, F. Konno, H. Arai, K. Chimoto and T. Kitada

I. Takayanagi, K. Okumura, F. Konno, K. Koike, N. Cho and M. Hirobe

P. S. Key, N. D. Vaziri and M. Childester

Camille F. Nassar, Michel G. Nasser and Zouheir M. Habbal

Vol. 16, No. 6

549 Hypoglycemic constituents of Panax ginseng

553 Are vascular mechanisms involved in antidepressant action?

557

561

567

573

579

The enzymatic systems involved in the mammalian metabo- lism of methylamine

Action of different agonists and antagonists of the cholinergic system on the rat lower esophageal sphincter

Endothelium-dependent inhibition of the use of extracellular calcium for the arterial response to vasoconstrictor agents

Targeting of liposomes containing methotrexate towards Tetrahymena pyriformis cells

The effect of peripherally administered GABA on noradren- aline-induced reflex vagal bradycardia in urethane ana- esthetized rats

585 Cardiac and systemic hemodynamic actions of the slow channel calcium blocking agent, KB-944

591

597

603

609

613

617

621

625

Effects of chronic ethanol treatment on glucose tolerance, insulin response and circulating metabolites in the pregnant rat

Effects of prostaglandin F2~ and indomethacin on the contractile activity of different compartments of the complex stomach

The action of intravenous anaesthetic and central depressant drugs on the contractures elicited by tetraethylammonium in the chick biventer cervicis muscle

Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons

Newly synthesized ~l-adrenoceptor blockers (SM911 and SM2470) and characterization of ct-adrenoceptors in rat aortic strips, rat vas deferens preparations and rabbit aortic strips

Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p and sodium ion on the affinity of dynorphin 1-13,nalorphine and nalorphine-7,8-oxide to kappa-opioid receptor

Effect of H 2 histamine receptor blockade and stimulation on urinary acidification

Receptors of prostaglandin E l in the plasma membrane of normal liver. Effect of membrane fluidity on PGE~ binding

ix

Page 8: Contents of volume 16

C. P~rez, M. E. Otero Losada and 629 M. C. Rubio

M. Salaices, A. de Gregorio 633 and J. Matin

Seico Hanada, Seizi Oga and Marcia T. Hirano

B. Bouscarel, J. C. Murat and H. Paris 641

Book Reviews 645

Changes in GABAergic system parameters after chronic administration of bicuculline

Study of vasodilator effects of papaverine, adenosine and related drugs in isolated cat cerebral arteries

637 Some characteristics of econazole-induced pleurisy in rats

Involvement of guanine nucleotide and sodium in regulation of yohimbine and clonidine binding sites in the HT29 human colon adenocarcinoma cell-line