VOL 28, NO 4 August 2013

CONTENTSEditorial

World Sepsis Day II; H7N9; Cardiopulmonary ResuscitationPhilip D. Lumb....................................................................................................................... 319

Infection

Myocardial Dysfunction During H1N1 Influenza InfectionDavid Fagnoul, Pierre Pasquier, Laurent Bodson, Julian Arias Ortiz, Jean-Louis Vincent, and Daniel De Backer. .......................................................................... 321

Acinetobacter baumannii Infection Was Decreased by the Structural Renovation of a Medical Intensive Care Unit

Seong-Su Nah, Yun-Hee Park, Joo Won Chung, Sunmi Yoo, Sang Bum Hong, Chae-Man Lim, and Younsuck Koh ........................................................................................ 328

Length of Stay and Mortality Due to Clostridium difficile Infection Acquired in the Intensive Care Unit

Peter M. Dodek, Monica Norena, Najib T. Ayas, Marc Romney, and Hubert Wong ............. 335

Dose Modulation: A New Concept of Antibiotic Therapy in the Critically Ill Patient?Joao Goncalves-Pereira and José-Artur Paiva ..................................................................... 341

Antibiotic Resistance Patterns in Medical and Surgical Patients in a Combined Medical-Surgical Intensive Care Unit

Jason A. Akulian and Mark L. Metersky ................................................................................ 347

Accuracy of the Chest Radiograph to Identify Bilateral Pulmonary Infiltrates Consistent With the Diagnosis of Acute Respiratory Distress Syndrome Using Computed Tomography as Reference Standard

Juan B. Figueroa-Casas, Noemi Brunner, Alok K. Dwivedi, and Anoop P. Ayyappan .......... 352

Low–Tidal Volume Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome Caused by Pandemic Influenza A/H1N1 Infection

Dong Kyu Oh, Myung Goo Lee, Eun Young Choi, Jaemin Lim, Hyun-Kyung Lee, Seok Chan Kim, Chae-Man Lim, Younsuck Koh, Sang-Bum Hong, and for The Korean Society of Critical Care H1N1 Alternative ........................................... 358

Acute Kidney Injury

Genetic Predisposition to Acute Kidney Injury Induced by Severe SepsisPablo Cardinal-Fernández, Antonio Ferruelo, Mariam El-Assar, Catalina Santiago, Félix Gómez-Gallego, Ana Martín-Pellicer, Fernando Frutos-Vivar, Oscar Peñuelas, Nicolás Nin, Andrés Esteban, and José A. Lorente ............................................................... 365

Urine Biochemistry in Septic and Non-Septic Acute Kidney Injury: A Prospective Observational StudySean M. Bagshaw, Michael Bennett, Prasad Devarajan, and Rinaldo Bellomo................... 371

Journal ofCritical Care

Urine Output is Associated With Prognosis in Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

Hyung Jung Oh, Dong Ho Shin, Mi Jung Lee, Kwang Il Ko, Chan Ho Kim, Hyang Mo Koo, Fa Mee Doh, Young Eun Kwon, Yung Ly Kim, Ki Heon Nam, Kyoung Sook Park, Seong Yeong An, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, and Shin-Wook Kang ............................................................................................................. 379

Acute Kidney Injury After Cardiac Surgery According to Risk/Injury/Failure/Loss/End-Stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes Classifications

Anthony J. Bastin, Marlies Ostermann, Andrew J. Slack, Gerhard-Paul Diller, Simon J. Finney, and Timothy W. Evans. ................................................................................ 389

Outcomes

Mortality and Complications in Elderly Patients Undergoing Cardiac SurgeryEmilio Curiel-Balsera, Juan M. Mora-Ordoñez, Encarnacion Castillo-Lorente, Josele Benitez-Parejo, Angel Herruzo-Avilés, Juan J. Ravina-Sanz, Miguel Alvarez-Bueno, and Ricardo Rivera-Fernandez. ....................................................... 397

Intensive Care Unit–Acquired Hypernatremia is an Independent Predictor of Increased Mortality and Length of Stay

Michael D. Waite, Steven A. Fuhrman, Omar Badawi, Ilene H. Zuckerman, and Christine S. Franey ......................................................................................................... 405

The Impact of Age on Outcome After Major Surgical ProceduresCristina Elia, Christian Schoenfeld, Ole Bayer, Christian Ewald, Konrad Reinhart, and Yasser Sakr. ..................................................................................................................... 413

The Clinical Quandary of Counseling the Moribund Critical Care Patient—A Registry Analysis of Postsurgical Outcomes

Leif Saager, Brian D. Hesler, Luke F. Reynolds, Anupa Deogaonkar, Jarrod E. Dalton, Andrea Kurz, and Alparslan Turan. ....................................................................................... 421

Relationships Between Mortality, Morbidity, and Physical Function in Adults Who Survived a Period of Prolonged Mechanical Ventilation

Kylie Hill, Diane M. Dennis, and Shane M. Patman ............................................................ 427

Nurse-Driven, Protocol-Directed Weaning From Mechanical Ventilation Improves Clinical Outcomes and is Well Accepted by Intensive Care Unit Physicians

Mauricio Danckers, Horiana Grosu, Raymonde Jean, Raul B. Cruz, Amelita Fidellaga, Qifa Han, Elizabeth Awerbuch, Nagesh Jadhav, Keith Rose, and Hassan Khouli................ 433

Music and Biological Stress Dampening in Mechanically-Ventilated Patients at the Intensive Care Unit Ward—A Prospective Interventional Randomized Crossover Trial

Genevieve Beaulieu-Boire, Solange Bourque, Frederic Chagnon, Lucie Chouinard, Nicole Gallo-Payet, and Olivier Lesur .................................................................................. 442

Administration

Effects of the Implementation of a Preventive Interventions Program on the Reduction of Medication Errors in Critically Ill Adult Patients

Carlos M. Romero, Nicole Salazar, Lorena Rojas, Leslie Escobar, Héctor Griñén, María Angélica Berasaín, Eduardo Tobar, and Marcela Jirón ............................................. 451

Impact of Bed Availability on Requesting and Offering in-Hospital Intensive Care Unit Transfers: A Survey Study of Generalists and Intensivists

Sean G. Kelly, Miles Hawley, and James O'Brien Jr. ............................................................ 461

Capture-Mark-Recapture as a Tool for Estimating the Number of Articles Available for Systematic Reviews in Critical Care Medicine

Daniel Lane, Jonathan Dykeman, Mauricio Ferri, Charles H. Goldsmith, and Henry T. Stelfox ............................................................................................................... 469

Assessing the Quality of Interdisciplinary Rounds in the Intensive Care UnitElsbeth C.M. Ten Have, Mariet Hagedoorn, Nicole D. Holman, Raoul E. Nap, Robbert Sanderman, and Jaap E. Tulleken. .......................................................................... 476

A Narrative-Based Study on Communication by Family Members in Intensive Care UnitStefania Di Gangi, Giuseppe Naretto, Nicole Cravero, and Sergio Livigni ......................... 483

Pediatric Upper Airway Obstruction: Interobserver Variability is the Road to PerditionRobinder G. Khemani, James B. Schneider, Rica Morzov, Barry Markovitz, and Christopher J.L. Newth. .................................................................................................. 490

Rapid Response Teams, Do Not Resuscitate Orders, and Potential Opportunities to Improve End-of-Life Care: A Multicentre Retrospective Study

James Downar, Danielle Rodin, Reeta Barua, Brandon Lejnieks, Rakesh Gudimella, Victoria McCredie, Chris Hayes, and Andrew Steel.. ........................................................... 498

Effects of Team Coordination During Cardiopulmonary Resuscitation: A Systematic Review of the Literature

Ezequiel Fernandez Castelao, Sebastian G. Russo, Martin Riethmüller, and Margarete Boos. ............................................................................................................. 504

Letters/Editorials

Team Coordination During Cardiopulmonary ResuscitationMichaela Kolbe and Bastian Grande .................................................................................... 522

PCR Diagnosis of CandidemiaSerge Alfandari, Pierre-Yves Delannoy, and Hugues Georges ............................................. 524

Polymerase Chain Reaction Diagnosis of CandidemiaFrank Bloos and Konrad Reinhart. ........................................................................................ 525

The Burden of Sepsis—A Call to Action in Support of World Sepsis Day 2013Konrad Reinhart, Ron Daniels, Niranjan Kissoon, James O'Brien, Falvia Machado, Edgar Jimenez, and On Behalf of the GSA Executive Board and WSD Executive Board ..... 526

Avian Influenza A (H7N9) Infections: Intensivists as Virus Hunters in the New CenturyXiuming Xi, Qiang Fang, Qin Gu, Bin Du, and for the China Critical Care Clinical Trial Group (CCCCTG) ......................................................................................................... 528

Electronic Articles

Characterization of the Spectrum of Hemodynamic Profiles in Trauma Patients With Acute Neurogenic Shock

Richard L. Summers, Stephen D. Baker, Sarah A. Sterling, John M. Porter, and Alan E. Jones .................................................................................................................. 531

Effect of Intraoperative Dobutamine on Splanchnic Tissue Perfusion and Outcome After Whipple Surgery

Amal Rashad Reyad, Walaa Elkharboutly, Ashraf Wahba, Mohamed Elmorshedi, and Nadia A. Hasaneen ......................................................................................................... 531

Survival of Septic Adults Compared With Nonseptic Adults Receiving Extracorporeal Membrane Oxygenation for Cardiopulmonary Failure: A Propensity-Matched Analysis

Aristine Cheng, Hsin-Yun Sun, Ching-Wen Lee, Wen-Je Ko, Pi-Ru Tsai, Yu-Chung Chuang, Fu-Chang Hu, Shan-Chwen Chang, and Yee-Chun Chen ..................... 532

Coronary Artery Disease in Patients Clinically Diagnosed With Myocardial Infarction in the Medical Intensive Care Unit

Yousang Ko, Chi-Min Park, Wooyoul Kim, Byeong-Ho Jeong, Gee Young Suh, So Yeon Lim, O Jung Kwon, and Kyeongman Jeon ............................................................... 532

Exhaled Nitrite/Nitrate Levels as a Marker of Respiratory Complications After Heart Valve SurgeryLívia Arcêncio, Daniella Alves Vento, Solange Bassetto, Paulo R.B. Évora, and Alfredo José Rodrigues ................................................................................................... 533

A 5-Year Observational Study of Lung-Protective Ventilation in the Operating Room: A Single-Center Experience

Dean R. Hess, Dhimiter Kondili, Edward Burns, Edward A. Bittner, and Ulrich H. Schmidt...... 533

Effectiveness of End-Expiratory Lung Volume Measurements During the Lung Recruitment Maneuver for Patients With Atelectasis

Susumu Nakahashi, Satoshi Gando, Takehiko Ishikawa, Takeshi Wada, Yuichiro Yanagida, Nobuhiko Kubota, Shinji Uegaki, Mineji Hayakawa, and Atsushi Sawamura. ...................... 534

Prescribing Nonopioids in Mechanically Ventilated Critically Ill PatientsJean-Francois Payen, Celine Genty, Olivier Mimoz, Jean Mantz, Jean-Luc Bosson, and Gerald Chanques ............................................................................................................ 534

Novel Device (AirWave) to Assess Endotracheal Tube Migration: A Pilot StudyGustavo Cumbo Nacheli, Manish Sharma, Xiaofeng Wang, Amit Gupta, Jorge A. Guzman, and Adriano R. Tonelli ............................................................................. 535

Safety and Feasibility of Femoral Catheters During Physical Rehabilitation in the Intensive Care Unit

Abdulla Damluji, Jennifer M. Zanni, Earl Mantheiy, Elizabeth Colantuoni, Michelle E. Kho, and Dale M. Needham ............................................................................... 535

The Effect of Electrical Muscle Stimulation on the Prevention of Disuse Muscle Atrophy in Patients With Consciousness Disturbance in the Intensive Care Unit

Tomoya Hirose, Tadahiko Shiozaki, Kentaro Shimizu, Tomoyoshi Mouri, Kazuo Noguchi, Mitsuo Ohnishi, Takeshi Shimazu .............................................................. 536

Hypophosphatemia in Critically Ill PatientsSatoshi Suzuki, Moritoki Egi, Antoine G. Schneider, Rinaldo Bellomo, Graeme K. Hart, and Colin Hegarty ..................................................................................... 536

Prediction of Fluid Responsiveness in Patients Admitted to the Medical Intensive Care UnitBernd Saugel, Stephanie V. Kirsche, Alexander Hapfelmeier, Veit Phillip, Caroline Schultheiss, Roland M. Schmid, and Wolfgang Huber ........................................... 537

Impaired Gastrointestinal Transit and Its Associated Morbidity in the Intensive Care UnitTiffany Nguyen, Anne-Julie Frenette, Christel Johanson, Robert D. MacLean, Rakesh Patel, Allison Simpson, Avinder Singh, Katelyn S. Balchin, Dean Fergusson, and Salmaan Kanji ................................................................................................................ 537

Correlation of Oxygen Saturation as Measured by Pulse Oximetry/Fraction of Inspired Oxygen Ratio With Pao2/Fraction of Inspired Oxygen Ratio in a Heterogeneous Sample of Critically Ill Children

Carlos Lobete, Alberto Medina, Corsino Rey, Juan Mayordomo-Colunga, Andrés Concha, and Sergio Menéndez. ................................................................................. 538

Severe Abnormalities in Microvascular Perfused Vessel Density Are Associated to Organ Dysfunctions and Mortality and Can Be Predicted by Hyperlactatemia and Norepinephrine Requirements in Septic Shock Patients

Glenn Hernandez, E. Christiaan Boerma, Arnaldo Dubin, Alejandro Bruhn, Matty Koopmans, Vanina Kanoore Edul, Carolina Ruiz, Ricardo Castro, Mario Omar Pozo, Cesar Pedreros, Enrique Veas, Andrea Fuentealba, Eduardo Kattan, Maximiliano Rovegno, and Can Ince ........................................................ 538

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