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Regulation of Th Cell Subset Differentiation

Cell Lineage Plasticity of Treg Cells

Therapeutic Application of Treg Cells

Therapeutic application of Foxp3-transduced Th cells in mouse models of human diseases. Left, inflammatory bowel diseases (massive inflammatory infiltration in the colon) were induced by adoptive transfer of CD25-CD45RBh conventional CD4 T cells to immune deficient mice. However, co-transfer of Foxp3-transduced Th1 or Th17 cells greatly alleviate the diseases. Center and right, similarly, Foxp3-transduced Th cells suppressed disease development in the mouse models of multiple sclerosis and allergic asthma, respectively.