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Graphically height- ed claim: 48/50 of the best selling drugs of 2013 were developed with Covance Central Your ideas make it possible. Our solutions make it happen. THE POWER OF NEW POSSIBILITIES. What happens when the largest, most trusted central laboratory and the broadest array of specialty clinical testing services come together? Reveal new opportunities and insights by partnering with our team of dedicated scientists and operational experts. Covance accelerates your clinical testing through unique insights, globally consistent processes and a commitment to on-time data delivery. Something new. Something powerful. Something unique. 48 OF THE 50 BEST-SELLING DRUGS OF 2015 WERE DEVELOPED IN PARTNERSHIP WITH COVANCE We generate more clinical trial data than any other central laboratory in the world.

CLS Capabilities 08Dec16

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Page 1: CLS Capabilities 08Dec16

Graphically height-ed claim: 48/50 of the best selling drugs of 2013 were developed with Covance Central

Your ideas make it possible. Our solutions make it happen.

THE POWER OF NEW POSSIBILITIES.What happens when the largest, most trusted central laboratory and the broadest array of specialty clinical testing services come together?

Reveal new opportunities and insights by partnering with our team of dedicated scientists and operational experts.

Covance accelerates your clinical testing through unique insights, globally consistent processes and a commitment to on-time data delivery.

Something new.Something powerful.Something unique.

48 OF THE 50BEST-SELLINGDRUGS OF 2015WERE DEVELOPEDIN PARTNERSHIPWITH COVANCE

We generate more clinical trial data than

any other central laboratory in the world.

Page 2: CLS Capabilities 08Dec16

YOUR PROTOCOL WILL BE THE STARTING POINTIt will be at the center of everything we do

• We will bring the unique insight that only the most experienced lab can provide.

• Complex biomarkers? Remote sites? No problem. We have solutions for that.

• Working together, we will conduct an efficient study, yielding more statistically powerful data.

WE UNDERSTAND YOUR SCIENCEWe put practically any test at your fingertips. Effortlessly.

5,100+STUDIES

IN THE LAST 5 YEARS

You get the insight you need to make better decisions. Sooner.

YOUR TIMEIS MONEY.Our experience

delivers results.

Faster.

• Diverse assay development platforms

that reveal elusive biomarker solutions

in the discovery/exploratory phase.

600+ASSAYSARE DONE WITHIN

OUR CENTRAL LABS

3,000+ASSAYSAND THE SCIENTISTS THAT

VALIDATED THEM — ARE

AVAILABLE WITHIN OUR LABCORP

SPECIALITY TESTING GROUP AND

MANAGED ACCORDING TO CLINICAL

TRIAL STANDARDS, FROM A TOTAL

MENU OF OVER 4,500 ASSAYS.

• Proven solutions for CDx and personalized

medicine that give you a new perspective

on your path to commercialization.

Page 3: CLS Capabilities 08Dec16

Whether you are pursuing an in vitro diagnostic (IVD) or a lab developed test (LDT) that can be FDA-approved as a companion diagnostic, we are ready to support your personalized medicine program. Each of these pathways requires highly specialized technical, regulatory and commercial insight.

CDx DEVELOPMENTMore proven pathways to success

In 2015 alone, we worked on

60+ CDx PROGRAMSsupporting more than

125 CLINICAL PROTOCOLSin most therapeutic areas such as cardiovascular, CNS, infectious disease, inflammation and oncology.

We provide expertise in:

Regulatory submissionCommercialization

Development

Market access

Validation

Testing

21

345

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We have helped bring MORE THAN 80 APPROVED DIAGNOSTIC TESTS to market through collaborations with diagnostic test developers.

Together, Covance and LabCorp have the proven experience required

TO SUCCESSFULLY DEVELOPAND COMMERCIALIZE YOURNEXT COMPANION DIAGNOSTIC.

Page 4: CLS Capabilities 08Dec16

EXECUTE YOUR CLINICAL TRIALS WITH CONFIDENCEGlobally consistent platforms ensure data quality

REVEAL NEWCOMMERCIALIZATIONOPPORTUNITIESExceptional statistical power lets you

uncover even the smallest differences in

physiological response to drug candidates.

EVERY PATIENT COUNTSAutomation from kit

production through data

delivery speeds results,

improves consistency

and reduces test

cancellations.

*data source: Life Science Strategy Group Survey, 2016

Dependable, proactive logistics

process and experienced

contingency planning deliver

>99% SAMPLERECEIPT WITHINSTABILITY.

EXPANDED LABORATORY MANAGEMENT SOLUTIONSEnsure testing performed outside

the central lab is backed by rigorous

quality agreements.

We were the first central lab to meet

ISO 15189:2012STANDARDS.

ENROLL FASTERInvestigator sites prefer Covance Central Laboratory Services*

INVESTIGATOR SITES PREFER COVANCECENTRAL LABORATORY SERVICES3X

Page 5: CLS Capabilities 08Dec16

BRING THE POWER OF SCALE TO YOUR TRIAL, NO MATTER HOW LARGE… OR SMALL

4.6 MILLION+CUSTOM KITSper year

99.993%ACCURACY

97.7%ON TIME FIRST SUPPLIES

25,000KIT CAPACITYper day

GLOBAL AUTOMATED KIT PRODUCTION FACILITY

SAMPLE RECEIPT WITHIN STABILITY

Investigator training & global logistics drive:

BETTER DECISIONS, FASTER

CONSISTENT SAMPLE COLLECTION AND PROACTIVE LOGISTICS

PRE-ANALYTICAL AUTOMATIONSaves time...saves money...saves samples

• Efficient barcode scanning

• Missing samples identified within 1 minute

• 80% container re-use saves money...and our environment

You may have a Phase III study needing thousands of sites. Or a small trial, with just a single Phase I clinic. Or a specialty biomarker validation. Whatever the scale of your trial, experience precision delivery based on thousands of trials across all therapeutic areas.

LABLINK+ ONLINE DATA ACCESS• Results available within minutes for fast access

• Customizable reports

99.2%

HEMATOLOGY AUTOMATION• Hardware and software automation

• Results hours earlier

• Consistency you can trust

Page 6: CLS Capabilities 08Dec16

YOUR UNIQUE TRIAL. OUR DIVERSE CAPABILITIES.CUSTOMIZED SOLUTIONS.

DIVERSE GLOBALLABORATORY SOLUTIONSStarting with your protocol, we will develop

a customized solution drawing from our

unmatched suite of testing capabilities.

Don’t get boxed in by a niche lab with limited capabilities.

AN AGILE PARTNERFOCUSED ON YOUR SUCCESS

Trialneeds

Central labs

Phase I solutions

Genomics solutions

Covance bioanalytical services

Translational biomarker solutions

LabCorp Specialty Testing Group

External labs

LET’S BEGIN THE CONVERSATIONabout how we can work together to transform your clinical trial with our testing solutions.

Covance Inc., headquartered in Princeton, NJ, USA, is the drug development business of

Laboratory Corporation of America Holdings (LabCorp). COVANCE is a registered

trademark and the marketing name for Covance Inc. and its subsidiaries around the world.

© Copyright 2016 Covance Inc. BROCLS031-1116

The Americas +1.888.COVANCE (+1.888.268.2623) +1.609.452.4440

Europe / Africa +00.800.2682.2682 +44.1423.500888

Asia Pacific +800.6568.3000 +65.6.5686588

Visit:www.covance.com/clsfor more information.

REMEMBER:TIME IS MONEY. SO DON’T WAIT.

WE THINK OUTSIDE OF THE BOX TO GIVE YOU THE MOST TESTING OPTIONS.