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CME QUESTIONS FOR JANUARY 2003 ISSUE OF THE JOURNAL OF UROLOGY 1. RANDOMIZED PROSPECTIVE EVALUATION OF EXTENDED VERSUS LIMITED LYMPH NODE DISSECTION IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER (vol. 169, pp. 145–148) Compared to a limited dissection an extended pelvic lymphadenectomy does not increase the risk of: a) lower extremity edema b) lymphocele c) impotence d) deep venous thrombosis e) ureteral injury 2. INTRAVESICAL BACILLUS CALMETTE-GUERIN VERSUS MITOMYCIN C FOR SUPERFICIAL BLADDER CANCER: A FORMAL META-ANALYSIS OF COMPARATIVE STUDIES ON RECURRENCE AND TOXICITY (vol. 169, pp. 90 –95) As opposed to intravesical therapy of bladder cancer with mitomycin C, bacillus Calmette-Guerin: a) has a lower tumor recurrence rate b) has no role in maintenance therapy c) has a lower toxicity rate d) needs only 6 treatment cycles for superior effect e) is ineffective at a low dose 3. CONSERVATIVE ELECTIVE TREATMENT OF UPPER URINARY TRACT TUMORS: A MULTIVARIATE ANALYSIS OF PROGNOSTIC FACTORS FOR RECURRENCE AND PROGRESSION (vol. 169, pp. 82– 85) Tumor excision instead of nephroureterectomy for upper urinary tract transitional cell carcinoma: a) is best with renal pelvic tumors b) is indicated after previous multi-recurrent bladder tumors c) rarely needs close followup d) will not lead to tumor progression e) may be followed by bilateral recurrence 4. COMPLICATIONS OF RADICAL CYSTECTOMY FOR NONMUSCLE INVASIVE DISEASE: COMPARISON WITH MUSCLE INVASIVE DISEASE (vol. 169, pp. 101–104) Radical cystectomy in patients with nonmuscle invasive disease as opposed to muscle invasive disease has: a) a lower minor complication rate b) a lower major complication rate c) a lower blood transfusion rate d) a shorter length of stay in the hospital e) the same incidence of ileus 5. THE EFFECT OF FINASTERIDE ON THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND MICROVESSEL DENSITY: A POSSIBLE MECHANISM FOR THE DECREASED PROSTATIC BLEEDING IN TREATED PATIENTS (vol. 169, pp. 20 –23) Vascular endothelial growth factor: a) inhibits the action of finasteride b) stimulates 5-reductase c) is a fundamental regulator of physiological and pathological angiogenesis d) inhibits angiogenesis e) has decreased expression in areas of increased microvessel density 335

CME QUESTIONS FOR JANUARY 2003 ISSUE OF THE JOURNAL OF UROLOGY®

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CME QUESTIONS FOR JANUARY 2003 ISSUE OFTHE JOURNAL OF UROLOGY�

1. RANDOMIZED PROSPECTIVE EVALUATION OF EXTENDED VERSUS LIMITED LYMPH NODE DISSECTION INPATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER (vol. 169, pp. 145–148)

Compared to a limited dissection an extended pelvic lymphadenectomy does not increase the risk of:

a) lower extremity edemab) lymphocelec) impotenced) deep venous thrombosise) ureteral injury

2. INTRAVESICAL BACILLUS CALMETTE-GUERIN VERSUS MITOMYCIN C FOR SUPERFICIAL BLADDERCANCER: A FORMAL META-ANALYSIS OF COMPARATIVE STUDIES ON RECURRENCE AND TOXICITY (vol.169, pp. 90–95)

As opposed to intravesical therapy of bladder cancer with mitomycin C, bacillus Calmette-Guerin:

a) has a lower tumor recurrence rateb) has no role in maintenance therapyc) has a lower toxicity rated) needs only 6 treatment cycles for superior effecte) is ineffective at a low dose

3. CONSERVATIVE ELECTIVE TREATMENT OF UPPER URINARY TRACT TUMORS: A MULTIVARIATEANALYSIS OF PROGNOSTIC FACTORS FOR RECURRENCE AND PROGRESSION (vol. 169, pp. 82–85)

Tumor excision instead of nephroureterectomy for upper urinary tract transitional cell carcinoma:

a) is best with renal pelvic tumorsb) is indicated after previous multi-recurrent bladder tumorsc) rarely needs close followupd) will not lead to tumor progressione) may be followed by bilateral recurrence

4. COMPLICATIONS OF RADICAL CYSTECTOMY FOR NONMUSCLE INVASIVE DISEASE: COMPARISON WITHMUSCLE INVASIVE DISEASE (vol. 169, pp. 101–104)

Radical cystectomy in patients with nonmuscle invasive disease as opposed to muscle invasive disease has:

a) a lower minor complication rateb) a lower major complication ratec) a lower blood transfusion rated) a shorter length of stay in the hospitale) the same incidence of ileus

5. THE EFFECT OF FINASTERIDE ON THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR ANDMICROVESSEL DENSITY: A POSSIBLE MECHANISM FOR THE DECREASED PROSTATIC BLEEDING INTREATED PATIENTS (vol. 169, pp. 20–23)

Vascular endothelial growth factor:

a) inhibits the action of finasterideb) stimulates 5�-reductasec) is a fundamental regulator of physiological and pathological angiogenesisd) inhibits angiogenesise) has decreased expression in areas of increased microvessel density

335