Embed Size (px)
DESCRIPTION
Chapter 5: Renal Allograft Biopsy Wong Hin Seng. Table 5.2.1: Number of renal allograft biopsy, 2004-2010. 4 th MRRB report 2010, Malaysia. Figure 5.2.1: Number of renal allograft biopsy, 2004-2010. Allograft biospy. 200. 180. 160. 140. 120. 100. Number of renal transplant biopsy. 80. - PowerPoint PPT Presentation
Citation preview
Chapter 5:Renal Allograft Biopsy
Wong Hin Seng
Table 5.2.1: Number of renal allograft biopsy, 2004-2010
Year 2004 2005 2006 2007 2008 2009 2010 Total
Number of renal transplant biopsy
52 71 118 124 124 133 180 802
4th MRRB report 2010, Malaysia
Figure 5.2.1: Number of renal allograft biopsy, 2004-2010
4th MRRB report 2010, Malaysia
0
20
40
60
80
100
120
140
160
180
200
2004 2005 2006 2007 2008 2009 2010
Year
Nu
mb
er o
f re
na
l tr
ansp
lan
t b
iop
sy
Allograft biospy
Table 5.2.2: Number of renal allograft biopsy by centre, 2004-2010
4th MRRB report 2010, Malaysia
Table 5.2.3: Renal allograft biopsy by year and age group, rate per million population, 2004-2010
Age group
2004 2005 2006 2007
n % Rate n % Rate n % Rate n % Rate
<15 3 5.8 0.0 0 0.0 0.0 6 5.1 0.1 7 5.6 0.1
15-<25 14 26.9 0.3 15 21.1 0.3 25 21.2 0.5 19 15.3 0.4
25-<35 15 28.8 0.3 11 15.5 0.2 25 21.2 0.6 15 12.1 0.3
35-<45 14 26.9 0.4 23 32.4 0.6 26 22.0 0.7 49 39.5 1.2
45-<55 5 9.6 0.2 12 16.9 0.4 24 20.3 0.8 24 19.4 0.8
55-<65 1 1.9 0.1 8 11.3 0.5 8 6.8 0.5 10 8.1 0.6
>65 0 0.0 0.0 2 2.8 0.2 4 3.4 0.3 0 0.0 0.0
Total 52 100 0.2 71 100 0.3 118 100 0.4 124 100 0.5
4th MRRB report 2010, Malaysia
Continue;
4th MRRB report 2010, Malaysia
Age group
2008 2009 2010 Total
n % Rate n % Rate n % Rate n % Rate
<15 9 7.3 0.1 9 6.8 0.1 8 4.4 0.1 42 5.2 0.1
15-<25 22 17.7 0.4 17 12.8 0.3 21 11.7 0.4 133 16.6 0.4
25-<35 20 16.1 0.4 30 22.6 0.6 29 16.1 0.6 145 18.1 0.5
35-<45 25 20.2 0.6 24 18 0.6 66 36.7 1.6 227 28.3 0.8
45-<55 35 28.2 1.1 36 27.1 1.1 40 22.2 1.2 176 21.9 0.9
55-<65 9 7.3 0.5 16 12 0.9 12 6.7 0.6 64 8 0.5
>65 4 3.2 0.3 1 0.8 0.1 4 2.2 0.3 15 1.9 0.2
Total 124 100 0.5 133 100 0.5 180 100 0.6 802 100 0.4
Figure 5.2.3: Renal allograft biopsy by year and age group, rate per million population, 2004-2010
4th MRRB report 2010, Malaysia
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
2004 2005 2006 2007 2008 2009 2010
Year
Rat
e (P
er m
illi
on
po
pu
lati
on
)
<15 15-<25 25-<35 35-<45 45-<55 55-<65 >65
Table 5.3: Indications for renal allograft biopsy, 2004-2010
* Patients may have one or more clinical presentation* 48 patients have no information on clinical presentation (neither urine abnormalities nor graft function)
For 2004, 1 patient has 2 indicationsFor 2006, 4 patients have 2 indicationsFor 2007, 5 patients have 2 indicationsFor 2008, 6 patients have 2 indications
For 2009, 11 patients have 2 indicationsFor 2010, 7 patients have 2 indications
4th MRRB report 2010, Malaysia
Table 5.4: Timing of renal allograft biopsy, 2004-2010 (dates: date of biopsy & date of transplant)
Timing of renal transplant biopsy
Within 1
week
>1 week to 1month
> 1month to 3
months
> 3 months to 6 months
> 6months to 1 year
>1 yr post transplant
Total
n % n % n % n % n % n % n %
2004 2 3.8 9 17.3 12 23.1 8 15.4 3 5.8 18 34.6 52 100
2005 1 1.4 9 12.7 8 11.3 12 16.9 6 8.5 35 49.3 71 100
2006 4 3.4 15 12.7 13 11.0 9 7.6 9 7.6 68 57.6 118 100
2007 5 4.0 14 11.3 15 12.1 10 8.1 8 6.5 72 58.1 124 100
2008 6 4.8 13 10.5 17 13.7 8 6.5 11 8.9 69 55.6 124 100
2009 5 3.8 15 11.3 20 15.0 8 6.0 6 4.5 79 59.4 133 100
2010 6 3.3 40 22.2 28 15.6 21 11.7 13 7.2 72 40.0 180 100
Total 29 3.6 115 14.3 113 14.1 76 9.5 56 7.0 413 51.5 802 100
4th MRRB report 2010, Malaysia
Figure 5.4: Timing of renal allograft biopsy, 2004-2010
4th MRRB report 2010, Malaysia
0
10
20
30
40
50
60
70
80
90
2004 2005 2006 2007 2008 2009 2010
Year
NU
mb
er o
f ti
min
g o
f g
raft
bio
psy
Within 1 week >1 week to 1month > 1month to 3 months
> 3 months to 6 months > 6months to 1 year >1 yr post transplant
Table 5.5.1: Biopsy method, 2004-2011
*No data on biopsy technique
4th MRRB report 2010, Malaysia
Figure 5.5.1: Biopsy method (censored for missing data), 2004-2010
4th MRRB report 2010, Malaysia
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
2004 2005 2006 2007 2008 2009 2010
Year
Pro
po
tio
n o
f b
iop
sy
me
tho
d
Blind Not US guided US guided: Real time US guided: Not real-time
Table 5.5.2: Number of passes, 2004-2011
4th MRRB report 2010, Malaysia
Figure 5.5.2: Number of passes, 2004-2011
4th MRRB report 2010, Malaysia
0
10
20
30
40
50
60
70
2004 2005 2006 2007 2008 2009 2010
Year
Pe
rce
nta
ge
(%
)
1 2 3 4 5 6
Table 5.5.3: Number of glomeruli obtained on biopsy, 2004-2010
* No data information on the number of glomeruli
4th MRRB report 2010, Malaysia
Figure 5.5.3: Number of glomeruli obtained on biopsy, 2004-2010
4th MRRB report 2010, Malaysia
0
10
20
30
40
50
60
2004 2005 2006 2007 2008 2009 2010
Year
Pe
rce
nta
ge
(%
)
0 1-9 10-19 >20 Missing/Unknown*
Table 5.5.4: Type of complications, 2004-2011
a Mild complication is defined as presence of gross hematuria, perirenal collection, hematoma, or AVM that do not require interventionb Severe complication is defined as presence of hypotension or complications requiring intervention.
c No data information for complications
4th MRRB report 2010, Malaysia
Figure 5.6: Histological diagnosis, 2004-2010
4th MRRB report 2010, Malaysia
0
10
20
30
40
50
60
2004 2005 2006 2007 2008 2009 2010
Year
Per
cen
tag
e(%
)Acute rejection Borderline rejection Calcineurin inhibitor toxicity
Chronic allograft nephropathy Acute tubular necrosis PTLD**
De novo Recurrent GN Diabetic nephropathy
Others
Table 5.6 Histological diagnosis, 2004-2010
* Patients may have more than 1 diagnosis classification**Post Transplant Lymphoproliferative disease
4th MRRB report 2010, Malaysia
