journal home page :www.journals.elsevier.com/journal-of-molecular-biology

ContentsVolume 425, Issues 9

Special Issue Part I: Allosteric Interactions and Biological RegulationGuest Editors: Charalampos Kalodimos and Stuart Edelstein

Editorial Overview

Allosteric Interactions after 50 Years S. J. Edelstein 1391–1395

Perspectives

The Origins of Allostery: From PersonalMemories to Material for the Future

J.-P. Changeux 1396–1406

The Design of an Enzyme: A Chronology onthe Controversy

H. Buc 1407–1409

The Propagation of Allosteric States in LargeMultiprotein Complexes

D. Bray 1410–1414

Allosteric Effects in the Regulation of 26SProteasome Activities

P. Sledz, F. Forster,and W. Baumeister

1415–1423

Reviews

Cooperativity of Allosteric Receptors S. J. Edelstein and N. Le Novere 1424–1432

Statistical Mechanics ofMonod–Wyman–Changeux (MWC) Models

S. Marzen, H. G. Garcia,and R. Phillips

1433–1460

The Energy and Work of a Ligand-GatedIon Channel

A. Auerbach 1461–1475

Structure and Allostery of the ChaperoninGroEL

H. R. Saibil, W. A. Fenton, D. K. Clare,and A. L. Horwich

1476–1487

Virus Assembly and Maturation:Auto-Regulation through Allosteric MolecularSwitches

T. Domitrovic, N. Movahed,B. Bothner, T. Matsui, Q. Wang,P. C. Doerschuk, and J. E. Johnson

1488–1496

Abstracted/indexed in: BIOSIS, Biochemistry and Biophysics Citation Index, Biological Abstracts, Biological and Agricultural Index, Biostatistica,Biotechnology Citation Index, Chemical Abstracts, Current Contents (Life Sciences, Clinical Medicine), EMBASE, EMBiology, Excerpta Medica, Food

Science and Technology Abstracts, Genetics Abstracts, Immunology Abstracts, MEDLINE®, Reference Update, Research Alert, SCISEARCH, ScienceCitation Index, etc. Also covered in the abstract and citation database SciVerse Scopus®. Full text available on SciVerse ScienceDirect®

Brevia

Derivation of the Crick–Wyman Equationfor Allosteric Proteins Defining theDifference between the Number of BindingSites and the Hill Coefficient

F. Poitevin and S. J. Edelstein 1497–1499

Communications

A Footnote on Allostery F. H. C. Crick and J. Wyman 1500–1508

Hidden Allostery in Human GlutathioneTransferase P1-1 Unveiled by UnnaturalAmino Acid Substitutions and InhibitionStudies

U. M. Hegazy, Y. Musdal,and B. Mannervik

1509–1514

Articles

Hemoglobin Allostery: New Views onOld Players

A. E. Miele, A. Bellelli,and M. Brunori

1515–1526

Long-Range Interactions in the Alpha Subunitof Tryptophan Synthase Help to CoordinateLigand Binding, Catalysis, and SubstrateChanneling

J. M. Axe and D. D. Boehr 1527–1545

The Membrane-Binding Domain of anAmphitropic Enzyme Suppresses Catalysisby Contact with an Amphipathic HelixFlanking Its Active Site

H. K.-H. Huang, S. G. Taneva, J. Lee,L. P. Silva, D. C. Schriemer,and R. B. Cornell

1546–1564

The Tropomyosin Binding Region of CardiacTroponin T Modulates CrossbridgeRecruitment Dynamics in Rat Cardiac MuscleFibers

S. K. Gollapudi, C. E. Gallon,and M. Chandra

1565–1581

Three Sites and You Are Out: TernarySynergistic Allostery Controls AromaticAmino Acid Biosynthesis inMycobacterium tuberculosis

N. J. Blackmore, S. Reichau, W. Jiao,R. D. Hutton, E. N. Baker,G. B. Jameson, and E. J. Parker

1582–1592