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Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

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Page 1: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 2: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 3: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 4: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 5: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Classical genetic analysis of the cell cycle in fission yeastIdentification of the CDK cdc2Edinburgh, Zoology 1973-1980

Murdoch Mitchison Urs Leupold

Page 6: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Molec. gen. Genet. 146, 167-178, March 18, 1976

Genetic Control of the Cell Division CycleIn the Fission Yeast Schizosaccharomyces pombePaul Nurse, Pierre Thuriaux and Kim NasmythDepartment of Zoology, West Mains Road, Edinburgh EH9 3JT, UK.Institut für Allgemeine Mikrobiologie, Universität Bern, Altenbergrain 21, CH 3013 Bern, Switzerland

Page 7: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 8: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Genetic control of cell size at cell division in yeastPaul NurseDepartment of Zoology, West Mains Road, Edinburgh EH9 3JT, UK

Nature, Vol, 256, No. 5518, pp. 547-551, August 14, 1975

Peter Fantes

Page 9: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Genetics 96: 627-637, November, 1980

Regulatory genes controlling mitosis in theFission Yeast Schizosaccharomyces pombePaul Nurse and Pierre Thuriaux

Page 10: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Genetics 96: 627-637, November, 1980

Page 11: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Gene required in G1 for commitment tocell cycle and in G2for control of mitosis in fission yeastPaul Nurse & Yvonne Bissett

Nature, Vol, 292, No. 5823, pp. 558-560, August 6, 1981

cdc2

cdc25cdc10

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Page 13: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Molecular characterisation of the CDK cdc2 protein kinase

Sussex, Biology 1980-1984ICRF, LIF London 1984-1988Oxford, Biochemistry 1988-1993

David Beach Sergio MorenoBarbara Durkacz Paul RussellKathy Gould Viesturs SimanisJacky Hayles

Page 14: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

High-frequency transformationof the fission yeastSchizosaccharomyces pombe

David Beach & Paul Nurse

Nature, Vol, 290, No. 5802, pp. 140-142, March 12, 1981 Nature, Vol, 300, No. 5894, pp. 706-709, December 22/30, 1982

Functionally homologous cell cycleControl genes in buddingand fission yeast

David Beach, Barbara Durkacz & Paul Nurse

Page 15: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 45: 261-268, April 25, 1986 Cell, Vol. 58: 361-372, July 28, 1989

Sergio Moreno

Page 16: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 45: 145-153, April 11, 1986

Cell, Vol. 49: 559-567, May 22, 1987

Paul Russell

Page 17: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Nature, Vol, 342, No. 6245, pp. 39-45, November 2, 1989

Kathy Gould

Page 18: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Journal of Cell Science, Vol, 91, 587-595, August 23, 1988

Iain Hagan

Page 19: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 20: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cdc2 conserved in humans, starfish and frogs

ICRF, LIF London 1984-1988Oxford, Biochemistry 1988-1993

Marcel Doree Melanie LeeIain Hagan Jim MallerJacky Hayles Chris Norbury

Page 21: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Nature, Vol, 327, No. 6117, pp. 31-35, May 7, 1987

Melanie Lee

Page 22: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 23: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 24: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 25: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 54: 433-439, July 29, 1988

Chris Norbury

Page 26: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Yoshio Masui

Page 27: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Jim Maller

Western

IP

Page 28: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 57: 253-263, April 21, 1989

Nature, Vol, 335, No. 6187, pp. 251-254, September 15, 1988

Marcel Doree

Page 29: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Nature, Vol, 344, No. 6266, pp. 503-508, April 5, 1990

Page 30: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
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Oxford, Biochemistry 1988-1993ICRF, LIF London 1993-2001

Further roles for cdc2

Tamar Enoch Jacky HaylesDaniel Brock Sergio Morenó

Page 33: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 34: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 60: 665-673, February 23, 1990

Tamar Enoch

Page 35: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

The EMBO Journal Vol 15, pp.850-860, 1996,

A single fission yeast mitotic cyclin B p34cdc2 kinasepromotes both S- phase and mitosis in the absence ofG1 cyclins

D.L.Fisher and P.Nurse Cell Cycle Laboratory, Imperial Cancer Research Fund, London, UK.

Page 36: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles
Page 37: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Jacky Hayles

Page 38: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles

Cell, Vol. 78: 813-822, September 9, 1994

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1. CDKs and cell cycle events 4. Cell cycle and development

2. Checkpoints 5. Cell cycle molecular machines

3. Meiotic cell cycles 6. Spatial and temporal organisation

Cell, Vol. 100: 71-78, January 7, 2000

Page 42: Cell Cycle Controlsuper7/23011-24001/23561.pdf · 1. CDKs and cell cycle events 4. Cell cycle and development 2. Checkpoints 5. Cell cycle molecular machines 3. Meiotic cell cycles